Uric Acid: The Oxidant-Antioxidant Paradox

REFERENCES

• Wu , X. W. , Muzny , D. M. , Lee , C. C. and Caskey , C. T. 1992 . Two independent mutational events in the loss of urate oxidase during hominoid evolution . J. Mol. Evol. , 34 : 78 – 84 .
   PubMed Web of Science ®Google Scholar
• Oda , M. , Satta , Y. , Takenaka , O. and Takahata , N. 2002 . Loss of urate oxidase activity in hominoids and its evolutionary implications . Mol. Biol. Evol. , 19 : 640 – 653 .
   PubMed Web of Science ®Google Scholar
• Johnson , R. J. , Kang , D. H. , Cade , J. R. , Rideout , B. A. and Oliver , W. J. 2005 . Uric acid, evolution and primitive cultures. In: Uric acid in Cardiovascular and Renal Disease . Semin. Nephrol. , 25 : 3 – 8 .
   PubMed Web of Science ®Google Scholar
• Ames , B. N. , Cathcart , R. , Schwiers , E. and Hochstein , P. 1981 . Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis . Proc. Natl. Acad. Sci. USA , 78 : 6858 – 6862 .
   PubMed Web of Science ®Google Scholar
• Alper , A. B. Jr. , Chen , W. , Yau , L. , Srinivasan , S. R. , Berenson , G. S. and Hamm , L. L. 2005 . Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study . Hypertension , 45 : 34 – 38 .
   PubMed Web of Science ®Google Scholar
• Johnson , R. J. , Kang , D. H. , Feig , D. , Kivlighn , S. , Kanellis , Watanabe , S. , Tuttle , K. R. , Rodriguez-Iturbe , B. , Herrera-Acosta , J. and Mazzali , M. 2003 . Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? . Hypertension , 41 : 1183 – 1190 .
   PubMed Web of Science ®Google Scholar
• Johnson , R. J. , Segal , M. S. , Srinivas , T. , Ejaz , A. , Mu , W. , Roncal , C. , Sanchez-Lozada , L. G. , Gersch , M. , Rodriguez-Iturbe , B. , Kang , D. H. and Acosta , J. H. 2005 . Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? . J. Am. Soc. Nephrol. , 16 : 1909 – 1919 .
   PubMed Web of Science ®Google Scholar
• Bonora , E. , Targher , G. , Zenere , M. B. , Saggiani , F. , Cacciatori , V. , Tosi , F. , Travia , D. , Zenti , M. G. , Branzi , P. , Santi , L. and Muggeo , M. 1996 . Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study . Int J. Obes. Relat. Metab. Disord. , 20 : 975 – 980 .
   PubMed Web of Science ®Google Scholar
• Masuo , K. , Kawaguchi , H. , Mikami , H. , Ogihara , T. and Tuck , M. L. 2003 . Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation . Hypertension , 42 : 474 – 480 .
   PubMed Web of Science ®Google Scholar
• Ogura , T. , Matsuura , K. , Matsumoto , Y. , Mimura , Y. , Kishida , M. , Otsuka , F. and Tobe , K. 2004 . Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002 . Metabolism , 53 : 448 – 453 .
   PubMed Web of Science ®Google Scholar
• Nakanishi , N. , Okamoto , M. , Yoshida , H. , Matsuo , Y. , Suzuki , K. and Tatara , K. 2003 . Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers . Eur. J. Epidemiol. , 18 : 523 – 530 .
   PubMed Web of Science ®Google Scholar
• Zavaroni , I. , Mazza , S. , Fantuzzi , M. , Dall'Aglio , E. , Bonora , E. , Delsignore , R. , Passeri , M. and Reaven , G. M. 1993 . Changes in insulin and lipid metabolism in males with asymptomatic hyperuricaemia . J. Intern. Med. , 234 : 25 – 30 .
   PubMed Web of Science ®Google Scholar
• Matsubara , M. , Chiba , H. , Maruoka , S. and Katayose , S. 2002 . Elevated serum leptin concentrations in women with hyperuricemia . J. Atheroscler. Thromb. , 9 : 28 – 34 .
