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Review

Interventions to improve outcomes in community-acquired pneumonia

ORCID Icon, ORCID Icon & ORCID Icon
Pages 1071-1086 | Received 22 Jun 2023, Accepted 06 Sep 2023, Published online: 14 Sep 2023

References

  • Torres A, Cilloniz C, Niederman MS, et al. Pneumonia. Nat Rev Dis Primers. 2021;7(1):25. doi: 10.1038/s41572-021-00259-0
  • Vos T, Lim SS, Abbafati C, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet. 2020;396(10258):1204–1222. doi: 10.1016/S0140-6736(20)30925-9
  • JustActions. The Missing Piece. Why the global pandemic is an inflection point for pneumonia control. Revised and updated for COVID-19 and the Global Burden of Disease 2019. Stop Pneumonia/Every Breath Counts. 2021 [cited 2022 Oct 31]. Available from: https://stoppneumonia.org/the-missing-piece-why-the-global-pandemic-is-an-inflection-point-for-pneumonia-control/
  • Ramirez JA, Wiemken TL, Peyrani P, et al. Adults hospitalized with pneumonia in the United States: incidence, epidemiology, and mortality. Clin Infect Dis. 2017;65(11):1806–1812. doi: 10.1093/cid/cix647
  • Cavallazzi R, Furmanek S, Arnold FW, et al. The burden of community-acquired pneumonia requiring admission to ICU in the United States. Chest. 2020;158(3):1008–1016. doi: 10.1016/j.chest.2020.03.051
  • Cillóniz C, Dominedò C, Pericàs JM, et al. Community-acquired pneumonia in critically ill very old patients: a growing problem. Eur Respir Rev. 2020;29(155):190126. doi: 10.1183/16000617.0126-2019
  • Cilloniz C, Ceccato A, San Jose A, et al. Clinical management of community acquired pneumonia in the elderly patient. Expert Rev Respir Med. 2016;10(11):1211–1220. doi: 10.1080/17476348.2016.1240037
  • Arnold FW, Reyes Vega AM, Salunkhe V, et al. Older adults hospitalized for pneumonia in the United States: incidence, epidemiology, and outcomes. J Am Geriatr Soc. 2020;68(5):1007–1014. doi: 10.1111/jgs.16327
  • Hu Y, Han Y, Yu C, et al. The hospitalization burden of all-cause pneumonia in China: a population-based study, 2009-2017. Lancet Reg Health West Pac. 2022;22:100443. doi: 10.1016/j.lanwpc.2022.100443
  • Naucler P, Henriques-Normark B, Hedlund J, et al. The changing epidemiology of community-acquired pneumonia: nationwide register-based study in Sweden. J Intern Med. 2019;286(6):689–701. doi: 10.1111/joim.12956
  • Søgaard M, Nielsen RB, Schønheyder HC, et al. Nationwide trends in pneumonia hospitalization rates and mortality, Denmark 1997–2011. Respir med. 2014;108(8):1214–1222. doi: 10.1016/j.rmed.2014.05.004
  • Dela Cruz CS, Feldman C. COVID-19. Semin Respir Crit Care Med. 2023;44(1):001–002. doi: 10.1055/s-0042-1759777
  • Lawrence H, Lim WS, McKeever TM. Variation in clinical outcomes and process of care measures in community acquired pneumonia: a systematic review. Pneumonia (Nathan). 2020;12(1):10. doi: 10.1186/s41479-020-00073-4
  • Moberley S, Holden J, Tatham DP, et al. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev. 2013. CD000422. doi: 10.1002/14651858.CD000422.pub3
  • Centers for Disease Control and Prevention (CDC). Current cigarette smoking among adults - United States, 2011. MMWR Morb Mortal Wkly Rep. 2012;61(44):889–894.
