Synthesis of 9-(2,3-Dideoxy-2,3-Difluoro-β-D- Arabinofuranosyl)Adenine

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• 1H NMR (CD3OD; δTMS, ppm; J, Hz); compound 9–8.30 (d, 1H, J 8,2′F = 2.3; H-8); 8.21 (s, 1H; H-2); 6.53 (ddd, 1H, J 1′,2′ = 3.97; J 1′,2′F = 17.67; 4 J 1′,3′F = 1.86; H-1′); 5.50 (dddd, 1H, J 2′,3′ = 2.17; J 2′, 3′F = 12.82; gem J 2′,2′F = 50.52; H-2′); 5.46 (dddd, 1H, J 3′,4′ = 3.76; J 3′,2′F = 15.29; gem J 3′,3′F = 51.24; H-3′); 4.30 (dm, 1H, J 4′,5′ = 4.27; J 4′,5” = 4.85; J 4′,3′,F = 24.80; H-4′); 3.89 (ddd, 1H, gem J 5′,5” = 12.80; J 5′,3′ F(2′F) ≈ 1.0; H-5′); 3.85 (m, 1H; H-5”). Compound 10: 8.40 & 8.39 (2s, 2H; H-8 & H-2); 6.53 (dd, 1H, J 1′,2′ = 2.42; J 1′,2′F = 15.90; H-1′); 6.04 (ddt, 1H, J 2′,3′ = 2.74; J 2′, 3′F = 14.00; gem J 2′,2′F = 49.70; H-2′); 5.47 (dddd, 1H, J 3′,4′ = 3.90; J 3′,2′F = 15.90; gem J 3′,3′F = 51.70; H-3′); 4.81 (ddt 1H, J 4′,5′ = 5.04; J 4′,5” = 4.98; J 4′,3′,F = 21.16; H-4′); 3.83 (dd, 1H, gem J 5′,5” = 12.85; H-5′); 3.79 (ddd, 1H; J 5′,3′F = 1.15; H-5”)
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