Design, synthesis, in vitro anticancer, antioxidant and antibacterial activity; DNA/BSA binding, photoleavage and docking studies of Cu(II) ternary metal complexes

References

• Sun, Y.; Bi, S.; Song, D.; Qiao, C.; Mu, D.; Zhang, H. Study on the Interaction Mechanism between DNA and the Main Active Components in Scutellaria Baicalensis Georgi. Sens. Actuators B. 2008, 129, 799. doi: 10.1016/j.snb.2007.09.082.
   PubMed Web of Science ®Google Scholar
• Mal, S. K.; Mitra, M.; Kaur, G.; Manikandamathavan, V. M.; Kiran, M. S.; Choudhury, A. R.; Nair, B. U.; Ghosh, R. Nuclease Activity and anti-Proliferative Effect on Human Cancerous Cells of a Newly Synthesized and Characterized Mononuclear Copper(II) Complex [CuII(L)(fu)2] [L = 2-(2-Pyridyl)Benzimidazole, fu=Furoate]. RSC Adv. 2014, 4, 61337. doi: 10.1039/C4RA09448D.
   Web of Science ®Google Scholar
• Lamani, D. S.; Venugopala Reddy, K. R.; Bhojya Naik, H. S.; Savyasachi, A.; Naik, H. R. Synthesis and DNA Bining Studies of Novel Heterocyclic Substituted Quinoline Schiff Bases: A Potent Antimicrobial Agent. J. Nucleos. Nucleot. Nucl. Acids 2008, 27, 1197–1210. doi: 10.1080/15257770802400081.
   PubMed Web of Science ®Google Scholar
• Iichenko, M.; Dubey, I. Quantum Chemical Approaches in Modeling the Structure of DNA Quadruplexes and Their Interaction with Metal Ions and Small Molecules, Application of Computational Techniques in Pharmacy and Medicine. Springer: Netherlands, 2014, 181.
   Google Scholar
• Mozaffar, A.; Zahra, A.; Zarei, L.; Sadi, S. B.; Fran, Z. A. Affinity to Bovine Serum Albumin and Anticancer Activity of Some New Water-Soluble Metal Schiff Base Complexes. Spect. Acta. Part A: Mole and Biom. Spec. 2014, 133, 697. doi: 10.1016/j.saa.2014.05.031.
   PubMed Web of Science ®Google Scholar
• Malonga, H.; Neault, J.-F.; Tajmir-Riahi, H.-A. Transfer RNA Binding to Human Serum Albumin: A Model for Protein-RNA Interaction. DNA Cell Biol. 2006, 25, 393. doi: 10.1089/dna.2006.25.393.
   PubMed Web of Science ®Google Scholar
• Palanimuthu, D.; Shinde, S. V.; Somasundaram, K.; Samuelson, A. G. In Vitro and in Vivo Anticancer Activity of Copper Bis(Thiosemicarbazone) Complexes. J. Med. Chem. 2013, 56, 722. doi: 10.1021/jm300938r.
   PubMed Web of Science ®Google Scholar
• Sava, G.; Jaouen, G.; Hillard, E. A.; Bergamo, A. Targeted Therapy vs. DNA-Adduct Formation- Guided Design: Thoughts about the Future of Metal-Based Anticancer Drugs. Dalton Trans. 2012, 41, 8226. doi: 10.1039/c2dt30075c.
   PubMed Web of Science ®Google Scholar
• Barry, N. P. E.; Sadler, P. J. Exploration of the Medical Periodic Table: Towards New targets. Chem. Commun. (Camb.) 2013, 49, 5106. doi: 10.1039/c3cc41143e.
   PubMed Web of Science ®Google Scholar
• Chauhan, M.; Banerjee, K.; Arjmand, F. Binding Studies of Novel Copper(II) Complexes Containing L-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu- Sn2 Complex in Human Neuroblastoma Cells. Inorg. Chem. 2007, 46, 3072. doi: 10.1021/ic061753a.