  • Luca DL, Kwong JC, Chu A, et al. Impact of pneumococcal vaccination on pneumonia hospitalizations and related costs in Ontario: a population-based ecological study. Clin Infect Dis. 2017;66(4):541–547. doi: 10.1093/cid/cix850
  • Johansson N, Kalin M, Tiveljung-Lindell A, et al. Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods. Clin Infect Dis. 2010;50(2):202–209. doi: 10.1086/648678
  • Rozenbaum MH, Pechlivanoglou P, van der Werf TS, et al. The role of streptococcus pneumoniae in community-acquired pneumonia among adults in Europe: a meta-analysis. Eur J Clin Microbiol Infect Dis. 2013;32(3):305–316. doi: 10.1007/s10096-012-1778-4
  • Huijts SM, Pride MW, Vos JMI, et al. Diagnostic accuracy of a serotype-specific antigen test in community-acquired pneumonia. Eur Respir J. 2013;42(5):1283–1290. doi: 10.1183/09031936.00137412
  • Cillóniz C, Ewig S, Polverino E, et al. Microbial aetiology of community-acquired pneumonia and its relation to severity. Thorax. 2011;66(4):340–346. doi: 10.1136/thx.2010.143982
  • Aliberti S, Cilloniz C, Chalmers JD, et al. Multidrug-resistant pathogens in hospitalised patients coming from the community with pneumonia: a European perspective: table 1. Thorax. 2013;68(11):997–999. doi: 10.1136/thoraxjnl-2013-203384
  • Prina E, Ranzani OT, Polverino E, et al. Risk factors associated with potentially antibiotic-resistant pathogens in community-acquired pneumonia. Ann Am Thorac Soc. 2015;12(2):153–160. doi: 10.1513/AnnalsATS.201407-305OC
  • Cilloniz C, Dominedo C, Peroni HJ, et al. Difficult to treat microorganisms in patients aged over 80 years with community-acquired pneumonia: the prevalence of PES pathogens. Eur Respir J. 2020;56(4):2000773. doi: 10.1183/13993003.00773-2020
  • Jain S, Self WH, Wunderink RG, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults N Engl J Med. 2015;373(5):415–427. doi: 10.1056/NEJMoa1500245
  • Karhu J, Ala-Kokko TI, Vuorinen T, et al. Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia. Clin Infect Dis. 2014;59(1):62–70. doi: 10.1093/cid/ciu237
  • Wu X, Wang Q, Wang M, et al. Incidence of respiratory viral infections detected by PCR and real-time PCR in adult patients with community-acquired pneumonia: a meta-analysis. Respiration. 2015;89(4):343–352. doi: 10.1159/000369561
  • Zhou F, Wang Y, Liu Y, et al. Disease severity and clinical outcomes of community acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicenter prospective registry study from CAP-China network. Eur Respir J. 2019;54(2):1802406. doi: 10.1183/13993003.02406-2018
  • Cillóniz C, Dominedò C, Magdaleno D, et al. Pure viral sepsis secondary to community-acquired pneumonia in adults: risk and prognostic factors. J Infect Dis. 2019;220(7):1166–1171. doi: 10.1093/infdis/jiz257
  • Marin-Corral J, Pascual-Guardia S, Amati F, et al. Aspiration risk factors, microbiology, and empiric antibiotics for patients hospitalized with community-acquired pneumonia. Chest. 2021;159(1):58–72. doi: 10.1016/j.chest.2020.06.079
  • Weinfurt KP, Reeve BB. Patient-reported outcome measures in clinical Research. JAMA. 2022;328(5):472–473. doi: 10.1001/jama.2022.11238
  • Lloyd M, Callander E, Karahalios A, et al. Patient-reported outcome measures in community-acquired pneumonia: a systematic review of application and content validity. BMJ Open Respir Res. 2019;6(1):e000398. doi: 10.1136/bmjresp-2018-000398
  • Pick HJ, Bolton CE, Lim WS, et al. Patient-reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review. Eur Respir J. 2019;53(3):1802165. doi: 10.1183/13993003.02165-2018
  • Lloyd MA, Tang CY, Callander EJ, et al. Patient-reported outcome measurement in community-acquired pneumonia: feasibility of routine application in an elderly hospitalized population. Pilot Feasibility Stud. 2019;5(1):97. doi: 10.1186/s40814-019-0481-y
  • Dong N, Eisenberg JD, Dharmarajan K, et al. Relationship between patient-reported hospital experience and 30-day mortality and readmission rates for acute myocardial infarction, heart failure, and pneumonia. J Gen Intern Med. 2019;34(4):526–528. doi: 10.1007/s11606-018-4746-6
  • Mandell LA, Wunderink RG, Anzueto A, et al. Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27–72. doi: 10.1086/511159
  • Garcia-Vidal C, Fernández-Sabé N, Carratalà J, et al. Early mortality in patients with community-acquired pneumonia: causes and risk factors. Eur Respir J. 2008;32(3):733–739. doi: 10.1183/09031936.00128107
