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Review

The democratization of de-labeling: a review of direct oral challenge in adults with low-risk penicillin allergy

ORCID Icon, ORCID Icon &
Pages 1143-1153 | Received 17 May 2020, Accepted 03 Jul 2020, Published online: 19 Jul 2020

References

  • Trubiano JA, Chen C, Cheng AC, et al. Antimicrobial allergy ‘labels’ drive inappropriate antimicrobial prescribing: lessons for stewardship. J Antimicrob Chemother. 2016;71(6):1715–1722.
  • Knezevic B, Sprigg D, Seet J, et al. The revolving door: antibiotic allergy labelling in a tertiary care centre: antibiotic allergy labelling. Intern Med J. 2016;46(11):1276–1283.
  • Lee CE, Zembower TR, Fotis MA, et al. The incidence of antimicrobial allergies in hospitalized patients: implications regarding prescribing patterns and emerging bacterial resistance. Arch Internal Med. 2000;160(18):2819.
  • Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin “allergy” in hospitalized patients: a cohort study. J Allergy Clin Immunol. 2014 Mar;133(3):790–796.
  • Unger NR, Gauthier TP, Cheung LW. Penicillin skin testing: potential implications for antimicrobial Stewardship. Pharmacother J Human Pharmacol Drug Ther. 2013;33(8):856–867.
  • Trubiano JA, Cairns KA, Evans JA, et al. The prevalence and impact of antimicrobial allergies and adverse drug reactions at an Australian tertiary centre. BMC Infect Dis. 2015;15(1):572.
  • Charneski L, Deshpande G, Smith SW. Impact of an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. Pharmacotherapy. 2011;31(8):742–747.
  • Huang KG, Cluzet V, Hamilton K, et al. The impact of reported beta-lactam allergy in hospitalized patients with hematologic malignancies requiring antibiotics. Clin Infect Dis. 2018 Jun 18;67(1):27–33.
  • Trubiano JA, Leung VK, Chu MY, et al. The impact of antimicrobial allergy labels on antimicrobial usage in cancer patients. Antimicrob Resist Infect Control. 2015;4:23.
  • van Dijk SM, Gardarsdottir H, Wassenberg MWM, et al. The high impact of penicillin allergy registration in hospitalized patients. J Allergy Clin Immunol. 2016;4(5):926–931.
  • Conway EL, Lin K, Sellick JA, et al. Impact of penicillin allergy on time to first dose of antimicrobial therapy and clinical outcomes. Clin Ther. 2017;39(11):2276–2283.
  • Picard M, Bégin P, Bouchard H, et al. Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital. J Allergy Clin Immunol. 2013;1(3):252–257.
  • Trubiano JA, Pai Mangalore R, Baey YW, et al. Old but not forgotten: antibiotic allergies in general medicine (the AGM study). Med J Aust. 2016;204(7):273.
  • Lutomski DM, LaFollette JA, Biaglow MA, et al. Antibiotic allergies in the medical record: effect on drug selection and assessment of validity. Pharmacotherapy. 2008;28(11):1348–1353.
  • Blumenthal KG, Lu N, Zhang Y, et al. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018;k2400. DOI:10.1136/bmj.k2400
  • Hui-Chih Wu J, Langford BJ, Schwartz KL, et al. Potential negative effects of antimicrobial allergy labelling on patient care: a systematic review. Can J Hosp Pharm. 2018;71(1). DOI:10.4212/cjhp.v71i1.1726
  • Trubiano JA, Thursky KA, Stewardson AJ, et al. Impact of an integrated antibiotic allergy testing program on antimicrobial Stewardship: a multicenter evaluation. Clin Infect Dis. 2017 Jul 1;65(1):166–174.
  • Bourke J, Pavlos R, James I, et al. Improving the effectiveness of penicillin allergy de-labeling. J Allergy Clin Immunol Pract. 2015 May-Jun;3(3):365–34 e1.
  • Barlam TF, Cosgrove SE, Abbo LM, et al. Implementing an antibiotic Stewardship program: guidelines by the infectious diseases society of America and the society for healthcare epidemiology of America. Clin Infect Dis. 2016;62(10):e51–e77.
  • Trubiano JA, Worth LJ, Urbancic K, et al. Return to sender: the need to re-address patient antibiotic allergy labels in Australia and New Zealand: a survey of antibiotic allergy practices. Intern Med J. 2016;46(11):1311–1317.
  • Trubiano JA, Beekmann SE, Worth LJ, et al. Improving antimicrobial stewardship by antibiotic allergy delabeling: evaluation of knowledge, attitude, and practices throughout the emerging infections network. Open Forum Infect Dis. 2016;3(3):ofw153.
  • Trubiano J, Phillips E. Antimicrobial stewardship’s new weapon? A review of antibiotic allergy and pathways to ‘de-labeling’. Curr Opin Infect Dis. 2013;26(6):526–537.
