An Overview of Ethical Issues Raised by Medicolegal Challenges to Death by Neurologic Criteria in the United Kingdom and a Comparison to Management of These Challenges in the USA

REFERENCES

• Academy of Medical Royal Colleges. 2008. A code of practice for the diagnosis and confirmation of death. https://aomrc.org.uk/wp-content/uploads/2016/04/Code_Practice_Confirmation_Diagnosis_Death_1008-4.pdf.
   Google Scholar
• Airedale NHS Trust v Bland. 1993.
   Google Scholar
• Ariz. Rev. Stat. §14-1107.
   Google Scholar
• Baillard, C., S. Bourdiau, P. Le Toumelin, K. F. Ait, B. Riou, M. Cupa, and C. M. Samama. 2004. Assessing residual neuromuscular blockade using acceleromyography can be deceptive in postoperative awake patients. Anesthesia and Analgesia 98 (3):854–7, table of contents.
   PubMed Web of Science ®Google Scholar
• Bell, C. F., J. M. Kelly, and R. S. Jones. 1986. Anaesthesia for Friedreich’s ataxia. Case report and review of the literature. Anaesthesia 41 (3):296–301. doi:10.1111/j.1365-2044.1986.tb12792.x.
   PubMed Web of Science ®Google Scholar
• Bernat, J., A. Manara, F. Goldenberg, P. Varelas, D. Greer, A. Lewis, G. Sung, S. Torrance, and S. Shemie. 2020. The concept of brain death/death by neurologic criteria. Supplement 3 of Determination of brain death/death by neurologic criteria: The World Brain Death Project. JAMA 324 (11):1078–97. doi:10.1001/jama.2020.11586.
   PubMed Web of Science ®Google Scholar
• Bevan, D. R. 1999. Monitoring and reversal of neuromuscular block. American Journal of Health-System Pharmacy 56 (11 Suppl 1):S10–S3. doi:10.1093/ajhp/56.S10.
   PubMed Web of Science ®Google Scholar
• Birchley, G. 2021. The theorisation of ‘best interests’ in bioethical accounts of decision-making. BMC Medical Ethics 22 (1):68. doi:10.1186/s12910-021-00636-0.
   PubMed Web of Science ®Google Scholar
• Brull, S. J., and A. F. Kopman. 2017. Current status of neuromuscular reversal and monitoring: Challenges and opportunities. Anesthesiology 126 (1):173–90. doi:10.1097/ALN.0000000000001409.
   PubMed Web of Science ®Google Scholar
• Capron, A. M. 2001. Brain death–well settled yet still unresolved. The New England Journal of Medicine 344 (16):1244–6. doi:10.1056/NEJM200104193441611.
   PubMed Web of Science ®Google Scholar
• Diagnosis of brain death. 1976. Statement issued by the honorary secretary of the Conference of Medical Royal Colleges and their Faculties in the United Kingdom on 11 October 1976. BMJ 2 (6045):1187–8.
   PubMedGoogle Scholar
• Goh, S. 2022. For want of another try. BMJ. Accessed July 25, 2022. https://www.bmj.com/content/378/bmj.o1788/rapid-responses.
   Google Scholar
• Goillandeau, M. 2022. British boy dies after life support stopped at end of long legal battle between his parents and doctors. CNN.com. Accessed November 22, 2022. https://www.cnn.com/2022/08/07/europe/archie-battersbee-dies-life-support-stopped-intl/index.html.
   Google Scholar
• Greer, D. M., S. Shemie, A. Lewis, S. Torrance, P. Varelas, F. Goldenberg, J. Bernat, M. Souter, M. Topcuoglu, A. Alexandrov, et al. 2020. Determination of brain death/death by neurologic criteria: The World Brain Death Project. JAMA 324 (11):1078–97. doi:10.1001/jama.2020.11586.
   PubMed Web of Science ®Google Scholar
• Greer, D. M., H. H. Wang, J. D. Robinson, P. N. Varelas, G. V. Henderson, and E. F. M. Wijdicks. 2016. Variability of Brain Death Policies in the United States. JAMA Neurology 73 (2):213–8. doi:10.1001/jamaneurol.2015.3943.
