Preventing healthcare-related infections among older adults: a focus on cross-transmission of antibiotic-resistant bacteria

References

• Laupland KB, Pasquill K, Steele L, et al. Burden of bloodstream infection in older persons: a population-based study. BMC Geriatr. 2021;21(1):31.
   PubMed Web of Science ®Google Scholar
• Johnstone J, Parsons R, Botelho F, et al. T-cell phenotypes predictive of frailty and mortality in elderly nursing home residents. J Am Geriatr Soc. 2017;65(1):153–159.
   PubMed Web of Science ®Google Scholar
• Tinelli M, Tiseo G, Falcone M. Prevention of the spread of multidrug-resistant organisms in nursing homes. Aging Clin Exp Res. 2021;33(3):679–687.
   PubMed Web of Science ®Google Scholar
• Laupland KB, Pasquill K, Dagasso G, et al. Population-based risk factors for community-onset bloodstream infections. Eur J Clin Microbiol Infect Dis. 2020;39(4):753–758.
   PubMed Web of Science ®Google Scholar
• Terveer EM, Fallon M, Kraakman MEM, et al. Spread of ESBL-producing Escherichia coli in nursing home residents in Ireland and the Netherlands may reflect infrastructural differences. J Hosp Infect. 2019;103(2):160–164.
   PubMed Web of Science ®Google Scholar
• Garnacho-Montero J, Amaya-Villar R, Ferrándiz-Millón C, et al. Optimum treatment strategies for carbapenem-resistant Acinetobacter baumannii bacteremia. Expert Rev Anti Infect Ther. 2015;13(6):769–777.
   PubMed Web of Science ®Google Scholar
• Sasahara T, Ae R, Yoshimura A, et al. Association between length of residence and prevalence of MRSA colonization among residents in geriatric long-term care facilities. BMC Geriatr. 2020;20(1):481.
   PubMed Web of Science ®Google Scholar
• Kasela M, Grzegorczyk A, Korona-Głowniak I, et al. Transmission and long-term colonization patterns of staphylococcus aureus in a nursing home. Int J Environ Res Public Health. 2020;17(21):8073.
   Web of Science ®Google Scholar
• Brown KA, McGeer A, Schwartz KL, et al. Interfacility patient sharing and Clostridioides difficile infection incidence in the Ontario hospital system: a 13-year cohort study. Infect Control Hosp Epidemiol. 2020;41(2):154–160.
   PubMed Web of Science ®Google Scholar
• Kahvecioglu D, Ramiah K, McMaughan D, et al. Multidrug-resistant organism infections in US nursing homes: a national study of prevalence, onset, and transmission across care settings, October 1, 2010-December 31, 2011. Infect Control Hosp Epidemiol. 2014;35 Suppl 3:S48–55.
   PubMed Web of Science ®Google Scholar
• Ikram R, Psutka R, Carter A, et al. An outbreak of multi-drug resistant Escherichia coli urinary tract infection in an elderly population: a case-control study of risk factors. BMC Infect Dis. 2015;15:224.
   PubMed Web of Science ®Google Scholar
• Cascio GL, Soldani F, Mazzariol A, et al. The high incidence of carbapenem-resistant Klebsiella pneumoniae in urine from elderly hospital patients may facilitate the spread of resistant strains to the community. Microb Drug Resist. 2014;20(1):67–72.
   PubMed Web of Science ®Google Scholar
• Fishbein SRS, Hink T, Reske KA, et al. Randomized controlled trial of oral vancomycin treatment in Clostridioides difficile-colonized patients. mSphere. 2021;6(1). 10.1128/mSphere.00936-20.
   PubMed Web of Science ®Google Scholar
• Lundebjerg NE, Trucil DE, Hammond EC, et al. When it comes to older adults, language matters: journal of the American geriatrics society adopts modified American medical association style. J Am Geriatr Soc. 2017;65(7):1386–1388.
   PubMed Web of Science ®Google Scholar
• Erb S, Frei R, Dangel M, et al. Multidrug-resistant organisms detected more than 48 hours after hospital admission are not necessarily hospital-acquired. Infect Control Hosp Epidemiol. 2017;38(1):18–23.
