251
Views
50
CrossRef citations to date
0
Altmetric
Original Articles

Chemically Modified Short Interfering Hybrids (siHYBRIDS): Nanoimmunoliposome Delivery In Vitro and In Vivo for RNAi of HER-2

, , , , , , & show all
Pages 889-907 | Received 23 Nov 2005, Accepted 04 May 2006, Published online: 16 Feb 2007

REFERENCES

  • Leung , R. K. and Whittaker , P. A. 2005 . RNA Interference: From Gene Silencing to Gene-Specific Therapeutics . Pharmacology & Therapeutics , 107 : 222 – 239 . [CSA]
  • Dorsett , Y. and Tuschl , T. 2004 . siRNAs: Applications in Functional Genomics and Potential as Therapeutics . Nature Reviews Drug Discovery , 3 : 318 – 329 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Crooke , S. T. 2004 . Antisense Strategies . Current Molecular Medicine , 4 : 465 – 487 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Kurreck , J. 2003 . Antisense Technologies. Improvement through Novel Chemical Modifications . European Journal of Biochemistry , 270 : 1628 – 1644 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Soutschek , J. , Akinc , A. , Bramlage , B. , Charisse , K. , Constien , R. , Donoghue , M. , Elbashir , S. , Geick , A. , Hadwiger , P. , Harborth , J. , John , M. , Kesavan , V. , Lavine , G. , Pandey , R. K. , Racie , T. , Rajeev , K. G. , Rohl , I. , Toudjarska , I. , Wang , G. , Wuschko , S. , Bumcrot , D. , Koteliansky , V. , Limmer , S. , Manoharan , M. and Vornlocher , H. P. 2004 . Therapeutic Silencing of an Endogenous Gene by Systemic Administration of Modified siRNAs . Nature , 432 : 173 – 178 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Allerson , C. R. , Sioufi , N. , Jarres , R. , Prakash , T. P. , Naik , N. , Berdeja , A. , Wanders , L. , Griffey , R. H. , Swayze , E. E. and Bhat , B. 2005 . Fully 2′-Modified Oligonucleotide Duplexes with Improved In Vitro Potency and Stability Compared to Unmodified Small Interfering RNA . Journal of Medicinal Chemistry , 48 : 901 – 904 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Amarzguioui , M. , Holen , T. , Babaie , E. and Prydz , H. 2003 . Tolerance for Mutations and Chemical Modifications in a siRNA . Nucleic Acids Research , 31 : 589 – 595 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Czauderna , F. , Fechtner , M. , Dames , S. , Aygun , H. , Klippel , A. , Pronk , G. J. , Giese , K. and Kaufmann , J. 2003 . Structural Variations and Stabilising Modifications of Synthetic siRNAs in Mammalian Cells . Nucleic Acids Research , 31 : 2705 – 2716 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Chiu , Y. L. and Rana , T. M. 2003 . siRNA Function in RNAi: A Chemical Modification Analysis . RNA , 9 : 1034 – 1048 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Harborth , J. , Elbashir , S. M. , Vandenburgh , K. , Manninga , H. , Scaringe , S. A. , Weber , K. and Tuschl , T. 2003 . Sequence, Chemical, and Structural Variation of Small Interfering RNAs and Short Hairpin RNAs and the Effect on Mammalian Gene Silencing . Antisense and Nucleic Acid Drug Development , 13 : 83 – 105 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Morrissey , D. V. , Lockridge , J. A. , Shaw , L. , Blanchard , K. , Jensen , K. , Breen , W. , Hartsough , K. , Machemer , L. , Radka , S. , Jadhav , V. , Vaish , N. , Zinnen , S. , Vargeese , C. , Bowman , K. , Shaffer , C. S. , Jeffs , L. B. , Judge , A. , MacLachlan , I. and Polisky , B. 2005 . Potent and Persistent In Vivo Anti-HBV Activity of Chemically Modified siRNAs . Nature Biotechnology , 23 : 1002 – 1007 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Braasch , D. A. , Jensen , S. , Liu , Y. , Kaur , K. , Arar , K. , White , M. A. and Corey , D. R. 2003 . RNA Interference in Mammalian Cells by Chemically-Modified RNA . Biochemistry , 42 : 7967 – 7975 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Li , Z. Y. , Mao , H. , Kallick , D. A. and Gorenstein , D. G. 2005 . The Effects of Thiophosphate Substitutions on Native siRNA Gene Silencing . Biochemical and Biophysical Research Communications , 329 : 