  • Luna CM, Palma I, Niederman MS, et al. The impact of age and comorbidities on the mortality of patients of different age groups admitted with community-acquired pneumonia. Ann Am Thorac Soc. 2016;13(9):1519–1526. doi: 10.1513/AnnalsATS.201512-848OC
  • Wadhera RK, Joynt Maddox KE, Wasfy JH, et al. Association of the hospital readmissions reduction program with mortality among medicare beneficiaries hospitalized for heart failure, acute myocardial infarction, and pneumonia. JAMA. 2018;320(24):2542–2552. doi: 10.1001/jama.2018.19232
  • Kolditz M, Tesch F, Mocke L, et al. Burden and risk factors of ambulatory or hospitalized CAP: a population based cohort study. Respir med. 2016;121:32–38. doi: 10.1016/j.rmed.2016.10.015
  • Glöckner V, Pletz MW, Rohde G, et al. Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool. Eur J Clin Microbiol Infect Dis. 2022;41(4):621–630. doi: 10.1007/s10096-022-04416-5
  • Eurich DT, Marrie TJ, Minhas-Sandhu JK, et al. Ten-year mortality after community-acquired pneumonia. A prospective cohort. Am J Respir Crit Care Med. 2015;192(5):597–604. doi: 10.1164/rccm.201501-0140OC
  • Johnstone J, Eurich DT, Majumdar SR, et al. Long-term morbidity and mortality after hospitalization with community-acquired pneumonia: a population-based cohort study. Medicine (Baltimore). 2008;87(6):329–334. doi: 10.1097/MD.0b013e318190f444
  • Uranga A, Quintana JM, Aguirre U, et al. Predicting 1-year mortality after hospitalization for community-acquired pneumonia. PLoS One. 2018;13(2):e0192750. doi: 10.1371/journal.pone.0192750
  • Bordon J, Slomka M, Gupta R, et al. Hospitalization due to community-acquired pneumonia in patients with chronic obstructive pulmonary disease: incidence, epidemiology and outcomes. Clin Microbiol Infect. 2020;26(2):220–226. doi: 10.1016/j.cmi.2019.06.025
  • Dupuis C, Sabra A, Patrier J, et al. Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs. Crit Care. 2021;25(1):24. doi: 10.1186/s13054-020-03442-z
  • Sangla F, Legouis D, Marti P-E, et al. One year after ICU admission for severe community-acquired pneumonia of bacterial, viral or unidentified etiology. What are the outcomes? PLoS One. 2020;15(12):e0243762. doi: 10.1371/journal.pone.0243762
  • Violi F, Cangemi R, Falcone M, et al. Cardiovascular complications and short-term mortality risk in community-acquired pneumonia. Clin Infect Dis. 2017;64(11):1486–1493. doi: 10.1093/cid/cix164
  • Cangemi R, Calvieri C, Falcone M, et al. Relation of cardiac complications in the early phase of community-acquired pneumonia to long-term mortality and cardiovascular events. Am J Cardiol. 2015;116(4):647–651. doi: 10.1016/j.amjcard.2015.05.028
  • Aliberti S, Ramirez JA. Cardiac diseases complicating community-acquired pneumonia. Curr Opin Infect Dis. 2014;27(3):295–301. doi: 10.1097/QCO.0000000000000055
  • Corrales-Medina VF, Suh KN, Rose G, et al. Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies. PLOS Med. 2011;8(6):e1001048. doi: 10.1371/journal.pmed.1001048
  • Feldman C. Cardiac complications in community-acquired pneumonia and COVID-19. Afr J Thorac Crit Care Med. 2020;26(2):26. doi: 10.7196/AJTCCM.2020.v26i2.077
  • Aldás I, Menéndez R, Méndez R, et al. Early and late cardiovascular events in patients hospitalized for community-acquired pneumonia. Archivos de Bronconeumología. 2020;56(9):551–558. doi: 10.1016/j.arbr.2020.07.003
  • Musher DM, Rueda AM, Kaka AS, et al. The association between pneumococcal pneumonia and acute cardiac events. Clin Infect Dis. 2007;45(2):158–165. doi: 10.1086/518849
  • Anderson R, Nel JG, Feldman C. Multifaceted role of pneumolysin in the pathogenesis of myocardial injury in community-acquired pneumonia. Int J Mol Sci. 2018;19(4):1147. doi: 10.3390/ijms19041147
  • Africano HF, Serrano-Mayorga CC, Ramirez-Valbuena PC, et al. Major adverse cardiovascular events during invasive pneumococcal disease are serotype dependent. Clin Infect Dis. 2021;72(11):e711–e719. doi: 10.1093/cid/ciaa1427
  • Musher DM, Abers MS, Corrales-Medina VF, et al. Acute infection and myocardial infarction. N Engl J Med. 2019;380(2):171–176. doi: 10.1056/NEJMra1808137
  • Putot A, Chague F, Manckoundia P, et al. Post-infectious myocardial infarction: new insights for improved screening. J Clin Med. 2019;8(6):827. doi: 10.3390/jcm8060827
