170
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid Conjugate—BAA

, , , , , & show all
Pages 190-199 | Received 15 Dec 2009, Accepted 22 Jan 2010, Published online: 19 Apr 2010

REFERENCES

  • Pelengaris , S. , Rudolph , B. and Littlewood , T. 2000 . Action of myc In Vivo—proliferation and apoptosis . Curr. Opin. Gen. Dev. , 10 : 100 – 105 .
  • Spencer , C. A. and Groudine , M. 1991 . Control of c-myc regulation in normal and neoplastic cells . Adv. Cancer Res. , 56 : 1 – 48 .
  • Marcu , K. B. , Bossone , S. A. and Patel , A. J. 1992 . MYC function and regulation . Ann. Rev. Biochem. , 61 : 809 – 860 .
  • Facchini , L. M. and Penn , L. Z. 1998 . The molecular role of MYC in growth and transformation: recent discoveries lead to new insights . FASEB J. , 12 : 633 – 651 .
  • Sakatsume , O. , Tsutsui , H. , Wang , Y. , Gao , H. , Tang , H. , Yamauchi , T. Murata , T. 1996 . Binding of THZif-1, a MAZ-like zinc finger protein to the nuclease-hypersensitive element in the promoter region of the c-MYC protooncogene . J. Biol. Chem. , 271 : 31322 – 31333 .
  • Postel , E. H. , Mango , S. E. and Flint , S. J. 1989 . A nuclease-hypersensitive element of the human c-myc promoter interacts with a transcription initiation factor . Mol. Cell. Biol. , 9 : 5123 – 5133 .
  • Siebenlist , U. , Hennighausen , L. , Battey , J. and Leder , P. 1984 . Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma . Cell , 37 : 381 – 391 .
  • Boles , T. C. and Hogan , M. E. 1987 . DNA structure equilibria in the human c-myc gene . Biochemistry , 26 : 367 – 376 .
  • Tomonaga , T. and Levens , D. 1996 . Activating transcription from single stranded DNA . Proc. Natl. Acad. Sci. USA , 93 : 5830 – 5835 .
  • Siddiqui-Jain , A. , Grand , C. L. , Bearss , D. J. and Hurley , L. H. 2002 . Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription . Proc. Natl. Acad. Sci. USA , 99 : 11593 – 11598 .
  • Grand , C. L. , Han , H. , Munoz , R. M. , Weitman , S. , VonHoff , D. D. , Hurley , L. H. and Bearss , D. J. 2002 . The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo . Mol. Cancer Ther. , 1 : 565 – 573 .
  • Seenisamy , J. , Bashyam , S. , Gokhale , V. , Vankayalapati , H. , Sun , D. , Siddiqui-Jain , A. Streiner , N. 2005 . Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure . J. Am. Chem. Soc. , 127 : 2944 – 2959 .
  • Sjövall , J. 2004 . Fifty years with bile acids and steroids in health and disease . Lipids , 39 : 703 – 722 .
  • Zhang , J. , Jing , B. and Regen , S. L. 2003 . Kinetic evidence for the existence and mechanism formation of a barrel stave structure from pore-forming dendrimers . J. Am. Chem. Soc. , 125 : 13984 – 13987 .
  • Li , Y. , Zhang , Z. , Ju , Y. and Zhao , C. Q. 2007 . Design, synthesis and antitumor activity of dimeric bile acid-amino acid conjugates . Lett. Org. Chem. , 4 : 414 – 418 .
  • Siddiqui-Jain , A. , Grand , C. L. , Bearss , D. J. and Hurley , L. H. 2002 . Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription . Proc. Natl. Acad. Sci. USA , 99 : 11593 – 11598 .
  • Li , J. , Correia , J. J. , Wang , L. , Trent , J. O. and Chaires , J. B. 2005 . Nucleic Acids Res. , 33 : 4649
  • Rujan , I. N. , Meleney , J. C. and Bolton , P. H. 2005 . Vertebrate telomere repeat DNAs favor external loop propeller quadruplex structures in the presence of high concentrations of potassium . Nucleic Acids Res. , 2 : 2022 – 2031 .
  • Ambrus , A. , Chen , D. , Dai , J. , Bialis , T. , Jones , R. A. and Yang , D. 2006 . Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution . Nucleic Acids Res. , 34 : 2723 – 2735 .
  • Ivan , S. and Richard , H. S. 2000 . Lead is unusually effective in sequence-specific folding of DNA . J. Mol. Biol. , 296 : 1 – 5 .
  • Dexheimer , T. S. , Sun , D. and Hurley , L. H. 2006 . Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter . J. Am. Chem. Soc. , 128 : 5404 – 5415 .
  • Dai , J. , Chen , D. , Jones , R. A. , Hurley , L. H. and Yang , D. 2006 . NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region . Nucleic Acids Res. , 34 : 5133 – 5144 .
  • Rankin , S. , Reszka , A. P. , Huppert , J. , Zloh , M. , Parkinson , G. N. , Todd , A. K. Ladame , S. 2005 . Putative DNA quadruplex formation within the human c-kit oncogene . J. Am. Chem. Soc. , 127 : 10584 – 10589 .
  • Fernando , H. , Reszka , A. P. , Huppert , J. , Ladame , S. , Rankin , S. , Venkitaraman , A. R. Neidle , S. 2006 . A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene . Biochemistry , 45 : 7854 – 7860 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.