References
- Naghavi, M.; Abajobir, A. A.; Abbafati, C.; Abbas, K. M.; Abd-Allah, F.; Abera, S. F.; Aboyans, V.; Adetokunboh, O.; Afshin, A.; Agrawal, A.; et al. Global, Regional, and National Age-Sex Specific Mortality for 264 Causes of Death, 1980–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. Lancet 2017, 390, 1151–1210. DOI: https://doi.org/10.1016/S0140-6736(17)32152-9.
- Davies, A.; Gandara, D. R.; Lara, P.; Goldberg, Z.; Roberts, P.; Lau, D. Current and Future Therapeutic Approaches in Locally Advanced (Stage III) Non-Small Cell Lung Cancer. Semin. Oncol. 2002, 29, 10–16.
- Khoubnasabjafari, M.; Ansarin, K.; Jouyban, A. Review of Exhaled Biomarkers in Different Pulmonary Diseases. Med. J. Tabriz Univ. Med. Sci. 2013, 35, 96–105.
- Pauling, L.; Robinson, A. B.; Teranishi, R.; Cary, P. Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography. Proc. Natl. Acad. Sci. U.S.A. 1971, 68, 2374–2376. DOI: https://doi.org/10.1073/pnas.68.10.2374.
- Nardi-Agmon, I.; Peled, N. Exhaled Breath Analysis for the Early Detection of Lung Cancer: Recent Developments and Future Prospects. Lung Cancer: Targets Ther. 2017, 8, 31–38.
- van der Schee, M. P.; Paff, T.; Brinkman, P.; van Aalderen, W. M. C.; Haarman, E. G.; Sterk, P. J. Breathomics in Lung Disease. Chest 2015, 147, 224–231. DOI: https://doi.org/10.1378/chest.14-0781.
- Grob, N.; Aytekin, M.; Dweik, R. Biomarkers in Exhaled Breath Condensate: A Review of Collection, Processing and Analysis. J. Breath Res. 2008, 2, 037004. DOI: https://doi.org/10.1088/1752-7155/2/3/037004.
- Montuschi, P. Analysis of Exhaled Breath Condensate in Respiratory Medicine: Methodological Aspects and Potential Clinical Applications. Ther. Adv. Respir. Dis. 2007, 1, 5–23. DOI: https://doi.org/10.1177/1753465807082373.
- Horváth, I.; Barnes, P. J.; Loukides, S.; Sterk, P. J.; Högman, M.; Olin, A.-C.; Amann, A.; Antus, B.; Baraldi, E.; Bikov, A.; et al. A European Respiratory Society Technical Standard: Exhaled Biomarkers in Lung Disease. Eur. Respir. J. 2017, 49, 1600965. DOI: https://doi.org/10.1183/13993003.00965-2016.
- Cariou, S.; Guillot, J.-M. Double-Layer Tedlar Bags: A Means to Limit Humidity Evolution of Air Samples and to Dry Humid Air Samples. Anal. Bioanal. Chem. 2006, 384, 468–474. DOI: https://doi.org/10.1007/s00216-005-0177-4.
- Standard B. Air Quality—Determination of Odour Concentration by Dynamic Olfactometry. BS EN. 2003;13725:2003.
- Rahimpour, E.; Khoubnasabjafari, M.; Jouyban-Gharamaleki, V.; Jouyban, A. Non-Volatile Compounds in Exhaled Breath Condensate: Review of Methodological Aspects. Anal. Bioanal. Chem. 2018, 410, 6411–6440. DOI: https://doi.org/10.1007/s00216-018-1259-4.
- Jouyban, A.; Khoubnasabjafari, M.; Ansarin, K.; Jouyban-Gharamaleki, V. Breath Sampling Setup. Iranian Patent. 2013;81363.
- Effros, R. M.; Peterson, B.; Casaburi, R.; Su, J.; Dunning, M.; Torday, J.; Biller, J.; Shaker, R. Epithelial Lining Fluid Solute Concentrations in Chronic Obstructive Lung Disease Patients and Normal Subjects. J. Appl. Physiol. 2005, 99, 1286–1292. DOI: https://doi.org/10.1152/japplphysiol.00362.2005.
- Bikov, A.; Galffy, G.; Tamasi, L.; Lazar, Z.; Losonczy, G.; Horvath, I. Exhaled Breath Condensate pH is Influenced by Respiratory Droplet Dilution. J. Breath Res. 2012, 6, 046002. DOI: https://doi.org/10.1088/1752-7155/6/4/046002.