  • Restrepo MI, Reyes LF. Pneumonia as a cardiovascular disease. Respirology. 2018;23(3):250–259. doi: 10.1111/resp.13233
  • Egelund GB, Jensen AV, Petersen PT, et al. Do-not-resuscitate orders in patients with community-acquired pneumonia: a retrospective study. BMC Pulm Med. 2020;20(1):201. doi: 10.1186/s12890-020-01236-1
  • Mortensen EM, Kapoor WN, Chang C-C, et al. Assessment of mortality after long-term follow-up of patients with community-acquired pneumonia. Clin Infect Dis. 2003;37(12):1617–1624. doi: 10.1086/379712
  • Krumholz HM, Lin Z, Keenan PS, et al. Relationship between hospital readmission and mortality rates for patients hospitalized with acute myocardial infarction, heart failure, or pneumonia. JAMA. 2013;309(6):587–593. doi: 10.1001/jama.2013.333
  • Schmitt JP, Kirfel A, Schmitz M-T, et al. The impact of drug interactions in patients with community-acquired pneumonia on hospital length of stay. Geriatrics (Basel). 2022;7(1):11. doi: 10.3390/geriatrics7010011
  • Mundy LM, Leet TL, Darst K, et al. Early mobilization of patients hospitalized with community-acquired pneumonia. Chest. 2003;124(3):883–889. doi: 10.1378/chest.124.3.883
  • Chen H, Hara Y, Horita N, et al. An early screening tool for discharge planning shortened length of hospital stay for elderly patients with community-acquired pneumonia. Clin Interv Aging. 2021;16:443–450. doi: 10.2147/CIA.S296390
  • Melgaard D, Baandrup U, Bøgsted M, et al. Early mobilisation of patients with community-acquired pneumonia reduce length of hospitalisation—a pilot study. J Phys Ther Sci. 2018;30(7):926–932. doi: 10.1589/jpts.30.926
  • Rice H, Hill K, Fowler R, et al. Reduced step count and clinical frailty in hospitalized adults with community-acquired pneumonia. Respir Care. 2020;65(4):455–463. doi: 10.4187/respcare.06992
  • Athanassa Z, Makris G, Dimopoulos G, et al. Early switch to oral treatment in patients with moderate to severe community-acquired pneumonia: a meta-analysis. Drugs. 2008;68(17):2469–2481. doi: 10.2165/0003495-200868170-00005
  • Lee RWW, Lindstrom ST. Early switch to oral antibiotics and early discharge guidelines in the management of community-acquired pneumonia. Respirology. 2007;12(1):111–116. doi: 10.1111/j.1440-1843.2006.00931.x
  • Ramirez JA, Srinath L, Ahkee S, et al. Early switch from intravenous to oral cephalosporins in the treatment of hospitalized patients with community-acquired pneumonia. Arch Intern Med. 1995;155(12):1273–1276. doi: 10.1001/archinte.1995.00430120050006
  • Lee JS, Giesler DL, Gellad WF, et al. Antibiotic therapy for adults hospitalized with community-acquired pneumonia: a systematic review. JAMA. 2016;315(6):593–602. doi: 10.1001/jama.2016.0115
  • Oosterheert JJ, Bonten MJM, Schneider MME, et al. Effectiveness of early switch from intravenous to oral antibiotics in severe community acquired pneumonia: multicentre randomised trial. BMJ. 2006;333(7580):1193. doi: 10.1136/bmj.38993.560984.BE
  • Dharmarajan K, Hsieh AF, Lin Z, et al. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA. 2013;309(4):355–363. doi: 10.1001/jama.2012.216476
  • Chakrabarti B, Lane S, Jenks T, et al. Predictors of 30-day readmission following hospitalisation with community-acquired pneumonia. BMJ Open Respir Res. 2021;8(1):e000883. doi: 10.1136/bmjresp-2021-000883
  • Toledo D, Soldevila N, Torner N, et al. Factors associated with 30-day readmission after hospitalisation for community-acquired pneumonia in older patients: a cross-sectional study in seven Spanish regions. BMJ Open. 2018;8(3):e020243. doi: 10.1136/bmjopen-2017-020243
  • Tang VL, Halm EA, Fine MJ, et al. Predictors of rehospitalization after admission for pneumonia in the veterans affairs healthcare system. J Hosp Med. 2014;9(6):379–383. doi: 10.1002/jhm.2184
  • Prescott HC, Sjoding MW, Iwashyna TJ. Diagnoses of early and late readmissions after hospitalization for pneumonia. A systematic review. Ann Am Thorac Soc. 2014;11(7):1091–1100. doi: 10.1513/AnnalsATS.201404-142OC
  • Capelastegui A, España Yandiola PP, Quintana JM, et al. Predictors of short-term rehospitalization following discharge of patients hospitalized with community-acquired pneumonia. Chest. 2009;136(4):1079–1085. doi: 10.1378/chest.08-2950