   PubMed Web of Science ®Google Scholar
• Laupland KB, Church DL. Population-based epidemiology and microbiology of community-onset bloodstream infections. Clin Microbiol Rev. 2014;27(4):647–664.
   PubMed Web of Science ®Google Scholar
• Lenz R, Leal JR, Church DL, et al. The distinct category of healthcare associated bloodstream infections. BMC Infect Dis. 2012;12:85.
   PubMed Web of Science ®Google Scholar
• Friedman ND, Kaye KS, Stout JE, et al. Health care–associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137(10):791–797.
   PubMed Web of Science ®Google Scholar
• Goto M, Al-Hasan MN. Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin Microbiol Infect. 2013;19(6):501–509.
   PubMed Web of Science ®Google Scholar
• Laupland KB. Incidence of bloodstream infection: a review of population-based studies. Clin Microbiol Infect. 2013;19(6):492–500.
   PubMed Web of Science ®Google Scholar
• Mehl A, Åsvold BO, Lydersen S, et al., Burden of bloodstream infection in an area of Mid-Norway 2002-2013: a prospective population-based observational study. BMC Infect Dis. 17(1): 205. 2017.
   PubMedGoogle Scholar
• Aliyu S, Smaldone A, Larson E. Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents: a systematic review and meta-analysis. Am J Infect Control. 2017;45(5):512–518.
   PubMed Web of Science ®Google Scholar
• Chen H, Matsumoto H, Horita N, et al. Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis. Sci Rep. 2021;11(1):11865.
   PubMed Web of Science ®Google Scholar
• Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ = Journal de l’Association Medicale Canadienne. 2005;173(5):489–495.
   PubMed Web of Science ®Google Scholar
• Cosentino CB, Mitchell BG, Brewster DJ, et al. The utility of frailty indices in predicting the risk of health care associated infections: a systematic review. Am J Infect Control. 2021;49(8):1078–1084.
   PubMed Web of Science ®Google Scholar
• Laupland KB, Church DL, Vidakovich J, et al. Community-onset extended-spectrum beta-lactamase (ESBL) producing Escherichia coli: importance of international travel. J Infect. 2008;57(6):441–448.
   PubMed Web of Science ®Google Scholar
• Pitout JD, Laupland KB. Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8(3):159–166.
   PubMed Web of Science ®Google Scholar
• Montoya A, Schildhouse R, Goyal A, et al. How often are health care personnel hands colonized with multidrug- resistant organisms? A systematic review and meta-analysis. Am J Infect Control. 2019;47(6):693–703.
   PubMed Web of Science ®Google Scholar
• Gontjes KJ, Gibson KE, Lansing BJ, et al. Association of exposure to high-risk antibiotics in acute care hospitals with multidrug-resistant organism burden in nursing homes. JAMA Network Open. 2022;5(2):e2144959.
   PubMed Web of Science ®Google Scholar
• Jackson SS, Lydecker AD, Magder LS, et al. Development and validation of a clinical prediction rule to predict transmission of methicillin-resistant staphylococcus aureus in nursing homes. Am J Epidemiol. 2019;188(1):214–221.
   PubMed Web of Science ®Google Scholar
• Couderc C, Jolivet S, Thiébaut AC, et al. Fluoroquinolone use is a risk factor for methicillin-resistant Staphylococcus aureus acquisition in long-term care facilities: a nested case-case-control study. Clin Infect Dis. 2014;59(2):206–215.
   PubMed Web of Science ®Google Scholar
• Flokas ME, Alevizakos M, Shehadeh F, et al. Extended-spectrum β-lactamase-producing Enterobacteriaceae colonisation in long-term care facilities: a systematic review and meta-analysis. Int J Antimicrob Agents. 2017;50(5):649–656.
   PubMed Web of Science ®Google Scholar
• Cochard H, Aubier B, Quentin R, et al. Extended-spectrum β-lactamase-producing Enterobacteriaceae in French nursing homes: an association between high carriage rate among residents, environmental contamination, poor conformity with good hygiene practice, and putative resident-to-resident transmission. Infect Control Hosp Epidemiol. 2014;35(4):384–389.