   PubMed Web of Science ®Google Scholar
• Gyermek, L., and N. Berman. 1992. “Train-of-four” fade during clinical nondepolarizing neuromuscular block. International Journal of Clinical Pharmacology, Therapy, and Toxicology 30 (4):122–7.
   PubMedGoogle Scholar
• Harris, J. 2003. Consent and end of life decisions. Journal of Medical Ethics 29 (1):10–5. doi:10.1136/jme.29.1.10.
   PubMed Web of Science ®Google Scholar
• Howell, T. P. 1982. Legislation: Oklahoma’s statutory definition of death. Oklahoma Law Review 35 (3):615–28.
   PubMedGoogle Scholar
• Israel Stinson v. Children’s Hospital Los Angeles. 2016. BS164387.
   Google Scholar
• Johnson, L. S. M. 2023. Arguments favoring continuation of “organ support” when families object to declaration of death by neurologic criteria. In Death determination by neurologic criteria: Areas of controversy and consensus, ed. A. Lewis and J. Bernat. New York: Springer Nature.
   Google Scholar
• Lazaridis, C., and L. Ross. 2023. The argument for personal choice in determining death. In Death determination by neurologic criteria: Areas of controversy and consensus, ed. A. Lewis and J. Bernat. New York: Springer Nature.
   Google Scholar
• Lewis, A. 2022a. Should the revised Uniform Determination of Death Act address objections to the use of neurologic criteria to declare death? Neurocritical Care 37 (2):377–85. doi:10.1007/s12028-022-01567-3.
   PubMed Web of Science ®Google Scholar
• Lewis, A. 2022b. The Uniform Determination of Death Act is being revised. Neurocritical Care 36 (2):335–8. doi:10.1007/s12028-021-01439-2.
   PubMed Web of Science ®Google Scholar
• Lewis, A., N. Adams, A. Chopra, and M. Kirschen. 2017. Organ support after death by neurologic criteria in pediatric patients. Critical Care Medicine 45 (9):e916-24–e924.
   Web of Science ®Google Scholar
• Lewis, A., N. Adams, P. Varelas, D. Greer, and A. Caplan. 2016. Organ support after death by neurologic criteria: Results of a survey of US neurologists. Neurology 87 (8):827–34. doi:10.1212/WNL.0000000000003008.
   PubMed Web of Science ®Google Scholar
• Lewis, A., A. Bakkar, E. Kreiger-Benson, A. Kumpfbeck, J. Liebman, S. Shemie, G. Sung, S. Torrance, and D. Greer. 2020. Determination of death by neurologic criteria around the world. Neurology 95 (3):e299–e309. doi:10.1212/WNL.0000000000009888.
   PubMed Web of Science ®Google Scholar
• Lewis, A., K. Cahn-Fuller, and A. Caplan. 2017. Shouldn’t dead be dead?: The search for a uniform definition of death. The Journal of Law, Medicine & Ethics 45 (1):112–28. doi:10.1177/1073110517703105.
   PubMed Web of Science ®Google Scholar
• Lewis, A., and D. Greer. 2017. POINT: Should informed consent be required for apnea testing in patients with suspected brain death? No. Chest 152 (4):700–2. doi:10.1016/j.chest.2017.05.030.
   PubMed Web of Science ®Google Scholar
• Lewis, A., M. Souter, M. Baldessari, D. Greer, S. D. Shemie, S. Torrance, and G. Sung. 2020. Somatic support after brain death/death by neurologic criteria for organ donation and other special circumstances. Supplement 11 of Determination of brain death/death by neurologic criteria: The world brain death project. JAMA 324 (11):1078–97.
   PubMed Web of Science ®Google Scholar
• McMath vs. California.2015. No. 3:15-06042 N.D. Cal.
   Google Scholar
• Nakagawa, T. A., S. Ashwal, M. Mathur, and M. Mysore. 2012. Guidelines for the determination of brain death in infants and children: An update of the 1987 Task Force recommendations-executive summary. Annals of Neurology 71 (4):573–85. doi:10.1002/ana.23552.
