61
Views
19
CrossRef citations to date
0
Altmetric
Original Articles

Oxidative Damage to Nuclear DNA in Hyperthyroid Rat Liver: Inability of Vitamin C to Prevent the Damage

, , , , , , & show all
Pages 413-420 | Accepted 01 Sep 2003, Published online: 12 Aug 2010

REFERENCES

  • Abu-Qare , A. W. and Abou-Donia , M. B. 2001 . Biomarkers of apoptosis: Release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′-deoxyguanosine, increased 3-nitrothyrosine, and alteration of p53 gene. . J. Toxicol. Environ. Health B , 4 : 313 – 332 .
  • Adali , M. , Inal , E. M. , Akalin , A. and Efe , B. 1999 . Effects of propylthiouracil, propranolol, and vitamin E on lipid peroxidation and antioxidant status in hyperthyroid patients. . Clin. Biochem. , 32 : 363 – 367 .
  • Asayama , K. , Dobashi , K. , Hayashibe , H. , Megata , Y. and Kato , K. 1987 . Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: A possible mechanism of injury to heart and skeletal muscle in hyperthyroidism. . Endocrinology , 121 : 2112 – 2118 .
  • Bianchi , G. , Solaroli , E. , Zaccheroni , V. , Grossi , G. , Bargossi , A. M. , Melchionda , N. and Marchesini , G. 1999 . Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: Effects of treatment. . Horm. Metab. Res. , 31 : 620 – 624 .
  • Cadenas , S. , Barja , G. , Poulsen , H. E. and Loft , S. 1997 . Oxidative DNA damage estimated by oxo8 dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and α-tocopherol. . Carcinogenesis , 18 : 2373 – 2377 .
  • Civelek , S. , Seymen , O. , Seven , A. , Yiğit , G. , Hatemi , H. and Burçak , G. 2001 . Oxidative stress in heart tissue of hyperthyroid and iron supplemented rats. . J. Toxicol. Environ. Health A , 64 : 499 – 506 .
  • Claycamp , H. G. 1992 . Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays. . Carcinogenesis , 13 : 1289 – 1292 .
  • Douki , T. , Martini , R. , Ravanat , J. L. , Turesky , R. J. and Cadet , J. 1997 . Measurement of 2,6-diamino-4hydroxy-5-formamidopyrimidine and 8-oxo-7,8-dihydroguanine in isolated DNA exposed to gamma radiation in aqueous solution. . Carcinogenesis , 18 : 2385 – 2391 .
  • Draper , H. H. , Agarwal , S. , Nelson , D. E. V. , Wee , J. J. , Ghoshal , A. K. and Farber , E. 1995 . Efects of peroxidative stress and age on the concentration of a deoxyguanosine–malondialdehyde adduct in rat DNA. . Lipids , 30 : 959 – 961 .
  • Faux , S. P. , Francis , J. E. , Smith , A. G. and Chipman , J. K. 1992 . Induction of 8-hydroxydeoxyguanosine in Ah-responsive mouse liver by iron and Aroclor 1254. . Carcinogenesis , 13 : 247 – 250 .
  • Fernandez , V. , Barrientos , X. , Kipreos , K. , Valenzuela , A. and Videla , L. A. 1985 . Superoxide radical generation, NADPH oxidase activity, and cytochrome p-450 content of rat liver microsomal fractions in an experimental hyperthyroid state: Relation to lipid peroxidation. . Endocrinology , 117 : 496 – 501 .
  • Finnegan , M. T. V. , Herbert , K. E. , Evans , M. D. , Griffiths , H. R. and Lunec , J. 1996 . Evidence for sensitisation of DNA to oxidative damage during isolation. . Free Radical Biol. Med. , 20 : 93 – 98 .
  • Floyd , R. A. , Watson , J. J. , Wong , P. K. , Altmiller , D. H. and Rickard , R. C. 1986 . Hydroxyl free radical adduct of deoxyguanosine: Sensitive detection and mechanisms of formation. . Free Radical Res. Commun. , 1 : 163 – 172 .
  • Fraga , C. G. , Motchnik , P. A. , Shigenaga , M. K. , Helbock , H. J. , Jacob , R. A. and Ames , B. N. 1991 . Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. . Proc. Natl. Acad. Sci. USA , 88 : 11003 – 11006 .
  • Gredilla , R. , Lopez-Torres , M. , Portero-Otin , M. , Pamplona , R. and Barja , G. 2001 . Influence of hyper-and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutation system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle. . Mol. Cell Biochem. , 221 : 41 – 48 .
  • Griffiths , H. R. and Lunec , J. 2001 . Ascorbic acid in the 21st century—More than a simple antioxidant. . Environ. Toxicol. Pharmacol. , 10 : 173 – 182 .
  • Haber , R. S. and Loeb , J. N. 1984 . Early enhancement of passive potassium efflux from rat liver by thyroid hormone: Relation to induction Na,K-ATPase. . Endocrinology , 115 : 291 – 297 .
  • Halliwell , B. and Dizdaroglu , M. 1992 . Commentary. The measurement of oxidative damage to DNA by HPLC and GC/MS techniques. . Free Radical Res. Commun. , 16 : 75 – 87 .