1026 – 1030 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Elmen , J. , Thonberg , H. , Ljungberg , K. , Frieden , M. , Westergaard , M. , Xu , Y. , Wahren , B. , Liang , Z. , Orum , H. , Koch , T. and Wahlestedt , C. 2005 . Locked Nucleic Acid (LNA) Mediated Improvements in siRNA Stability and Functionality . Nucleic Acids Research , 33 : 439 – 447 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Pham , J. W. and Sontheimer , E. J. 2005 . Molecular Requirements for RNA-Induced Silencing Complex Assembly in the Drosophila RNA Interference Pathway . Journal of Biological Chemistry , 280 : 39278 – 39293 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Hohjoh , H. 2002 . and RNA Interference (RNA(i)) Induction with Various Types of Synthetic Oligonucleotide Duplexes in Cultured Human Cells . FEBS Letters , 521 : 195 – 199 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Lamberton , J. S. and Christian , A. T. 2003 . Varying the Nucleic Acid Composition of siRNA Molecules Dramatically Varies the Duration and Degree of Gene Silencing . Molecular Biotechnology , 24 : 111 – 120 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Christian , A. T. and Lamberton , J. S. 2004 . Short Interfering Nucleic Acid Hybrids and Methods Thereof WO 022771 A2
  • Judge , A. D. , Sood , V. , Shaw , J. R. , Fang , D. , McClintock , K. and MacLachlan , I. 2005 . Sequence-Dependent Stimulation of the Mammalian Innate Immune Response by Synthetic siRNA . Nature Biotechnology , 23 : 457 – 462 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Jackson , A. L. , Bartz , S. R. , Schelter , J. , Kobayashi , S. V. , Burchard , J. , Mao , M. , Li , B. , Cavet , G. and Linsley , P. S. 2003 . Expression Profiling Reveals Off-Target Gene Regulation by RNAi . Nature Biotechnology , 21 : 635 – 637 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Brazas , R. M. and Hagstrom , J. E. 2005 . Delivery of Small Interfering RNA to Mammalian Cells in Culture by Using Cationic Lipid/Polymer-Based Transfection Reagents . Methods in Enzymology , 392 : 112 – 124 . [INFOTRIEVE] [CSA]
  • Chien , P. Y. , Wang , J. , Carbonaro , D. , Lei , S. , Miller , B. , Sheikh , S. , Ali , S. M. , Ahmad , M. U. and Ahmad , I. 2005 . Novel Cationic Cardiolipin Analogue-Based Liposome for Efficient DNA and Small Interfering RNA Delivery In Vitro and In Vivo . Cancer Gene Therapy , 12 : 321 – 328 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Choudhury , A. , Charo , J. , Parapuram , S. K. , Hunt , R. C. , Hunt , D. M. , Seliger , B. and Kiessling , R. 2004 . Small Interfering RNA (siRNA) Inhibits the Expression of the Her2/neu Gene, Upregulates HLA Class I and Induces Apoptosis of Her2/neu Positive Tumor Cell Lines . International Journal of Cancer , 108 : 71 – 77 . [CROSSREF] [CROSSREF] [CSA]
  • Rait , A. S. , Pirollo , K. F. , Ulick , D. , Cullen , K. and Chang , E. H. 2003 . HER-2-Targeted Antisense Oligonucleotide Results in Sensitization of Head and Neck Cancer Cells to Chemotherapeutic Agents . Annals of the New York Academy of Sciences , 1002 : 78 – 89 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Rait , A. S. , Pirollo , K. F. , Xiang , L. , Ulick , D. and Chang , E. H. 2002 . Tumor-Targeting, Systemically Delivered Antisense HER-2 Chemosensitizes Human Breast Cancer Xenografts Irrespective of HER-2 Levels . Molecular Medicine , 8 : 475 – 486 . [INFOTRIEVE] [CSA]
  • Rait , A. S. , Pirollo , K. F. , Rait , V. , Krygier , J. E. , Xiang , L. and Chang , E. H. 2001 . Inhibitory Effects of the Combination of HER-2 Antisense Oligonucleotide and Chemotherapeutic Agents Used for the Treatment of Human Breast Cancer . Cancer Gene Therapy , 8 : 728 – 739 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Kariko , K. , Buckstein , M. , Ni , H. and Weissman , D. 2005 . Suppression of RNA Recognition by Toll-Like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA . Immunity , 23 : 165 – 175 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Pirollo , K. F. , Zon , G. , Rait , A. , Zhou , Q. , Yu , W. , Hogrefe , R. I. and Chang , E. H. 2006 . A Tumor Targeting Nanoimmunoliposome Complex for siRNA Delivery . Human Gene Therapy , 17 : 117 – 124 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Xu , L. , Huang , C. C. , Huang , W. , Tang , W. H. , Rait , A. , Yin , Y. Z. , Cruz , I. , Xiang , L. M. , Pirollo , K. F. and Chang , E. H. 2002 . Systemic Tumor-Targeted Gene Delivery by Anti-Transferrin Receptor scFv-Immunoliposomes . Molecular Cancer Therapeutics , 1 : 337 – 346 . [INFOTRIEVE] [CSA]