   PubMedGoogle Scholar
• Alderman , M. H. , Cohen , H. , Madhavan , S. and Kivlighn , S. 1999 . Serum uric acid and cardiovascular events in successfully treated hypertensive patients . Hypertension , 34 : 144 – 150 .
   PubMed Web of Science ®Google Scholar
• Tomita , M. , Mizuno , S. , Yamanaka , H. , Hosoda , Y. , Sakuma , K. , Matuoka , Y. , Odaka , M. , Yamaguchi , M. , Yosida , H. , Morisawa , H. and Murayama , T. 2000 . Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers . J. Epidemiol. , 10 : 403 – 409 .
   PubMedGoogle Scholar
• Berg , A. H. , Lin , Y. , Lisanti , M. P. and Scherer , P. E. 2004 . Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity . Am. J Physiol. Endocrinol. Metab. , 287 : E1178 – 1188 .
   PubMed Web of Science ®Google Scholar
• Furukawa , S. , Fujita , T. , Shimabukuro , M. , Iwaki , M. , Yamada , Y. , Nakajima , Y. , Nakayama , O. , Makishima , M. , Matsuda , M. and Shimomura , I. 2004 . Increased oxidative stress in obesity and its impact on metabolic syndrome . J. Clin. Invest. , 114 : 1752 – 1761 .
   PubMed Web of Science ®Google Scholar
• Houstis , N. , Rosen , E. D. and Lander , E. S. 2006 . Reactive oxygen species have a causal role in multiple forms of insulin resistance . Nature , 440 : 944 – 948 .
   PubMed Web of Science ®Google Scholar
• Stocker , R. and Keaney , J. F. Jr. 2004 . Role of oxidative modifications in atherosclerosis . Physiol. Rev. , 84 : 1381 – 1478 .
   PubMed Web of Science ®Google Scholar
• Wellen , K. E. and Hotamisligil , G. S. 2005 . Inflammation, stress, and diabetes . J. Clin. Invest. , 115 : 1111 – 1119 .
   PubMed Web of Science ®Google Scholar
• Kellogg , E. W. 3rd and Fridovich , I. 1977 . Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide . J. Biol. Chem. , 252 : 6721 – 6728 .
   PubMed Web of Science ®Google Scholar
• Frei , B. , Stocker , R. and Ames , B. N. 1988 . Antioxidant defenses and lipid peroxidation in human blood plasma . Proc. Natl. Acad. Sci. USA , 85 : 9748 – 9752 .
   PubMed Web of Science ®Google Scholar
• Amaro , S. , Soy , D. , Obach , V. , Cervera , A. , Planas , A. M. and Chamorro , A. 2007 . Pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke . Stroke , 38 : 2173 – 2175 .
   PubMed Web of Science ®Google Scholar
• Duan , W. , Ladenheim , B. , Cutler , R. G. , Kruman II , Cadet , J. L. and Mattson , M. P. 2002 . Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease . J. Neurochem. , 80 : 101 – 110 .
   PubMed Web of Science ®Google Scholar
• Hooper , D. C. , Spitsin , S. , Kean , R. B. , Champion , J. M. , Dickson , G. M. , Chaudhry , I. and Koprowski , H. 1998 . Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis . Proc. Natl. Acad. Sci. USA , 95 : 675 – 680 .
   PubMed Web of Science ®Google Scholar
• Spitsin , S. V. , Scott , G. S. , Mikheeva , T. , Zborek , A. , Kean , R. B. , Brimer , C. M. , Koprowski , H. and Hooper , D. C. 2002 . Comparison of uric acid and ascorbic acid in protection against EAE . Free Radic. Biol. Med. , 33 : 1363 – 1371 .
   PubMed Web of Science ®Google Scholar
• Mazza , A. , Pessina , A. C. , Pavei , A. , Scarpa , R. , Tikhonoff , V. and Casiglia , E. 2001 . Predictors of stroke mortality in elderly people from the general population. The CArdiovascular STudy in the ELderly . Eur. J. Epidemiol. , 17 : 1097 – 1104 .
   PubMed Web of Science ®Google Scholar
• Weir , C. J. , Muir , S. W. , Walters , M. R. and Lees , K. R. 2003 . Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke . Stroke , 34 : 1951 – 1956 .
