Physiological and Pharmacological Roles of Nucleoside Transporter Proteins

REFERENCES

• Baldwin , S. A. , Beal , P. R. , Yao , S. Y. , King , A. E. , Cass , C. E. and Young , J. D. 2004 . The equilibrative nucleoside transporter family. SLC29 . Pflugers Arch. , 447 : 735 – 743 .
   PubMed Web of Science ®Google Scholar
• Gray , J. H. , Owen , R. P. and Giacomini , K. M. 2004 . The concentrative nucleoside transporter family, SLC28 . Pflugers Arch. , 447 : 728 – 734 .
   PubMed Web of Science ®Google Scholar
• Podgorska , M. , Kocbuch , K. and Pawelczyk , T. 2005 . Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters . Acta Biochim. , 52 : 749 – 758 .
   PubMed Web of Science ®Google Scholar
• King , A. E. , Ackley , M. A. , Cass , C. E. , Young , J. D. and Baldwin , S. A. 2006 . Nucleoside transporters: From scavengers to novel therapeutic targets . Trends Pharmacol. Sci. , 27 : 416 – 425 .
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada , M. and Casado , F. J. 2006 . “ Nucleoside transport into cells ” . In Cancer Drug Discovery and Development: Deoxynucleoside Analogs in Cancer Therapy , Edited by: Peters , G. J. 1 – 28 . Humana Press Inc. .
   Google Scholar
• Thwaites , D. T. and Anderson , C. M. 2007 . Deciphering the mechanisms of intestinal imino (and amino) acid transport: the redemption of SLC36A1 . Biochim. Biophys. Acta , 1768 : 179 – 197 .
   PubMed Web of Science ®Google Scholar
• Daniel , H. , Spanier , B. , Kottra , G. and Weitz , D. 2006 . From bacteria to man: archaic proton-dependent peptide transporters at work . Physiology (Bethesda) , 21 : 93 – 102 .
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada , M. , Errasti-Murugarren , E. , Aymerich , I. and Casado , F. J. 2007 . Concentrative Nucleoside Transporters (CNTs) in epithelia: from absorption to cell signalling . J. Physiol. Biochem. , 63 : 97 – 110 .
   PubMed Web of Science ®Google Scholar
• Barnes , K. , Dobrzynski , H. , Foppolo , S. , Beal , P. R. Ismat , F. 2006 . Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH . Circ. Res. , 99 : 510 – 519 .
   PubMed Web of Science ®Google Scholar
• Loewen , S. K. , Yao , S. Y. , Slugoski , M. D. , Mohabir , N. N. Turner , R. J. 2004 . Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes . Mol. Membr. Biol. , 21 : 1 – 10 .
   PubMed Web of Science ®Google Scholar
• Lu , H. , Chen , C. and Klaassen , C. 2004 . Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice . Drug Metab. Dispos. , 32 : 1455 – 1461 .
   PubMed Web of Science ®Google Scholar
• Valdes , R. , Ortega , M. A. , Casado , F. J. , Felipe , A. Gil , A. 2000 . Nutritional regulation of nucleoside transporter expression in rat small intestine . Gastroenterology , 119 : 1623 – 1630 .
   PubMed Web of Science ®Google Scholar
• Lai , Y. , Bakken , A. H. and Unadkat , J. D. 2002 . Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies . J. Biol. Chem. , 277 : 37711 – 37717 .
   PubMed Web of Science ®Google Scholar
• Mangravite , L. M. , Badagnani , I. and Giacomini , K. M. 2003 . Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney . Eur. J. Pharmacol. , 479 : 269 – 281 .
   PubMed Web of Science ®Google Scholar
• Errasti-Murugarren , E. , Pastor-Anglada , M. and Casado , F. J. 2007 . Role of Cnt3 in the Transepithelial Flux of Nucleosides and Nucleoside-Derived Drugs . J. Physiol. , 582 : 1249 – 1260 .
   PubMed Web of Science ®Google Scholar
• Aymerich , I. , Pastor-Anglada , M. and Casado , F. J. 2004 . Long term endocrine regulation of nucleoside transporters in rat intestinal epithelial cells . J. Gen. Physiol. , 124 : 505 – 512 .
