78
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of A Branched Locked Nucleic Acid (LNA) Analogue

, &
Pages 1505-1508 | Published online: 05 Dec 2007

REFERENCES

  • Wengel , J. 2004 . Nucleic acid nanotechnology-towards Ångström-scale engineering . Org. Biomol. Chem. , 2 : 277 – 280 .
  • Singh , S. K. , Nielsen , P. , Koshkin , A. A. and Wengel , J. 1998 . LNA (locked nucleic acids): Synthesis and high-affinity nucleic acid recognition . Chem. Commun. , : 455 – 456 .
  • Obika , S. , Nanbu , D. , Hari , Y. , Andoh , J. , Morio , K. , Doi , T. and Imanishi , T. 1998 . Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides . Tetrahedron Lett. , 39 : 5401 – 5405 .
  • Jepsen , J. S. and Wengel , J. 2004 . LNA-Antisense rivals siRNA for gene silencing . Curr. Opinion Drug Dis. Dev. , 7 : 188 – 194 .
  • Hrdlicka , P. J. , Babu , B. R. , S⊘rensen , M. D. , Harrit , N. and Wengel , J. 2005 . Multilabeled pyrene-functionalized 2′-Amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays . J. Am. Chem. Soc. , 127 : 13293 – 13299 .
  • J⊘rgensen , P. N. , Stein , P. C. and Wengel , J. 1994 . Synthesis of 3′-C-(Hydroxymethyl)thymidine: Introduction of a novel class of deoxynucleosides and Oligodeoxynucleotides . J. Am. Chem. Soc. , 116 : 2231 – 2232 .
  • Wang , G. , Middleton , P. J. , He , L. , Stoisavljevic , V. and Seifert , W. E. 1997 . Synthesis and evaluation of oligodeoxynucleotides containing 3′-C-aminomethyl- and 3′-C-methylthymidine . Nucleosides Nucleotides. , 16 : 445 – 454 .
  • Pfundheller , H. M. , J⊘rgensen , P. N. , S⊘rensen , U. S. , Sharma , S. K. , Grimstrup , M. , Ströch , C. , Nielsen , P. , Viswanadham , G. , Olsen , C. E. and Wengel , J. 1998 . Synthesis of novel 3′-C-branched 2′-deoxynucleotides. Incorporation of 3′-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides . J. Chem. Soc. Perkin Trans. , 1 : 1409
  • Meldgaard , M. , Hansen , F. G. and Wengel , J. 2004 . 3′-C-Branced LNA-type nucleosides locked in an N-Type furanose ring conformation: synthesis, incorporation into oligodeoxynucleotides, and hybridization studies . J. Org. Chem. , 69 : 6310 – 6322 .
  • Gable , K. P. and Benz , G. A. 1991 . Rhodium(I)-Catalyzed Cyclizations of 3-C-Alkenyl pentodialdose derivatives . Tetrahedron Lett. , 32 : 3473 – 3476 .
  • Nielsen , P. , Petersen , M. and Jacobsen , J. P. 2000 . Tricyclic nucleosides derived from D-glucose. Synthesis and conformational behaviour . J. Chem. Soc. Perkin Trans. 1 , : 3706 – 3713 .
  • Sharma , P. K. and Nielsen , P. 2004 . New Ruthenium-Based protocol for cleavage of terminal olefins to primary alcohols: improved synthesis of a bicyclic nucleoside . J. Org. Chem. , 69 : 5742 – 5745 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.