Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) from Guanosine

References

• Elion , G. B. , Furman , P. A. , Fyfe , J. A. , de Miranda , P. , Beauchamp , L. and Schaeffer , H. J. 1977 . Proc. Natl. Acad. Sci. USA , 74 : 5716
   PubMed Web of Science ®Google Scholar
• Schaeffer , H. J. , Beauchamp , L. , de Miranda , P. , Elion , G. B. , Bauer , D. J. and Collins , P. 1978 . Nature , 272 : 583
   PubMed Web of Science ®Google Scholar
• Kelley , J. L. and Schaeffer , H. J. 1986 . J. Heterocycl. Chem. , 23 ( 1 ) : 271
   Web of Science ®Google Scholar
• Chu , C. K. and Cutler , S. J. 1986 . J. Heterocycl. Chem. , 23 : 289
   Web of Science ®Google Scholar
• Moorman , A. R. and Hill , J. A. 1988 . J. Labelled Compd. Radiopharm , 25 ( 9 ) : 963
   Web of Science ®Google Scholar
• Kusmierek , J. T. , Czochralska , B. , Johansson , N. G. and Shugar , D. 1987 . Acta Chem. Scand, Ser. B. , B41 ( 10 ) : 701
   Google Scholar
• Krenitsky , T. A. , Hall , W. W. , Pauro , D. M. , Beauchamp , L. M. , Schaeffer , H. J. and Whiteman , P. D. 1984 . Proc. Natl. Acad. Sci. USA , 8 ( 10 ) : 3209
   Google Scholar
• Matsumoto , H. , Kaneko , K. T. , Mori , T. and Mizuno , Y. 1989 . Chem. Pharm. Bull. , 37 ( 1 ) : 229
   Web of Science ®Google Scholar
• Kaneko , C. , Matsumoto , H. , Yamada , K. , Takeuchi , T. , Mori , T. and Mizuno , Y. 1988 . Chem. Pharm. Bull. , 36 ( 4 ) : 1283
   Web of Science ®Google Scholar
• Boryski , J and Golankiewicz , B. 1987 . Nucleosides & Nucleotides , 6 : 385
   Web of Science ®Google Scholar
• 1989 . 8 : 529 The 7-isomer was converted to a 55:45 mixture of the 9- and 7-isomers by heating at 230°C for 5 min without catalyst.
   Google Scholar
• Reese , C. B. and Saffhill , R. J. 1972 . J. Chem. Soc., Perkin Trans. II , 2937
   Google Scholar
• Senkus , M. 1946 . J. Am. Chem. Soc. , 68 : 734
   Web of Science ®Google Scholar