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Editorial

How can we improve uptake of oral HIV pre-exposure prophylaxis for transgender individuals?

ORCID Icon, ORCID Icon & ORCID Icon
Pages 835-838 | Received 24 Jan 2020, Accepted 20 Apr 2020, Published online: 05 May 2020

References

  • Baral SD, Poteat T, Stromdahl S, et al. Worldwide burden of HIV in transgender women: a systematic review and meta-analysis. Lancet Infect Dis. 2013 Mar;13(3):214–222. Epub 2012 Dec 21. Review.
  • Becasen JS, Denard CL, Mullins MM, et al. Estimating the prevalence of HIV and sexual behaviors among the US transgender population: a systematic review and meta-analysis, 2006–2017. Am J Public Health. 2018 Nov 29;109(1):e1–e8.
  • Clark H, Babu AS, Wiewel EW, et al. Diagnosed HIV infection in transgender adults and adolescents: results from the National HIV Surveillance System, 2009–2014. AIDS Behav. 2017 Sep;21(9):2774–2783.
  • Rowniak S, Chesla C, Rose CD, et al. Transmen: the HIV risk of gay identity. AIDS Educ Prev. 2011 Dec;23(6):508–520.
  • Scheim AI, Bauer GR, Travers R. HIV-related sexual risk among transgender men who are gay, bisexual, or have sex with men. J Acquired Immune Deficiency Syndromes. 2017 Apr 1;74(4):e89–e96.
  • Sevelius J. “There’s no pamphlet for the kind of sex I have”: HIV-related risk factors and protective behaviors among transgender men who have sex with nontransgender men. J Assoc Nurses AIDS Care. 2009 Sep-Oct;20(5):398–410.
  • Stephens SC, Bernstein KT, Philip SS. Male to female and female to male transgender persons have different sexual risk behaviors yet similar rates of STDs and HIV. AIDS Behav. 2011 Apr;15(3):683–686.
  • Wansom T, Guadamuz TE, Vasan S. Transgender populations and HIV: unique risks, challenges and opportunities. J Virus Erad. 2016 Apr 1;2(2):87–93.
  • (WHO) WHO. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. September 2015 [cited 2015 Nov 3]. Available from: http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf
  • Castillo R, Konda KA, Leon SR, et al. HIV and sexually transmitted infection incidence and associated risk factors among high-risk MSM and male-to-female transgender women in Lima, Peru. J Acquired Immune Deficiency Syndromes. 2015 Aug 15;69(5):567–575.
  • Dos Ramos Farias MS, Garcia MN, Reynaga E, et al. First report on sexually transmitted infections among trans (male to female transvestites, transsexuals, or transgender) and male sex workers in Argentina: high HIV, HPV, HBV, and syphilis prevalence. Int J Infect Dis. 2011 Sep;15(9):e635–40.
  • Buchbinder SP, Glidden DV, Liu AY, et al. HIV pre-exposure prophylaxis in men who have sex with men and transgender women: a secondary analysis of a phase 3 randomised controlled efficacy trial. Lancet Infect Dis. 2014 Jun;14(6):468–475.
  • Kimani M, van der Elst EM, Chiro O, et al. PrEP interest and HIV-1 incidence among MSM and transgender women in coastal Kenya. J Int AIDS Soc. 2019 Jun;22(6):e25323.
  • Poteat T, Wirtz A, Malik M, et al. A gap between willingness and uptake: findings from mixed methods research on HIV prevention among Black and Latina transgender women. J Acquired Immune Deficiency Syndromes. 2019 Oct 1;82(2):131–140.
  • Holder CL, Perez-Gilbe HR, Fajardo FJ, et al. Disparities of HIV risk and PrEP use among transgender women of color in South Florida. J Natl Med Assoc. 2019 Dec;111(6):625–632.
  • Hood JE, Eljallad T, Abad J, et al. Getting pre-exposure prophylaxis to high-risk transgender women: lessons from Detroit, USA. Sex Health. 2018 Nov;15(6):562–569.
  • Reisner SL, Jadwin-Cakmak L, White Hughto JM, et al. Characterizing the HIV prevention and care continua in a sample of transgender youth in the U.S. AIDS Behav. 2017 Dec;21(12):3312–3327.
