Advanced search
Publication Cover
Nucleosides, Nucleotides & Nucleic Acids Volume 29, 2010 - Issue 4-6
Submit an article Journal homepage
159
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Methylation Specific PCR to Characterize Methylation of the Promoter of Deoxycytidine Kinase

G. J. Peters Deptartment of Medical Oncology VU University Medical Center, Amsterdam, the Netherlands
,
J. Hodzic Deptartment of Medical Oncology VU University Medical Center, Amsterdam, the Netherlands
,
B. Ortega Pediatric Hematology/Oncology, VU University Medical Center, Amsterdam, the Netherlands
,
E. Giovannetti Deptartment of Medical Oncology VU University Medical Center, Amsterdam, the Netherlands
,
A. D. Adema Deptartment of Medical Oncology VU University Medical Center, Amsterdam, the Netherlands
,
R. Broekhuizen Pediatric Hematology/Oncology, VU University Medical Center, Amsterdam, the Netherlands
,
G. J. Kaspers Pediatric Hematology/Oncology, VU University Medical Center, Amsterdam, the Netherlands
&
I. Hubeek Pediatric Hematology/Oncology, VU University Medical Center, Amsterdam, the Netherlands
 show all
Pages 408-413 | Published online: 11 Jun 2010

REFERENCES

  • Eriksson , S. , Munch-Petersen , B. , Johansson , K. and Eklund , H. 2002 . Structure and function of cellular deoxyribonucleoside kinases . Cell Mol. Life Sci. , 59 : 1327 – 1346 .
  • Peters , G. J. , van der Wilt , C. L. , Van Moorsel , C. J. , Kroep , J. R. , Bergman , A. M. and Ackland , S. P. 2000 . Basis for effective combination cancer chemotherapy with antimetabolites . Pharmacol. Ther. , 87 : 227 – 253 .
  • Al Madhoun , A. S. , van der Wilt , C. L. , Loves , W. J. , Padron , J. M. , Eriksson , S. , Talianidis , I. and Peters , G. J. 2004 . Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2′-2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 . Biochem. Pharmacol , 68 : 601 – 609 .
  • Galmarini , C. M. , Mackey , J. R. and Dumontet , C. 2001 . Nucleoside analogues: mechanisms of drug resistance and reversal strategies . Leukemia , 15 : 875 – 890 .
  • Kroep , J. R. , Loves , W. J. , van der Wilt , C. L. , Alvarez , E. , Talianidis , L. , Boven , E. , Braakhuis , B. J. , Van Groeningen , C. J. , Pinedo , H. M. and Peters , G. J. 2001 . Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity . Mol. Cancer Ther. , 1 : 371 – 376 .
  • Chottiner , E. G. , Shewach , D. S. , Datta , N. S. , Ashcraft , E. , Gribbin , D. , Ginsburg , D. , Fox , I. H. and Mitchell , B. S. 1991 . (1991) Cloning and expression of human deoxycytidine kinase cDNA . Proc. Natl. Acad. Sci. USA , 88 : 1531 – 1535 .
  • Song , J. J. , Walker , S. , Chen , E. , Johnson , E. E. , Spychala , J. , Gribbin , T. and Mitchell , B. S. 1993 . Genomic structure and chromosomal localization of the human deoxycytidine kinase gene . Proc. Natl. Acad. Sci. USA , 90 : 431 – 434 . 1993
  • Mitchell , B. S. , Song , J. J. , Johnson , E. E. , Chen , E. and Dayton , J. S. 1993 . (1993) Regulation of human deoxycytidine kinase expression . Adv. Enzyme Regul. , 33 : 61 – 68 .
  • Arner , E. S. and Eriksson , S. 1995 . Mammalian deoxyribonucleoside kinases . Pharmacol. Ther. , 67 : 155 – 186 .
  • Chen , E. H. , Johnson , E. E. , Vetter , S. M. and Mitchell , B. S. 1995 . Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines . J. Clin. Invest. , 95 : 1660 – 1668 .
  • Leegwater , P. A. , De Abreu , R. A. and Albertioni , F. 1998 . Analysis of DNA methylation of the 5′ region of the deoxycytidine kinase gene in CCRF-CEM-sensitive and cladribine (CdA)- and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine (CAFdA)-resistant cells . Cancer Lett. , 130 : 169 – 173 .
  • Ding , S. , Gong , B. D. , Yu , J. , Gu , J. , Zhang , H. Y. , Shang , Z. B. , Fei , Q. , Wang , P. and Zhu , J. D. 2004 . Methylation profile of the promoter CpG islands of 14 “drug-resistance” genes in hepatocellular carcinoma . World J. Gastroenterol. , 10 : 3433 – 3440 .
  • Adema , A. D. , Van der Born , K. , Honeywell , R. J. and Peters , G. J. 2009 . Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines . J. Chemotherapy , 21 : 338 – 346 .
  • Antonsson , B. E. , Avramis , V. I. , Nyce , J. and Holcenberg , J. S. 1987 . Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine kinase in the human lymphoid cell lines CCRF/CEM/0 and CCRF/CEM/dCk-1 . Cancer Res. , 47 : 3672 – 3678 .
  • Ge , Y. , Jensen , T. L. , Matherly , L. H. and Taub , J. W. 2003 . Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity . J. Biol. Chem. , 278 : 49901 – 49910 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.