Therapeutic potential of 5-aminolevulinic acid and sodium-ferrous citrate for viral insults: relevance to the COVID-19 crisis

References

• Razzaque MS. Exacerbation of antimicrobial resistance: another casualty of the COVID-19 pandemic? Expert Rev Anti Infect Ther. 2020 Dec;23:1–5 .
   Google Scholar
• Razzaque MS. Implementation of antimicrobial stewardship to reduce antimicrobial drug resistance. Expert Rev Anti Infect Ther. 2020 Nov;16:1–4 .
   Google Scholar
• Liang F, Han P, Chen R, et al. Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment. Photodiagnosis Photodyn Ther. 2019;28:136–141.
   PubMed Web of Science ®Google Scholar
• Liu C, Zhu P, Fujino M, et al. 5-ALA/SFC attenuated binge alcohol-induced gut leakiness and inflammatory liver disease in HIV transgenic rats. Alcohol Clin Exp Res. 2019 Aug;43(8):1651–1661.
   PubMed Web of Science ®Google Scholar
• Wu RWK, Chu ESM, Yow CMN. Evaluation of the effect of 5-aminolevulinic acid hexyl ester (H-ALA) PDT on EBV LMP1 protein expression in human nasopharyngeal cells. Photodiagnosis Photodyn Ther. 2020 Jun;30:101801.
   PubMed Web of Science ®Google Scholar
• ClinicalTrials. Pilot study to evaluate the safety, tolerability, and efficacy of 5-ALA-phosphate + SFC as an immune system enhancer along with vaccination against COVID-19 . ClinicalTrialsgov Identifier: NCT04854876. 2021.
   Google Scholar
• Izumikawa K. Exploratory examination of Efficacy and safety of functional food included 5-aminolevulinic phosphoric acid/sodium ferrous citrate on COVID-19 . JPRN; 29/10/2020; TrialID: JPRN-jRCTs071200048. 2021
   Google Scholar
• Ferreira GC, Zhang JS. Mechanism of 5-aminolevulinate synthase and the role of the protein environment in controlling the cofactor chemistry. Cell Mol Biol (Noisy-le-grand). 2002 Dec;48(8):827–833.
   PubMed Web of Science ®Google Scholar
• Laver WG, Neuberger A, Udenfriend S. Initial stages in the biosynthesis of porphyrins. I. The formation of delta-am-inolaevulic acid by particles obtained from chicken erythrocytes. Biochem J. 1958 Sep;70(1):4–14.
   PubMed Web of Science ®Google Scholar
• Ito H, Nishio Y, Hara T, et al. Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron. Eur J Pharmacol. 2018 Aug 15;833:25–33 .
   PubMed Web of Science ®Google Scholar
• Mahmoudi K, Garvey KL, Bouras A, et al. 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. J Neurooncol. 2019 Feb;141(3):595–607.
   PubMed Web of Science ®Google Scholar
• Rodriguez BL, Curb JD, Davis J, et al. Use of the dietary supplement 5-aminiolevulinic acid (5-ALA) and its relationship with glucose levels and hemoglobin A1C among individuals with prediabetes. Clin Transl Sci. 2012 Aug;5(4):314–320.
   PubMed Web of Science ®Google Scholar
• Whatley SD, Ducamp S, Gouya L, et al. C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload. Am J Hum Genet. 2008 Sep;83(3):408–414.
   PubMed Web of Science ®Google Scholar
• Cruz-Oliveira C, Almeida AF, Freire JM, et al. Mechanisms of vesicular stomatitis virus inactivation by protoporphyrin IX, zinc-protoporphyrin IX, and mesoporphyrin IX. Antimicrob Agents Chemother. 2017 Jun;61(6):e00053–17. DOI:https://doi.org/10.1128/AAC.00053-17.
   PubMed Web of Science ®Google Scholar
• Neris RLS, Figueiredo CM, Higa LM, et al. Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope. Sci Rep. 2018 Jun 28;8(1):9805.
   PubMed Web of Science ®Google Scholar
• Sakurai Y, Ngwe Tun MM, Kurosaki Y, et al. 5-amino levulinic acid inhibits SARS-CoV-2 infection invitro. Biochem Biophys Res Commun. 2021;545:203–207 .
   PubMed Web of Science ®Google Scholar
• Motowo N, Kazutoshi K. Case reports: safety, tolerability, and efficacy of 5-aminolevulinic acid phosphate, an inducer of heme oxygenase 1, in combination with sodium ferrous citrate for the treatment of COVID-19 patients. Open COVID J. 2021;1:52–61 .
   Google Scholar
• Ishizuka M, Abe F, Sano Y, et al. Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy. Int Immunopharmacol. 2011 Mar;11(3):358–365.
   PubMed Web of Science ®Google Scholar
• Asamitsu S, Yabuki Y, Ikenoshita S, et al. Pharmacological prospects of G-quadruplexes for neurological diseases using porphyrins. Biochem Biophys Res Commun. 2020 Oct 8;531(1):51–55.
   PubMed Web of Science ®Google Scholar
• Lane AN, Chaires JB, Gray RD, et al. Stability and kinetics of G-quadruplex structures. Nucleic Acids Res. 2008 Oct;36(17):5482–5515.
   PubMed Web of Science ®Google Scholar
• Fay MM, Lyons SM, Ivanov P. RNA G-quadruplexes in biology: principles and molecular mechanisms. J Mol Biol. 2017 Jul 7;429(14):2127–2147.
   PubMed Web of Science ®Google Scholar
• Kwok CK, Marsico G, Sahakyan AB, et al. rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome. Nat Methods. 2016 Oct;13(10):841–844.
