Percutaneous Absorption of Topical N , N -Diethyl- m -Toluamide (Deet): Effects of Exposure Variables and Coadministered Toxicants

References

• Riviere , J. E. , Williams , P. L. , Hillman , R. and Mishky , L. 1992 . Quantitative prediction of transdermal iontophoretic delivery of arbutamine in humans using the in vitro isolated perfused porcine skin flap (IPPSF) . J. Pharm. Sci. , 81 : 504 – 507 .
   PubMed Web of Science ®Google Scholar
• Riviere , J. E. , Brooks , J. D. , Williams , P. L. and Monteiro-Riviere , N. A. 1995 . Toxicokinetics of topical sulfur mustard penetration, disposition, and vascular toxicity in isolated perfused porcine skin . Toxicol. Appl. Pharmacol. , 135 : 25 – 34 .
   PubMed Web of Science ®Google Scholar
• Riviere , J. E. , Monteiro-Riviere , N. A. and Baynes , R. E. 2002 . Gulf War related exposure factors influencing topical absorption of 14C-permethrin . Toxicol. Lett. , 135 : 61 – 71 .
   PubMed Web of Science ®Google Scholar
• Ross , J. S. and Shah , J. C. 2000 . Reduction in skin permeation of N,N-diethyl-m-toluamide (DEET) by altering the skin/vehicle partition coefficient.J . Contral. Release , 67 : 211 – 212 .
   PubMed Web of Science ®Google Scholar
• Selim , S. , Hartnagel , R. E. , Osmitz , T. G. , Gabriel , K. L. and Schoenig , G. P. 1995 . Absorption, metabolism, and excretion of N,N-diethyl-m-toluamide following dermal application to human volunteers . Fundam. Appl. Toxicol. , 25 : 95 – 100 .
   PubMedGoogle Scholar
• Stinecipher , J. and Shah , J. 1997 . Percutaneous permeation of N,N-diethyl-m-toluamide (DEET) from commercial mosquito repellents and the effect of solvent . J. Toxicol. Environ. Health , 52 : 119 – 135 .
   PubMed Web of Science ®Google Scholar
• Wessely , S. 2001 . Ten years on: What do we know about the Gulf War Syndrome? Clin . Med. JRCPL , 1 : 28 – 37 .
   PubMed Web of Science ®Google Scholar
• Wester , R. C. and Maibach , H. I. 1993 . “ Animal models for percutaneous absorption ” . In Health risk assessment: Dermal and inhalation exposure and absorption of toxicants , Edited by: Wang , R. G. M. , Knowls , J. B. and Maibach , H. I. 89 – 103 . Boca Raton, FL : CRC Press .
   Google Scholar
• Wester , R. C. , Melendres , J. , Sedik , L. , Maibach , H. I. and Riviere , J. E. 1998 . Percutaneous absorption of salicylic acid, theophylline, 2,4-dimethylamine, diethyl hexylphthalic acid, and p-aminobenzoic acid in the isolated perfused porcine skin flap compared to man . Toxicol. Appl. Pharmacol. , 151 : 159 – 165 .
   PubMed Web of Science ®Google Scholar
• Abou-Donia , M. B. , Wilmarth , K. R. , Jensen , K. F. , Oehme , F. W. and Kurt , T. L. 1996 . Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin . J. Toxicol. Environ. Health , 48 : 35 – 56 .
   PubMed Web of Science ®Google Scholar
• Young , D. G. and Evans , S. 1998 . Safety and efficacy of DEET and permethrin in the prevention of arthropod attack . Military Med. , 163 : 324 – 330 .
   PubMed Web of Science ®Google Scholar
• Zhang , Z. , Riviere , J. E. and Monteiro-Riviere , N. A. 1995 . Topical sulfur mustard induces changes in prostaglandins and interleudin-1 a in isolated perfused porcine skin . In Vitro Toxicol. , 8 : 149 – 158 .
   Google Scholar
• Abou-Donia , M. B. , Goldstein , L. B. , Dechovskaia , A. , Bullman , S. , Jones , K. H. , Herrick , E. A. , Abdel-Rahman , A. A. and Khan , W. A. 2001 . Effects of daily dermal application of DEET and permethrin, alone or in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats . J.Toxicol. Environ. Health A , 62 : 523 – 541 .