   PubMed Web of Science ®Google Scholar
• Yu , Z. F. , Bruce-Keller , A. J. , Goodman , Y. and Mattson , M. P. 1998 . Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo . J. Neurosci. Res. , 53 : 613 – 625 .
   PubMed Web of Science ®Google Scholar
• Danilov , A. I. , Jagodic , M. , Wiklund , N. P. , Olsson , T. and Brundin , L. 2005 . Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE . Nitric Oxide , 13 : 188 – 195 .
   PubMed Web of Science ®Google Scholar
• Khosla , U. M. , Zharikov , S. , Finch , J. L. , Nakagawa , T. , Roncal , C. , Mu , W. , Krotova , K. , Block , E. R. , Prabhakar , S. and Johnson , R. J. 2005 . Hyperuricemia induces endothelial dysfunction . Kidney Int. , 67 : 1739 – 1742 .
   PubMed Web of Science ®Google Scholar
• Tsukada , K. , Hasegawa , T. , Tsutsumi , S. , Katoh , H. , Kuwano , H. , Miyazaki , T. and Yamamoto , Y. 2000 . Effect of uric acid on liver injury during hemorrhagic shock . Surgery , 127 : 439 – 446 .
   PubMed Web of Science ®Google Scholar
• Becker , B. F. , Reinholz , N. , Ozcelik , T. , Leipert , B. and Gerlach , E. 1989 . Uric acid as radical scavenger and antioxidant in the heart . Pflugers Arch. , 415 : 127 – 135 .
   PubMed Web of Science ®Google Scholar
• Skinner , K. A. , White , C. R. , Patel , R. , Tan , S. , Barnes , S. , Kirk , M. , Darley-Usmar , V. and Parks , D. A. 1998 . Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor . J. Biol. Chem. , 273 : 24491 – 24497 .
   PubMed Web of Science ®Google Scholar
• Sautin , Y. Y. , Nakagawa , T. , Zharikov , S. and Johnson , R. J. 2007 . Adverse effects of the classical antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress . Am. J. Physiol. Cell. Physiol. , 293 : 584 – 596 .
   PubMed Web of Science ®Google Scholar
• Kuzkaya , N. , Weissmann , N. , Harrison , D. G. and Dikalov , S. 2005 . Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase . Biochem. Pharmacol. , 70 : 343 – 354 .
   PubMed Web of Science ®Google Scholar
• Whiteman , M. , Ketsawatsakul , U. and Halliwell , B. 2002 . A reassessment of the peroxynitrite scavenging activity of uric acid . Ann. NY Acad. Sci. , 962 : 242 – 259 .
   PubMed Web of Science ®Google Scholar
• Muraoka , S. and Miura , T. 2003 . Inhibition by uric acid of free radicals that damage biological molecules . Pharmacol. Toxicol. , 93 : 284 – 289 .
   PubMedGoogle Scholar
• Khairutdinov , R. F. , Coddington , J. W. and Hurst , J. K. 2000 . Permeation of phospholipid membranes by peroxynitrite . Biochemistry , 39 : 14238 – 14249 .
   PubMed Web of Science ®Google Scholar
• Bartesaghi , S. , Ferrer-Sueta , G. , Peluffo , G. , Valez , V. , Zhang , H. , Kalyanaraman , B. and Radi , R. 2007 . Protein tyrosine nitration in hydrophilic and hydrophobic environments . Amino Acids , 32 : 501 – 515 .
   PubMed Web of Science ®Google Scholar
• Bartesaghi , S. , Valez , V. , Trujillo , M. , Peluffo , G. , Romero , N. , Zhang , H. , Kalyanaraman , B. and Radi , R. 2006 . Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester . Biochemistry , 45 : 6813 – 6825 .
   PubMed Web of Science ®Google Scholar
• Maples , K. R. and Mason , R. P. 1988 . Free radical metabolite of uric acid . J. Biol. Chem. , 263 : 1709 – 1712 .