   PubMed Web of Science ®Google Scholar
• Nevada Acts ch. 2017. 315 (A.B. 424).
   Google Scholar
• Neves Briard, J., and M. Chassé. 2023. Arguments opposing the requirement to demonstrate absence of brain circulation to determine death by neurologic criteria. In Death determination by neurologic criteria: Areas of controversy and consensus, ed. A. Lewis and J. Bernat. New York: Springer Nature.
   Google Scholar
• New York State Guidelines for Determining Brain Death. 2011. https://www.health.ny.gov/professionals/hospital_administrator/letters/2011/brain_death_guidelines.htm
   Google Scholar
• Omelianchuk, A., and D. Magnus. 2023. Arguments opposing continuation of organ support when families object to declaration of death by neurologic criteria. In Death determination by neurologic criteria: Areas of controversy and consensus, ed. A. Lewis and J. Bernat. New York: Springer Nature.
   Google Scholar
• Paris, J. J., J. Ahluwalia, B. M. Cummings, M. P. Moreland, and D. J. Wilkinson. 2017. The Charlie Gard case: British and American approaches to court resolution of disputes over medical decisions. Journal of Perinatology 37 (12):1268–71. doi:10.1038/jp.2017.138.
   PubMed Web of Science ®Google Scholar
• Pope, T. M. 2023. Is consent required for clinicians to make a determination of death by neurologic criteria? In Death determination by neurologic criteria: Areas of controversy and consensus, ed. A. Lewis and J. Bernat. New York: Springer Nature.
   Google Scholar
• President’s Council on Bioethics. 2008. Controversies in the determination of death: A white paper by the President’s Council on Bioethics. Washington, DC: President’s Council on Bioethics.
   Google Scholar
• R v Malcherek; R v Steel. 1981.
   Google Scholar
• Re: A (A Child). 2015. EWHC 443 (Fam).
   Google Scholar
• Re: AB (A Minor), CD and EF. 2019. EWHC 3516.
   Google Scholar
• Re: Allen Callaway. 2016. DG-16-08.
   Google Scholar
• Re: Archie Battersbee. 2022. EWHC 1435.
   Google Scholar
• Re: BN. 2022. EWHC 663.
   Google Scholar
• Re: Guardianship of Hailu. 2015. 361 P.3d 5.
   Google Scholar
• Re: Midrar Namiq. 2020. EWHC 5.
   Google Scholar
• Re: Mirranda Grace Lawson. 2016. CL16-2358, City of Richmond Circuit Court.
   Google Scholar
• Re: RL. 2022. NIFam 17.
   Google Scholar
• Robbins, N. 2023. Arguments in favor of requiring the absence of brain circulation to determine death by neurologic criteria. In Death determination by neurologic criteria: Areas of controversy and consensus, ed. A. Lewis and J. Bernat. New York: Springer Nature.
   Google Scholar
• Ross, L. F. 2020. Reflections on Charlie Gard and the best interests standard from both sides of the atlantic ocean. Pediatrics 146 (Suppl 1):S60–S5. doi:10.1542/peds.2020-0818L.
   PubMedGoogle Scholar
• Rothstein, A., and A. Lewis. 2018. Right brain: Withholding treatment from a child with an epileptic encephalomyopathy. Neurology 90 (18):857–9. doi:10.1212/WNL.0000000000005416.
   PubMed Web of Science ®Google Scholar
• Royal College of Pediatrics and Child Health. 2015. The diagnosis of death by neurological criteria in infants less than 2 month old. https://www.rcpch.ac.uk/resources/diagnosis-death-neurological-criteria-dnc-infants-less-two-months-old-clinical-guideline
   Google Scholar
• Rubin, M. A., M. P. Kirschen, and A. Lewis. 2021. The neurocritical care brain death determination course: Purpose, design, and early findings. Neurocritical Care 35 (3):913–5.
   PubMed Web of Science ®Google Scholar
• Russell, J. A., L. G. Epstein, D. M. Greer, M. Kirschen, M. A. Rubin, and A. Lewis. 2019. Brain death, the determination of brain death, and member guidance for brain death accommodation requests. Neurology 92 (5):228–32. doi:10.1212/WNL.0000000000006750.
