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Original Articles

CRITICAL ROLE OF REACTIVE OXYGEN SPECIES FORMATION IN MICROCYSTIN-INDUCED CYTOSKELETON DISRUPTION IN PRIMARY CULTURED HEPATOCYTES

Pages 507-519 | Published online: 07 Jan 2011

References

  • Alberts , B. , Bray , D. , Lewis , J. , Raff , M. , Roberts , K. and Watson , J. D. 1983 . “ The cytoskeleton ” . In Molecular biology of cell , 549 – 688 . New York : Garland Press .
  • Beasley , V. R. , Lovell , R. A. , Holmes , K. R. , Walcott , H. E. , Schaeffer , D. J. , Hoffmann , W. E. and Carmichael , W. W. 2000 . Microcystin-LR decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly dosed swine . J. Toxicol. Environ. Health A , 61 : 2 81 – 303 .
  • Carmichael , W. W. 1994 . The toxins of cyanobacteria . Sci. Am. , 270 : 78 – 86 .
  • Chorus , I. , Falconer , I. R. , Salas , H. J. and Bartram , J. 2000 . Health risks caused by freshwater cyanobacteria in recreational waters. 7 . Toxicol. Environ. Health , 83 : 323 – 347 .
  • Cohen , P. , Holmes , C. F. and Tsukitani , Y. 1990 . Okadaic acid: A new probe for the study of cellular regulation . Trends Biochem. Sci. , 15 : 98 – 102 .
  • Ding , W. X. , Shen , H. M. and Ong , C. N. 2000 . Microcystic cyanobacteria extract induces cytoskeleton disruption and intracellular glutathione alteration in hepatocytes . Environ. Health Perspect. , 108 : 605 – 609 .
  • Eriksson , J. E. , Paatero , G. I. , Meriluoto , J. A. , Codd , G. A. , Kass , G. E. , Nicotera , P. and Orrenius , S. 1989 . Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystinLR, a cyclic peptide toxin . Exp. Cell Res. , 185 : 86 – 100 .
  • Fiorentini , C , Falzano , L. , Rivabene , R. , Fabbri , A. and Malorni , W. 1999 . N-Acetylcysteine protects epithelial cells against the oxidative imbalance due to Clostridium difficile toxins . FEBS Lett. , 453 : 124 – 128 .
  • Franz , D. R. , Leclaire , R. D. , Lawrence , W. B. and Bunner , D. L. 1988 . No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication . Toxicon , 26 : 1098 – 1101 .
  • Guzman , R. E. , Kerlin , R. L. and Zimmerman , T. E. 1999 . Histologie lesions in cynomolgus monkeys (Macaca fascicularis) naturally infected with simian retrovirus type D: Comparison of seropositive, virus-positive, and uninfected animals . Toxicol. Pathol. , 27 : 672 – 677 .
  • Schmidt , K. N. , Traenckner , E. B. , Meier , B. and Baeuerle , P. A. 1995 . Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B . J. Biol. Chem. , 270 : 27136 – 27142 .
  • Shen , H. M. , Ong , C. N. and Shi , C. Y. 1995 . Involvement of reactive oxygen species in aflatoxin Bl-induced cell injury in cultured rat hepatocytes . Toxicology , 99 : 115 – 123 .
  • Shen , H. M. , Yang , C. F. and Ong , C. N. 1999 . Sodium selenite-induced oxidative stress and apoptosis in human hepatoma HepG2 cells . Int. J. Cancer , 81 : 820 – 828 .
  • Shi , X. , Castranova , V. , Hal I i well , B. and Vallyathan , V. 1998 . Reactive oxygen species and silicainduced carcinogenesis . J. Toxicol. Environ. Health , 81 : 181 – 197 .
  • Tan , S. , Sagara , Y. , Liu , Y. , Maher , P. and Schubert , D. 1998 . The regulation of reactive oxygen species production during programmed cell death . 7. Cell Biol. , 141 : 1423 – 1432 .
  • Hermansky , S. J. , Stohs , S. J. , Eldeen , Z. M. , Roche , V. F. and Mereish , K. A. 1991 . Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice . J. Appl. Toxicol. , 11 : 65 – 73 .
