Increased Migration by Stimulation of Thymidine Phosphorylase in Endothelial Cells of Different Origin

REFERENCES

• Bronckaers , A. , Gago , F. , Balzarini , J. and Liekens , S. 2009 . The dual role of thymidine phosphorylase in cancer development and chemotherapy . Med. Res. Rev. , 29 : 903 – 953 .
   PubMed Web of Science ®Google Scholar
• De Bruin , M. , Temmink , O. H. , Hoekman , K. , Pinedo , H. M. and Peters , G. J. 2006 . Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in health and disease . Cancer Therapy , 4 : 99 – 124 .
   Google Scholar
• Asahara , T. , Murohara , T. , Sullivan , A. , Silver , M. , van der Zee , R. , Li , T. , Witzenbichler , B. , Schatteman , G. and Isner , J. M. 1997 . Isolation of putative progenitor endothelial cells for angiogenesis . Science , 275 : 964 – 967 .
   PubMed Web of Science ®Google Scholar
• Nolan , D. J. , Ciarrocchi , A. Mellick , A. S. 2007 . Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization . Genes Developm. , 21 : 1546 – 58 .
   PubMed Web of Science ®Google Scholar
• Huang , L. , Hou , D. , Thompson , M. A. , Baysden , S. E. , Shelley , W. C. , Ingram , D. A. , March , K. L. and Yoder , M. C. 2007 . Acute myocardial infarction in swine rapidly and selectively releases highly proliferative endothelial colony forming cells (ECFCs) into circulation . Cell Transplant , 16 : 887 – 97 .
   PubMed Web of Science ®Google Scholar
• Javed , M. J. , Mead , L. E. , Prater , D. , Bessler , W. K. , Foster , D. , Case , J. , Goebel , W. S. , Yoder , M. C. , Haneline , L. S. and Ingram , D. A. 2008 . Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood . Pediatr. Res. , 64 : 68 – 73 .
   PubMed Web of Science ®Google Scholar
• van Hinsbergh , V. W. and Draijer , R. 1996 . “ Culture and characterization of human endothelial cells ” . 87 – 110 . Oxford : University Press Shaw A J .
   Google Scholar
• Timmermans , F. , Van Hauwermeiren , F. , De Smedt , M. , Raedt , R. , Plasschaert , F. , De Buyzere , M. L. , Gillebert , T. C. , Plum , J. and Vandekerckhove , B. 2007 . Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors . Arterioscler. Thromb. Vasc. Biol. , 27 : 1572 – 9 .
   PubMed Web of Science ®Google Scholar
• de Bruin , M. , Peters , G. J. , Oerlemans , R. , Assaraf , Y. G. , Masterson , A. J. , Adema , A. D. , Dijkmans , B. A. , Pinedo , H. M. and Jansen , G. 2004 . Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells . Mol. Pharmacol. , 66 : 1054 – 60 .
   PubMed Web of Science ®Google Scholar
• Bijman , M. N. , van Nieuw Amerongen , G. P. , Laurens , N. , van Hinsbergh , V. W. and Boven , E. 2006 . Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton . Mol. Cancer Ther. , 5 : 2348 – 57 .
   PubMed Web of Science ®Google Scholar
• de Bruin , M. , van Capel , T. , Van der Born , K. , Kruyt , F. A. , Fukushima , M. , Hoekman , K. , Pinedo , H. M. and Peters , G. J. 2003 . Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity . Br. J. Cancer , 88 : 957 – 64 .
   PubMed Web of Science ®Google Scholar
• Pula , G. , Mayr , U. , Evans , C. , Prokopi , M. , Vara , D. S. , Yin , X. , Astroulakis , Z. , Xiao , Q. , Hill , J. , Xu , Q. and Mayr , M. 2009 . Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures . Circ. Res. , 104 : 32 – 40 .
   PubMed Web of Science ®Google Scholar
• Sgarrella , F. , Poddie , F. P. , Meloni , M. A. , Sciola , L. , Pippia , P. and Tozzi , M. G. 1997 . Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase . Comp. Biochem. Physiol. B Biochem. Mol. Biol. , 117 : 253 – 7 .
   PubMed Web of Science ®Google Scholar
• Sgarrella , F. , Del Corso , A. , Tozzi , M. G. and Camici , M. 1992 . Deoxyribose 5-phosphate aldolase of Bacillus cereus: purification and properties . Biochim. Biophys. Acta , 1118 : 130 – 3 .
   PubMedGoogle Scholar
• Brown , N. S. , Jones , A. , Fujiyama , C. , Harris , A. L. and Bicknell , R. 2000 . Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors . Cancer Res. , 60 : 6298 – 302 .
   PubMed Web of Science ®Google Scholar
• Hotchkiss , K. A. , Ashton , A. W. , Klein , R. S. , Lenzi , M. L. , Zhu , G. H. and Schwartz , E. L. 2003 . Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration . Cancer Res. , 63 : 527 – 33 .
   PubMed Web of Science ®Google Scholar
• Hotchkiss , K. A. , Ashton , A. W. and Schwartz , E. L. 2003 . Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3 . J. Biol. Chem. , 278 : 19272 – 9 .
   PubMed Web of Science ®Google Scholar
• Seeliger , H. , Guba , M. , Koehl , G. E. , Doenecke , A. , Steinbauer , M. , Bruns , C. J. , Wagner , C. , Frank , E. , Jauch , K. W. and Geissler , E. K. 2004 . Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy . Clin. Cancer Res. , 10 : 1843 – 52 .
   PubMed Web of Science ®Google Scholar
• Brown , N. S. , Jones , A. , Fujiyama , C. , Harris , A. L. and Bicknell , R. 2000 . Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors . Cancer Res. , 60 : 6298 – 302 .
   PubMed Web of Science ®Google Scholar