Functional Inactivity and Mutations of p53 Differentially Affect Sensitivity to 5-Fluorouracil and Antifolate Inhibitors of Thymidylate Synthase (TS) by Altering TS Levels in Colorectal Cancer Cells

REFERENCES

• Giacchetti , S. , Perpoint , B. , Zidani , R. , Le Bail , N. , Faggiuolo , R. , Focan , C. , Chollet , P. , Llory , J. F. , Letourneau , Y. , Coudert , B. , Bertheaut-Cvitkovic , F. , Larregain-Fournier , D. , Le Rol , A. , Walter , S. , Adam , R. , Misset , J. L. and Lévi , F. 2000 . Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracileucovorin as first-line treatment of metastatic colorectal cancer . J. Clin. Oncol. , 18 : 136 – 147 .
   PubMed Web of Science ®Google Scholar
• Carreras , C. W. and Santi , D. V. 1995 . The catalytic mechanism and structure of thymidylate synthase . Ann. Rev. Biochem. , 64 : 721 – 76 .
   PubMed Web of Science ®Google Scholar
• Peters , G. J. , Backus , H. H. J. , Freemantle , S. , van Triest , B. , Codacci-Pisanelli , G. , van der Wilt , C. L. , Smid , K. , Lunec , J. , Calvert , A. H. , Marsh , S. , McLeod , H. L. , Bloemena , E. , Meijer , S. , Jansen , G. , van Groeningen , C. J. and Pinedo , H. M. 2002 . Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism . Biochim. Biophys. Acta , 1587 : 194 – 205 .
   PubMed Web of Science ®Google Scholar
• Lee , Y. , Chen , Y. , Chang , L. S. and Johnson , L. F. 1997 . Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein . Exp. Cell Res. , 234 : 270 – 276 .
   PubMed Web of Science ®Google Scholar
• Giovannetti , E. , Backus , H. H. , Wouters , D. , Ferreira , C. G. , van Houten , V. M. , Brakenhoff , R. H. , Poupon , M. F. , Azzarello , A. , Pinedo , H. M. and Peters , G. J. 2007 . Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels . Br. J. Cancer , 96 : 769 – 775 .
   PubMed Web of Science ®Google Scholar
• Van Triest , B. , Pinedo , H. M. , Giaccone , G. and Peters , G. J. 2000 . Downstream molecular determinants of response to 5-fluorouracil and antifolate synthase inhibitors . Ann. Oncol. , 11 : 385 – 391 .
   PubMed Web of Science ®Google Scholar
• Russo , A. , Bazan , V. , Iacopetta , B. , Kerr , D. , Soussi , T. , Gebbia , N. and TP53-CRC Collaborative Study Group . 2005 . The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment . J. Clin. Oncol. , 23 : 7518 – 7528 .
   PubMed Web of Science ®Google Scholar
• Backus , H. H. , Wouters , D. , Ferreira , C. G. , van Houten , V. M. , Brakenhoff , R. H. , Pinedo , H. M. and Peters , G. J. 2003 . Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines . Eur. J. Cancer , 39 : 1310 – 1317 .
   PubMed Web of Science ®Google Scholar
• Rots , M. G. , Willey , J. C. , Jansen , G. , Van Zantwijk , C. H. , Noordhuis , P. , DeMuth , J. P. , Kuiper , E. , Veerman , A. J. , Pieters , R. and Peters , G. J. 2000 . mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method . Leukemia , 14 : 2166 – 2175 .
   PubMed Web of Science ®Google Scholar
• Lowe , S. W. , Ruley , H. E. , Jacks , T. and Housman , D. E. 1993 . P53-dependent apoptosis modulates the cytotoxicity of anticancer agents . Cell , 74 : 957 – 967 .
   PubMed Web of Science ®Google Scholar
• Blandino , G. , Levine , A. J. and Oren , M. 1999 . Mutant p53 gain of function: differential effect of different p53 mutants on resistance of cultured cells to chemotherapy . Oncogene , 8 : 477 – 485 .
   Google Scholar
• Momand , J. , Zambetti , G. P. , Olson , D. C. , George , D. and Levine , A. J. 1992 . The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation . Cell , 69 : 1237 – 1245 .
   PubMed Web of Science ®Google Scholar