   PubMed Web of Science ®Google Scholar
• Arjmand, F.; Aziz, M. Synthesis and Characterization of Dinuclear Macrocyclic Cobalt(II), Copper(II) and Zinc(II) Complexes Derived from 2,2,2',2'-S,S[Bis(bis-N,N′-2-Thiobenzimi-Dazolyloxalato-1,2-Ethane)]: DNA Binding and Cleavage Studies. Eur. J. Med. Chem. 2009, 44, 834. doi: 10.1016/j.ejmech.2008.05.006.
   PubMed Web of Science ®Google Scholar
• Jevtovic, V.; Pelosi, G.; Ianelli, S.; Kovacevic, R.; Kaisarevic, S. Synthesis, Structural Studies and Biological Activity of a Dioxovanadium(V) Complex with Pyridoxal Semicarbazon. Acta Chim. Slo 2010, 57, 363.
   PubMed Web of Science ®Google Scholar
• Zhu, L.; Zheng, K.; Li, Y. T.; Li, Z. Y.; Yan, C. W. Synthesis and Structure Elucidation of New μ-Oxamido-Bridged Dicopper(II) Cosmplex with in Vitro Anticancer Activity: A Combined Study from Experiment Verification and Docking Calculation on DNA/Protein-Binding Property. J. Photochem. Photobiol. B. 2016, 155, 86. doi: 10.1016/j.jphotobiol.2015.12.015.
   PubMed Web of Science ®Google Scholar
• Muniyandi, V.; Pravin, N.; Subbaraj, P.; Raman, N. Persistent DNA Binding, Cleavage Performance and Eco-Friendly Catalytic Nature of Novel Complexes Having 2-Aminobenzophenone Precursor. J. Photochem. Photobiol. B. 2016, 156, 11. doi: 10.1016/j.jphotobiol.2016.01.004.
   PubMed Web of Science ®Google Scholar
• Jevtovic, S. V. Anticancer Activity of Copper (II) Complexes with a Pyridoxal-Semicarbazone Ligand. Res. Cancer Tumor. 2014, 3, 1.
   Web of Science ®Google Scholar
• Shreelekha, A.; Vivek, B.; Chen, D.; Ahmed, F.; Dou, Q. P.; Padhye, S.; Sarkar, F. H. Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells. J. Med. Chem. 2006, 49, 7242. doi: 10.1021/jm060712l.
   PubMed Web of Science ®Google Scholar
• Erkkila, K. E.; Odom, D. T.; Barton, J. K. Recognition and Reaction of Metallointercalators with DNA. Chem. Rev. 1999, 99, 2777.
   PubMed Web of Science ®Google Scholar
• Pyle, A. M.; Barton, J. K. Probing Nucleic Acids with Transition Metal Complexes. Prog. Inorg. Chem. 1990, 38, 413. doi: 10.1002/chin.199143288.
   Web of Science ®Google Scholar
• Barton, J. K. Metals and DNA: Molecular Left-Handed Complements. Science 1986, 233, 727.
   PubMed Web of Science ®Google Scholar
• Barton, J. K.; Raphael, A. L. Site-Specific Cleavage of Left-Handed DNA in pBR322 by Lambda-Tris(diphenylphenanthroline) Cobalt(III). Proc. Natl. Acad. Sci. USA. 1985, 82, 6460. doi: 10.1073/pnas.82.19.6460.
   PubMed Web of Science ®Google Scholar
• Delaney, S.; Pascaly, M.; Bhattacharya, P. K.; Han, K.; Barton, J. K. Oxidative Damage by Ruthenium Complexes Containing the Dipyridophenazine Ligand or Its Derivatives: A Focus on Intercalation. Inorg. Chem. 2002, 41, 1966.
   PubMed Web of Science ®Google Scholar
• Creaven, S.; Duff, B.; Egan, D. A.; Kavanagh, K.; Rosair, G.; Reddy, T. V.; Walsh, M. Anticancer and Antifungal Activity of Copper(II) Complexes of Quinolin-2(1H)-One-Derived Schiff Bases Bernadette. Inorg. Chim. Acta 2010, 363, 4048. doi: 10.1016/j.ica.2010.08.009.