  • Halliwell , B. and Gutteridge , J. M. C. 1999 . Free radicals in biology and medicine , 3rd , London : Oxford University Press .
  • Hamilton , M. L. , Guo , Z. M. , Fuller , C. D. , Van Remmen , H. , Ward , W. F. , Austad , S. N. , Troyer , D. A. , Thompson , I. and Richardson , A. 2001 . A reliable assesment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. . Nucleic Acids Res. , 29 : 2117 – 2126 .
  • Helbock , H. J. , Beckman , K. B. , Shigenaga , M. K. , Walter , P. B. , Woodal , A. A. , Yeo , H. C. and Ames , B. N. 1998 . DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. . Proc. Natl. Acad. Sci. USA , 95 : 288 – 293 .
  • Helbock , H. J. , Beckman , K. B. and Ames , B. N. 1999 . 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. . Methods Enzymol. , 300 : 156 – 166 .
  • Huffman , L. J. , Judy , D. J. , Rao , M. K. , Frazer , D. G. and Goldsmith , W. T. 2000 . Lung responses to hypothyroidism, hyperthyroidism and lipopolysaccharide challenge in rats. . J. Toxicol. Environ. Health A , 61 : 623 – 639 .
  • Ichinose , T. , Yajima , Y. , Nagashima , M. , Takenoshita , S. , Nagamachi , Y. and Sagai , M. 1997 . Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles. . Carcinogenesis , 18 : 185 – 192 .
  • Jacob , R. A. , Kelley , D. S. , Pianalto , F. S. , Swendseid , M. E. , Hennigs , S. M. , Zhang , J. Z. , Ames , B. N. , Fraga , C. G. and Peters , J. H. 1991 . Immunocompetence and oxidant defence during ascorbate depletion of healthy men. . Am. J. Clin. Nutr. , 54 : 1302S – 1309S .
  • Kendall , T. L. , Byerley , D. J. and Dean , R. 1991 . Isolation of DNA from blood. . Anal. Biochem. , 95 : 74 – 76 .
  • Lopez-Torres , M. , Romero , M. and Barja , G. 2000 . Efects of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in rat heart. . Mol. Cell Endocrinol. , 168 : 127 – 134 .
  • McCormick , D. B. and Greene , H. L. 1999 . “ Vitamins ” . In Tietz textbook of clinical chemistry , Edited by: Ashwood , E. R. 999 – 1028 . Philadelphia : W. B. Saunders .
  • Morini , P. , Casalino , E. , Sblano , C. and Landriscina , C. 1991 . The response of rat liver lipid peroxidation, antioxidant enzyme activities and glutathione concentration to the thyroid hormone. . Int. J. Biochem. , 23 : 1025 – 1030 .
  • Padmore , I. D. , Griffiths , H. R. , Herbert , K. E. , Mistry , N. , Mistry , P. and Lunec , J. 1998 . Vitamin C exhibits pro-oxidant properties. . Nature , 392 : 559
  • Pamplona , R. , Portero-Otin , M. , Riba , D. , Ruiz , C. , Belmunt , M. J. , Requenan , J. R. , Thorpe , S. R. , Baynes , J. W. , Romero , M. , Lopez-Torres , M. and Barja , G. 1999 . Thyroid status modulates glycooxidative and lipoxidative modification of tissue proteins. . Free Radical Biol. Med. , 27 : 901 – 910 .
  • Prieme , H. , Loft , S. , Nyyssšnen , K. , Salonen , J. T. and Poulsen , H. E. 1997 . No effects of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. . Am. J. Clin. Nutr. , 65 : 503 – 507 .
  • Sai , K. , Umemura , T. , Takagi , A. , Hasegawa , R. and Kurokawa , Y. 1992 . The protective role of glutathione, cysteine and vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate. . Jpn. J. Cancer Res. , 83 : 45 – 51 .
  • Seven , A. , Tasan , E. , Inci , F. , Hatemi , H. and Burçk , G. 1998 . Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients: Effects of vitamin C supplementation. . Clin. Chem. Lab. Med. , 36 : 767 – 770 .
  • Seven , R. , Gelisgen , R. , Seven , A. , Erbil , Y. , Bozbora , A. and Burcak , G. 2001 . Influence of propylthiouracil treatment on oxidative stress and nitric oxide in Basedow disease patients. . J. Toxicol. Environ. Health A , 62 : 495 – 503 .
  • Seymen , H. O. , Seven , A. , Civelek , S. , Yiğit , G. , Hatemi , H. and Burçak , G. 1999 . Evaluation of antioxidant status in liver tissues: Effect of iron supplementation in experimental hyperthyroidism. . J. Basic Clin. Physiol. Pharmacol. , 10 : 315 – 325 .
  • Shigenaga , M. K. , Aboujaoude , E. N. , Chen , Q. and Ames , B. N. 1994 . Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. . Methods Enzymol. , 234 : 16 – 32 .
  • Shinohara , R. , Mano , T. , Nagasaka , A. , Hayashi , R. , Uchimura , K. , Nakano , I. , Watanabe , F. , Tsugawa , T. , Makimo , M. , Kakizawa , H. , Nagata , M. , Iwase , K. , Ishizuki , Y. and Itoh , M. J. 2000 . Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status. . J. Endocrinol. , 164 : 97 – 102 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.