Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV

REFERENCES

• Baba , M. , Tanaka , H. , De Clercq , E. , Pauwels , R. , Balzarini , J. , Schols , D. , Nakashima , H. , Perno , C.-F. , Walker , R. T. and Miyasaka , T. 1989 . Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative . Biochem. Biophys. Res. Commun. , 165 : 1375 – 1381 .
   PubMed Web of Science ®Google Scholar
• Szczech , G. M. , Furman , P. , Painter , G. R. , Barry , D. W. , Borroto-esoda , K. , Grizzle , T. B. , Blum , M. R. , Sommadossi , J.-P. , Endoh , R. , Niwa , T. , Yamamoto , M. and Moxham , C. 2000 . Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 . Antimicrobial Agents Chemother. , 44 : 123 – 130 .
   PubMed Web of Science ®Google Scholar
• Buckheit , R. W. Jr. , Watson , K. , Fliakas-Boltz , V. , Russell , J. , Loftus , T. L. , Osterling , M. C. , Turpin , J. A. , Pallansch , L. A. , White , E. L. , Lee , J.-W. , Lee , S.-H. , Oh , J.-W. , Kwon , H.-S. , Chung , S.-G. and Cho , E.-H. 2001 . SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2 . Antimicrobial Agents Chemother. , 45 : 393 – 400 .
   PubMed Web of Science ®Google Scholar
• Maruyama , T. , Kozai , S. , Yamasaki , T. , Witvrouw , M. , Pannecouque , C. , Balzarini , J. , Snoeck , R. , Andrei , G. and De Clercq , E. 2003 . Synthesis and antiviral acitivity of 1,3-disubstituted uracils against HIV-1 and HCMV . Antiviral Chem. Chemother. , 14 : 271 – 279 .
   PubMedGoogle Scholar
• Maruyama , T. , Kozai , S. , Demizu , Y. , Witvrouw , M. , Pannecouque , C. , Balzarini , J. , Snoeck , R. , Andrei , G. and De Clercq , E. 2006 . Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives . Chem. Pharm. Bull. , 54 : 325 – 333 .
   PubMed Web of Science ®Google Scholar
• Kim , J. C. , Dong , E.-S. , Ahn , J.-W. and Kim , S.-H. 1994 . Synthesis and evaluation of antitumor activity of a homologous series of 1-(ω -cyanoalkyl)- and 1,3-bis(ω -cyanoalkyl)uracil nucleoside analogs . Arch. Pharm. Res. , 17 : 135 – 138 .
   Google Scholar
• Kim , J. C. , Dong , E.-S. , Park , J. II , Bae , S.-D. and Kim , S.-H. 1994 . 5-Substituted pyrimidine acyclic nucleoside analogs 1-cyanomethyl- and 1-(4-cyanobutyl)-5-substituted uracils as candidate antitumor agents . Arch. Pharm. Res. , 17 : 480 – 482 .
   PubMedGoogle Scholar
• Das , K. , Clark , A. D. Jr. , Lewi , P. J. , Heeres , J. , De Jonge , M. R. , Koymans , L. M.H.H. , Vinkers , M. , Daeyaert , F. , Ludovici , D. W. , Kukla , M. J. , Corte , B. D. , Kavash , R. W. , Ho , C. Y. , Ye , H. , Lichtenstein , M. A. , Andries , K. , Pauwels , R. , de Béthune , M.-P. , Boyer , P. L. , Clark , P. , Hughes , S. H. , Janssen , P. A.J. and Eddy , A. 2004 . Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants . J. Med. Chem. , 47 : 2550 – 2560 .
   PubMed Web of Science ®Google Scholar