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HIV Clinical Trials Volume 19, 2018 - Issue 5
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Original Articles

Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults

Zao ZhangHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ;The Queen’s Medical Center, Honolulu, HI, USA; ORCID Iconhttp://orcid.org/0000-0003-3552-8078View further author information
ORCID Icon,
Glen M. ChewDepartment of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ORCID Iconhttp://orcid.org/0000-0001-6186-4353View further author information
ORCID Icon,
Cecilia M. ShikumaHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; View further author information
,
Louie Mar A. GangcuangcoDepartment of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; View further author information
,
Scott A. SouzaHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; View further author information
,
Bruce ShiramizuHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ;Department of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; View further author information
,
Beau K. NakamotoHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ;Straub Medical Center, Hawaii Pacific Health, Honolulu, HI, USAORCID Iconhttp://orcid.org/0000-0001-6506-9672View further author information
ORCID Icon,
Ting GongDepartment of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; View further author information
,
Santhosh R MannemThe Queen’s Medical Center, Honolulu, HI, USA; View further author information
,
Brooks I. MitchellDepartment of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; View further author information
,
Kalpana J. KallianpurHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ;Department of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ORCID Iconhttp://orcid.org/0000-0002-9978-097XView further author information
ORCID Icon,
Lishomwa C. NdhlovuHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ;Department of Tropical Medicine, Medical Microbiology & Pharmacology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; ORCID Iconhttp://orcid.org/0000-0001-5427-4187View further author information
ORCID Icon &
Dominic C. ChowHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-7395-038XView further author information
ORCID Icon show all
Pages 172-176 | Received 23 Apr 2018, Accepted 15 Aug 2018, Published online: 13 Nov 2018

References

  • Freiberg MS, Chang CC, Kuller LH, et al. HIV infection and the risk of acute myocardial infarction. JAMA Intern Med. 2013;173(8):614–622.
  • Chew GM, Fujita T, Webb GM, et al. TIGIT marks exhausted T cells, correlates with disease progression, and serves as a target for immune restoration in HIV and SIV infection. PLoS Pathog. 2016;12(1):e1005349.
  • Spell DW, Jones DV, Jr., Harper WF, David Bessman J. The value of a complete blood count in predicting cancer of the colon. Cancer Detect Prev. 2004;28(1):37–42.
  • Danese E, Lippi G, Montagnana M. Red blood cell distribution width and cardiovascular diseases. J Thorac Dis. 2015;7(10):E402–E411.
  • Shikuma CM, Seto T, Liang CY, et al. Vitamin D levels and markers of arterial dysfunction in HIV. AIDS Res Hum Retroviruses. 2012;28(8):793–797.
  • Shikuma CM, Barbour JD, Ndhlovu LC, et al. Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-alpha levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors. AIDS Res Hum Retroviruses. 2014;30(2):142–146.
  • Deeks SG, Walker BD. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity. 2007;27(3):406–416.
  • Al-Kindi SG, Zidar DA, McComsey GA, Longenecker CT. Association of anisocytosis with markers of immune activation and exhaustion in treated HIV. Pathog Immun. 2017;2(1):138–150.
  • Fromentin R, Bakeman W, Lawani MB, et al. CD4+ T cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART. PLoS Pathog. 2016;12(7):e1005761.
  • Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006;443(7109):350–354.
  • Dhurve SA, Dhurve AS. Bone marrow abnormalities in HIV disease. Mediterr J Hematol Infect Dis. 2013;5(1):e2013033.
  • Sultana GS, Haque SA, Sultana T, Ahmed AN. Value of red cell distribution width (RDW) and RBC indices in the detection of iron deficiency anemia. Mymensingh Med J. 2013;22(2):370–376.
  • Vaya A, Alis R, Suescun M, et al. Association of erythrocyte deformability with red blood cell distribution width in metabolic diseases and thalassemia trait. Clin Hemorheol Microcirc. 2015;61(3):407–415.
  • Allen LA, Felker GM, Mehra MR, et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Card Fail. 2010;16(3):230–238.
  • Girelli D, Nemeth E, Swinkels DW. Hepcidin in the diagnosis of iron disorders. Blood. 2016;127(23):2809–2813.
  • Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA. 2005;102(6):1906–1910.
  • Yu J, Wang L, Peng Y, et al. Dynamic monitoring of erythrocyte distribution width (rdw) and platelet distribution width (pdw) in treatment of acute myocardial infarction. Med Sci Monit. 2017;23:5899–5906.

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