- Kazeminasab, S.; Emamalizadeh, B.; Jouyban-Gharamaleki, V.; Taghizadieh, A.; Khoubnasabjafari, M.; Jouyban, A. Tips for Improving the Quality and Quantity of the Extracted DNA from Exhaled Breath Condensate Samples. Nucleosides Nucleotides Nucleic Acids 2020, 39, 688–698. DOI: https://doi.org/10.1080/15257770.2019.1677910.
- Zamani-Kalajahi, M.; Hasanzadeh, M.; Shadjou, N.; Khoubnasabjafari, M.; Ansarin, K.; Jouyban-Gharamaleki, V.; Jouyban, A. Electrodeposition of Taurine on a Gold Electrode for Electrooxidation of Malondialdehyde in Human Serum and Exhaled Breath Condensate. Surf. Eng. 2015, 31, 194–201. DOI: https://doi.org/10.1179/1743294414Y.0000000349.
- Hatefi, A.; Rahimpour, E.; Khoubnasabjafari, M.; Edalat, M.; Jouyban-Gharamaleki, V.; Alvani-Alamdari, S.; Nokhodchi, A.; Pournaghi-Azar, M. H.; Jouyban, A. A Single-Shot Diagnostic Platform Based on Copper Nanoclusters Coated with Cetyl Trimethylammonium Bromide for Determination of Carbamazepine in Exhaled Breath Condensate. Microchim. Acta 2019, 186, 1–8. DOI: https://doi.org/10.1007/s00604-019-3278-z.
- Jouyban, A.; Farajzadeh, M. A.; Mogaddam, M. R. A.; Nemati, M.; Khoubnasabjafari, M.; Jouyban-Gharamaleki, V. Molecularly Imprinted Polymer Based-Solid Phase Extraction Combined with Dispersive Liquid–Liquid Microextraction Using New Deep Eutectic Solvent; Selective Extraction of Valproic Acid from Exhaled Breath Condensate Samples. Microchem. J. 2021, 161, 105772. DOI: https://doi.org/10.1016/j.microc.2020.105772.
- Jouyban, A.; Samadi, A.; Khoubnasabjafari, M.; Jouyban-Gharamaleki, V.; Ranjbar, F. Amidosulfonic Acid Capped Silver Nanoparticles as a New Spectrophotometric Probe for Rapid Quantification of Lamotrigine in Exhaled Breath Condensate. Microchim. Acta 2017, 184, 2991–2998. DOI: https://doi.org/10.1007/s00604-017-2325-x.
- Rahimpour, E.; Khoubnasabjafari, M.; Hosseini, M. B.; Jouyban, A. Copper Nanocluster-Based Sensor for Determination of Vancomycin in Exhaled Breath Condensate: A Synchronous Fluorescence Spectroscopy. J. Pharm. Biomed. Anal. 2021, 196, 113906. DOI: https://doi.org/10.1016/j.jpba.2021.113906.
- Sepehr, B.; Bavili-Tabrizi, A.; Jouyban-Gharamaleki, V.; Khoubnasabjafari, M.; Jouyban, A. A Sensitive Determination of Ammonia and Nitrite in Exhaled Breath Condensate of Healthy Humans by Using Berthelot Reaction. Curr. Pharm. Anal. 2018, 14, 555–561. DOI: https://doi.org/10.2174/1573412913666170918162236.
- Khoubnasabjafari, M.; Rahimpour, E.; Jouyban, A. Exhaled Breath Condensate as an Alternative Sample for Drug Monitoring. Bioanalysis 2018, 10, 61–64. DOI: https://doi.org/10.4155/bio-2017-0205.
- Khoubnasabjafari, M.; Fathi-Azarbayjani, A.; Rahimpour, E.; Jouyban-Gharamaleki, V.; Kim, H. Y.; Alffenaar, J.; Chan, H.-K.; Jouyban, A. Concentration Profile of Tobramycin in Exhaled Breath Condensate after Inhalation of a Single Dose: A Pilot Study. J. Drug Deliv. Sci. Technol. 2021, 62, 102394. DOI: https://doi.org/10.1016/j.jddst.2021.102394.
- Khoubnasabjafari, M.; Jouyban-Gharamaleki, V.; Ghanbari, R.; Jouyban, A. Exhaled Breath Condensate as a Potential Specimen for Diagnosing COVID-19. Bioanalysis 2020, 12, 1195–1197.
- Sawano, M.; Takeshita, K.; Ohno, H.; Oka, H. RT-PCR Diagnosis of COVID-19 from Exhaled Breath Condensate: A Clinical Study. J. Breath Res. 2021, 15, 037103. DOI: https://doi.org/10.1088/1752-7163/ac0414.