   PubMed Web of Science ®Google Scholar
• Abu-Qare , A. W. and Abou-Donia , M. B. 2001a . Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin induced release of rat brain mitochondrial cytochrome c. . J. Toxicol. Environ. Health A , 63 : 243 – 252, (2000)1 .
   PubMed Web of Science ®Google Scholar
• Abu-Qare , A. W. and Abou-Donia , M. B. 2001b . DEET (N,N-diethyl-m-toluamide) alone or in combination with permethrin increased urinary excretion of 6B-hydroxycortisol in rats, a marker of hepatic CYP3A induction . J. Toxicol. Environ. Health A , 64 : 373 – 384 .
   PubMed Web of Science ®Google Scholar
• Baynes , R. E. , Halling , K. B. and Riviere , J. E. 1997 . The influence of diethyl-m-toluamide (DEET) on percutaneous absorption of permethrin and carbaryl . Toxicol. Appl. Pharmacol. , 144 : 332 – 339 .
   PubMed Web of Science ®Google Scholar
• Baynes , R. E. , Monteiro-Riviere , N. A. and Riviere , J. E. 2002 . Pyridostigmine bromide modulates the dermal disposition of 14C-permethrin . Toxicol. Appl. Pharmacol , 181 : 164 – 173 .
   PubMed Web of Science ®Google Scholar
• Moody , R. P. , Nadeau , B. and Chu , I. 1995 . In vitro dermal absorption of N,N-diethyl-m-toluamide (DEET) in rat, guinea pig, and human skin . In Vitro Toxicol. , 8 : 263 – 275 .
   Google Scholar
• National Research Council . 1994 . Health effects of permethrin-impregnated Army battle-dress uniforms , Washington, DC : National Academy Press .
   Google Scholar
• Osimitz , T. G. and Grothaus , R. H. 1995 . The present safety assessment of DEET.J . Am. Mosquito Control Assoc. , 11 : 274 – 278 .
   PubMed Web of Science ®Google Scholar
• Qiu , H. and Jun , H. W. 1996 . Solid-phase extraction and liquid Chromatographic quantitation of insect repellent N,N-diethyl-toluamide in plasma.J . Pharm. Biomed.Anal. , 15 : 241 – 250 .
   PubMed Web of Science ®Google Scholar
• Bowman , K. F. , Monteiro-Riviere , N. A. and Riviere , J. E. 1991 . Development of surgical techniques for preparation of in vitro isolated perfused porcine skin flaps for percutaneous absorption studies . Am. J. Vet. Res. , 52 : 75 – 82 .
   PubMed Web of Science ®Google Scholar
• Bronaugh , R. L. and Stewart , R. F. 1985 . Methods for in vitro percutaneous absorption studies IV: The flowthrough diffusion cell . J. Pharm. Sci. , 74 : 64 – 67 .
   PubMed Web of Science ®Google Scholar
• Bronaugh , R. L. , Hod , H. L. , Kraeling , M. E. and Yourick , J. J. 1999 . “ Determination of percutaneous absorption by in vitro techniques ” . In Percutaneous absorption. Drugs-cosmetics-mechanisms-methodology , 3rd , Edited by: Bronaugh , R. L. and Maibach , H. I. 229 – 233 . New York : Marcel Dekker .
   Google Scholar
• Carver , M. P. , Williams , P. L. and Riviere , J. E. 1989 . The isolated perfused porcine skin flap. III. Percutaneous absorption pharmacokinetics of organophosphates, steroids, benzoic acid and caffeine . Toxicol. Appl. Pharmacol. , 97 : 324 – 337 .
   PubMed Web of Science ®Google Scholar
• Fulco , C E. , Liverman , C. T. and Sox , H. C. 2000 . Guff War and health, Vol. I, Depleted uranium, sarin, pyridostigmine bromide, vaccines , Washington, DC : National Academy Press .