  • Xu , L. , Tang , W. H. , Huang , C. C. , Alexander , W. , Xiang , L. M. , Pirollo , K. F. , Rait , A. and Chang , E. H. 2001 . Systemic p53 Gene Therapy of Cancer with Immunolipoplexes Targeted by Anti-Transferrin Receptor scFv . Molecular Medicine , 7 : 723 – 734 . [INFOTRIEVE] [CSA]
  • Yu , W. , Pirollo , K. F. , Yu , B. , Rait , A. , Xiang , L. , Huang , W. , Zhou , Q. , Ertem , G. and Chang , E. H. 2004 . Enhanced Transfection Efficiency of a Systemically Delivered Tumor-Targeting Immunolipoplex by Inclusion of a pH-Sensitive Histidylated Oligolysine Peptide . Nucleic Acids Research , 32 : e48 [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Hawser , S. P. , Norris , H. , Jessup , C. J. and Ghannoum , M. A. 1998 . Comparison of a 2,3-bis(2-Methoxy-4-Nitro-5-Sulfophenyl)-5-[(Phenylamino)Carbonyl]-2H-tetrazolium Hydroxide (XTT) Colorimetric Method with the Standardized National Committee for Clinical Laboratory Standards Method of Testing Clinical Yeast Isolates for Susceptibility to Antifungal Agents . Journal of Clinical Microbiology , 36 : 1450 – 1452 . [INFOTRIEVE] [CSA]
  • Day , J. D. , Digiuseppe , J. A. , Yeo , C. , Lai-Goldman , M. , Anderson , S. M. , Goodman , S. N. , Kern , S. E. and Hruban , R. H. 1996 . Immunohistochemical Evaluation of HER-2/neu Expression in Pancreatic Adenocarcinoma and Pancreatic Intraepithelial Neoplasms . Human Pathology , 27 : 119 – 124 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Apple , S. K. , Hecht , J. R. , Lewin , D. N. , Jahromi , S. A. , Grody , W. W. and Nieberg , R. K. 1999 . Immunohistochemical Evaluation of K-ras, p53, and HER-2/neu Expression in Hyperplastic, Dysplastic, and Carcinomatous Lesions of the Pancreas: Evidence for Multistep Carcinogenesis . Human Pathology , 30 : 123 – 129 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Lieberman , S. M. , Horig , H. and Kaufman , H. L. 2001 . Innovative Treatments for Pancreatic Cancer . Surgical Clinics of North America , 81 : 715 – 739 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Rabindran , S. K. 2005 . Antitumor Activity of HER-2 Inhibitors . Cancer Letters , 227 : 9 – 23 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Luwor , R. B. , Lu , Y. , Li , X. , Mendelsohn , J. and Fan , Z. 2005 . The Antiepidermal Growth Factor Receptor Monoclonal Antibody Cetuximab/C225 Reduces Hypoxia-Inducible Factor-1 Alpha, Leading to Transcriptional Inhibition of Vascular Endothelial Growth Factor Expression . Oncogene , 24 : 4433 – 4441 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Yu , W. , Pirollo , K. F. , Rait , A. , Yu , B. , Xiang , L. M. , Huang , W. Q. , Zhou , Q. , Ertem , G. and Chang , E. H. 2006 . A Sterically Stabilized Immunolipoplex for Systemic Administration of a Therapeutic Gene . Gene Therapy , 11 : 1434 – 1440 . [CROSSREF] [CROSSREF] [CSA]
  • Khvorova , A. , Reynolds , A. and Jayasena , S. D. 2003 . Functional siRNAs and miRNAs Exhibit Strand Bias . Cell , 115 : 209 – 216 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Ge , Q. , McManus , M. T. , Nguyen , T. , Shen , C. H. , Sharp , P. A. , Eisen , H. N. and Chen , J. 2003 . RNA Interference of Influenza Virus Production by Directly Targeting mRNA for Degradation and Indirectly Inhibiting All Viral RNA Transcription . Proceedings of the National Academy of Sciences, USA , 100 : 2718 – 2723 . [CROSSREF] [CROSSREF] [CSA]
  • Allerson , C. R. , Bhat , B. , Eldrup , A. B. , Monoharan , M. , Griffey , R. H. , Baker , B. F. and Swayze , E. E. Compositions Comprising Alternating 2′-Modified Nucleosides for Use in Gene Modulation US 2005/0187178 A1
