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Original Articles

2′,3′-Isopropylidene Group, A Molecular Scaffold to Study the Activity of Adenosine and Adenylate Deaminase on Adenosine Analogues Modified in the Ribose Moiety

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Pages 1311-1313 | Published online: 05 Dec 2007

REFERENCES

  • Zielke , C. L. and Suelter , C. H. 1971 . “ Purine, purine nucleoside, and purine nucleotide aminohydrolases ” . In The Enzymes , Edited by: Boyer , P. D. vol. 4 , 47 – 78 . New York : Academic Press .
  • Santaniello , E. , Ciuffreda , P. and Alessandrini , L. 2005 . Purine nucleosides and related compounds mediated by adenosine deaminase (ADA) and adenylate deaminase (AMPDA) . Synthesis , : 509 – 526 .
  • Ciuffreda , P. , Loseto , A. and Santaniello , E. 2002 . Deamination of 5′-substituted-2′,3′-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5.4.4) and complementary enzymatic biotransformations catalyzed by adenylate deaminase (AMPDA, EC 3.5.4.6): A viable route for the preparation of 5′-substituted inosine derivatives . Tetrahedron , 58 : 5767 – 5771 .
  • Ciuffreda , P. , Alessandrini , L. and Santaniello , E. 2007 . Deamination of 2′,3′-O-isopropylideneadenosine-5′-carboxylic acid catalyzed by adenosine deaminase (ADA) and adenylate deaminase (AMPDA): Influence of substrate ionization on the activity of the enzymes . Nucleos. Nucleot. Nucl. , 26 : 121 – 127 .
  • Ciuffreda , P. , Loseto , A. and Santaniello , E. 2002 . Stereoselective deamination of (5′RS)-5′-methyl-2′,3′-isopropylidene adenosine catalyzed by adenosine deaminase: Preparation of diastereomerically pure 5′-methyl adenosine and inosine derivatives . Tetrahedron , 13 : 239 – 241 .
  • Ciuffreda , P. , Loseto , A. and Santaniello , E. 2004 . Stereoselective adenylate deaminase (5′-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5′-alkyl substituted adenosines: A comparison with the action of adenosine deaminase (ADA) . Tetrahedron , 15 : 203 – 206 .
  • Ciuffreda , P. , Buzzi , B. , Alessandrini , L. and Santaniello , E. 2004 . Activity of adenosine deaminase (ADA) and adenylate deaminase (AMPDA) towards 6-chloropurine nucleosides modified in the ribose moiety . Eur. J. Org. Chem. , : 4405 – 4409 .
  • Cappellacci , L. , Barboni , G. , Palmieri , M. , Pasqualini , M. , Grifantini , M. , Costa , B. , Martini , C. and Fianchetti , P. 2002 . Ribose-modified nucleosides as ligands for adenosine receptors: Synthesis, conformational analysis, and biological evaluation of 1′-C-methyl adenosine analogues . J. Med. Chem. , 45 : 1196 – 1202 .

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