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Original Articles

Telomere Shortening in Human HL60 Cells by Treatment with 3′-Azido-2′,3′-Dideoxynucleosides and Telomerase Inhibition by Their 5′-Triphosphates

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Pages 1067-1071 | Published online: 10 Dec 2007

REFERENCES

  • Blackburn , E. H. 1992 . Telomerases . Ann. Rev. Biochem. , 61 : 113 – 129 .
  • Harley , C. B. , Futcher , A. B. and Greider , C. W. 1990 . Telomeres shorten during ageing of human fibroblasts . Nature , 345 : 458 – 460 .
  • Lingner , J. , Hughes , T. R. , Shevchenko , A. , Mann , M. , Lundblad , V. and Cech , T. R. 1997 . Reverse tranriptase motifs in the catalytic subunit of telomerase . Science , 276 : 561 – 567 .
  • Morin , G. B. 1989 . The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats . Cell , 59 : 521 – 529 .
  • Strahl , C. and Blackburn , E. H. 1996 . Effects of reverse tranriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines . Mol. Cell. Biol. , 16 : 53 – 65 .
  • Yamaguchi , T. , Takahashi , H. , Jinmei , H. , Takayama , Y. and Saneyoshi , M. 2003 . Inhibition of vertebrate telomerases by the triphosphate derivatives of some biologically active nucleosides . Nucleosides, Nucleotides Nucleic Acids , 22 : 1575 – 1577 .
  • Imazawa , M. and Eckstein , F. 1978 . Synthesis of 3′-azido-2′,3′-dideoxyribofuranosylpurines . J. Org. Chem. , 43 : 3044 – 3048 .
  • Robins , M. J. , Wood , S. G. , Dalley , N. K. , Herdewijn , P. , Balzarini , J. and De Clercq , E. 1989 . Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3′-azido-2′,3′-dideoxy-2,6-diaminopurine ribosides . J. Med. Chem. , 32 : 1763 – 1768 .
  • Yamaguchi , T. , Yamada , R. , Tomikawa , A. , Shudo , K. , Saito , M. , Ishikawa , F. and Saneyoshi , M. 2000 . Recognition of 2′-deoxy-L-ribonucleoside 5′-triphosphates by human telomerase . Biochem. Biophy. Res. Comm. , 279 : 475 – 481 .
  • Yamaguchi , T. , Saneyoshi , M. , Takahashi , H. , Hirokawa , S. , Amano , R. , Liu , X. , Inomata , M. and Maruyama , T. 2006 . Synthetic nucleosides and nucleotides. 43. Inhibition of vertebrate telomerases by carbocyclic oxetanocin G (C.OXT-G) triphosphate analogues and influence of C.OXT-G treatment on telomere length in human HL60 cells . Nucleosides, Nucleotides Nucleic Acids , 25 : 539 – 551 .

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