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Review

Management of bacterial skin and skin structure infections with polymicrobial etiology

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Pages 17-25 | Received 27 Sep 2018, Accepted 22 Nov 2018, Published online: 07 Dec 2018

References

  • Miller LG, Eisenberg DF, Liu H, et al. Incidence of skin and soft tissue infections in ambulatory and inpatient settings, 2005–2010. BMC Infect Dis. 2015;15:362.
  • Esposito S, De Simone G. Update on the main MDR pathogens: prevalence and treatment options. Infez Med. 2017;25:301–310.
  • Swartz MN. Clinical practice. Cellulitis. N Engl J Med. 2004;350:904–912.
  • Esposito S, Leone S, Noviello S, et al. Antibiotic resistance in long-term care facilities. New Microbiol. 2007;30:326–331.
  • Henig O, Cober E, Richter SS, et al. A prospective observational study of the epidemiology, management, and outcomes of skin and soft tissue infections due to carbapenem-resistant enterobacteriaceae. Open Forum Infect Dis. 2017;4:ofx157.
  • Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59:147–159.
  • Corey GR, Wilcox MH, Talbot GH, et al. CANVAS 1: the first phase III, randomized, double-blind study evaluated ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. J Antimicrob Chemother. 2010;65(4):41–51.
  • Esposito S, Leone S, Petta E, et al. Skin and soft tissue infections: classification and epidemiology. Infez Med. 2009;17(Suppl 4):6–17.
  • Esposito S, Noviello S, De Caro F, et al. New insights into classification, epidemiology and microbiology of SSTIs, including diabetic foot infections. Infez Med. 2018;26:3–14.
  • Bakker K, Apelqvist J, Lipsky BA, et al. The 2015 IWGDF guidance documents on prevention and management of foot problems in diabetes: development of an evidence‐based global consensus. Diabetes Metab Res Rev. 2016;32:2–6.
  • Lipsky BA, Silverman MH, Joseph WS. A proposed new classification of skin and soft tissue infections modelled on the subset of diabetic foot infection. Open Forum Infect Dis. 2017;4:ofw255.
  • US Food and Drug Administration. Guidance for industry. Acute bacterial skin and skin structure infections: developing drugs for treatment. Silver Spring (MD): US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER); 2013.
  • Bisno AL, Stevens DL. Streptococcal infections of skin and soft tissues. N Engl J Med. 1996;334:240–245.
  • Santagati M, Noviello S, Iannelli F, et al. Macrolide-resistance genes in clinical isolates of Streptococcus pyogenes. Microbial Drug Resist. 2002;8:229–232.
  • Dryden MS. Complicated skin and soft tissue infection. J Antimicrob Chemother. 2010;65(Suppl 3):35–44.
  • Dunyach-Remy C, Ngba Essebe C, Sotto A, et al. Staphylococcus aureus toxins and diabetic foot ulcers: role in pathogenesis and interest in diagnosis. Toxins (Basel). 2016;8:209.
  • Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355:666–674.
  • Arakaki RY, Strazzula L, Woo E, et al. The impact of dermatology consultation on diagnostic accuracy and antibiotic use among patients with suspected cellulitis seen at outpatient internal medicine offices: a randomized clinical trial. JAMA Dermatol. 2014;150:1056–1061.
  • Ballus J, Lopez-Delgado JC, Sabater-Riera J, et al. Surgical site infection in critically ill patients with secondary and tertiary peritonitis: epidemiology, microbiology and influence in outcomes. BMC Infect Dis. 2015;15:304.
  • Micozzi A, Venditti M, Monaco M, et al. Bacteremia due to Stenotrophomonas maltophilia in patients with hematologic malignancies. Clin Infect Dis. 2000;31:705–711.
  • Bodey GP. Unusual presentations of infection in neutropenic patients. Int J Antimicrob Agents. 2000;16:93–95.
  • Esposito S, Bassetti M, Borre’ S, et al. Diagnosis and management of skin and soft-tissue infections (SSTI): a literature review and consensus statement on behalf of the Italian Society of Infectious Diseases and International Society of Chemotherapy. J Chemother. 2011;23:251–262.