  • Nowotny , M. , Gaidamakov , S. A. , Crouch , R. J. and Yang , W. 2005 . Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis . Cell , 121 : 1005 – 1016 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Yang , W. , Wang , Q. , Howell , K. L. , Lee , J. T. , Cho , D. S. , Murray , J. M. and Nishikura , K. 2005 . ADAR1 RNA Deaminase Limits Short Interfering RNA Efficacy in Mammalian Cells . Journal of Biological Chemistry , 280 : 3946 – 3953 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Yang , G. , Cai , K. Q. , Thompson-Lanza , J. A. , Bast , R. C. Jr. and Liu , J. 2004 . Inhibition of Breast and Ovarian Tumor Growth Through Multiple Signaling Pathways by Using Retrovirus-Mediated Small Interfering RNA against Her-2/neu Gene Expression . Journal of Biological Chemistry , 279 : 4339 – 4345 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Faltus , T. , Yuan , J. , Zimmer , B. , Kramer , A. , Loibl , S. , Kaufmann , M. and Strebhardt , K. 2004 . Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells . Neoplasia , 6 : 786 – 795 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Urban-Klein , B. , Werth , S. , Abuharbeid , S. , Czubayko , F. and Aigner , A. 2005 . RNAi-Mediated Gene-Targeting through Systemic Aapplication of Polyethylenimine (PEI)-Complexed siRNA In Vivo . Gene Therapy , 12 : 461 – 466 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • McSwiggen , J. , Beigelman , L. , Pavco , P. , Fosnaugh , K. and Jamison , S. 2005 . RNA Interference Mediated Inhibition of Epidermal Growth Factor Receptor (EGFR) Gene Expression Using Short Interfering Nucleic Acid (SINA), US 0176024 A1,
  • Ren , S. H. , Zhang , W. , Qu , P. , Liu , Y. , Wang , J. W. and Zhang , L. 2005 . Effect of RNAi-Mediated Gene Silencing of C-erbB-2 on Proliferation of Lung Adenocarcinoma Cell Line calu-3 . Ai Zheng , 24 : 1173 – 1178 . [INFOTRIEVE] [CSA]
  • Moghimi , S. M. , Symonds , P. , Murray , J. C. , Hunter , A. C. , Debska , G. and Szewczyk , A. 2005 . A Two-Stage Poly(Ethylenimine)-Mediated Cytotoxicity: Implications for Gene Transfer/Therapy . Molecular Therapy , 11 : 990 – 995 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Song , E. , Zhu , P. , Lee , S. K. , Chowdhury , D. , Kussman , S. , Dykxhoorn , D. M. , Feng , Y. , Palliser , D. , Weiner , D. B. , Shankar , P. , Marasco , W. A. and Lieberman , J. 2005 . Antibody Mediated In Vivo Delivery of Small Interfering RNAs via Cell-Surface Receptors . Nature Biotechnology , 23 : 709 – 717 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Schiffelers , R. M. , Ansari , A. , Xu , J. , Zhou , Q. , Tang , Q. , Storm , G. , Molema , G. , Lu , P. Y. , Scaria , P. V. and Woodle , M. C. 2004 . Cancer siRNA Therapy by Tumor Selective Delivery with Ligand-Targeted Sterically Stabilized Nanoparticle . Nucleic Acids Research , 32 : e149 [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Landen , C. N. Jr. , Chavez-Reyes , A. , Bucana , C. , Schmandt , R. , Deavers , M. T. , Lopez-Berestein , G. and Sood , A. K. 2005 . Therapeutic EphA2 Gene Targeting In Vivo Using Neutral Liposomal Small Interfering RNA Delivery . Cancer Research , 65 : 6910 – 6918 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Kunisawa , J. , Masuda , T. , Katayama , K. , Yoshikawa , T. , Tsutsumi , Y. , Akashi , M. , Mayumi , T. and Nakagawa , S. 2005 . Fusogenic Liposome Delivers Encapsulated Nanoparticles for Cytosolic Controlled Gene Release . Journal of Controlled Release , 105 : 344 – 353 . [INFOTRIEVE] [CROSSREF] [CROSSREF] [CSA]
  • Pal , A. , Ahmad , A. , Khan , S. , Sakabe , I. , Zhang , C. , Kasid , U. N. and Ahmad , I. 2005 . Systemic Delivery of RafsiRNA Using Cationic Cardiolipin Liposomes Silences Raf-1 Expression and Inhibits Tumor Growth in Xenograft Model of Human Prostate Cancer . International Journal of Oncology , 26 : 1087 – 1091 . [INFOTRIEVE] [CSA]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.