   PubMed Web of Science ®Google Scholar
• Iwasa , Y. , Iwasa , M. , Ohmori , Y. , Fukutomi , T. and Ogoshi , S. 2000 . The effect of the administration of nucleosides and nucleotides for parenteral use . Nutrition , 16 : 598 – 602 .
   PubMed Web of Science ®Google Scholar
• Govindarajan , R. , Bakken , A. H. , Hudkins , K. L. , Lai , Y. Casado , F. J. 2007 . In Situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and the placenta . Am. J. Physiol. Regul. Intergr. Comp. Physiol. , 293 : R1809 – R1822 .
   PubMed Web of Science ®Google Scholar
• Redzic , Z. B. , Biringer , J. , Barnes , K. , Baldwin , S. A. Al-Sarraf , H. 2005 . Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells . J. Neurochem. , 94 : 1420 – 1426 .
   PubMed Web of Science ®Google Scholar
• Kato , R. , Maeda , T. , Akaike , T. and Tamai , I. 2005 . Nucleoside transport at the blood-testis barrier studied with primary-cultured sertoli cells . J. Pharmacol. Exp. Ther. , 312 : 601 – 608 .
   PubMed Web of Science ®Google Scholar
• Valentino , M. L. , Marti , R. , Tadesse , S. , Lopez , L. C. Manes , J. L. 2007 . Thymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) . FEBS Lett. , 581 : 3410 – 3414 .
   PubMed Web of Science ®Google Scholar
• Soler , C. , Garcia-Manteiga , J. , Valdes , R. , Xaus , J. , Comalada , M. Casado , F. J. 2005 . Macrophages require different nucleoside transport systems for proliferation and activation . FASEB J. , 15 : 1979 – 1988 .
   Google Scholar
• Soler , C. , Valdes , R. , Garcia-Manteiga , J. , Xaus , J. Comalada , M. 2001 . Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and -independent mechanisms . J. Biol. Chem. , 276 : 30043 – 30049 .
   PubMed Web of Science ®Google Scholar
• Valdes , R. , Fernandez-Veledo , S. , Aymerich , I. , Casado , F. J. and Pastor-Anglada , M. 2006 . TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells . Cell Mol. Life Sci. , 63 : 2527 – 2537 .
   PubMed Web of Science ®Google Scholar
• Fernandez-Veledo , S. , Valdes , R. , Wallenius , V. , Casado , F. J. and Pastor-Anglada , M. 2004 . Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells . J. Hepatol. , 41 : 538 – 544 .
   PubMed Web of Science ®Google Scholar
• Larrayoz , I. M. , Casado , F. J. , Pastor-Anglada , M. and Lostao , M. P. 2004 . Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function . J. Biol. Chem. , 279 : 8999 – 9007 .
   PubMed Web of Science ®Google Scholar
• Duflot , S. , Riera , B. , Fernandez-Veledo , S. , Casado , V. Norman , R. I. 2004 . ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors . Mol. Cell Biol. , 24 : 2710 – 2719 .
   PubMed Web of Science ®Google Scholar
• Aymerich , I. , Foufelle , F. , Ferre , P. , Casado , F. J. and Pastor-Anglada , M. 2006 . Extracellular adenosine activates AMP-dependent protein kinase (AMPK) . J. Cell Sci. , 119 : 1612 – 1621 .
   PubMed Web of Science ®Google Scholar
• Hardie , D. G. 2007 . AMP-activated protein kinase as a drug target . Annu. Rev. Pharmacol. Toxicol. , 47 : 185 – 210 .
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada , M. , Cano-Soldado , P. , Molina-Arcas , M. , Lostao , M. P. Larrayoz , I. 2005 . Cell entry and export of nucleoside analogues . Virus Res. , 107 : 151 – 164 .
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada , M. , Molina-Arcas , M. , Casado , F. J. , Bellosillo , B. , Colomer , D. and Gil , J. 2004 . Nucleoside transporters in chronic lymphocytic leukaemia . Leukemia , 18 : 385 – 393 .