  • Kuhns LM, Reisner SL, Mimiaga MJ, et al. Correlates of PrEP indication in a multi-site cohort of young HIV-uninfected transgender women. AIDS Behav. 2016 Jul;20(7):1470–1477.
  • Wilson EC, Jin H, Liu A, et al. Knowledge, indications and willingness to take pre-exposure prophylaxis among transwomen in San Francisco, 2013. PLoS One. 2015;10(6):e0128971.
  • Oldenburg CE, Le B, Toan T, et al. HIV pre-exposure prophylaxis indication and readiness among HIV-uninfected transgender women in Ho Chi Minh City, Vietnam. AIDS Behav. 2016 Dec;20(Suppl 3):365–370.
  • Pacifico de Carvalho N, Mendicino CCP, Candido RCF, et al. HIV pre-exposure prophylaxis (PrEP) awareness and acceptability among trans women: a review. AIDS Care. 2019 Oct;31(10):1234–1240.
  • Sevelius JM, Keatley J, Calma N, et al. ‘I am not a man’: trans-specific barriers and facilitators to PrEP acceptability among transgender women. Glob Public Health. 2016 Aug-Sep;11(7-8):1060–75.
  • Wood S, Gross R, Shea JA, et al. Barriers and facilitators of PrEP adherence for young men and transgender women of color. AIDS Behav. 2019 Oct;23(10):2719–2729.
  • Reisner SL, Moore CS, Asquith A, et al. High risk and low uptake of pre-exposure prophylaxis to prevent HIV acquisition in a national online sample of transgender men who have sex with men in the United States. J Int AIDS Soc. 2019 Sep;22(9):e25391.
  • Golub SA, Fikslin RA, Starbuck L, et al. High rates of PrEP eligibility but low rates of PrEP access among a national sample of transmasculine individuals. J Acquired Immune Deficiency Syndromes. 2019 Sep 1;82(1):e1–e7.
  • Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–2599.
  • Deutsch MB, Glidden DV, Sevelius J, et al. HIV pre-exposure prophylaxis in transgender women: a subgroup analysis of the iPrEx trial. Lancet HIV. 2015 Dec;2(12):e512–9. Epub 2015 Nov 6.PMID: 26614965.
  • Mehrotra ML, Westreich D, McMahan VM, et al. Baseline characteristics explain differences in effectiveness of randomization to daily oral TDF/FTC PrEP between transgender women and cisgender men who have sex with men in the iPrEx trial. J Acquired Immune Deficiency Syndromes. 2019 Jul 1;81(3):e94–e98.
  • Grant RM, Anderson PL, McMahan V, et al. Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis. 2014 Sep;14(9):820–829.
  • Shieh E, Marzinke MA, Fuchs EJ, et al. Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men. J Int AIDS Soc. 2019 Nov;22(11):e25405.
  • Hiransuthikul A, Janamnuaysook R, Himmad K, et al. Drug-drug interactions between feminizing hormone therapy and pre-exposure prophylaxis among transgender women: the iFACT study. J Int AIDS Soc. 2019 Jul;22(7):e25338.
  • Wilson EC, Jalil EM, Castro C, et al. Barriers and facilitators to PrEP for transwomen in Brazil. Glob Public Health. 2018;7:1–9.
  • Rowniak S, Ong-Flaherty C, Selix N, et al. Attitudes, beliefs, and barriers to PrEP among trans men. AIDS Educ Prev. 2017 Aug;29(4):302–314.
  • Veloso VG, Mesquita F, Grinsztejn B. Pre-exposure prophylaxis for men and transgender women who have sex with men in Brazil: opportunities and challenges. J Int AIDS Soc. 2015;18(4 Suppl 3):20010.
  • Jalil EM, Grinsztejn B, Velasque L, et al. Awareness, willingness, and PrEP eligibility among transgender women in Rio de Janeiro, Brazil. J Acquired Immune Deficiency Syndromes. 2018 Dec 1;79(4):445–452.
  • Rael CT, Martinez M, Giguere R, et al. Barriers and facilitators to oral PrEP use among transgender women in New York City. AIDS Behav. 2018 Nov;22(11):3627–3636.
  • Cahill SR, Keatley J, Wade Taylor S, et al. “Some of us, we don’t know where we’re going to be tomorrow.” Contextual factors affecting PrEP use and adherence among a diverse sample of transgender women in San Francisco. AIDS Care. 2020 May;32(5):585–593.