  • van Walraven C, Bennett C, Jennings A, et al. Proportion of hospital readmissions deemed avoidable: a systematic review. CMAJ. 2011;183(7):E391–402. doi: 10.1503/cmaj.101860
  • Boussat B, Cazzorla F, Le Marechal M, et al. Incidence of avoidable 30-day readmissions following hospitalization for community-acquired pneumonia in France. JAMA Netw Open. 2022;5(4):e226574. doi: 10.1001/jamanetworkopen.2022.6574
  • Halm EA, Fine MJ, Marrie TJ, et al. Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines. JAMA. 1998;279(18):1452–1457. doi: 10.1001/jama.279.18.1452
  • Dinh A, Duran C, Ropers J, et al. Factors associated with treatment failure in moderately severe community-acquired pneumonia: a secondary analysis of a randomized clinical trial. JAMA Netw Open. 2021;4(10):e2129566. doi: 10.1001/jamanetworkopen.2021.29566
  • Aliberti S, Peyrani P, Filardo G, et al. Association between time to clinical stability and outcomes after discharge in hospitalized patients with community-acquired pneumonia. Chest. 2011;140(2):482–488. doi: 10.1378/chest.10-2895
  • Takada K, Matsumoto S, Kojima E, et al. Predictors and impact of time to clinical stability in community-acquired pneumococcal pneumonia. Respir med. 2014;108(5):806–812. doi: 10.1016/j.rmed.2014.02.007
  • Halm EA, Fine MJ, Kapoor WN, et al. Instability on hospital discharge and the risk of adverse outcomes in patients with pneumonia. Arch Intern Med. 2002;162(11):1278–1284. doi: 10.1001/archinte.162.11.1278
  • Menéndez R, Torres A, Rodríguez de Castro F, et al. Reaching stability in community-acquired pneumonia: the effects of the severity of disease, treatment, and the characteristics of patients. Clin Infect Dis. 2004;39(12):1783–1790. doi: 10.1086/426028
  • Flateau C, Dinia M, Raulet N, et al. Does a 5-day course of antibiotics in elderly patients with community-acquired pneumonia achieve the established criteria of clinical stability? Infect Dis Now. 2021;51(4):377–379. doi: 10.1016/j.medmal.2020.10.015
  • Garin N, Felix G, Chuard C, et al. Predictors and implications of early clinical stability in patients hospitalized for moderately severe community-acquired pneumonia. PLoS One. 2016;11(6):e0157350. doi: 10.1371/journal.pone.0157350
  • El Solh AA, Aquilina AT, Gunen H, et al. Radiographic resolution of community-acquired bacterial pneumonia in the elderly. J Am Geriatr Soc. 2004;52(2):224–229. doi: 10.1111/j.1532-5415.2004.52059.x
  • Han X, Liu X, Chen L, et al. Disease burden and prognostic factors for clinical failure in elderly community acquired pneumonia patients. BMC Infect Dis. 2020;20(1):668. doi: 10.1186/s12879-020-05362-3
  • Cillóniz C, Torres A, Niederman MS. Management of pneumonia in critically ill patients. BMJ. 2021;375:e065871. doi: 10.1136/bmj-2021-065871
  • Cao B, Huang Y, She D-Y, et al. Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese thoracic society, Chinese medical association. Clin Respir J. 2018;12(4):1320–1360. doi: 10.1111/crj.12674
  • Lim WS, Baudouin SV, George RC, et al. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax. 2009;64(Suppl 3):iii1–55. doi: 10.1136/thx.2009.121434
  • Valencia M, Badia JR, Cavalcanti M, et al. Pneumonia severity index class v patients with community-acquired pneumonia: characteristics, outcomes, and value of severity scores. Chest. 2007;132(2):515–522. doi: 10.1378/chest.07-0306
  • Ranzani OT, Prina E, Menéndez R, et al. New sepsis definition (sepsis-3) and community-acquired pneumonia mortality. A validation and clinical decision-making study. Am J Respir Crit Care Med. 2017;196(10):1287–1297. doi: 10.1164/rccm.201611-2262OC
  • Charles PGP, Wolfe R, Whitby M, et al. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis. 2008;47(3):375–384. doi: 10.1086/589754
  • Postma DF, van Werkhoven CH, van Elden LJR, et al. Antibiotic treatment strategies for community-acquired pneumonia in adults. N Engl J Med. 2015;372(14):1312–1323. doi: 10.1056/NEJMoa1406330
  • Garin N, Genné D, Carballo S, et al. β-lactam monotherapy vs β-lactam–Macrolide combination treatment in moderately severe community-acquired pneumonia. JAMA Intern Med. 2014;174(12):1894–1901. doi: 10.1001/jamainternmed.2014.4887
  • Nie W, Li B, Xiu Q. β-lactam/macrolide dual therapy versus β-lactam monotherapy for the treatment of community-acquired pneumonia in adults: a systematic review and meta-analysis. J Antimicrob Chemother. 2014;69(6):1441–1446. doi: 10.1093/jac/dku033