   PubMed Web of Science ®Google Scholar
• Krinitski D, Kasina R, Klöppel S, et al. Associations of delirium with urinary tract infections and asymptomatic bacteriuria in adults aged 65 and older: a systematic review and meta-analysis. J Am Geriatr Soc. 2021;69(11):3312–3323.
   PubMed Web of Science ®Google Scholar
• Tandan M, Thapa P, Maharjan P, et al. Impact of antimicrobial stewardship program on antimicrobial resistant and prescribing in nursing home: a systematic review and meta-analysis. J Glob Antimicrob Resist. 2022. 10.1016/j.jgar.2022.02.002
   PubMed Web of Science ®Google Scholar
• Crespo-Rivas JC, Guisado-Gil AB, Peñalva G, et al. Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis. Clin Microbiol Infect. 2021;27(10):1431–1438.
   PubMed Web of Science ®Google Scholar
• Aliyu S, Travers JL, Heimlich SL, et al. Antimicrobial stewardship interventions to optimize treatment of infections in nursing home residents: a systematic review and meta-analysis. J Appl Gerontol: Off J South Gerontol Soc. 2022;41(3):892–901.
   PubMed Web of Science ®Google Scholar
• Raban MZ, Gasparini C, Li L, et al. Effectiveness of interventions targeting antibiotic use in long-term aged care facilities: a systematic review and meta-analysis. BMJ Open. 2020;10(1):e028494.
   PubMed Web of Science ®Google Scholar
• Arnold SH, Nygaard Jensen J, Bjerrum L, et al., Effectiveness of a tailored intervention to reduce antibiotics for urinary tract infections in nursing home residents: a cluster, randomised controlled trial. Lancet Infect Dis. 21(11): 1549–1556. 2021.
   PubMed Web of Science ®Google Scholar
• Nace DA, Hanlon JT, Crnich CJ, et al., A multifaceted antimicrobial stewardship program for the treatment of uncomplicated cystitis in nursing home residents. JAMA Intern Med. 180(7): 944–951. 2020.
   PubMed Web of Science ®Google Scholar
• Pasay DK, Guirguis MS, Shkrobot RC, et al., Antimicrobial stewardship in rural nursing homes: impact of interprofessional education and clinical decision tool implementation on urinary tract infection treatment in a cluster randomized trial. Infect Control Hosp Epidemiol. 40(4): 432–437. 2019.
   PubMed Web of Science ®Google Scholar
• Fleet E, Gopal Rao G, Patel B, et al. Impact of implementation of a novel antimicrobial stewardship tool on antibiotic use in nursing homes: a prospective cluster randomized control pilot study. J Antimicrob Chemother. 2014;69(8):2265–2273.
   PubMed Web of Science ®Google Scholar
• Pettersson E, Vernby A, Mölstad S, et al. Can a multifaceted educational intervention targeting both nurses and physicians change the prescribing of antibiotics to nursing home residents? A cluster randomized controlled trial. J Antimicrob Chemother. 2011;66(11):2659–2666.
   PubMed Web of Science ®Google Scholar
• Lee MH, Lee GA, Lee SH, et al. Effectiveness and core components of infection prevention and control programmes in long-term care facilities: a systematic review. J Hosp Infect. 2019;102(4):377–393.
   PubMed Web of Science ®Google Scholar
• Wong VWY, Huang Y, Wei WI, et al. Approaches to multidrug-resistant organism prevention and control in long-term care facilities for older people: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2022;11(1):7.
   PubMed Web of Science ®Google Scholar
• Mody L, Gontjes KJ, Cassone M, et al. Effectiveness of a multicomponent intervention to reduce multidrug-resistant organisms in nursing homes: a cluster randomized clinical trial. JAMA Network Open. 2021;4(7):e2116555.
   PubMed Web of Science ®Google Scholar
• Temime L, Cohen N, Ait-Bouziad K, et al. Impact of a multicomponent hand hygiene-related intervention on the infectious risk in nursing homes: a cluster randomized trial. Am J Infect Control. 2018;46(2):173–179.