  • Deveci O, Dal T, Tekin R, et al. Carbapenem resistance in Acinetobacter baumannii: where is it heading? Infez Med. 2013;21:211–215.
  • Sarani B, Strong M, Pascual J, et al. Necrotizing fasciitis: current concepts and review of the literature. J Am Coll Surg. 2009;208:279–288.
  • Brook I. Microbiology and management of soft tissue and muscle infections. Int J Surg. 2008;6:328–338.
  • Esposito S, Leone S, Noviello S, et al. Foot infections in diabetes (DFIs) in the out-patient setting: an Italian multicentre observational survey. Diabet Med. 2008;25:979–984. 23.
  • Esposito S, Russo E, Noviello S, et al. Management of diabetic foot infections. Infez Med. 2012;20(Suppl 1):28–34.
  • Linder KE, Nicolau DP, Nailor MD. Epidemiology, treatment, and economics of patients presenting to the emergency department for skin and soft tissue infections. Hosp Pract. 2017;45:9–15.
  • Esposito S, De Simone G, Gioia R, et al. Deep tissue biopsy vs. superficial swab culture, including microbial loading determination, in the microbiological assessment of Skin and Soft Tissue Infections (SSTIs). J Chemother. 2017;29:154–158.
  • White-Chu EF, Flock P, Struck B, et al. Pressure ulcers in long-term care. Clin Geriatr Med. 2011;27:241–258.
  • White BAB, Dea N, Street JT, et al. The economic burden of urinary tract infection and pressure ulceration in acute traumatic spinal cord injury admissions: evidence for comparative economics and decision analytics from a matched case-control study. J Neurotrauma. 2017;34:20,2892–2900.
  • Jugun K, Richard JC, Lipsky BA, et al. Factors associated with treatment failure of infected pressure sores. Ann Surg. 2016;264:399–403.
  • Dana AN, Bauman WA. Bacteriology of pressure ulcers in individuals with spinal cord injury: what we know and what we should know. J Spinal Cord Med. 2015;38:147–160.
  • Braga IA, Pirett CC, Ribas RM, et al. Bacterial colonization of pressure ulcers: assessment of risk for bloodstream infection and impact on patient outcomes. J Hosp Infect. 2013;83:314–320.
  • Arzt H, Fromantin I, Ribinik P, et al. Which medical device and/or which local treatment are to be used, as of 2012, in patients with infected pressure sore? Developing French guidelines for clinical practice. Ann Phys Rehabil Med. 2012;55:498–507.
  • Dinh A, Bouchand F, Davido B, et al. Management of established pressure ulcer infections in spinal cord injury patients. Med Mal Infect. 2018.21. pii:so399.077x(17)30728-X. doi:10.1016/j.medmal.2018.05.004.
  • Barwell ND, Devers MC, Kennon B, et al. Diabetic foot infection: antibiotic therapy and good practice recommendations. Int J Clin Pract. 2017;71:e13006.
  • Jia L, Parker CN, Parker TJ, et al. Incidence and risk factors for developing infection in patients presenting with uninfected diabetic foot ulcers. PLOS ONE. 2017;12:e0177916.
  • White R, McIntosh C. Topical therapies for diabetic foot ulcers. J Wound Care. 2008;426:428–432.
  • Hex N, Bartlett C, Wright D, et al. Estimating the current and future costs of Type 1 and Type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs. Diabet Med. 2013;29:855–862.
  • Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:e132–E173.
  • Abbas M, Uçkay I, Lipsky A. In diabetic foot infections antibiotics are to treat infection, not to heal wounds. Expert Opin Phamacother. 2015;16:821–832.
  • Lipsky BA, Aragón-Sánchez J, Diggle M, et al. IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes. Diabetes Metab Res Rev. 2016;32(Suppl 1):45–74.
  • Jääskeläinen IH, Hagberg L, Forsblom E, et al. Microbiological etiology and treatment of complicated skin and skin structure infections in diabetic and nondiabetic patients in a population-based study. Open Forum Infect Dis. 2017;4:ofx044.