   Web of Science ®Google Scholar
• Ravi, M.; Kishan, P. C.; Ushaiah, B.; Kumar, E. R.; Shyam, P.; Rajanna, A.; Sarala Devi, C. A Study on Spectro-Analytical Aspects, DNA-Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic Activities, Antibacterial and Docking Properties of 3 – (1 – (6 –Methoxybenzo [d] Thiazol – 2 – Ylimino) Ethyl) – 6 – Methyl – 3H –Pyran - 2, 4 – Dione and Its Metal Complexes. J. Fluoresc. 2015, 25, 1279. doi: 10.1007/s10895-015-1616-z.
   PubMed Web of Science ®Google Scholar
• Ranford, J. D.; Sadler, P. J.; Tocher, D. A. Cytotoxicity and Antiviral Activity of Transition-Metal Salicylato Complexes and Crystal Structure of Bis(Diisopropylsalicylato)(1,10-Phenanthroline)Copper(II). J. Chem. Soc, Dalton Trans. 1993, 3393–3399. doi: 10.1039/DT9930003393.
   Google Scholar
• Ng, C. H.; Kong, K. C.; Von, S. T.; Balraj, P.; Jensen, P. V.; Thirthagiri, E.; Hamada, H.; Chikira, M. Synthesis, Characterization, DNA-Binding Study and Anticancer Properties of Ternary Metal(II) Complexes of Edda and an Intercalating Ligand. Dalton Trans. 2008, 447–454. doi: 10.1039/B709269E.
   PubMed Web of Science ®Google Scholar
• Zhang, S.; Zhu, Y.; Tu, C.; Wei, H.; Yang, Z.; Lin, L.; Ding, J.; Zhang, J.; Guo, Z. A Novel Cytotoxic Ternary Copper(II) Complex of 1,10-phenanthroline and L-threonine with DNA Nuclease Activity. J. Inorg. Biochem. 2004, 98, 2099. doi: 10.1016/j.jinorgbio.2004.09.014.
   PubMed Web of Science ®Google Scholar
• Rajendiran, V.; Karthik, R.; Palaniandavar, M.; Evans, H. S.; Periasamay, V. S.; Akbarsha, M. A.; Srinag, V. S.; Krishnamurthy, H. Mixed-Ligand Copper(II)-Phenolate Complexes: Effect of Coligand on Enhanced DNA and Protein Binding, DNA Cleavage, and Anticancer Activity. Inorg. Chem. 2007, 46, 8208. doi: 10.1021/ic700755p.
   PubMed Web of Science ®Google Scholar
• Goswami, T. K.; Roy, M.; Nethaji, M.; Chakravarty, A. R. Photoinduced DNA and Protein Cleavage Activity of Ferrocene-Appended l-Methionine Reduced Schiff Base Copper(II) Complexes of Phenanthroline Bases. Organometallics 2009, 28, 1992. doi: 10.1021/om900012b.
   Web of Science ®Google Scholar
• Kathiresan, S.; Mugesh, S.; Murugan, M.; Ahamed, F.; Annaraj, J. Mixed-Ligand Copper(II)-Phenolate Complexes: Structure and Studies on DNA/Protein Binding Profiles, DNA Cleavage, Molecular Docking and Cytotoxicity. RSC Adv. 2016, 6, 1810. doi: 10.1039/C5RA20607C.
   Web of Science ®Google Scholar
• Galindo-Murillo, R.; García-Ramos, J. C.; Ruiz-Azuara, L.; Cheatham, T. E.; Cortés-Guzmán, F. Intercalation Processes of Copper Complexes in DNA. Nucl. Acids Res 2015, 43, 5364. doi: 10.1093/nar/gkv467.
   PubMed Web of Science ®Google Scholar
• Cozzi, P. G. Metal-Salen Schiff Base Complexes in Catalysis: practical Aspects. Chem. Soc. Rev 2004, 33, 410. doi: 10.1039/B307853C.
   PubMed Web of Science ®Google Scholar
• Arjmand, F.; Muddassir, M.; Yousuf, I. Design and Synthesis of Enantiomeric (R)- and (S)-Copper(II) and Diorganotin(IV)-Based Antitumor Agents: Their in Vitro DNA Binding Profile, Cleavage Efficiency and Cytotoxicity Studies. J. Photochem. Photobiol. B 2014, 136, 62. doi: 10.1016/j.jphotobiol.2014.04.024.