   Google Scholar
• Hoy , J. B. , Cornell , J. A. , Karlix , J. L. , Tebbett , I. R. and van Haaren , F. 2000 . Repeated coadministrations of pyridostigmine bromide, DEET, and permethrin alter locomotor behavior of rats . Vet. Human Toxicol. , 42 : 72 – 76 .
   PubMedGoogle Scholar
• Jagannathan , R. , Husain , K. and Somani , S. M. 2000 . Interaction of pyridostigmine and physical stress on antioxidant defense system in skeletal muscle of mice . J. Appl. Toxicol. , 21 : 341 – 348 .
   Web of Science ®Google Scholar
• Marino , M. T. , Schuster , B. G. , Brueckner , R. P. , Lin , E. , Kaminskis , A. and Lasseter , K. 1998 . Population pharmacokinetics and pharmacodynamics of pyridostigmine bromide for prophylaxis against nerve agents in humans.J . Clin. Pharmacol. , 38 : 227 – 235 .
   Google Scholar
• McCain , W. C , Lee , R. , Johnson , M. S. , Whaley , J. E. , Ferguson , J. W. , Beall , P. and Leach , G. 1997 . Acute oral toxicity study of pyridostigmine bromide, permethrin, and DEET in the laboratory rat J . Toxicol. Environ. Health , 50 : 113 – 124 .
   PubMed Web of Science ®Google Scholar
• Monteiro-Riviere , N. A. 1990 . “ Specialized technique: Isolated perfused porcine skin flap ” . In Methods for skin absorption , Edited by: Kemppainen , B. W. and Reifenrath , W. G. 175 – 189 . Boca Raton, FL : CRC Press .
   Google Scholar
• Qiu , H. , Jun , H. W. and McCall , J. W. 1998 . Pharmacokinetics, formulation, and safety of insect repellent N,N-diethyl-3-methylbenzamide (DEET): A review.J . Am. Mosquito Control Assoc. , 14 : 12 – 27 .
   PubMed Web of Science ®Google Scholar
• Reifenrath , W. G. and Robinson , P. B. 1982 . In vitro skin evaporation and penetration characteristics of mosquito repellents.J . Pharm. Sci. , 71 : 1014 – 1018 .
   PubMed Web of Science ®Google Scholar
• Riviere , J. E. 1999 . Comparative pharmacokinetics: Principles, techniques and applications , Ames : Iowa State University Press .
   Google Scholar
• Riviere , J. E. and Monteiro-Riviere , N. A. 1991 . The isolated perfused porcine skin flap as an in vitro model for percutaneous absorption and cutaneous toxicology . Crit. Rev. Toxicol. , 21 : 329 – 344 .
   PubMed Web of Science ®Google Scholar
• Riviere , J. E. , Bowman , K. F. , Monteiro-Riviere , N. A. , Dix , L. P. and Carver , M. P. 1986 . The isolated perfused porcine skin flap (IPPSF). I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies . Fundam. Appl. Toxicol. , 7 : 444 – 453 .
   PubMedGoogle Scholar
• Monteiro-Riviere , N. A. 1991 . “ Comparative anatomy, physiology, and biochemistry of mammalian skin ” . In Dermal and ocular toxicology: Fundamentals and methods , Edited by: Hobson , D. W. 3 – 71 . Boca Raton, FL : CRC Press .
   Google Scholar
• Monteiro-Riviere , N. A. and lnman , A. O. 1995 . Indirect immunohistochemistry and immunoelectronmicroscopy distribution of eight epidermal-dermal junction epitopes in the pig and in isolated perfused skin treated with bis(2-chloroethyl) sulfide . Toxicol. Pathol. , 23 : 313 – 325 .
   PubMed Web of Science ®Google Scholar
• Monteiro-Riviere , N. A. and lnman , A. O. 1997 . Ultrastructural characterization of sulfur-mustard-induced vesication in isolated perfused skin . Microsc. Res. Technique , 37 : 229 – 241 .
   PubMed Web of Science ®Google Scholar
• Monteiro-Riviere , N. A. and lnman , A. O. 2000 . Characterization of sulfur mustard-induced toxicity by enzyme histochemistry in porcine skin . Toxicol. Methods , 10 : 127 – 142 .
   Web of Science ®Google Scholar