  • Sligl WI, Asadi L, Eurich DT, et al. Macrolides and mortality in critically ill patients with community-acquired pneumonia: a systematic review and meta-analysis. Crit Care Med. 2014;42(2):420–432. doi: 10.1097/CCM.0b013e3182a66b9b
  • De la Calle C, Ternavasio-de la Vega HG, Morata L, et al. Effectiveness of combination therapy versus monotherapy with a third-generation cephalosporin in bacteraemic pneumococcal pneumonia: a propensity score analysis. J Infect. 2018;76:342–347. doi: 10.1016/j.jinf.2018.01.003
  • Ito A, Ishida T, Tachibana H, et al. Azithromycin combination therapy for community-acquired pneumonia: propensity score analysis. Sci Rep. 2019;9(1):18406. doi: 10.1038/s41598-019-54922-4
  • Okumura J, Shindo Y, Takahashi K, et al. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: impact of β-lactam plus macrolide combination therapy. Respirology. 2018;23(5):526–534. doi: 10.1111/resp.13232
  • Phua J, Dean NC, Guo Q, et al. Severe community-acquired pneumonia: timely management measures in the first 24 hours. Crit Care. 2016;20(1):237. doi: 10.1186/s13054-016-1414-2
  • Ceccato A, Cilloniz C, Martin-Loeches I, et al. Effect of combined β-lactam/Macrolide therapy on mortality according to the microbial etiology and inflammatory status of patients with community-acquired pneumonia. Chest. 2019;155(4):795–804. doi: 10.1016/j.chest.2018.11.006
  • Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American thoracic society and infectious diseases society of America. Am J Respir Crit Care Med. 2019;200(7):e45–e67. doi: 10.1164/rccm.201908-1581ST
  • Martin-Loeches I, Torres A, Nagavci B, et al. ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Intensive care Med. 2023;49(6):615–632. doi: 10.1007/s00134-023-07033-8
  • Webb BJ, Sorensen J, Jephson A, et al. Broad-spectrum antibiotic use and poor outcomes in community-onset pneumonia: a cohort study. Eur Respir J. 2019;54(1):1900057. doi: 10.1183/13993003.00057-2019
  • Cillóniz C, Pericàs JM, Rojas JR, et al. Severe infections due to respiratory viruses. Semin Respir Crit Care Med. 2022;43(1):060–074. doi: 10.1055/s-0041-1740982
  • Martin-Loeches I, Schultz MJ, Vincent J-L, et al. Increased incidence of co-infection in critically ill patients with influenza. Intensive care Med. 2017;43(1):48–58. doi: 10.1007/s00134-016-4578-y
  • Lee C-C, Chen P-L, Huang Y-T, et al. Prognostic effects of delayed administration of antimicrobial therapy in older persons experiencing bacteremia with or without initial sepsis presentations. J Am Med Dir Assoc. 2022;23(1):73–80. doi: 10.1016/j.jamda.2021.09.021
  • Torres A, Lee N, Cilloniz C, et al. Laboratory diagnosis of pneumonia in the molecular age. Eur Respir J. 2016;48(6):1764–1778. doi: 10.1183/13993003.01144-2016
  • Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive care Med. 2017;43(3):304–377. doi: 10.1007/s00134-017-4683-6
  • Uranga A, España PP, Bilbao A, et al. Duration of antibiotic treatment in community-acquired pneumonia: a multicenter randomized clinical trial. JAMA Intern Med. 2016;176(9):1257–1265. doi: 10.1001/jamainternmed.2016.3633
  • Dinh A, Ropers J, Duran C, et al. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial. Lancet. 2021;397(10280):1195–1203. doi: 10.1016/S0140-6736(21)00313-5
  • Niederman MS, Mandell LA. How low can we go in community-acquired pneumonia therapy? Lancet. 2021;397(10280):1160–1161. doi: 10.1016/S0140-6736(21)00627-9
  • Falcone M, Russo A, Shindo Y, et al. A hypothesis-generating study of the combination of aspirin plus macrolides in patients with severe community-acquired pneumonia. Antimicrob Agents Chemother. 2019;63(2):e01556–18. doi: 10.1128/AAC.01556-18
  • Falcone M, Russo A, Cangemi R, et al. Lower mortality rate in elderly patients with community-onset pneumonia on treatment with aspirin. J Am Heart Assoc. 2015;4(1):e001595. doi: 10.1161/JAHA.114.001595
  • Sexton TR, Zhang G, Macaulay TE, et al. Ticagrelor reduces thromboinflammatory markers in patients with pneumonia. JACC Basic Transl Sci. 2018;3(4):435–449. doi: 10.1016/j.jacbts.2018.05.005
  • Grudzinska FS, Dosanjh DP, Parekh D, et al. Statin therapy in patients with community-acquired pneumonia. Clin Med. 2017;17(5):403–407. doi: 10.7861/clinmedicine.17-5-403