   PubMed Web of Science ®Google Scholar
• Zuo, J.; Bi, C. F.; Fan, Y. H.; Buac, D.; Nardon, C.; Daniel, K. G.; Dou, Q. P. Cellular and Computational Studies of Proteasome Inhibition and Apoptosis Induction in Human Cancer Cells by Amino Acid Schiff Base–Copper Complexes. J. Inorg. Biochem. 2013, 118, 83. doi: 10.1016/j.jinorgbio.2012.10.006.
   PubMed Web of Science ®Google Scholar
• Dwyer, F. P.; Mayhew, E.; Roe, E.; Shulman, M. Inhibition of Landschütz Ascites Tumour Growth by Metal Chelates Derived from 3,4,7,8-Tetramethyl-1,10-Phenanthroline. Br. J. Cancer 1965, 19, 195. doi: 10.1038/bjc.1965.24.
   PubMed Web of Science ®Google Scholar
• Cai, X. Q.; Pan, N.; Zou, G. Copper-1,10-Phenanthroline-Induced Apoptosis in Liver Carcinoma Bel-7402 Cells Associates with Copper Overload, Reactive Oxygen Species Production, Glutathione Depletion and Oxidative DNA Damage. Biometals. 2007, 20, 1. doi: 10.1007/s10534-006-9008-0.
   PubMed Web of Science ®Google Scholar
• Santini, C.; Pellei, M.; Pellei, V.; Porchia, X. M.; Tisato, F.; Marzano, C. Advances in Copper Complexes as Anticancer Agents. Chem. Rev. 2014, 114, 815. doi: 10.1021/cr400135x.
   PubMed Web of Science ®Google Scholar
• Daniel, K. G.; Chen, D.; Harbach, R. H.; Guida, W. C.; Dou, Q. P. Clioquinol and Pyrrolidine Dithiocarbamate Complex with Copper to Form Proteasome Inhibitors and Apoptosis Inducers in Human Breast Cancer Cells. Breast Cancer Res. 2005, 7, R897.
   PubMed Web of Science ®Google Scholar
• Futera, J.; Li, Z.; Tateyama, H.; Li, Y.; Higuchi, M. Conjugation of Organic-Metallic Hybrid Polymers and Calf-Thymus DNA . Phys. Chem. Chem. Phys. 2011, 13, 4839. doi: 10.1039/c0cp02037k.
   PubMed Web of Science ®Google Scholar
• Vyas, K. M.; Jadeja, R. N.; Patel, D.; Devkar, R. V.; Gupta, V. K. Effect of Ligand Substitution in Pyrazolone Based Binary and Ternary Cu(II) Complexes on DNA Binding, Protein Binding and anti-Cancer Activity on A549 Lung Carcinoma Cell Lines. Polyhedron 2014, 80, 20. doi: 10.1016/j.poly.2013.12.037.
   Web of Science ®Google Scholar
• Nithya, P.; Simpson, J.; Govindarajan, S. Syntheses, Structural Diversity and Thermal Behavior of First Row Transition Metal Complexes Containing Potential Multidentate Ligands Based on 2,6-Diacetylpyridine and Benzyl Carbazate. Polyhedron 2018, 141, 5. doi: 10.1016/j.poly.2017.11.009.
   Web of Science ®Google Scholar
• Rabindra, P.; Raju, N.; Raghavaiah, P.; Hussain, S. Picolinic Acid Based Cu(II) Complexes with Heterocyclic Bases – Crystal Structure, DNA Binding and Cleavage Studies. Euro. J. Med. Chem. 2014, 79, 117.
   PubMed Web of Science ®Google Scholar
• Kumaramangalam, J.; Yuvaraj, A.; Bhuvanesh, N. S. P.; Perumal, P. T.; Sreekantha, A.; Ramasamy, K. DNA/Protein Binding, DNA Cleavage, Cytotoxicity, Superoxide Radical Scavenging and Molecular Docking Studies of Copper(II) Complexes Containing N-benzyl-N’-aryl-N’’-Benzoylguanidine Ligands. Inorg. Chem. Front. 2015, 2, 780–798. doi: 10.1039/C4QI00234B.