   PubMed Web of Science ®Google Scholar
• Kwok CK, Merrick CJ. G-quadruplexes: prediction, characterization, and biological application. Trends Biotechnol. 2017 Oct;35(10):997–1013.
   PubMed Web of Science ®Google Scholar
• Saad M, Guédin A, Amor S, et al. Mapping and characterization of G-quadruplexes in the genome of the social amoeba dictyostelium discoideum. Nucleic Acids Res. 2019 May 21;47(9):4363–4374.
   PubMed Web of Science ®Google Scholar
• Hänsel-Hertsch R, Di Antonio M, Balasubramanian S. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential. Nat Rev Mol Cell Biol. 2017 May;18(5):279–284.
   PubMed Web of Science ®Google Scholar
• Mukherjee AK, Sharma S, Chowdhury S. Non-duplex G-quadruplex structures emerge as mediators of epigenetic modifications. Trends Genet. 2019 Feb;35(2):129–144.
   PubMed Web of Science ®Google Scholar
• Panera N, Tozzi AE, Alisi A. The G-quadruplex/helicase world as a potential antiviral approach against COVID-19. Drugs. 2020 Jul;80(10):941–946.
   PubMed Web of Science ®Google Scholar
• Zhao C, Qin G, Niu J, et al. Targeting RNA G-quadruplex in SARS-CoV-2: a promising therapeutic target for COVID-19? Angew Chem Int Ed Engl. 2021 Jan 4;60(1):432–438.
   PubMed Web of Science ®Google Scholar
• Perrone R, Butovskaya E, Daelemans D, et al. Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19. J Antimicrob Chemother. 2014 Dec;69(12):3248–3258.
   PubMed Web of Science ®Google Scholar
• Perrone R, Doria F, Butovskaya E, et al. Synthesis, binding and antiviral properties of potent core-extended naphthalene diimides targeting the HIV-1 long terminal repeat promoter G-quadruplexes. J Med Chem. 2015 Dec 24;58(24):9639–9652.
   PubMed Web of Science ®Google Scholar
• Wang SR, Min YQ, Wang JQ, et al. A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target. Sci Adv. 2016 Apr;2(4):e1501535.
   PubMed Web of Science ®Google Scholar
• Sun XQ, Wu C, Qiu YB, et al. Heme oxygenase-1 attenuates seawater drowning-induced acute lung injury through a reduction in inflammation and oxidative stress. Int Immunopharmacol. 2019;74:105634.
   PubMed Web of Science ®Google Scholar
• Mulchandani R, Lyngdoh T, Kakkar AK. Deciphering the COVID-19 cytokine storm: systematic review and meta-analysis. Eur J Clin Invest. 2021 Jan;51(1):e13429.
   PubMed Web of Science ®Google Scholar
• Yan W, Chen D, Bigambo FM, et al. Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis. BMC Infect Dis. 2021 Feb 08;21(1):156.
   PubMed Web of Science ®Google Scholar
• Kang S, Tanaka T, Inoue H, et al. IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22351–22356.
   PubMed Web of Science ®Google Scholar
• Ahmed S, Zimba O, Gasparyan AY. Thrombosis in coronavirus disease 2019 (COVID-19) through the prism of Virchow’s triad. Clin Rheumatol. 2020 Sep;39(9):2529–2543.
   PubMed Web of Science ®Google Scholar
• Negoro H, Soo Shin W, Hakamada-Taguchi R, et al. Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. J Hypertens. 2002 Jul;20(7):1347–1354.
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Ishikawa K, Itabe H, et al. Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction. Mol Cell Biochem. 2006 Oct;291(1–2):21–28.
   PubMed Web of Science ®Google Scholar
• Constantin M, Choi AJ, Cloonan SM, et al. Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease. Int J Hypertens. 2012;2012:859235.
   PubMedGoogle Scholar
• Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006 Apr;86(2):583–650.
   PubMed Web of Science ®Google Scholar
• Ryter SW, Morse D, Choi AM. Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease. Am J Respir Cell Mol Biol. 2007 Feb;36(2):175–182.
   PubMed Web of Science ®Google Scholar
• El Kalamouni C, Frumence E, Bos S, et al. Subversion of the heme oxygenase-1 antiviral activity by Zika virus. Viruses. 2018 Dec 20;11(1):2. DOI:https://doi.org/10.3390/v11010002.
   Web of Science ®Google Scholar
• Doberer D, Haschemi A, Andreas M, et al. Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects. Br J Pharmacol. 2010 Dec;161(8):1751–1762.
   PubMed Web of Science ®Google Scholar
• Lin S, Yin Q, Zhong Q, et al. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation. 2012 Mar 6;9:46.
   PubMed Web of Science ®Google Scholar
• Hooper PL. COVID-19 and heme oxygenase: novel insight into the disease and potential therapies. Cell Stress Chaperones. 2020 Sep;25(5):707–710.
   PubMed Web of Science ®Google Scholar
• Nishio Y, Fujino M, Zhao M, et al. 5-aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1. Int Immunopharmacol. 2014 Apr;19(2):300–307.
   PubMed Web of Science ®Google Scholar
• Razzaque MS. COVID-19 pandemic: can maintaining optimal zinc balance enhance host resistance? Tohoku J Exp Med. 2020 Jul;251(3):175–181.
   PubMed Web of Science ®Google Scholar
• Razzaque MS. COVID-19 pandemic: can zinc supplementation provide an additional shield against the infection? Comput Struct Biotechnol J. 2021;19:1371–1378 .
   PubMed Web of Science ®Google Scholar
• Razzaque MS. Commentary: microbial resistance movements: an overview of global public health threats posed by antimicrobial resistance, and how best to counter. Front Public Health. 2021 January 20;8:1017.
   Web of Science ®Google Scholar