  • Chung S-D, Tsai M-C, Lin H-C, et al. Statin use and clinical outcomes among pneumonia patients. Clin Microbiol Infect. 2014;20(9):879–885. doi: 10.1111/1469-0691.12544
  • Chalmers JD, Singanayagam A, Murray MP, et al. Prior statin use is associated with improved outcomes in community-acquired pneumonia. Am j med. 2008;121(11):1002–1007.e1. doi: 10.1016/j.amjmed.2008.06.030
  • Havers F, Bramley AM, Finelli L, et al. Statin use and hospital length of stay among adults hospitalized with community-acquired pneumonia. Clin Infect Dis. 2016;62(12):1471–1478. doi: 10.1093/cid/ciw174
  • Sapey E, Patel JM, Greenwood H, et al. Simvastatin improves neutrophil function and clinical outcomes in pneumonia. A pilot randomized controlled clinical trial. Am J Respir Crit Care Med. 2019;200(10):1282–1293. doi: 10.1164/rccm.201812-2328OC
  • Wu A, Good C, Downs JR, et al. The association of cardioprotective medications with pneumonia-related outcomes. PLoS One. 2014;9(1):e85797. doi: 10.1371/journal.pone.0085797
  • Cangemi R, Falcone M, Taliani G, et al. Corticosteroid use and incident myocardial infarction in adults hospitalized for community-acquired pneumonia. Ann Am Thorac Soc. 2019;16(1):91–98. doi: 10.1513/AnnalsATS.201806-419OC
  • Glass F, Lippton H, Kadowitz PJ. Effects of methylprednisolone and hydrocortisone on aggregation of rabbit platelets induced by arachidonic acid and other aggregating substances. Thromb Haemost. 1981;46(4):676–679. doi: 10.1055/s-0038-1653450
  • Cangemi R, Carnevale R, Nocella C, et al. Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia. Pharmacol Res. 2018;131:66–74. doi: 10.1016/j.phrs.2018.03.014
  • Bi J, Yang J, Wang Y, et al. Efficacy and safety of adjunctive corticosteroids therapy for severe community-acquired pneumonia in adults: an updated systematic review and meta-analysis. PLoS One. 2016;11(11):e0165942. doi: 10.1371/journal.pone.0165942
  • Siemieniuk RAC, Meade MO, Alonso-Coello P, et al. Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: a systematic review and meta-analysis. Ann Intern Med. 2015;163(7):519–528. doi: 10.7326/M15-0715
  • Tang Q, Chen Q, Li Y, et al. Association between glucocorticoids and mortality in patients with severe pneumonia: a systematic review and meta-analysis based on randomized controlled trials. Comput Math Methods Med. 2022;2022:1–10. doi: 10.1155/2022/1191205
  • Stern A, Skalsky K, Avni T, et al. Corticosteroids for pneumonia. Cochrane Database Syst Rev. 2017;12(12): CD007720. doi: 10.1002/14651858.CD007720.pub3
  • Wu J-Y, Tsai Y-W, Hsu W-H, et al. Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2023;27(1):274. doi: 10.1186/s13054-023-04561-z
  • Saleem N, Kulkarni A, Snow TAC, et al. Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: a systematic review, meta-analysis, and meta-regression of randomized control trials. Chest. 2023;163(3):484–497. doi: 10.1016/j.chest.2022.08.2229
  • Shafiq M, Mansoor MS, Khan AA, et al. Adjuvant steroid therapy in community-acquired pneumonia: a systematic review and meta-analysis. J Hosp Med. 2013;8(2):68–75. doi: 10.1002/jhm.1992
  • Meduri GU, Shih M-C, Bridges L, et al. Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia. Intensive care Med. 2022;48(8):1009–1023. doi: 10.1007/s00134-022-06684-3
  • Dequin P-F, Meziani F, Quenot J-P, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med. 2023;388(21):1931–1941. doi: 10.1056/NEJMoa2215145
  • Frat J-P, Thille AW, Mercat A, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015;372(23):2185–2196. doi: 10.1056/NEJMoa1503326
  • Leeies M, Flynn E, Turgeon AF, et al. High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis. Syst Rev. 2017;6(1):202. doi: 10.1186/s13643-017-0593-5
  • Lewis SR, Baker PE, Parker R, et al. High-flow nasal cannulae for respiratory support in adult intensive care patients. Cochrane Database Syst Rev. 2021;3(3): CD010172. doi: 10.1002/14651858.CD010172.pub3
  • Cutuli SL, Grieco DL, Menga LS, et al. Noninvasive ventilation and high-flow oxygen therapy for severe community-acquired pneumonia. Curr Opin Infect Dis. 2021;34(2):142–150. doi: 10.1097/QCO.0000000000000715
  • Cilloniz C, Pericàs JM, Rojas J. Ceftaroline in severe community-acquired pneumonia. Rev Esp Quimioter. 2022;35(Suppl 1):28–30. doi: 10.37201/req/s01.06.2022
  • Cillóniz C, Dominedò C, Garcia-Vidal C, et al. Ceftobiprole for the treatment of pneumonia. Rev Esp Quimioter. 2019;32 (Suppl 3):17–23.
