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Research Articles

The lncRNA expression profile signature of leukemia stem cells is altered upon PI3K/mTOR inhibition: an in vitro and in silico study

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Pages 99-115 | Received 23 May 2022, Accepted 07 Jul 2023, Published online: 20 Jul 2023

References

  • Ferlay, J.; Colombet, M.; Soerjomataram, I.; Parkin, D. M.; Pineros, M.; Znaor, A.; Bray, F. Cancer Statistics for the Year 2020: An Overview. Int. J. Cancer 2021, 149, 778–789. DOI: 10.1002/ijc.33588.
  • Kantarjian, H. M.; Jain, N.; Garcia-Manero, G.; Welch, M. A.; Ravandi, F.; Wierda, W. G.; Jabbour, E. J. The Cure of Leukemia through the Optimist’s Prism. Cancer 2022, 128, 240–259. DOI: 10.1002/cncr.33933.
  • O’Reilly, E.; Zeinabad, H. A.; Szegezdi, E. Hematopoietic Versus Leukemic Stem Cell Quiescence: Challenges and Therapeutic Opportunities. Blood Rev. 2021, 50, 100850. DOI: 10.1016/j.blre.2021.100850.
  • Martinez-Climent, J. A.; Fontan, L.; Gascoyne, R. D.; Siebert, R.; Prosper, F. Lymphoma Stem Cells: Enough Evidence to Support Their Existence? Haematologica 2010, 95, 293–302. DOI: 10.3324/haematol.2009.013318.
  • Li, H.; Liu, L.; Zhuang, J.; Liu, C.; Zhou, C.; Yang, J.; Gao, C.; Liu, G.; Sun, C. Identification of Key Candidate Targets and Pathways for the Targeted Treatment of Leukemia Stem Cells of Chronic Myelogenous Leukemia Using Bioinformatics Analysis. Mol. Genet. Genomic Med. 2019, 7, e851. DOI: 10.1002/mgg3.851.
  • Bertacchini, J.; Heidari, N.; Mediani, L.; Capitani, S.; Shahjahani, M.; Ahmadzadeh, A.; Saki, N. Targeting Pi3k/Akt/Mtor Network for Treatment of Leukemia. Cell Mol. Life Sci. 2015, 72, 2337–2347. DOI: 10.1007/s00018-015-1867-5.
  • Hu, T.; Li, C.; Zhang, Y.; Wang, L.; Peng, L.; Cheng, H.; Wang, W.; Chu, Y.; Xu, M.; Cheng, T.; et al. Phosphoinositide-Dependent Kinase 1 Regulates Leukemia Stem Cell Maintenance in Mll-Af9-Induced Murine Acute Myeloid Leukemia. Biochem. Biophys. Res. Commun. 2015, 459, 692–698. DOI: 10.1016/j.bbrc.2015.03.007.
  • Skorski, T.; Kanakaraj, P.; Nieborowska-Skorska, M.; Ratajczak, M. Z.; Wen, S. C.; Zon, G.; Gewirtz, A. M.; Perussia, B.; Calabretta, B. Phosphatidylinositol-3 Kinase Activity Is Regulated by Bcr/Abl and Is Required for the Growth of Philadelphia Chromosome-Positive Cells. Blood 1995, 86, 726–736.
  • Kapranov, P.; Cheng, J.; Dike, S.; Nix, D. A.; Duttagupta, R.; Willingham, A. T.; Stadler, P. F.; Hertel, J.; Hackermuller, J.; Hofacker, I. L.; et al. Rna Maps Reveal New Rna Classes and a Possible Function for Pervasive Transcription. Science 2007, 316, 1484–1488. DOI: 10.1126/science.1138341.
  • Bhan, A.; Soleimani, M.; Mandal, S. S. Long Noncoding Rna and Cancer: A New Paradigm. Cancer Res. 2017, 77, 3965–3981. DOI: 10.1158/0008-5472.CAN-16-2634.
  • Garitano-Trojaola, A.; Agirre, X.; Prosper, F.; Fortes, P. Long Non-Coding Rnas in Haematological Malignancies. Int. J. Mol. Sci. 2013, 14, 15386–15422. DOI: 10.3390/ijms140815386.
  • Nobili, L.; Lionetti, M.; Neri, A. Long Non-Coding Rnas in Normal and Malignant Hematopoiesis. Oncotarget 2016, 7, 50666–50681. DOI: 10.18632/oncotarget.9308.