- López-Sánchez, L. M.; Jurado-Gámez, B.; Feu-Collado, N.; Valverde, A.; Cañas, A.; Fernández-Rueda, J. L.; Aranda, E.; Rodríguez-Ariza, A. Exhaled Breath Condensate Biomarkers for the Early Diagnosis of Lung Cancer Using Proteomics. Am. J. Physiol. Lung Cell Mol. Physiol. 2017, 313, L664–L676. DOI: https://doi.org/10.1152/ajplung.00119.2017.
- de Castro Mendes, A. F. S. Exhaled Breath Condensate microRNAs as Potential Biomarkers to Identify and Endotype Asthma in School-Aged Children. Biomarkers 2013, 18, 679–686.
- Pérez-Sánchez, C.; Barbarroja, N.; Pantaleão, L. C.; López-Sánchez, L. M.; Ozanne, S. E.; Jurado-Gámez, B.; Aranda, E.; Lopez-Pedrera, C.; Rodríguez-Ariza, A. Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer. J. Person. Med. 2021, 11, 111. DOI: https://doi.org/10.3390/jpm11020111.
- Khoubnasabjafari, M.; Mogaddam, M. R. A.; Rahimpour, E.; Soleymani, J.; Saei, A. A.; Jouyban, A. Breathomics: Review of Sample Collection and Analysis, Data Modeling and Clinical Applications. Crit. Rev. Anal. Chem. 2021, 1–27. DOI: https://doi.org/10.1080/10408347.2021.1889961.
- Villalobos, P.; Wistuba, I. I. Lung Cancer Biomarkers. Hematol. Oncol. Clin. North Am. 2017, 31, 13–29. DOI: https://doi.org/10.1016/j.hoc.2016.08.006.
- Marshall, H. Genetic and Epigenetic Factors in Development of Lung Cancer. Lancet. Oncol. 2012, 13, 1188. DOI: https://doi.org/10.1016/S1470-2045(12)70523-5.
- Campanella, A.; De Summa, S.; Tommasi, S. Exhaled Breath Condensate Biomarkers for Lung Cancer. J. Breath Res. 2019, 13, 044002. DOI: https://doi.org/10.1088/1752-7163/ab2f9f.
- Kazeminasab, S.; Emamalizadeh, B.; Jouyban, A.; Shoja, M. M.; Khoubnasabjafari, M. Macromolecular Biomarkers of Chronic Obstructive Pulmonary Disease in Exhaled Breath Condensate. Biomark. Med. 2020, 14, 1047–1063. DOI: https://doi.org/10.2217/bmm-2020-0121.
- Paris, D.; Palomba, L.; Mirra, V.; Borrelli, M.; Corcione, A.; Santamaria, F.; Maniscalco, M.; Motta, A. NMR Profiling of Exhaled Breath Condensate Defines Different Metabolic Phenotypes of Non-Cystic Fibrosis Bronchiectasis. Int. J. Mol. Sci. 2020, 21, 8600. DOI: https://doi.org/10.3390/ijms21228600.
- Aoshiba, K.; Nagai, A. Oxidative Stress, Cell Death, and Other Damage to Alveolar Epithelial Cells Induced by Cigarette Smoke. Tob. Induc. Dis. 2003, 1, 219–226. DOI: https://doi.org/10.1186/1617-9625-1-3-219.
- Patsiris, S.; Exarchos, T.; Vlamos, P. Exhaled Breath Condensate (EBC): is It a Viable Source of Biomarkers for Lung Diseases. Adv. Exp. Med. Biol. 2020, 1195, 13–18.
- Gessner, C.; Kuhn, H.; Toepfer, K.; Hammerschmidt, S.; Schauer, J.; Wirtz, H. Detection of p53 Gene Mutations in Exhaled Breath Condensate of Non-Small Cell Lung Cancer Patients. Lung Cancer 2004, 43, 215–222. DOI: https://doi.org/10.1016/j.lungcan.2003.08.034.
- Youssef, O.; Sarhadi, V. K.; Armengol, G.; Piirilä, P.; Knuuttila, A.; Knuutila, S. Exhaled Breath Condensate as a Source of Biomarkers for Lung Carcinomas. A Focus on Genetic and Epigenetic Markers-A Mini-Review. Genes Chromosomes Cancer 2016, 55, 905–914. DOI: https://doi.org/10.1002/gcc.22399.
- Tetik Vardarli, A.; Pelit, L.; Aldag, C.; Korba, K.; Celebi, C.; Dizdas, T. N.; Uzun, U. C.; Tayfur, E.; Aykut, A.; Karakus, H. S.; et al. Concordance in Molecular Genetic Analysis of Tumour Tissue, Plasma, and Exhaled Breath Condensate Samples from Lung Cancer Patients. J. Breath Res. 2020, 14, 036001. DOI: https://doi.org/10.1088/1752-7163/ab739b.