   PubMed Web of Science ®Google Scholar
• Spratlin , J. , Sangha , R. , Glubrecht , D. , Dabbagh , L. and Young , J. D. 2004 . The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma . Clin. Cancer Res. , 10 : 6956 – 6961 .
   PubMed Web of Science ®Google Scholar
• Marce , S. , Molina-Arcas , M. , Villamor , N. , Casado , F. J. Campo , E. 2006 . Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma . Haematologica , 91 : 895 – 902 .
   PubMed Web of Science ®Google Scholar
• Molina-Arcas , M. , Moreno-Bueno , G. , Cano-Soldado , P. , Hernandez-Vargas , H. Casado , F. J. 2006 . Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells . Biochem. Pharmacol. , 72 : 1646 – 1656 .
   PubMed Web of Science ®Google Scholar
• Mata , J. F. , Garcia-Manteiga , J. M. , Lostao , M. P. , Fernandez-Veledo , S. Guillen-Gomez , E. 2001 . Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug . Mol. Pharmacol. , 59 : 1542 – 1548 .
   PubMed Web of Science ®Google Scholar
• Gloeckner-Hofmann , K. , Guillen-Gomez , E. , Schmidtgen , C. , Porstmann , R. Ziegler , R. 2006 . Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer . Oncology , 70 : 238 – 244 .
   PubMed Web of Science ®Google Scholar
• Cano-Soldado , P. , Molina-Arcas , M. , Algueró , B. , Larráyoz , B. Lostao , P. 2008 . Compensatory effects of the human nucleoside transporters hENT1 and hCNT1 on the transcriptomic response triggered by nucleoside-derived drugs in breast cancer MCF7 cells . Biochem. Pharmacol. , 75 : 639 – 648 .
   PubMed Web of Science ®Google Scholar
• Wiley , J. S. , Jones , S. P. , Sawyer , W. H. and Paterson , A. R. 1982 . Cytosine arabinoside influx and nucleoside transport sites in acute leukemia . J. Clin. Invest. , 69 : 479 – 489 .
   PubMed Web of Science ®Google Scholar
• Wright , A. M. , Paterson , A. R. , Sowa , B. , Akabutu , J. J. , Grundy , P. E. and Gati , W. P. 2002 . Cytotoxicity of 2-chlorodeoxyadenosine and arabinosylcytosine in leukaemic lymphoblasts from paediatric patients: significance of cellular nucleoside transporter content . Br. J. Haematol. , 116 : 528 – 537 .
   PubMed Web of Science ®Google Scholar
• Galmarini , C. M. , Thomas , X. , Calvo , F. , Rousselot , P. Jafaari , A. E. 2002 . Potential mechanisms of resistance to cytarabine in AML patients . Leuk. Res. , 26 : 621 – 629 .
   PubMed Web of Science ®Google Scholar
• Stam , R. W. , den Boer , M. L. , Meijerink , J. P. , Ebus , M. E. Peters , G. J. 2003 . Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia . Blood , 101 : 1270 – 1276 .
   PubMed Web of Science ®Google Scholar
• Gati , W. P. , Paterson , A. R. , Larratt , L. M. , Turner , A. R. and Belch , A. R. 1997 . Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein . Blood , 90 : 346 – 353 .
   PubMed Web of Science ®Google Scholar
• Hubeek , I. , Stam , R. W. , Peters , G. J. , Broekhuizen , R. Meijerink , J. P. 2005 . The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia . Br. J. Cancer , 93 : 1388 – 1394 .
   PubMed Web of Science ®Google Scholar
• Giovannetti , E. , Del Tacca , M. , Mey , V. , Funel , N. Nannizzi , S. 2006 . Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine . Cancer Res. , 66 : 3928 – 3935 .
   PubMed Web of Science ®Google Scholar
• Molina-Arcas , M. , Marce , S. , Villamor , N. , Huber-Ruano , I. Casado , F. J. 2005 . Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells . Leukemia , 19 : 64 – 68 .
   PubMed Web of Science ®Google Scholar
• Mackey , J. R. , Galmarini , C. M. , Graham , K. A. , Joy , A. A. Delmer , A. 2005 . Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations . Blood , 105 : 767 – 774 .
   PubMed Web of Science ®Google Scholar