  • Kayabasi, C.; Caner, A.; Yilmaz Susluer, S.; Balci Okcanoglu, T.; Ozmen Yelken, B.; Asik, A.; Mutlu, Z.; Caliskan Kurt, C.; Goker Bagca, B.; Biray Avci, C.; et al. Comparative Expression Analysis of Dasatinib and Ponatinib-Regulated Lncrnas in Chronic Myeloid Leukemia and Their Network Analysis. Med. Oncol. 2022, 39, 29. DOI: 10.1007/s12032-021-01629-0.
  • Huang, T.; Wang, M.; Huang, B.; Chang, A.; Liu, F.; Zhang, Y.; Jiang, B. Long Noncoding Rnas in the Mtor Signaling Network: Biomarkers and Therapeutic Targets. Apoptosis 2018, 23, 255–264. DOI: 10.1007/s10495-018-1453-z.
  • Heydarnezhad Asl, M.; Pasban Khelejani, F.; Bahojb Mahdavi, S. Z.; Emrahi, L.; Jebelli, A.; Mokhtarzadeh, A. The Various Regulatory Functions of Long Noncoding Rnas in Apoptosis, Cell Cycle, and Cellular Senescence. J. Cell Biochem. 2022, 123, 995–1024. DOI: 10.1002/jcb.30221.
  • Kayabasi, C.; Yelken, B. O.; Asik, A.; Okcanoglu, T. B.; Sogutlu, F.; Gasimli, R.; Susluer, S. Y.; Saydam, G.; Avci, C. B.; Gunduz, C. Pi3k/Mtor Dual-Inhibition with Vs-5584 Enhances Anti-Leukemic Efficacy of Ponatinib in Blasts and Ph-Negative Lscs of Chronic Myeloid Leukemia. Eur. J. Pharmacol. 2021, 910, 174446. DOI: 10.1016/j.ejphar.2021.174446.
  • Hart, S.; Novotny-Diermayr, V.; Goh, K. C.; Williams, M.; Tan, Y. C.; Ong, L. C.; Cheong, A.; Ng, B. K.; Amalini, C.; Madan, B.; et al. Vs-5584, a Novel and Highly Selective Pi3k/Mtor Kinase Inhibitor for the Treatment of Cancer. Mol. Cancer Ther. 2013, 12, 151–161. DOI: 10.1158/1535-7163.MCT-12-0466.
  • Li, Z.; Liu, L.; Jiang, S.; Li, Q.; Feng, C.; Du, Q.; Zou, D.; Xiao, J.; Zhang, Z.; Ma, L. Lncexpdb: An Expression Database of Human Long Non-Coding Rnas. Nucleic Acids Res. 2021, 49, D962–D968. DOI: 10.1093/nar/gkaa850.
  • Deelen, P.; van Dam, S.; Herkert, J. C.; Karjalainen, J. M.; Brugge, H.; Abbott, K. M.; van Diemen, C. C.; van der Zwaag, P. A.; Gerkes, E. H.; Zonneveld-Huijssoon, E.; et al. Improving the Diagnostic Yield of Exome- Sequencing by Predicting Gene-Phenotype Associations Using Large-Scale Gene Expression Analysis. Nat. Commun. 2019, 10, 2837. DOI: 10.1038/s41467-019-10649-4.
  • Keenan, A. B.; Torre, D.; Lachmann, A.; Leong, A. K.; Wojciechowicz, M. L.; Utti, V.; Jagodnik, K. M.; Kropiwnicki, E.; Wang, Z.; Ma’ayan, A. Chea3: Transcription Factor Enrichment Analysis by Orthogonal Omics Integration. Nucleic Acids Res. 2019, 47, W212–W224. DOI: 10.1093/nar/gkz446.
  • Junge, A.; Refsgaard, J. C.; Garde, C.; Pan, X.; Santos, A.; Alkan, F.; Anthon, C.; von Mering, C.; Workman, C. T.; Jensen, L. J.; et al. Rain: Rna-Protein Association and Interaction Networks. Database (Oxford) 2017, 2017, article ID bax007. DOI: 10.1093/database/baw167.
  • Huang da, W.; Sherman, B. T.; Lempicki, R. A. Systematic and Integrative Analysis of Large Gene Lists Using David Bioinformatics Resources. Nat. Protoc. 2009, 4, 44–57. DOI: 10.1038/nprot.2008.211.
  • Huang da, W.; Sherman, B. T.; Lempicki, R. A. Bioinformatics Enrichment Tools: Paths toward the Comprehensive Functional Analysis of Large Gene Lists. Nucleic Acids Res. 2009, 37, 1–13. DOI: 10.1093/nar/gkn923.
  • Thul, P. J.; Lindskog, C. The Human Protein Atlas: A Spatial Map of the Human Proteome. Protein Sci. 2018, 27, 233–244. DOI: 10.1002/pro.3307.