   PubMed Web of Science ®Google Scholar
• Vasquez-Vivar , J. , Santos , A. M. , Junqueira , V. B. and Augusto , O. 1996 . Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acid-derived free radicals . Biochem. J. , 314 : 869 – 876 . (Pt 3)
   PubMed Web of Science ®Google Scholar
• Santos , C. X. , Anjos , E. I. and Augusto , O. 1999 . Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation . Arch. Biochem. Biophys. , 372 : 285 – 294 .
   PubMed Web of Science ®Google Scholar
• Bagnati , M. , Perugini , C. , Cau , C. , Bordone , R. , Albano , E. and Bellomo , G. 1999 . When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid . Biochem. J. , 340 : 143 – 152 . (Pt 1)
   PubMed Web of Science ®Google Scholar
• Green , H. and Kehinde , O. 1975 . An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion . Cell , 5 : 19 – 27 .
   PubMed Web of Science ®Google Scholar
• Rosen , E. D. and Spiegelman , B. M. 2000 . Molecular regulation of adipogenesis . Annu. Rev. Cell. Dev. Biol. , 16 : 145 – 171 .
   PubMed Web of Science ®Google Scholar
• Martyn , K. D. , Frederick , L. M. , von Loehneysen , K. , Dinauer , M. C. and Knaus , U. G. 2006 . Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases . Cell. Signal. , 18 : 69 – 82 .
   PubMed Web of Science ®Google Scholar
• Bedard , K. and Krause , K. H. 2007 . The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology . Physiol. Rev. , 87 : 245 – 313 .
   PubMed Web of Science ®Google Scholar
• Bokoch , G. M. and Knaus , U. G. 2003 . NADPH oxidases: not just for leukocytes anymore! . Trends Biochem. Sci. , 28 : 502 – 508 .
   PubMed Web of Science ®Google Scholar
• Cross , A. R. and Segal , A. W. 2004 . The NADPH oxidase of professional phagocytes–prototype of the NOX electron transport chain systems . Biochim. Biophys. Acta , 1657 : 1 – 22 .
   PubMed Web of Science ®Google Scholar
• Lambeth , J. D. 2004 . NOX enzymes and the biology of reactive oxygen . Nat. Rev. Immunol. , 4 : 181 – 189 .
   PubMed Web of Science ®Google Scholar
• Kanellis , J. , Watanabe , S. , Li , J. H. , Kang , D. H. , Li , P. , Nakagawa , T. , Wamsley , A. , Sheikh-Hamad , D. , Lan , H. Y. , Feng , L. and Johnson , R. J. 2003 . Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2 . Hypertension , 41 : 1287 – 1293 .
   PubMed Web of Science ®Google Scholar
• Kang , D. H. , Park , S. K. , Lee , I. K. and Johnson , R. J. 2005 . Uric Acid-Induced C-Reactive Protein Expression: Implication on Cell Proliferation and Nitric Oxide Production of Human Vascular Cells . J. Am. Soc. Nephrol. , 16 : 3553 – 3562 .
   PubMed Web of Science ®Google Scholar
• Shi , Y. , Evans , J. E. and Rock , K. L. 2003 . Molecular identification of a danger signal that alerts the immune system to dying cells . Nature , 425 : 516 – 521 .
   PubMed Web of Science ®Google Scholar
• Chen , C. J. , Shi , Y. , Hearn , A. , Fitzgerald , K. Golenbock , D. 2006 . MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals . J. Clin. Invest. , 116 : 2262 – 2271 .
   PubMed Web of Science ®Google Scholar
• Charriere , G. , Cousin , B. , Arnaud , E. , Andre , M. , Bacou , F. , Penicaud , L. and Casteilla , L. 2003 . Preadipocyte conversion to macrophage. Evidence of plasticity . J. Biol. Chem. , 278 : 9850 – 9855 .
   PubMed Web of Science ®Google Scholar
• Cousin , B. , Munoz , O. , Andre , M. , Fontanilles , A. M. Dani , C. 1999 . A role for preadipocytes as macrophage-like cells . FASEB J. , 13 : 305 – 312 .
   PubMed Web of Science ®Google Scholar
• Berg , A. H. and Scherer , P. E. 2005 . Adipose tissue, inflammation, and cardiovascular disease . Circ. Res. , 96 : 939 – 949 .
   PubMed Web of Science ®Google Scholar