  • Hooser , S. B. , Beasley , V. R. , Waite , L. L. , Kuhlenschmidt , M. S. , Carmichael , W. W. and Haschek , W. M. 1991 . Actin filament alterations in rat hepatocytes induced in vivo and in vitro by microcystin-LR, a hepatotoxin from the blue-green alga, Microcystis aeruginosa . Vet. Pathol. , 28 : 259266
  • Hoyal , C. R. , Giron-Calle , J. and Forman , H. J. 1998 . The alveolar macrophage as a model of calcium signaling in oxidative stress . J. Toxicol. Environ. Health , 81 : 117 – 134 .
  • Humpage , A. R. , Hardy , S. J. , Moore , E. J. , Froscio , S. M. and Falconer , I. R. 2000 . Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon . J. Toxicol. Environ. Health A , 61 : 155 – 165 .
  • Jochimsen , E. M. , Carmichael , W. W. , An , J. S. , Cardo , D. M. , Cookson , S. T. , Holmes , C. E. , Antunes , M. B. , de MeIo , Filho , D. A. , Lyra , T. M. , Barreto , V. S. , Azevedo , S. M. and Jarvis , W. R. 1998 . Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil . N. Engl.j. Med. , 338 : 873 – 878 .
  • Krishna , M. C. , Russo , A. , Mitchell , J. B. , Goldstein , S. , Dafni , H. and Samuni , A. 1996 . Do nitroxide antioxidants act as scavengers of O2'' or as SOD mimics? J . Biol. Chem. , 271 : 26026 – 26031 .
  • Li , Y. , Zhu , H. and Trush , M. A. 1999 . Detection of mitochondria-derived reactive oxygen species production by the chemilumigenic probes lucigenin and luminol . Biochem. Biophys. Acta , 1428 : 1 – 12 .
  • Mereish , K. A. , Bunner , D. L. , Ragland , D. R. and Creasia , D. A. 1991 . Protection against microcystin-LR-induced hepatotoxicity by Silymarin: Biochemistry, histopathology, and lethality . Pharm. Res. , 8 : 273 – 277 .
  • Milzani , A. , DalleDonne , I. and Colombo , R. 1997 . Prolonged oxidative stress on actin . Arch. Biochem. Biophys. , 339 : 267 – 274 .
  • Newell , S. W. , Perchellet , E. M. , Gao , X. M. , Chen , G. and Perchellet , J. P. 1996 . Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo . Cancer Lett. , 98 : 241 – 251 .
  • Pouria , S. , Andrate , A. , Barbosa , J. , Cavalcanti , R. L. , Barreto , V. T. , Ward , C. J. , Preiser , W. , Poon , G. K. , Neild , G. H. and Codd , G. A. 1998 . Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil . Lancet , 352 : 21 – 26 .
  • Samuni , A. , Krishna , C. M. , Riesz , P. , Finkelstein , E. and Russo , A. 1988 . A novel metal-free low molecular weight Superoxide dismutase mimic . J. Biol. Chem. , 263 : 17921 – 17924 .
  • Thor , H. , MirabelIi , F. , Salis , A. , Cohen , G. M. , Bellomo , G. and Orrenius , S. 1988 . Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinines . Arch. Biochem. Biophys. , 266 : 397 – 407 .
  • Toivola , D. M. , Goldman , R. D. , Garrod , D. R. and Eriksson , J. E. 1997 . Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments . J. Cell Sci. , 110 : 23 – 33 .
  • van Gorp , R. M. , Broers , J. L. , Reutelingsperger , C. P. , Bronnenberg , N. M. , Hornstra , G. , van DamMieras , M. C. and Heemskerk , J. W. 1999 . Peroxide-induced membrane blebbing in endotheliaI cells associated with glutathione oxidation but not apoptosis . Am. J. Physiol. , 277 : C20 – C28 .
  • Wang , H. and Joseph , J. A. 1999 . Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader . Free Radical Biol. Med. , 27 : 612 – 616 .

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