   Web of Science ®Google Scholar
• Sellamuthu, A.; Anup, P.; Ravishankaran, R.; Fatima, M. C.; Silva, G.; Anjali, A. K.; Armando, J. L. P. Phenyl Carbohydrazone Conjugated 2-Oxoindoline as a New Scaffold That Augments the DNA and BSA Binding Affinity and anti-Proliferative Activity of a 1,10-Phenanthroline Based Copper(II) Complex. Inorg Chim Acta 2014, 423, 183. doi: 10.1016/j.ica.2014.07.016.
   Web of Science ®Google Scholar
• Vargas, J. F. C.; Tiscornia, I.; Porro, V.; Castelli, S.; Katkar, P.; Desideri, A.; Fogolin, M. B.; Etcheverry, S. B. Oxidovanadium(IV) Complexes with Chrysin and Silibinin: anticancer Activity and Mechanisms of Action in a Human Colon Adenocarcinoma Model. J. Biol. Inorg. Chem. 2015, 20, 1175. doi: 10.1007/s00775-015-1298-7.
   PubMed Web of Science ®Google Scholar
• Sartaj, T.; Ahmad, A.; Rais, A. K.; Zahid, H.; Saurabh, S.; Saripella, S.; Farukh, A. Chiral Heterobimetallic Complexes Targeting Human DNA-Topoisomerase Iα. Dalton Trans. 2013, 42, 16749.
   PubMed Web of Science ®Google Scholar
• Mukherjee, S.; Ishani, M.; Reddy, V. P.; Fouzder, B. C.; Mukherjee, S.; Ghosh, S.; Chatterji, U.; Sankar Moi, C. Effect of Pt(II) Complexes on Cancer and Normal Cells Compared to Clinically Used Anticancer Drugs: Cell Cycle Analysis, Apoptosis and DNA/BSA Binding Study. J. Mole. Liqu 2017, 247, 126. doi: 10.1016/j.molliq.2017.09.104.
   Web of Science ®Google Scholar
• Manikandamathavan, V. M.; Thangaraj, M.; Weyhermuller, T.; Parameswari, R. P.; Punitha, V.; Narasimha Murthy, N.; Nair, B. U. Novel Mononuclear Cu (II) Terpyridine Complexes: Impact of Fused Ring Thiophene and Thiazole Head Groups towards DNA/BSA Interaction, Cleavage and Antiproliferative Activity on HepG2 and Triple Negative CAL-51 Cell Line. Euro. J. Med. Chem. 2017, 135, 434. doi: 10.1016/j.ejmech.2017.04.030.
   PubMed Web of Science ®Google Scholar
• Jin, Y.; Cowan, J. A. DNA Cleavage by Copper-ATCUN Complexes. Factors Influencing Cleavage Mechanism and Linearization of dsDNA. J. Am. Chem. Soc. 2005, 127, 8408. doi: 10.1021/ja0503985.
   PubMed Web of Science ®Google Scholar
• Alvarez, M. G.; Alzuet, G.; Borras, J.; Macias, B.; Castineiras, A. Castineiras, Oxidative Cleavage of DNA by a New Ferromagnetic Linear Trinuclear Copper(II) Complex in the Presence of H2O2/Sodium Ascorbate. Inorg. Chem. 2003, 42, 2992. doi: 10.1021/ic020611n.
   PubMed Web of Science ®Google Scholar
  (a) Ushaiah, B.; Leela, D. S.; Ravi, M.; Anupama, B.; Perugu, S.; Kumari, C. G. Synthesis, Characterization, Antibacterial, DNA Binding and Cleavage Studies of Mixed Ligand Cu(II), Co(II) Complexes. J Fluoresc 2014, 24, 1687. ;
   PubMed Web of Science ®Google Scholar
  (a) Joshua, D.; Chandlera, D.; Day, B. J. Thiocyanate: A Potentially Useful Therapeutic Agent with Host Defense and Antioxidant Properties. Biochem. Pharma 2012, 84, 1381.
   PubMed Web of Science ®Google Scholar
• Chennam, K. P.; Ravi, M.; Ushaiah, B.; Srinu, V.; Kumar, E. R.; Devi, C. H. S. Synthesis, Characterization, DNA Interactions, DNA Cleavage, Radical Scavenging Activity, Antibacterial, anti-Proliferative and Docking Studies of New Transition Metal Complexes. J. Fluoresc. 2016, 26, 189. doi: 10.1007/s10895-015-1701-3.