  • Chakrapani V, Shunmugam M, Rawat S, et al. Acceptability of HIV pre-exposure prophylaxis among transgender women in India: a qualitative investigation. AIDS Patient Care STDS. 2020 Jan 17;34(2):92–98.
  • Yang D, Chariyalertsak C, Wongthanee A, et al. Acceptability of pre-exposure prophylaxis among men who have sex with men and transgender women in Northern Thailand. PLoS One. 2013;8(10):e76650.
  • Silva-Santisteban A, Eng S, de la Iglesia G, et al. HIV prevention among transgender women in Latin America: implementation, gaps and challenges. J Int AIDS Soc. 2016;19(3 Suppl 2):20799.
  • Seekaew P, Pengnonyang S, Jantarapakde J, et al. Discordance between self-perceived and actual risk of HIV infection among men who have sex with men and transgender women in Thailand: a cross-sectional assessment. J Int AIDS Soc. 2019 Dec;22(12):e25430.
  • Mustanski B, Ryan DT, Hayford C, et al. Geographic and individual associations with PrEP stigma: results from the RADAR cohort of diverse young men who have sex with men and transgender women. AIDS Behav. 2018 Sep;22(9):3044–3056.
  • Horvath KJ, Todd K, Arayasirikul S, et al. Underutilization of pre-exposure prophylaxis services among transgender and nonbinary youth: findings from project moxie and techstep. Transgend Health. 2019;4(1):217–221.
  • Pitasi MA, Oraka E, Clark H, et al. HIV testing among transgender women and men - 27 states and Guam, 2014–2015. MMWR Morb Mortal Wkly Rep. 2017 Aug 25;66(33):883–887.
  • Phillips G 2nd, Raman AB, Felt D, et al. PrEP4Love: the role of messaging and prevention advocacy in PrEP attitudes, perceptions, and uptake among YMSM and transgender women. J Acquired Immune Deficiency Syndromes. 2020 Apr 15;83(5):450–456.
  • McMahan VM, Martin A, Garske L, et al. Development of a targeted educational intervention to increase pre-exposure prophylaxis uptake among cisgender men and transgender individuals who have sex with men and use methamphetamine in Seattle (WA, USA). Sex Health. 2019 Apr;16(2):139–147.
  • Reback CJ, Clark KA, Runger D, et al. A promising PrEP navigation intervention for transgender women and men who have sex with men experiencing multiple syndemic health disparities. J Community Health. 2019 Dec;44(6):1193–1203.
  • Longino A, Montano MA, Sanchez H, et al. Increasing PrEP uptake and adherence among MSM and TW sex workers in Lima, Peru: what and whom do different patients trust? AIDS Care. 2020 Feb;32(2):255–260.
  • Restar AJ, Kuhns L, Reisner SL, et al. Acceptability of antiretroviral pre-exposure prophylaxis from a cohort of sexually experienced young transgender women in two U.S. cities. AIDS Behav. 2018 Nov;22(11):3649–3657.
  • Sevelius J, Murray LR, Martinez Fernandes N, et al. Optimising HIV programming for transgender women in Brazil. Cult Health Sex. 2019 May;21(5):543–558.
  • Klein A, Golub SA. Increasing access to pre-exposure prophylaxis among transgender women and transfeminine nonbinary individuals. AIDS Patient Care STDS. 2019 Jun;33(6):262–269.
  • Escudero DJ, Kerr T, Operario D, et al. Inclusion of trans women in pre-exposure prophylaxis trials: a review. AIDS Care. 2015;27(5):637–641.
  • Rael CT, Martinez M, Giguere R, et al. Transgender women’s concerns and preferences on potential future long-acting biomedical HIV prevention strategies: the case of injections and implanted medication delivery devices (IMDDs). AIDS Behav. 2019 Oct 25. DOI:10.1007/s10461-019-02703-554
  • Coelho LE, Torres TS, Veloso VG, et al. Pre-exposure prophylaxis 2.0: new drugs and technologies in the pipeline. Lancet HIV. 2019 Nov 6;(11):e788–e799. DOI:10.1016/S2352-3018(19)30238-3

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