Immune induction identified by TMT proteomics analysis in Fusobacterium nucleatum autoinducer-2 treated macrophages

References

• Ismail AS, Valastyan J, SandBassler BL. A host-produced autoinducer-2 mimic activates bacterial quorum sensing. Cell Host Microbe. 2016;19:470–480.
   PubMed Web of Science ®Google Scholar
• Sethi V, Kurtom S, Tarique M, et al. Gut microbiota promotes tumor growth in mice by modulating immune response. Gastroenterology. 2018;155:33–37 e6.
   PubMed Web of Science ®Google Scholar
• Forslund K, Hildebrand F, Nielsen T, et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. 2015;528:262–266.
   PubMed Web of Science ®Google Scholar
• Maruvada P, Leone V, Kaplan LM, et al. The human microbiome and obesity: moving beyond associations. Cell Host Microbe. 2017;22:589–599.
   PubMed Web of Science ®Google Scholar
• Hall AB, Tolonen A, CandXavier RJ. Human genetic variation and the gut microbiome in disease. Nat Rev Genet. 2017;18:690–699.
   PubMed Web of Science ®Google Scholar
• Bivar Xavier K. Bacterial interspecies quorum sensing in the mammalian gut microbiota. C R Biol. 2018;341:297–299.
   PubMed Web of Science ®Google Scholar
• Kaper J, BandSperandio V. Bacterial cell-to-cell signaling in the gastrointestinal tract. Infect Immun. 2005;73:3197–3209.
   PubMed Web of Science ®Google Scholar
• Moreno-Gamez S, Sorg RA, Domenech A, et al. Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence. Nat Commun. 2017;8:854.
   PubMed Web of Science ®Google Scholar
• Thompson JA, Oliveira RA, Djukovic A, et al. Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota. Cell Rep. 2015;10:1861–1871.
   PubMed Web of Science ®Google Scholar
• Li Q, Peng W, Wu J, et al. Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages. Oncoimmunology. 2019;8:e1626192.
   PubMed Web of Science ®Google Scholar
• Scheres N, Lamont RJ, Crielaard W, et al. LuxS signaling in Porphyromonas gingivalis-host interactions. Anaerobe. 2015;35:3–9.
   PubMed Web of Science ®Google Scholar
• Holt R, AandCochrane K. Tumor potentiating mechanisms of fusobacterium nucleatum, a multifaceted microbe. Gastroenterology. 2017;152:694–696.
   PubMed Web of Science ®Google Scholar
• Song J, Duncan MJ, Li G, et al. A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLoS Pathog. 2007;3:e60.
   PubMed Web of Science ®Google Scholar
• Mortha A, Chudnovskiy A, Hashimoto D, et al. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science. 2014;343:1249288.
   PubMed Web of Science ®Google Scholar
• Park SR, Kim DJ, Han SH, et al. Diverse Toll-like receptors mediate cytokine production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages. Infect Immun. 2014;82:1914–1920.
   PubMed Web of Science ®Google Scholar
• Chen T, Li Q, Wu J, et al. Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism. Cancer Immunol Immunother. 2018;67:1635–1646.
   PubMed Web of Science ®Google Scholar
• Tilg H, Adolph TE, Gerner RR, et al. The intestinal microbiota in colorectal cancer. Cancer Cell. 2018;33:954–964.
   PubMed Web of Science ®Google Scholar
• Sears CL. The who, where and how of fusobacteria and colon cancer. Elife. 2018;7:e28434.
   Web of Science ®Google Scholar
• Karpinski TM. Role of oral microbiota in cancer development. Microorganisms. 2019;7.
   PubMed Web of Science ®Google Scholar
• Wu J, Li K, Peng W, et al. Autoinducer-2 of Fusobacterium nucleatum promotes macrophage M1 polarization via TNFSF9/IL-1beta signaling. Int Immunopharmacol. 2019;74:105724.
   PubMed Web of Science ®Google Scholar
• Mima K, Ogino S, Nakagawa S, et al. The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms. Surg Oncol. 2017;26:368–376.
   PubMed Web of Science ®Google Scholar
• Ohtani, NandKawada N, Ohtani N. Role of the gut-liver axis in liver inflammation, fibrosis, and cancer: a special focus on the gut microbiota relationship. Hepatol Commun. 2019;3:456–470.
   PubMed Web of Science ®Google Scholar
• Riquelme E, Zhang Y, Zhang L, et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell. 2019;178:795–806 e12.
   PubMed Web of Science ®Google Scholar
• Sperandio V, Torres AG, Jarvis B, et al. Bacteria-host communication: the language of hormones. Proc Natl Acad Sci U S A. 2003;100:8951–8956.
   PubMed Web of Science ®Google Scholar
• Raut N, Pasini P, Daunert S. Deciphering bacterial universal language by detecting the quorum sensing signal, autoinducer-2, with a whole-cell sensing system. Anal Chem. 2013;85:9604–9609.
