Troxacitabine Prodrugs for Pancreatic Cancer

REFERENCES

• Grove , K. L. , Guo , X. , Liu , S. H. , Gao , Z. , Chu , C. K. and Cheng , Y. C. 1995 . Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration . Cancer Res. , 55 : 3008 – 3011 .
   PubMed Web of Science ®Google Scholar
• Gourdeau , H. and Jolivet , J. 2006 . “ Troxacitabine (Troxatyl™) a deoxycytidine nucleoside analog with potent antitumor activity ” . In Cancer Drug Diovery and Developement: Deoxynucleoside Analogs in Cancer Therapy , Edited by: Peters , G. J. 199 – 214 . Totowa , NJ : Humana Press Inc. .
   Google Scholar
• Gumina , G. , Chong , Y. and Chu , C. K. 2006 . “ L-Nucleosides as chemotherapeutic agents ” . In Cancer Drug Diovery and Developement: Deoxynucleoside Analogs in Cancer Therapy , Edited by: Peters , G. J. 173 – 198 . Totowa , NJ : Humana Press Inc. .
   Google Scholar
• Gourdeau , H. , Clarke , M. L. , Ouellet , F. , Mowles , D. , Selner , M. , Richard , A. , Lee , N. , Mackey , J. R. , Young , J. D. , Jolivet , J. , Lafreniere , R. G. and Cass , C. E. 2001 . Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines . Cancer Res. , 61 : 7217 – 7224 .
   PubMed Web of Science ®Google Scholar
• Kukhanova , M. , Liu , S. H. , Mozzherin , D. , Lin , T. S. , Chu , C. K. and Cheng , Y. C. 1995 . L- and D-enantiomers of 2′,3′-dideoxycytidine 5′-triphosphate analogs as substrates for human DNA polymerases. Implications for the mechanism of toxicity . J. Biol. Chem. , 270 : 23055 – 23059 .
   PubMed Web of Science ®Google Scholar
• Chou , K. M. , Kukhanova , M. and Cheng , Y. C. 2000 . A novel action of human apurinic/apyrimidinic endonuclease: Excision of L-configuration deoxyribonucleoside analogs from the 3′ termini of DNA . J. Biol. Chem. , 275 : 31009 – 31015 .
   PubMed Web of Science ®Google Scholar
• Chou , K. M. and Cheng , Y. C. 2003 . The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G . J. Biol. Chem. , 278 : 18289 – 18296 .
   PubMed Web of Science ®Google Scholar
• Weitman , S. , Marty , J. , Jolivet , J. , Locas , C. and Von Hoff , D. D. 2000 . The new dioxolane, (−)-2′-deoxy-3′-oxacytidine (BCH-4556, troxacitabine), has activity against pancreatic human tumor xenografts . Clin. Cancer Res. , 6 : 1574 – 1578 .
   PubMed Web of Science ®Google Scholar
• Lapointe , R. , Letourneau , R. , Steward , W. , Hawkins , R. E. , Batist , G. , Vincent , M. , Whittom , R. , Eatock , M. , Jolivet , J. and Moore , M. 2005 . Phase II study of troxacitabine in chemotherapy-naive patients with advanced cancer of the pancreas: Gastrointestinal tumors . Ann. Oncol. , 16 : 289 – 293 .
   PubMed Web of Science ®Google Scholar
• de Bono , J. S. , Stephenson , J. Jr. , Baker , S. D. , Hidalgo , M. , Patnaik , A. , Hammond , L. A. , Weiss , G. , Goetz , A. , Siu , L. , Simmons , C. , Jolivet , J. and Rowinsky , E. K. 2002 . Troxacitabine, an L-stereoisomeric nucleoside analog, on a five-times-daily hedule: A phase I and pharmacokinetic study in patients with advanced solid malignancies . J. Clin. Oncol. , 20 : 96 – 109 .
   PubMed Web of Science ®Google Scholar
• Kim , H. O. , Schinazi , R. F. , Nampalli , S. , Shanmuganathan , K. , Cannon , D. L. , Alves , A. J. , Jeong , L. S. , Beach , J. W. and Chu , C. K. 1993 . 1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes . J. Med. Chem. , 36 : 30 – 37 .
   PubMed Web of Science ®Google Scholar
• Keepers , Y. P. , Pizao , P. E. , Peters , G. J. , Ark-Otte , J. , Winograd , B. and Pinedo , H. M. 1991 . Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing . Eur. J. Cancer , 27 : 897 – 900 .
   PubMed Web of Science ®Google Scholar
• Radi , M. , Adema , A. D. , Daft , J. R. , Cho , J. H. , Hoebe , E. K. , Alexander , L. E. , Peters , J. and Chu , C. K. 2007 . In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine prodrugs . J. Med. Chem. , 50 : 2249 – 2253 .
   PubMed Web of Science ®Google Scholar
• Bergman , A. M. , Kuiper , C. M. , Voorn , D. A. , Comijn , E. M. , Myhren , F. , Sandvold , M. L. , Hendriks , H. R. and Peters , G. J. 2004 . Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines . Biochem. Pharmacol. , 67 : 503 – 511 .
   PubMed Web of Science ®Google Scholar
• Koller-Lucae , S. K. , Suter , M. J. , Renth , K. M. , Schott , H. and Schwendener , R. A. 1999 . Metabolism of the new liposomal anticancer drug N4-octadecyl-1-beta-D-arabinofuranosylcytosine in mice . Drug Metab Dispos. , 27 : 342 – 350 .
   PubMed Web of Science ®Google Scholar
• Hamilton , J. A. 2003 . Fast flip-flop of cholesterol and fatty acids in membranes: Implications for membrane transport proteins . Curr. Opin. Lipidol. , 14 : 263 – 271 .
   PubMed Web of Science ®Google Scholar