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Original Articles

Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents

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Pages 199-216 | Received 16 Apr 2017, Accepted 19 Mar 2018, Published online: 03 May 2018

References

  • Kren, V.; Martinkova, L. Glycosides in Medicine: the Role of Glycosidic Residue in Biological Activity. Curr. Med. Chem. 8, 1303–1328. Curr. Med. Chem. 2001, 8, 1303–1328.
  • Tiwari, N. A.; Shortancy-Fowler, A. T.; Parker, W. B.; Woud, W. R.; Secrist, J. A. Synthesis and Anticancer Evaluation of 4′-C-Methyl-2′-Fluoro Arabino Nucleosides. Nucleosides Nucleotides Nucleic Acids 2009, 28, 657–677.
  • Elgemeie, G. H.; Masoud, D. Microwave-Assisted Synthesis of Heterocyclic Nucleosides. Book, Publisher: Lap Lampert Academic Publishing; Saarbrücken, Germany, ISBN: 978-3-659-78816-1. 2015; pp 1–220.
  • Elgemeie, G. H.; Elsayed, S. H.; Hassan, A. S. Direct Route to a New Class of Acrylamide Thioglycosides and their Conversions to Pyrazole Derivatives Synth. Commun. 2008, 38, 2700–2706.
  • Elgemeie, G. H.; Kamal, E. A. Pyrimidinethione Nucleosides and their Deaza Analogues. Nucleosides Nucleotides Nucleic Acids 2002, 21, 287–325.
  • Elgemeie, G. H.; Farag, A. B.; Amin, K. M.; El-Badry, O. M.; Hassan, G. S. Design, Synthesis and Cytotoxic Evaluation of Novel Heterocyclic Thioglycosides. Med. Chem. (omics) 2014, 4, 814–820.
  • Elgemeie, G. H.; Saber, N. M. Synthesis and in Vitro Anti-tumor Activity of a New Class of Acyclic Thioglycosides. Nucleosides Nucleotides 2015, 34, 463–474.
  • Elgemeie, G. H.; Abu-Zaied, M.; Alsaid, S.; Hebishy, A.; Essa, H. Novel Nucleoside Analogues: First Synthesis of Pyridine 4-Thioglycosides and their Cytotoxic Evaluation. Nucleosides Nucleotides Nucleic Acids 2015, 34, 659–673.
  • Elgemeie, G. H.; Abou-Zeid, M. Purine and Guanine Thioglycoside Analogs: Novel Synthesis of a New Class of Pyrazolo[1,5-A][1,3,5]Triazine-4-Thioglycoside Derivatives Under Microwave Activation. Nucleosides Nucleotides Nucleic Acids 2015, 34, 834–847.
  • Yoshimura, Y.; Kitano, K.; Yamada, K.; Sakata, S.; Miura, S.; Ashida, N.; Machida, H. Synthesis and Biological Activities of 2′-Deoxy-2′-Fluoro-4′-Thioarabinofuranosylpyrimidine and -Purine Nucleosides. Bioorg. Med. Chem. 2000, 8, 1545–58.
  • Komor, R.; Pastuch-Gawołek, G.; Sobania, A.; Jadwi´nski, M.; Szeja, W. Application of Different Alpha-1-Thioglycosides Preparation Methods in Synthesis of 5-nitro-2-Pyridyl-1-Thioglycosides Substrates in Synthesis of Conjugates with Uridine Moiety. Part I. Acta Pol. Pharm. 2012, 69, 1259.
  • Kananovich, D. G.; Reino, A.; Ilmarinen, K.; Roomusoks, M.; Mati Karelson, M.; Lopp, M. A. General Approach to the Synthesis of 5-S-Functionalized Pyrimidine Nucleosides and their Analogues. Org. Biomol. Chem. 2014, 12, 5634.
  • Scala, S.; Akhmed, N.; Rao, U. S.; Paull, K.; Lan, L.; Dickstein, B.; Lee, J.; Elgemeie, G. H.; Stein, W. D.; Bates, S. E. P-Glycoprotein Substrates and Antagonists Cluster into Two Distinct Groups. Mol. Pharmacol. 1997, 51, 1024–1033.
  • Elgemeie, G. H.; Mahdy, E. M.; Elgawish, M. A.; Ahmed, M. M.; Shousha, W. G.; Eldin, M. E. A New Class of Antimetabolites: Pyridine Thioglycosides as Potential Anticancer Agents. Z. Naturforsch. 2010, 65, 577–587.
  • Elgemeie, G. H.; Hussein, M.; Jones, P. G. 2-(2′,3′,4′,6′-Tetra-O-Cetyl-D-Glucopyranosylthio)-4-Pyridine-4-yl-6,7,8,9-Tetrahedro-5H-Cycloheptapyridine-3-Carbonitril. Acta Cryst. 2002, E58, 1244–1245.
  • Mosmann, T. Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays J. Immunol. Methods 1983, 65, 55–63.

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