- Youssef, O.; Knuuttila, A.; Piirilä, P.; Böhling, T.; Sarhadi, V.; Knuutila, S. Hotspot Mutations Detectable by Next-Generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer. Anticancer Res. 2018, 38, 5627–5634. DOI: https://doi.org/10.21873/anticanres.12897.
- Kordiak, J.; Szemraj, J.; Grabska-Kobylecka, I.; Bialasiewicz, P.; Braun, M.; Kordek, R.; Nowak, D. Intratumor Heterogeneity and Tissue Distribution of KRAS Mutation in Non-Small Cell Lung Cancer: implications for Detection of Mutated KRAS Oncogene in Exhaled Breath Condensate. J. Cancer Res. Clin. Oncol. 2019, 145, 241–251. DOI: https://doi.org/10.1007/s00432-018-2779-1.
- Smyth, R. J.; Toomey, S. M.; Sartori, A.; O’Hanrahan, E.; Cuffe, S. D.; Breathnach, O. S.; Morgan, R. K.; Hennessy, B. T. Brief Report on the Detection of the EGFR T790M Mutation in Exhaled Breath Condensate from Lung Cancer Patients. J. Thorac. Oncol. 2018, 13, 1213–1216. DOI: https://doi.org/10.1016/j.jtho.2018.04.033.
- Massion, P. P.; Carbone, D. P. The Molecular Basis of Lung Cancer: Molecular Abnormalities and Therapeutic Implications. Respir. Res. 2003, 4, 12. DOI: https://doi.org/10.1186/1465-9921-4-12.
- Toufektchan, E.; Toledo, F. The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure. Cancers 2018, 10, 135. DOI: https://doi.org/10.3390/cancers10050135.
- Liu, M. C.; Gelmann, E. P. P53 Gene Mutations: Case Study of a Clinical Marker for Solid Tumors. Semin. Oncol. 2002, 29, 246–257. editors. DOI: https://doi.org/10.1053/sonc.2002.32900.
- Greenblatt, M.; Bennett, W. P.; Hollstein, M.; Harris, C. Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis. Cancer Res. 1994, 54, 4855–4878.
- Hainaut, P.; Hollstein, M. p53 and Human Cancer: The First Ten Thousand Mutations. Adv. Cancer Res. 2000, 77, 81–137.
- Thiberville, L.; Payne, P.; Vielkinds, J.; LeRiche, J.; Horsman, D.; Nouvet, G.; Palcic, B.; Lam, S. Evidence of Cumulative Gene Losses with Progression of Premalignant Epithelial Lesions to Carcinoma of the Bronchus. Cancer Res. 1995, 55, 5133–5139.
- Fathi, Z.; Mousavi, S. A. J.; Roudi, R.; Ghazi, F. Distribution of KRAS, DDR2, and TP53 Gene Mutations in Lung Cancer: An Analysis of Iranian Patients. PloS One. 2018, 13, e0200633. DOI: https://doi.org/10.1371/journal.pone.0200633.
- Lewis, P.; Parry, J. In Silico p53 Mutation Hotspots in Lung Cancer. Carcinogenesis 2004, 25, 1099–1107. DOI: https://doi.org/10.1093/carcin/bgh068.
- Rivlin, N.; Brosh, R.; Oren, M.; Rotter, V. Mutations in the p53 Tumor Suppressor Gene: important Milestones at the Various Steps of Tumorigenesis. Genes Cancer. 2011, 2, 466–474. DOI: https://doi.org/10.1177/1947601911408889.
- Westcott, P. M.; To, M. D. The Genetics and Biology of KRAS in Lung Cancer. Chin. J. Cancer. 2013, 32, 63–70. DOI: https://doi.org/10.5732/cjc.012.10098.
- Dearden, S.; Stevens, J.; Wu, Y.-L.; Blowers, D. Mutation Incidence and Coincidence in Non Small-Cell Lung Cancer: Meta-Analyses by Ethnicity and Histology (mutMap). Ann. Oncol. 2013, 24, 2371–2376. DOI: https://doi.org/10.1093/annonc/mdt205.
- Riely, G. J.; Kris, M. G.; Rosenbaum, D.; Marks, J.; Li, A.; Chitale, D. A.; Nafa, K.; Riedel, E. R.; Hsu, M.; Pao, W.; et al. Frequency and Distinctive Spectrum of KRAS Mutations in Never Smokers with Lung Adenocarcinoma. Clin. Cancer Res. 2008, 14, 5731–5734. DOI: https://doi.org/10.1158/1078-0432.CCR-08-0646.