29
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis and Biological Activity of 4-Amino-1-(β-D-ribofuranosyl)imidazo[4,5-d]pyridazin-7-one

, , &
Pages 2001-2011 | Received 24 Feb 1994, Accepted 22 Jun 1994, Published online: 24 Sep 2006

References

  • Doskocil , J. and Holy , A. 1974 . Inducible and Constitutive Nucleoside-Binding Sites in Escherichia coli. Differential Inhibition by Nucleoside Analogs . Nuc. Acid. Res. , 1 : 645 – 652 .
  • Huang , M. , Shimizu , H. and Daly , J. W. 1972 . Accumulation of Cyclic Adenosine Monophosphate in Incubated Slices of Brain Tissue. 2. Effects of Depolarizing Agents, Membrane Stabilizers, Phosphodiesterase Inhibitors, and Adenosine Analogs . J. Med. Chem. , 15 : 462 – 466 .
  • Quinn , R. J. , Gregson , R. P. , Cook , A. F. and Bartlett , R. T. 1980 . Isolation and Synthesis of 1-Methylisoguanosine, A Potent Pharmacologically Active Constituent from the Marine Sponge . Tedania digitata. Tetrahedron Lett. , : 567 – 568 .
  • Ruccia , M. , Vivona , N. and Spinelli , D. 1981 . “ Mononuclear Heterocyclic Rearrangements ” . In Advances in Heterocyclic Chemistry , Edited by: Katritzky , A. R. and Boulton , A. J. Vol. 29 , pp 141 – 169 . New York : Academic Press .
  • Turk , S. R. , Shipman , C. Jr. , Nassiri , M. R. , Genzlinger , G. , Krawczyk , S. H. , Townsend , L. B. and Drach , J. C. 1987 . Pyrrolo[2,3-d]pyrimidine Nucleosides as Inhibitors of Human Cytomegalovirus . Antimicrob. Agents and Chemother. , 31 : 544 – 550 .
  • Pudlo , J. S. , Saxena , N. K. , Nassiri , M. R. , Turk , S. R. , Drach , J. C. and Townsend , L. B. 1988 . Synthesis and Antiviral Activity of Certain 4- and 4,5-Disubstituted-7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines . J. Med. Chem. , 37 : 2086 – 2092 .
  • Pudlo , J. S. , Nassiri , M. R. , Kern , E. R. , Wotring , L. L. , Drach , J. C. and Townsend , L. B. 1990 . Synthesis, Antiproliferative, and Antiviral Activity of Certain 4-Substituted and 4,5-Disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines . J. Med. Chem. , 33 : 1984 – 1992 .
  • Krawczyk , S. H. , Bernier-Rodriguez , M. , Nassiri , M. R. , Kern , E. R. , Wotring , L. L. , Drach , J. C. and Townsend , L. B. 1990 . Arabinofuranosylpyrrolo[2,3-d]pyrimidmes as Potential Agents for Human Cytomegalovirus Infections . J. Med. Chem. , 33 : 3160 – 3169 .
  • Meade , E. A. , Wotring , L. L. , Drach , J. C. and Townsend , L. B. 1992 . Synthesis, Antiproliferative, and Antiviral Activity of Certain 4-Aminopyrrolo[2,3-d]pyridazine Nucleosides: An Entry into a Novel Series of Adenosine Analogues . J. Med. Chem. , 35 : 526 – 533 .
  • Meade , E. A. , Wotring , L. L. , Drach , J. C. and Townsend , L. B. 1993 . Synthesis, Antiproliferative, and Antiviral Activity of 4-Amino-1-(B-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and Related Derivatives . J. Med. Chem. , 36 : 3834 – 3842 .
  • Niedballa , U. and Vorbruggen , H. 1974 . A General Synthesis of N-Glycosides. V. Synthesis of 5-Azacytidines . J. Org. Chem. , 39 : 3672 – 3674 .
  • Vorbruggen , H. , Krolikiewicz , K. and Niedballa , U. 1975 . Synthesis of Nucleosides with Use of Trimethylsily-heterocycles . Ann. N. Y. Acad. Sci. , 255 : 82 – 90 .
  • Berry, David , A. “ The Synthesis and Biological Evaluation of Azapentalene Analogues of Adenine and Adenosine, PhD Thesis ” . Ann Arbor, MI : University of Michigan Library .
  • Gagnier , R. P. , Halat , M. J. and Otter , B. A. 1984 . Synthesis and NMR Studies of Some Imidazo[4,5-d]pyridazine Nucleosides . J. Heterocycl. Chem. , 21 : 481 – 489 .
  • Wotring , L. L. and Townsend , L. B. 1979 . Study of the Cytotoxicity and Metabolism of 4-Amino-3-carboxamido-1-(B-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine Using Inhibitors of Adenosine Kinase and Adenosine Deaminase . Cancer Res. , 39 : 3018 – 3023 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.