  • Ghandi, M.; Huang, F. W.; Jane-Valbuena, J.; Kryukov, G. V.; Lo, C. C.; McDonald, E. R.; 3rd; Barretina, J.; Gelfand, E. T.; Bielski, C. M.; Li, H.; et al. Next-Generation Characterization of the Cancer Cell Line Encyclopedia. Nature 2019, 569, 503–508. DOI: 10.1038/s41586-019-1186-3.
  • Chen, C.; Liu, Y.; Liu, Y.; Zheng, P. Mtor Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells. Sci. Signal 2009, 2, ra75. DOI: 10.1126/scisignal.2000559.
  • Zhang, C.; Zhu, N.; Liu, C.; Wu, H.; Yin, Y.; Shi, Y.; Liao, D.; Qin, L. Steroid Receptor Rna Activator Inhibits the Migration, Invasion and Stemness Characteristics of Renal Cell Carcinoma Cells. Int. J. Mol. Med. 2020, 46, 1765–1776. DOI: 10.3892/ijmm.2020.4730.
  • Zhang, T. J.; Zhou, J. D.; Zhang, W.; Lin, J.; Ma, J. C.; Wen, X. M.; Yuan, Q.; Li, X. X.; Xu, Z. J.; Qian, J. H19 Overexpression Promotes Leukemogenesis and Predicts Unfavorable Prognosis in Acute Myeloid Leukemia. Clin. Epigenetics 2018, 10, 47. DOI: 10.1186/s13148-018-0486-z.
  • Benetatos, L.; Benetatou, A.; Vartholomatos, G. Long Non-Coding Rnas and Myc Association in Hematological Malignancies. Ann. Hematol. 2020, 99, 2231–2242. DOI: 10.1007/s00277-020-04166-4.
  • Allain, E. P.; Rouleau, M.; Levesque, E.; Guillemette, C. Emerging Roles for Udp-Glucuronosyltransferases in Drug Resistance and Cancer Progression. Br. J. Cancer 2020, 122, 1277–1287. DOI: 10.1038/s41416-019-0722-0.
  • Zahreddine, H. A.; Culjkovic-Kraljacic, B.; Assouline, S.; Gendron, P.; Romeo, A. A.; Morris, S. J.; Cormack, G.; Jaquith, J. B.; Cerchietti, L.; Cocolakis, E.; et al. The Sonic Hedgehog Factor Gli1 Imparts Drug Resistance through Inducible Glucuronidation. Nature 2014, 511, 90–93. DOI: 10.1038/nature13283.
  • Gruber, M.; Bellemare, J.; Hoermann, G.; Gleiss, A.; Porpaczy, E.; Bilban, M.; Le, T.; Zehetmayer, S.; Mannhalter, C.; Gaiger, A.; et al. Overexpression of Uridine Diphospho Glucuronosyltransferase 2b17 in High-Risk Chronic Lymphocytic Leukemia. Blood 2013, 121, 1175–1183. DOI: 10.1182/blood-2012-08-447359.
  • Kumar, V.; Singh, P.; Gupta, S. K.; Ali, V.; Verma, M. Transport and Metabolism of Tyrosine Kinase Inhibitors Associated with Chronic Myeloid Leukemia Therapy: A Review. Mol. Cell Biochem. 2022, 477, 1261–1279. DOI: 10.1007/s11010-022-04376-6.
  • Peters, J. M.; Shah, Y. M.; Gonzalez, F. J. The Role of Peroxisome Proliferator-Activated Receptors in Carcinogenesis and Chemoprevention. Nat. Rev. Cancer 2012, 12, 181–195. DOI: 10.1038/nrc3214.
  • Yang, L.; Shi, P.; Zhao, G.; Xu, J.; Peng, W.; Zhang, J.; Zhang, G.; Wang, X.; Dong, Z.; Chen, F.; et al. Targeting Cancer Stem Cell Pathways for Cancer Therapy. Signal Transduct Target Ther. 2020, 5, 8. DOI: 10.1038/s41392-020-0110-5.
  • Prost, S.; Relouzat, F.; Spentchian, M.; Ouzegdouh, Y.; Saliba, J.; Massonnet, G.; Beressi, J. P.; Verhoeyen, E.; Raggueneau, V.; Maneglier, B.; et al. Erosion of the Chronic Myeloid Leukaemia Stem Cell Pool by Ppargamma Agonists. Nature 2015, 525, 380–383. DOI: 10.1038/nature15248.
  • Rosenbauer, F.; Tenen, D. G. Transcription Factors in Myeloid Development: Balancing Differentiation with Transformation. Nat. Rev. Immunol. 2007, 7, 105–117. DOI: 10.1038/nri2024.

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