   PubMed Web of Science ®Google Scholar
• Kitamura H, Nakagawa T, Takayama M, et al. Post-transcriptional effects of phorbol 12-myristate 13-acetate on transcriptome of U937 cells. FEBS Lett. 2004;578:180–184.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Xie F, Zhou B, et al. Differentially expressed proteins identified by TMT proteomics analysis in bone marrow microenvironment of osteoporotic patients. Osteoporos Int. 2019;30:1089–1098.
   PubMed Web of Science ®Google Scholar
• Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77:e108–e110.
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98–W102.
   PubMed Web of Science ®Google Scholar
• Siemers NO, Holloway JL, Chang H, et al. Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors. PLoS One. 2017;12:e0179726.
   PubMed Web of Science ®Google Scholar
• Hamada T, Zhang X, Mima K, et al. Fusobacterium nucleatum in colorectal cancer relates to immune response differentially by tumor microsatellite instability status. Cancer Immunol Res. 2018;6:1327–1336.
   PubMed Web of Science ®Google Scholar
• Zambirinis CP, Pushalkar S, Saxena D, et al. Pancreatic cancer, inflammation, and microbiome. Cancer J. 2014;20:195–202.
   PubMed Web of Science ®Google Scholar
• Jacobi CA, Grundler S, Hsieh CJ, et al. Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor) - evidence that furanosyl borate diester (AI-2) is influencing the cytokine expression in the DSS colitis mouse model. Gut Pathog. 2012;4:8.
   PubMed Web of Science ®Google Scholar
• Zargar A, Quan DN, Carter KK, et al. Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signaling. MBio. 2015;6:e00025.
   PubMed Web of Science ®Google Scholar
• Shao Z, Schwarz H. CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J Leukoc Biol. 2011;89:21–29.
   PubMed Web of Science ®Google Scholar
• Langstein J, Becke FM, Sollner L, et al. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem Biophys Res Commun. 2000;273:117–122.
   PubMed Web of Science ®Google Scholar
• Drenkard D, Becke FM, Langstein J, et al. CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. Faseb J. 2007;21:456–463.
   PubMed Web of Science ®Google Scholar
• Kim DK, Lee S, CandLee HW. CD137 ligand-mediated reverse signals increase cell viability and cytokine expression in murine myeloid cells: involvement of mTOR/p70S6 kinase and Akt. Eur J Immunol. 2009;39:2617–2628.
   PubMed Web of Science ®Google Scholar
• Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489:220–230.
   PubMed Web of Science ®Google Scholar
• Wang B, Shi L, Sun X, et al. Production of CCL20 from lung cancer cells induces the cell migration and proliferation through PI3K pathway. J Cell Mol Med. 2016;20:920–929.
   PubMed Web of Science ®Google Scholar
• Saalbach A, Janik T, Busch M, et al. Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1. Exp Dermatol. 2015;24:598–604.
   PubMed Web of Science ®Google Scholar
• Liu M, Hu Y, Zhang MF, et al. MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma. Cancer Lett. 2016;377:97–104.
   Google Scholar
• Rasooly R, Schuster GU, Gregg JP, et al. Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. J Immunol. 2005;175:7916–7929.
   PubMed Web of Science ®Google Scholar
• Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem Pharmacol. 2003;66:1403–1408.
   PubMed Web of Science ®Google Scholar
• Pin AL, Houle F, Fournier P, et al. Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J Biol Chem. 2012;287:30541–30551.
   PubMed Web of Science ®Google Scholar
• Kwon B. Is CD137 ligand (CD137L) signaling a fine tuner of immune responses? Immune Netw. 2015;15:121–124.
   PubMed Web of Science ®Google Scholar
• Mima K, Sukawa Y, Nishihara R, et al. Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol. 2015;1:653–661.
   PubMed Web of Science ®Google Scholar
• Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013;14:207–215.
   PubMed Web of Science ®Google Scholar
• Den Breems NY, Eftimie R. The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes. J Theor Biol. 2016;390:23–39.
   PubMed Web of Science ®Google Scholar
• Shen YL, Gan Y, Gao HF, et al. TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma. J Dig Dis. 2017;18:395–403.
   PubMed Web of Science ®Google Scholar
• Clark CE, Hingorani SR, Mick R, et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 2007;67:9518–9527.
   PubMed Web of Science ®Google Scholar
• Zheng L, Xue J, Jaffee EM, et al. Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. Gastroenterology. 2013;144:1230–1240.
   PubMed Web of Science ®Google Scholar
• Murray PJ. Macrophage Polarization. Annu Rev Physiol. 2017;79:541–566.
   PubMed Web of Science ®Google Scholar
• Mendez R, Kesh K, Arora N, et al. Microbial dysbiosis and polyamine metabolism as predictive markers for early detection of pancreatic cancer. Carcinogenesis. 2019.
   PubMedGoogle Scholar