  • Chen JR, Khan DA. Evaluation of penicillin allergy in the hospitalized patient: opportunities for antimicrobial Stewardship. Curr Allergy Asthma Rep. 2017;17(6):40.
  • Blumenthal KG, Peter JG, Trubiano JA, et al. Antibiotic allergy. Lancet. 2019;393(10167):183–198.
  • Bland CM, Bookstaver PB, Griffith NC, et al. A practical guide for pharmacists to successfully implement penicillin allergy skin testing. Am J Health Syst Pharm. 2019;76(3):136–147.
  • Devchand M, Kirkpatrick CMJ, Stevenson W, et al. Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention. J Antimicrob Chemother. 2019;74(6):1725–1730.
  • Du Plessis T, Walls G, Jordan A, et al. Implementation of a pharmacist-led penicillin allergy de-labelling service in a public hospital. J Antimicrob Chemother. 2019 May 1;74(5):1438–1446.
  • Caubet J-C, Kaiser L, Lemaître B, et al. The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge. J Allergy Clin Immunol. 2011;127(1):218–222.
  • Mill C, Primeau MN, Medoff E, et al. Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and nonimmediate reactions to amoxicillin in children. JAMA Pediatr. 2016 Jun 6;170(6):e160033.
  • Blumenthal KG, Shenoy ES, Wolfson AR, et al. Addressing inpatient beta-lactam allergies: a multihospital implementation. J Allergy Clin Immunol. 2017;5(3):616–625.e7.
  • Demoly P, Adkinson NF, Brockow K, et al. International consensus on drug allergy. Allergy. 2014;69(4):420–437.
  • Romano A, Warrington R. Antibiotic allergy. Immunol Allergy Clin North Am. 2014;34(3):489–506.
  • Vezir E, Dibek Misirlioglu E, Civelek E, et al. Direct oral provocation tests in non-immediate mild cutaneous reactions related to beta-lactam antibiotics. Pediatr Allergy Immunol. 2016 Feb;27(1):50–54.
  • Confino-Cohen R, Rosman Y, Meir-Shafrir K, et al. Oral challenge without skin testing safely excludes clinically significant delayed-onset penicillin hypersensitivity. J Allergy Clin Immunol Pract. 2017 May - Jun;5(3):669–675.
  • Tucker MH, Lomas CM, Ramchandar N, et al. Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits. J Allergy Clin Immunol Pract. 2017 May - Jun;5(3):813–815.
  • Banks TA, Tucker M, Macy E. Evaluating penicillin allergies without skin testing. Curr Allergy Asthma Rep. 2019 Mar 22;19(5):27.
  • Kuruvilla M, Shih J, Patel K, et al. Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy. Allergy Asthma Proc. 2019 Jan 1;40(1):57–61.
  • Stevenson B, Trevenen M, Klinken E, et al. Multicenter Australian study to determine criteria for low- and high-risk penicillin testing in outpatients. J Allergy Clin Immunol Pract. 2020 Feb;8(2):681–689 e3.
  • Iammatteo M, Alvarez Arango S, Ferastraoaru D, et al. Safety and outcomes of oral graded challenges to amoxicillin without prior skin testing. J Allergy Clin Immunol Pract. 2019 Jan;7(1):236–243.
  • Mustafa SS, Conn K, Ramsey A. Comparing direct challenge to penicillin skin testing for the outpatient evaluation of penicillin allergy: a randomized controlled trial. J Allergy Clin Immunol. 2019;7(7):2163–2170.
  • Savic L, Gurr L, Kaura V, et al. Penicillin allergy de-labelling ahead of elective surgery: feasibility and barriers. Br J Anaesth. 2019 Jul;123(1):e110–e116.
  • Trubiano JA, Vogrin S, Chua KYL, et al. Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med. 2020;180(5):745.
  • Macy E. The falling rate of positive penicillin skin tests from 1995 to 2007. Perm J. 2009;13(2). DOI:10.7812/TPP/08-073
  • Chen JR, Tarver SA, Alvarez KS, et al. A proactive approach to penicillin allergy testing in hospitalized patients. J Allergy Clin Immunol. 2017;5(3):686–693.
  • Blumenthal KG, Wickner PG, Hurwitz S, et al. Tackling inpatient penicillin allergies: assessing tools for antimicrobial stewardship. J Allergy Clin Immunol. 2017;140(1):154–161.e6.
  • Devchand M, Urbancic KF, Khumra S, et al. Pathways to improved antibiotic allergy and antimicrobial stewardship practice: the validation of a beta-lactam antibiotic allergy assessment tool. J Allergy Clin Immunol Pract. 2019 Mar;7(3):1063–1065 e5.
  • Blumenthal KG, Li Y, Hsu JT, et al. Outcomes from an inpatient beta-lactam allergy guideline across a large US health system. Infect Control Hosp Epidemiol. 2019 May;40(5):528–535.