  • Saltoglu N, Ergonul O, Yemisen M, et al. Influence of multidrug resistant organisms on the outcome of diabetic foot infection. Int J Infect Dis. 2018;70:10–14.
  • Peters EJ. Pitfalls in diagnosing diabetic foot infections. Diabetes Metab Res Rev. 2016;32:254–260.
  • Kirsner R, Vivas A. Lower-extremity ulcers: diagnosis and management. Br J Dermatol. 2015;173:379–390.
  • Elmarsafi T, Kumar A, Cooper PS, et al. Concordance between bone pathology and bone culture for the diagnosis of osteomyelitis in the presence of charcot neuro-osteoarthropathy. J Foot Ankle Surg. 2018;57:919–923.
  • Spichler A, Hurwitz BL, Armstrong DG, et al. Microbiology of diabetic foot infections: from Louis Pasteur to ‘crime scene investigation’. BMC Med. 2015;13:2.
  • Gardner SE, Hillis SL, Heilmann K, et al. The neuropathic diabetic foot ulcer microbiome is associated with clinical factors. Diabetes. 2013;62(3):923–930.
  • Tiwari S, Pratyush D, Dwivedi A, et al. Microbiological and clinical characteristics of diabetic foot infection in northern India. J Infect Dev Ctries. 2012;6:329–332.
  • Jneid J, Cassir N, Schuldiner S, et al. Exploring the microbiota of diabetic foot infections with culturomics. Front Cell Infect Microbiol. 2018;8:282.
  • Ertugrul BM, Lipsky BA, Ture M, et al. Risk factors for infection with pseudomonas aeruginosa in diabetic foot infections. J Am Podiatr Med Assoc. 2017;107:483–489.
  • Torrence GM, Schmidt BM. Fungal osteomyelitis in diabetic foot infections: a case series and comparative analysis. Int J Low Extrem Wounds. 2018;17:184–189.
  • Church D, Elsayed S, Reid O, et al. Burn wound infections. Clin Microbiol Rev. 2006;19:403–434.
  • Batac JN, Simpson RL, Sinnott CJ, et al. Incidence of cellulitis in lower extremity burns: 6-year analysis. Ann Plast Surg. 2018;80(Suppl 4):S140–S143.
  • Wanis M, Walker SA, Daneman N, et al. Impact of hospital length of stay on the distribution of Gram negative bacteria and likelihood of isolating a resistant organism in a Canadian burn center. Burns. 2016;42:104–111.
  • Sarabahi S, Tiwari VK, Arora S, et al. Changing patterns of fungal infections in burn patients. Burns. 2012;38:520–528.
  • Taneja N, Chari P, Singh M, et al. Evolution of bacterial flora in burn wounds: key role of environmental disinfection in control of infection. Int J Burns Trauma. 2013;3:102–107.
  • Jeschke MG, Finnerty CC, Kulp GA, et al. Can we use C-reactive protein levels to predict severe infection or sepsis in severely burned patients? Int J Burns Trauma. 2013;3:137–143.
  • Lavrentieva A, Kontakiotis T, Lazaridis L, et al. Inflammatory markers in patients with severe burn injury. What is the best indicator of sepsis? Burns. 2007;33:189–194.
  • Halstead FD, Lee KC, Kwei J, et al. A systematic review of quantitative burn wound microbiology in the management of burns patients. Burns. 2018;44:39–56.
  • Owlia P, Azimi L, Gholami A, et al. ESBL- and MBL-mediated resistance in Acinetobacter baumannii: a global threat to burn patients. Infez Med. 2012;20:182–187.
  • Shams A, Milad S, Nikokar I, et al. Epidemiology of Panton-Valentine Leukocidin harbouring Staphylococcus aureus in cutaneous infections from Iran: a systematic review and meta-analysis. Infez Med. 2017;25:217–223.
  • Lachiewicz AM, Hauck CG, Weber DJ, et al. Bacterial infections after burn injuries: impact of multidrug resistance. Clin Infect Dis. 2017;65:2130–2136.
  • Issler-Fisher AC, McKew G, Fisher OM, et al. Risk factors for, and the effect of MRSA colonization on the clinical outcomes of severely burnt patients. Burns. 2015;41:1212–1220.
