Oligonucleotide Conjugate GRN163L Targeting Human Telomerase as Potential Anticancer and Antimetastatic Agent

Sergei M. Gryaznov Geron Corporation, Menlo Park, California, USA

Shalmica Jackson Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Gunnur Dikmen Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Calvin Harley Geron Corporation, Menlo Park, California, USA

Brittney-Shea Herbert Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indianapolis, USA

Woodring E. Wright Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Jerry W. Shay Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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REFERENCES

Dikmen , Z. G. , Gellert , G. C. , Jackson , S. , Gryaznov , S. , Tressler , R. , Dogan , P. , Wright , W. E. and Shay , J. W. 2005 . In vivo Inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor . Cancer Res. , 65 : 7866 – 7873 .
PubMed Web of Science ®Google Scholar
Gellert , G. C. , Dikmen , Z. G. , Wright , W. E. , Gryaznov , S. and Shay , J. W. 2006 . Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer . Breast Cancer Res. Treat. , 96 : 73 – 81 .
PubMed Web of Science ®Google Scholar
Hochreiter , A. E. , Xiao , H. , Goldblatt , E. M. , Gryaznov , S. M. , Miller , K. D. , Badve , S. , Sledge , G. W. and Herbert , B.-S. 2006 . Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer . Clin. Cancer Res. , 12 : 3184 – 3192 .
PubMed Web of Science ®Google Scholar

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Oligonucleotide Conjugate GRN163L Targeting Human Telomerase as Potential Anticancer and Antimetastatic Agent

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Oligonucleotide Conjugate GRN163L Targeting Human Telomerase as Potential Anticancer and Antimetastatic Agent

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