  • Li J, Shahabi-Sirjani A, Figtree M, et al. Safety of direct drug provocation testing in adults with penicillin allergy and association with health and economic benefits. Ann Allergy Asthma Immunol. 2019 Nov;123(5):468–475.
  • Ramsey A, Mustafa SS, Holly AM, et al. Direct challenges to penicillin-based antibiotics in the inpatient setting. J Allergy Clin Immunol Pract. 2020 Mar 7. DOI:10.1016/j.jaip.2020.02.033
  • Chua KY, Vogrin S, Bury S, et al. The penicillin allergy delabeling program-a multicentre whole-of-hospital health services intervention and comparative effectiveness study. Clin Infect Dis. 2020; Forthcoming.
  • Trubiano JA, Grayson ML, Phillips EJ, et al. Antibiotic allergy testing improves antibiotic appropriateness in patients with cancer. J Antimicrob Chemother. 2018 Nov 1;73(11):3209–3211.
  • Trubiano JA, Grayson ML, Thursky KA, et al. How antibiotic allergy labels may be harming our most vulnerable patients. Med J Aust. 2018 Jun 18;208(11):469–470.
  • Trubiano JA, Worth LJ, Thursky KA, et al. The prevention and management of infections due to multidrug resistant organisms in haematology patients. Br J Clin Pharmacol. 2015 Feb;79(2):195–207.
  • Spleen Australia: vaccines recommended for adults (>18 years) with asplenia/hyposplenism. Vol. 38. 2020 [updated 2020 Apr 6; cited 2020 May 13]. Available from: https://spleen.org.au/VSR/files/RECOMMENDATIONS_Spleen_Registry.pdf
  • Engelhard D, Akova M, Boeckh MJ, et al. Bacterial infection prevention after hematopoietic cell transplantation. Bone Marrow Transplant. 2009;44(8):467–470.
  • Taremi M, Artau A, Foolad F, et al. Safety, efficacy, and clinical impact of penicillin skin testing in immunocompromised cancer patients. J Allergy Clin Immunol. 2019;7(7):2185–2191.e1.
  • Trubiano JA, Slavin MA, Thursky KA, et al. Beta-lactam and sulfonamide allergy testing should be a standard of care in immunocompromised hosts. J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2151–2153.
  • Trubiano JA, Smibert O, Douglas A, et al. The safety and efficacy of an oral penicillin challenge program in cancer patients: a multicenter pilot study. Open Forum Infect Dis. 2018 Dec;5(12):ofy306.
  • Moran R, Devchand M, Churilov L, et al. The burden of antibiotic allergies in adults in an Australian intensive care unit: the BASIS study. Crit Care Resusc. 2019;21(4):9.
  • Arroliga ME, Wagner W, Bobek MB, et al. A pilot study of penicillin skin testing in patients with a history of penicillin allergy admitted to a medical ICU. Chest. 2000;118(4):1106–1108.
  • Saunders H, Helgeson S, Burnside R, et al. Clinical outcomes of patients with sepsis in the intensive care unit and patient reported penicillin allergy. Am J Respir Crit Care Med. 2020;201.A3508
  • Sacco KA, Bates A, Brigham TJ, et al. Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis. Allergy. 2017 Sep;72(9):1288–1296.
  • Heil EL, Bork JT, Schmalzle SA, et al. Implementation of an infectious disease fellow-managed penicillin allergy skin testing service. Open Forum Infect Dis. 2016 Sep;3(3):ofw155.
  • Geng B, Thakor A, Clayton E, et al. Factors associated with negative histamine control for penicillin allergy skin testing in the inpatient setting. Ann Allergy Asthma Immunol. 2015 Jul;115(1):33–38.
  • Del Real GA, Rose ME, Ramirez-Atamoros MT, et al. Penicillin skin testing in patients with a history of β-lactam allergy. Ann Allergy Asthma Immunol. 2007;98(4):355–359.
  • Stone C, Lindsell C, Stollings J, et al. Risk-stratified management offers a safe approach to removing low-risk penicillin allergy labels in the intensive care unit. J Allergy Clin Immunol. 2020;145(2):AB94.
  • Shenoy ES, Macy E, Rowe T, et al. Evaluation and management of penicillin allergy: a review. JAMA. 2019 Jan 15;321(2):188–199.
  • Rimawi R, Shah K, Cook P. Risk of redocumenting penicillin allergy in a cohort of patients with negative penicillin skin tests. J Hosp Med. 2013 Nov 1;8(11):615–618.
  • Gerace K, Phillips E. Penicillin allergy label persists despite negative testing. J Allergy Clin Immunol. 2015 Feb 1;135(2, Supplement):AB113.
  • Tan N, Holmes NE, Chua KY, et al. Long-term impacts of antibiotic allergy testing on patient perceptions and antibiotic utilization. JAC Antimicrob Resist. 2019;1(2). DOI:10.1093/jacamr/dlz058

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