   PubMed Web of Science ®Google Scholar
• Carmichael, J.; DeGraff, W. G.; Gazdar, A. F.; Minna, J. D.; Mitchell, J. B. Evaluation of a Tetrazolium-Based Semiautomated Colorimetric Assay: assessment of Chemosensitivity Testing. Cancer Res. 1987, 47, 936.
   PubMed Web of Science ®Google Scholar
• Nagababu, P.; Barui, A. K.; Thulasiram, B.; Devi, C. H. S.; Satyanarayana, S.; Patra, C. R.; Sreedhar, B. Antiangiogenic Activity of Mononuclear Copper(II) Polypyridyl Complexes for the Treatment of Cancers. J. Med. Chem. 2015, 58, 5226. doi: 10.1021/acs.jmedchem.5b00651.;
   PubMed Web of Science ®Google Scholar
  (a) Rosu, T.; Pahontu, E.; Pasculescu, S.; Georgescu, R.; Stanica, N.; Curaj, A.; Popescu, A.; Leabu, M. Synthesis, Characterization Antibacterial and Antiproliferative Activity of Novel Cu(II) and Pd(II) Complexes with 2-Hydroxy-8-R-Tricyclo[7.3.1.0.2,7]Tridecane-13-One Thiosemicarbazone. Eur. J. Med. Chem. 2010, 45, 1627.;
   PubMed Web of Science ®Google Scholar
  (b) Pait, M.; Subhas, B.; Kundu, C.; Ray, D. Copper(II) Complexes of Piperazine Based Ligand: Synthesis, Crystal Structure, Protein Binding and Evaluation of anti-Cancerous Therapeutic Potential. Inorg. Chim. Acta 2014, 418, 30.
   Web of Science ®Google Scholar
• Putta, V. R.; Mallepally, R. R.; Avudoddi, S.; Yata, P. K.; Chintakuntla, N.; Nancherla, D.; Nagasuryaprasad, K.; Surya, S. S.; Sirasani, S. Design, synthesis, DNA-binding affinity, cytotoxicity, apoptosis, and cell cycle arrest of Ru(II) polypyridyl complexes. Analytical Biochemistry. 2015, 485, 49. doi: 10.1016/j.ab.2015.06.015.
   Google Scholar
• Thompson et Al and Mark. A B Arguslab 4.0.1 www.arguslab.com planaria software LLC, Seattle, WA.
   Google Scholar
• Panne, D.; Maniatis, T.; Harrison, S. C. An Atomic Model of the Interferon-Beta Enhanceosome. Cell (Cambridge, Mass) 2007, 129, 1111. doi: 10.1016/j.cell.2007.05.019.
   PubMed Web of Science ®Google Scholar
• Nissink, J. W. M.; Murray, C.; Hartshorn, M.; Verdonk, M. L.; Cole, J. C.; Taylor, R. A New Test Set for Validating Predictions of Protein-Ligand Interaction. Proteins 2002, 49, 457. doi: 10.1002/prot.10232.
   PubMed Web of Science ®Google Scholar
• Kelly, J. M. A.; Tossi, B.; Mc Connell, D. J.; OhUigin, C. A.; Study of the Interactions of Some Polypyridylruthenium (II) Complexes with DNA Using Fluorescence Spectroscopy, Topoisomerisation and Thermal Denaturation. Nucl. Acids Res. 1985, 13, 6017. doi: 10.1093/nar/13.17.6017.;
   PubMed Web of Science ®Google Scholar
  (a) Ramakrishnan, S.; Rajendiran, V.; Palaniandavar, M.; Periasamy, V. S.; Srinag, B. S.; Krishnamurthy, H.; Akbarsha, M. A. Induction of Cell Death by Ternary Copper(II) Complexes of L-Tyrosine and Diimines: Role of Coligands on DNA Binding and Cleavage and Anticancer Activity. Inorg. Chem. 2009, 48, 1309.