   PubMed Web of Science ®Google Scholar
• Peterson LR, Boehm S, Beaumont JL, et al. Reduction of methicillin-resistant Staphylococcus aureus infection in long-term care is possible while maintaining patient socialization: a prospective randomized clinical trial. Am J Infect Control. 2016;44(12):1622–1627.
   PubMed Web of Science ®Google Scholar
• Chuang VW, Tsang IH, Keung JP, et al. Infection control intervention on meticillin resistant Staphylococcus aureus transmission in residential care homes for the elderly. J Infect Prev. 2015;16(2):58–66.
   PubMedGoogle Scholar
• Juthani-Mehta M, Van Ness PH, McGloin J, et al. A cluster-randomized controlled trial of a multicomponent intervention protocol for pneumonia prevention among nursing home elders. Clin Infect Dis. 2015;60(6):849–857.
   PubMed Web of Science ®Google Scholar
• Bellini C, Petignat C, Masserey E, et al. Universal screening and decolonization for control of MRSA in nursing homes: a cluster randomized controlled study. Infect Control Hosp Epidemiol. 2015;36(4):401–408.
   PubMed Web of Science ®Google Scholar
• Mody L, Krein SL, Saint S, et al., A targeted infection prevention intervention in nursing home residents with indwelling devices: a randomized clinical trial. JAMA Intern Med. 175(5): 714–723. 2015.
   PubMed Web of Science ®Google Scholar
• Ho ML, Seto WH, Wong LC, et al. Effectiveness of multifaceted hand hygiene interventions in long-term care facilities in Hong Kong: a cluster-randomized controlled trial. Infect Control Hosp Epidemiol. 2012;33(8):761–767.
   PubMed Web of Science ®Google Scholar
• Chami K, Gavazzi G, Bar-Hen A, et al. A short-term, multicomponent infection control program in nursing homes: a cluster randomized controlled trial. J Am Med Dir Assoc. 2012;13(6):569.e569–517.
   Web of Science ®Google Scholar
• Yeung WK, Tam WS, Wong TW. Clustered randomized controlled trial of a hand hygiene intervention involving pocket-sized containers of alcohol-based hand rub for the control of infections in long-term care facilities. Infect Control Hosp Epidemiol. 2011;32(1):67–76.
   PubMed Web of Science ®Google Scholar
• Bourigault C, Lietard C, Golmard JL, et al. Impact of bucco-dental healthcare on the prevention of pneumonia in geriatrics: a cluster-randomised trial. J Hosp Infect. 2011;77(1):78–80.
   PubMed Web of Science ®Google Scholar
• Nishiyama Y, Inaba E, Uematsu H, et al. Effects of mucosal care on oral pathogens in professional oral hygiene to the elderly. Arch Gerontol Geriatr. 2010;51(3):e139–143.
   PubMed Web of Science ®Google Scholar
• Baldwin NS, Gilpin DF, Tunney MM, et al. Cluster randomised controlled trial of an infection control education and training intervention programme focusing on meticillin-resistant Staphylococcus aureus in nursing homes for older people. J Hosp Infect. 2010;76(1):36–41.
   PubMed Web of Science ®Google Scholar
• Hall RG 2nd, Blaszczyk AT, Thompson KA, et al. Impact of empiric weight-based vancomycin dosing on nephrotoxicity and mortality in geriatric patients with methicillin-resistant Staphylococcus aureus bacteraemia. J Clin Pharm Ther. 2014;39(6):653–657.
   PubMed Web of Science ®Google Scholar
• Dickinson DT, Rashid S, Weiland A, et al. Errors in antibiotic transitions between hospital and nursing home: how often do they occur? Infect Control Hosp Epidemiol. 2019;40(12):1416–1419.
   PubMed Web of Science ®Google Scholar
• Brandeis GH, Hogan M, Murphy M, et al. Electronic health record implementation in community nursing homes. J Am Med Dir Assoc. 2007;8(1):31–34.
   PubMed Web of Science ®Google Scholar
• Clemens S, Wodchis W, McGilton K, et al. The relationship between quality and staffing in long-term care: a systematic review of the literature 2008-2020. Int J Nurs Stud. 2021;122:104036.
   PubMed Web of Science ®Google Scholar