  • Leone S, Noviello S, Boccia G, et al. Methicillin-resistant Staphylococcus aureus infections: role of daptomycin/β-lactams combination. Infez Med. 2015;23:99–104.
  • Altoparlak U, Koca O, Ozkurt Z. Incidence and risk factors of vancomycin-resistant enterococcus colonization in burn unit patients. Burns. 2011;37:49–53.
  • Posluszny JA, Conrad P, Halerz M, et al. Surgical burn wound infections and their clinical implications. J Burn Care Res. 2011;32:324–333.
  • Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34:1249–1257.
  • Frank C, Bayoumi I, Westendorp C. Approach to infected skin ulcers. Can Fam Physician. 2005;51:1352–1359.
  • Lawall H. Treatment of chronic wounds. Vasa. 2012;41:396–409.
  • Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–1053.
  • Powell FC, Schroeter AL, Su WP, et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med. 2004;55:173–186.
  • Firnhaber JM. Diagnosis and treatment of basal cell and squamous cell carcinoma. Am Fam Physician. 2012;86:161–168.
  • Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376:2367–2375.
  • Di Domenico EG, Farulla I, Prignano G, et al. Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. Int J Mol Sci. 2017;18:1077.
  • Ramsey MM, Freire MO, Gabrilska RA, et al. Staphylococcus aureus shifts toward commensalism in response to Corynebacterium Species. Front Microbiol. 2016;7:1230.
  • Boldock E, Surewaard BGJ, Shamarina D, et al. Human skin commensals augment Staphylococcus aureus pathogenesis. Nat Microbiol. 2018;3:881–890.
  • Serra R, Grande R, Butrico L, et al. Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus. Expert Rev Anti Infect Ther. 2015;13:605–613.
  • Pereira SG, Moura J, Carvalho E, et al. Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies. Front Microbiol. 2017;8:1791.
  • Pineda C, Espinosa R, Pena A. Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging, and scintigraphy. Semin Plast Surg. 2009;23:80–89.
  • Bassetti M, Baguneid M, Bouza E, et al. European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid. Clin Microbiol Infect. 2014;20(Suppl 4):3–18.
  • Garau J, Ostermann H, Medina J, et al. Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010–2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study. Clin Microbiol Infect. 2013;19:E377–E385.
  • Burnham JP, Kollef MH. Treatment of severe skin and soft tissue infections: a review. Curr Opin Infect Dis. 2018;31:113–119.
  • Jones ME, Karlowsky JA, Draghi DC, et al. Epidemiology and antibiotic susceptibility of bacteria causing skin and soft tissue infections in the USA and Europe: a guide to appropriate antimicrobial therapy. Int J Antimicrob Agents. 2003;22:406–419.
  • Jaaskelainen IH, Hagberg L, Forsblom E, et al. Factors associated with time to clinical stability in complicated skin and skin structure infections. Clin Microbiol Infect. 2017;23:674.e1–674.e5.
  • Changchien C-H, Chen S-W, Chen -Y-Y, et al. Antibiotic susceptibility and genomic variations in Staphylococcus aureus associated with Skin and Soft Tissue Infection (SSTI) disease groups. BMC Infect Dis. 2016;16:276.
  • Raphael E, Riley LW. Infections caused by antimicrobial drug-resistant saprophytic Gram-negative bacteria in the environment. Front Med. 2017;4:183.
  • Esposito S, Bassetti M, Concia E, et al. Diagnosis and management of skin and soft-tissue infections (SSTI). A literature review and consensus statement: an update. J. Chemother. 2017;29:197–214.
  • Pressure ulcers: prevention and management. National Institute for Health and Care Excellence. Published date: April 2014.
  • Mosier MJ, Gibran NS. Surgical excision of the burn wound. Clin Plast Surg. 2009;36:617–625.
  • Williamson DA, Carter GP, Howden BP. Current and emerging topical antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev. 2017;30:827–860.
  • Norman G, Dumville JC, Moore ZE, et al. Antibiotics and antisepsis for pressure ulcers. Cochrane Database Syst Rev. 2016 Apr 4;4:CD011586.

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