   PubMed Web of Science ®Google Scholar
• Silvester, W., R. Dawson, S. Quayyum, T. M. Pope, J. L. Bernat, D. Greer, G. Sung, S. Torrance, S. D. Shemie, and A. Lewis. 2020. Brain death/death by neurologic criteria and the law. Supplement 13 of Determination of brain death/death by neurologic criteria: The world brain death project. JAMA 324 (11):1078–97. doi:10.1001/jama.2020.11586.
   PubMed Web of Science ®Google Scholar
• Skegg, P. D., and G. 1976. The case for a statutory “definition of death”. Journal of Medical Ethics 2 (4):190–2. doi:10.1136/jme.2.4.190.
   PubMed Web of Science ®Google Scholar
• Stucke, A. G., and E. A. E. Stuth. 2001. Use of rapacuronium in a child with spinal muscular atrophy. Paediatric Anaesthesia 11 (6):725–8. doi:10.1046/j.1460-9592.2001.00732.x.
   PubMedGoogle Scholar
• Truog, R. D. 2020. Is “best interests” the right standard in cases like that of Charlie Gard? Journal of Medical Ethics 46 (1):16–7. doi:10.1136/medethics-2019-105808.
   PubMed Web of Science ®Google Scholar
• Uchida, S., R. Kudo, D. Takekawa, and K. Hirota. 2022. Anesthetic management of a patient with subclinical myasthenia gravis who underwent a thymectomy: A case report. JA Clinical Reports 8 (1):49. doi:10.1186/s40981-022-00541-4.
   PubMed Web of Science ®Google Scholar
• United States. President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. 1981. Defining death: Medical, legal and ethical issues in the determination of death. Washington, DC: The President's Council on Bioethics.
   Google Scholar
• van Beinum, A., A. Healey, J. Chandler, S. Dhanani, M. Hartwick, A. Lewis, C. Marshall, J. Marshall, S. Shemie, and J. M. Singh. 2021. Requests for somatic support after neurologic death determination: Canadian physician experiences. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie 68 (3):293–314. doi:10.1007/s12630-020-01852-9.
   PubMed Web of Science ®Google Scholar
• Wahlster, S., E. Wijdicks, P. Patel, D. Greer, J. Hemphill, M. Carone, and F. Mateen. 2015. Brain death declaration: Practices and perceptions worldwide. Neurology 84 (18):1870–9. doi:10.1212/WNL.0000000000001540.
   PubMed Web of Science ®Google Scholar
• Wijdicks, E. F. 2012. The transatlantic divide over brain death determination and the debate. Brain : a Journal of Neurology 135 (Pt 4):1321–31. doi:10.1093/brain/awr282.
   PubMed Web of Science ®Google Scholar
• Wijdicks, E. F. M., P. N. Varelas, G. S. Gronseth, and D. M. Greer. 2010. Evidence-based guideline update: Determining brain death in adults. Neurology 74 (23):1911–8. doi:10.1212/WNL.0b013e3181e242a8.
   PubMed Web of Science ®Google Scholar
• Workum, J. D., Janssen, S. H. V. H., and R. W. Touw. 2020. Considerations in Neuromuscular Blockade in the ICU: A Case Report and Review of the Literature. Case Reports in Critical Care 2020:8780979.
   PubMedGoogle Scholar
• Zheng, K., S. Sutherland, L. Hornby, S. D. Shemie, L. Wilson, and A. J. Sarti. 2022. Public understandings of the definition and determination of death: A scoping review. Transplantation Direct 8 (5):e1300. doi:10.1097/TXD.0000000000001300.
   PubMed Web of Science ®Google Scholar
• Zheng, K., S. Sutherland, L. Hornby, L. Wilson, S. D. Shemie, and A. J. Sarti. 2022. Healthcare professionals’ understandings of the definition and determination of death: A scoping review. Transplantation Direct 8 (4):e1309. doi:10.1097/TXD.0000000000001309.
   PubMed Web of Science ®Google Scholar