   PubMed Web of Science ®Google Scholar
  (b) Maity, B.; Roy, M.; Banik, B.; Majumdar, R.; Dighe, R. R.; Chakravarty, R. R. Ferrocene-Promoted Photoactivated DNA Cleavage and Anticancer Activity of Terpyridyl Copper(II) Phenanthroline Complexes. Organometallics 2010, 29, 3632.
   Web of Science ®Google Scholar
• Raja, D. S.; Bhuvanesh, N. S. P.; Natarajan, K. Structure–Activity Relationship Study of Copper(II) Complexes with 2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde (40 -Methylbenzoyl) Hydrazone: synthesis, Structures, DNA and Protein Interaction Studies, Antioxidative and Cytotoxic Activity. J. Biol. Inorg. Chem. 2012, 17, 223. doi: 10.1007/s00775-011-0844-1.
   PubMed Web of Science ®Google Scholar
• Senthil Raja, D.; Paramaguru, G.; Bhuvanesh, N. S. P. J.; Reibenspies, H.; Renganathan, R.; Natarajan, K. Effect of Terminal N-Substitution in 2-Oxo-1,2-Dihydroquinoline-3-Carbaldehydethiosemicarbazones on the Mode of Coordination, Structure, Interaction with Protein, Radical Scavenging and Cytotoxic Activity of Copper(II) Complexes. Dalton Trans. 2011, 40, 4548. doi: 10.1039/c0dt01657h.
   PubMed Web of Science ®Google Scholar
• Devappa, S. L.; Badiger, G.; Venugopala Reddy, K. R.; Bhojya Naik, H. S. Macrocyclic Complexes: synthesis, Characterization, Antitumor and DNA Binding Studies. J. Nucleos. Nucleot. Nucl. Acids. 2018, 37(9), 498–517. doi: 10.1080/15257770.2018.1498515.
   PubMed Web of Science ®Google Scholar
• Lakowicz, J. R. Fluorescence Quenching: Theory and Applications. Principles of Fluorescence Spectroscopy. Kluwer Academic/Plenum Publishers: New York, 1999, 53.
   Google Scholar
• Chen, Z.; Zhang, J.; Zhang, S. Oxidative DNA Cleavage Promoted by Two Phenolate-Bridged Binuclear Copper(II) Complexes. New J. Chem. 2015, 39, 1814. doi: 10.1039/C4NJ01623H.
   Web of Science ®Google Scholar
• Kumar, V. R.; Nagababu, P.; Srinivasa, G.; Rani, M. V.; Ravi, M.; Satyanarayana, S. Investigation of DNA/BSA Binding of Three Ru(II) Complexes by Various Spectroscopic Methods, Molecular Docking and Their Antimicrobial Activity. J. Coor. Che. 2017, 70, 3790. doi: 10.1080/00958972.2017.1407410.
   Web of Science ®Google Scholar
• Narsimha, N.; Sudeepa Jaheer, M.; Ravi, M.; Sreekanth, S.; Sarala Devi, C. S. Spectro Analytical, Computational and in Vitro Biological Studies of Novel Substituted Quinolone Hydrazone and It’s Metal Complexes. J. Fluoresc. 2018, 28, 225. doi: 10.1007/s10895-017-2185-0.
   PubMed Web of Science ®Google Scholar
• Sudeepa, K.; Narsimha, N.; Aparn, A,; Sreekanth, S.; Aparna, A.; Ravi, M.; Zaheer Khan, Md.; Sarala Devi, Ch. Synthesis, Spectral Characterization, Antimicrobial, DNA Interactions and Molecular Modeling Studies of Metal Complexes of 1,3-Benzothiazole Carbohydrazone. J. Chem. Scien, 2018, 130, 52. doi: 10.1007/s12039-018-1437-0.
   Google Scholar
• Ravi kumar, U.; Nagababu, P.; Srinivas, G.; Rajender Reddy, M.; Vinoda Rani, M.; Ravi, M.; Satyanarayana. S. Investigation of DNA/BSA binding of three Ru(II) complexes by various spectroscopic methods, molecular docking and their antimicrobial activity. J. Coord Chem., 2017, 22, 3790. doi: 10.1080/00958972.2017.1407410.
   Google Scholar