  • Kollef MH, Betthauser KD. New antibiotics for community-acquired pneumonia. Curr Opin Infect Dis. 2019;32(2):169–175. doi: 10.1097/QCO.0000000000000526
  • Zhanel GG, Hartel E, Adam H, et al. Solithromycin: a novel fluoroketolide for the treatment of community-acquired bacterial pneumonia. Drugs. 2016;76(18):1737–1757. doi: 10.1007/s40265-016-0667-z
  • Gadsby NJ, Russell CD, McHugh MP, et al. Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia. Clin Infect Dis. 2016;62(7):817–823. doi: 10.1093/cid/civ1214
  • Aliberti S, Di Pasquale M, Zanaboni AM, et al. Stratifying risk factors for multidrug-resistant pathogens in hospitalized patients coming from the community with pneumonia. Clin Infect Dis. 2012;54(4):470–478. doi: 10.1093/cid/cir840
  • Shorr AF, Zilberberg MD, Reichley R, et al. Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis. 2012;54(2):193–198. doi: 10.1093/cid/cir813
  • Webb BJ, Dascomb K, Stenehjem E, et al. Derivation and multicenter validation of the drug resistance in pneumonia clinical prediction score. Antimicrob Agents Chemother. 2016;60(5):2652–2663. doi: 10.1128/AAC.03071-15
  • Lui G, HKW T, Lee N, et al. Adherence to treatment guideline improves patient outcomes in a prospective cohort of adults hospitalized for community-acquired pneumonia. Open Forum Infect Dis. 2020;7(5):ofaa146. doi: 10.1093/ofid/ofaa146
  • Dambrava PG, Torres A, Vallès X, et al. Adherence to guidelines’ empirical antibiotic recommendations and community-acquired pneumonia outcome. Eur Respir J. 2008;32(4):892–901. doi: 10.1183/09031936.00163407
  • Kang SH, Jo YH, Lee JH, et al. Antibiotic prescription consistent with guidelines in emergency department is associated with 30-day survival in severe community-acquired pneumonia. BMC Emerg Med. 2021;21(1):108. doi: 10.1186/s12873-021-00505-4
  • Eticha EM, Gemechu WD. Adherence to guidelines for assessment and empiric antibiotics recommendations for community-acquired pneumonia at Ambo University referral hospital: prospective observational study. Patient Prefer Adherence. 2021;15:467–473. doi: 10.2147/PPA.S295118
  • Arnold FW, LaJoie AS, Brock GN, et al. Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: community-acquired pneumonia organization international cohort study results. Arch Intern Med. 2009;169(16):1515–1524. doi: 10.1001/archinternmed.2009.265
  • Niederman MS, Cilloniz C. Aspiration pneumonia. Rev Esp Quimioter. 2022;35(Suppl 1):73–77. doi: 10.37201/req/s01.17.2022
  • Mandell LA, Niederman MS, Longo DL. Aspiration pneumonia. N Engl J Med. 2019;380(7):651–663. doi: 10.1056/NEJMra1714562
  • Khadka S, Khan S, King A, et al. Poor oral hygiene, oral microorganisms and aspiration pneumonia risk in older people in residential aged care: a systematic review. Age Ageing. 2021;50(1):81–87. doi: 10.1093/ageing/afaa102
  • Dela Cruz CS, Evans SE, Restrepo MI, et al. Understanding the host in the management of pneumonia. An official American thoracic society workshop report. Ann Am Thorac Soc. 2021;18(7):1087–1097. doi: 10.1513/AnnalsATS.202102-209ST
  • Cilloniz C, Ward L, Mogensen ML, et al. Machine-learning model for mortality prediction in patients with community-acquired pneumonia: development and validation study. Chest. 2023;163(1):77–88. doi: 10.1016/j.chest.2022.07.005
  • Chumbita M, Cillóniz C, Puerta-Alcalde P, et al. Can artificial intelligence improve the management of pneumonia. J Clin Med. 2020;9(1):248. doi: 10.3390/jcm9010248
  • Stokes K, Castaldo R, Federici C, et al. The use of artificial intelligence systems in diagnosis of pneumonia via signs and symptoms: a systematic review. Biomed Signal Process Control. 2022;72:103325. doi: 10.1016/j.bspc.2021.103325

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