44
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Inhibitory Effects of Ochratoxin A on Nerve Growth Factor-Induced Neurite Extension Through Downregulation of p38 Map Kinase and AP-1 Activation in Cultured Pheochromocytoma Cells

, , , , , , , , , , , & show all
Pages 357-371 | Accepted 01 Aug 2003, Published online: 12 Aug 2010

REFERENCES

  • Bendele , A. M. , Carlton , W. W. , Kroug , P. and Lillehoj , E. B. 1985 . Ochratoxin A carcinogenesis in the (C57BL/6J × C3H) F1 mouse. . J. Natl. Cancer Inst. , 75 : 733 – 742 .
  • Bondy , G. S. and Pestka , J. J. 2000 . Immunomodulation by fungal toxins. . J. Toxicol. Environ. Health B , 3 : 109 – 143 .
  • Creppy , E. E. , Kane , A. , Dirheimer , G. , Lafarge-Frayssinet , C. , Mousset , S. and Frayssinet , C. 1985 . Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney. . Toxicol. Lett. , 28 : 29 – 35 .
  • Crumpton , T. , Atkins , D. S. , Zawia , N. H. and Barone , S. Jr. 2001 . Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Sp1 DNA-binding. . Neurotoxicology , 22 : 49 – 62 .
  • Dharmavaram , R. M. , Liu , G. , Mowers , S. D. and Jimenez , S. A. 1997 . Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation. . J. Biol. Chem. , 272 : 26918 – 26925 .
  • Feng , Z. and Porter , A. G. 1999 . NF-kappaB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells. . J. Biol. Chem. , 274 : 30341 – 30344 .
  • Froquet , R. , Sibiril , Y. and Parent-Massin , D. 2001 . Improvement of megakaryocytic progenitor culture for toxicological investigations. . Toxicol. In Vitro , 15 : 691 – 699 .
  • Fukui , Y. , Hoshino , K. , Kameyama , Y. , Yasui , T. , Toda , C. and Nagano , H. 1987 . Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryonic brain. . Food Chem. Toxicol. , 25 : 17 – 24 .
  • Furukawa , K. , Guo , Q. , Schellenberg , G. D. and Mattson , M. P. 1998 . Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells. . J. Neurosci. Res. , 52 : 618 – 624 .
  • Gilani , S. H. , Bancroft , J. and Reily , M. 1978 . Teratogenicity of ochratoxin A in chick embryos. . Toxicol. Appl. Pharmacol. , 46 : 543 – 546 .
  • Gekle , M. , Gassner , B. , Freudinger , R. , Mildenberger , S. , Silbernagl , S. , Pfaller , W. and Schramek , H. 1998 . Characterization of an ochratoxin-A-dedifferentiated and cloned renal epithelial cell line. . Toxicol. Appl. Pharmacol. , 152 : 282 – 291 .
  • Guo , Q. , Xie , J. , Chang , X. , Zhang , X. and Du , H. 2001 . Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation. . Brain Res. , 903 : 13 – 25 .
  • Harwig , J. , Kuiper-Goodman , T. and Scott , P. M. 1983 . “ Microbial food toxicants: Ochratoxins ” . In Handbook of foodborne diseases of biological orig , Edited by: Rechcigl , M. 193 – 238 . Boca Raton, FL : CRC Press .
  • Hong , J. T. , Park , K. L. , Han , S. Y. , Park , K. S. , Kim , H. S. , Oh , S. D. , Lee , R. D. and Jang , S. J. 2000 . Effect of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic mid brain cells. . J. Toxicol. Environ. Health A , 61 : 609 – 612 .
  • Hong , J. T. , Lee , M. K. , Park , K. S. , Jung , K. M. , Lee , R. D. , Jung , H. K. , Park , K. L. , Yang. , K. H. and Chung , Y. S. 2002 . Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. . J. Toxicol. Environ. Health A , 65 : 407 – 418 .
  • Iwasaki , S. , Iguchi , M. , Watanabe , K. , Hoshino , R. , Tsujimoto , M. and Kohno , M. 1999 . Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2. . J. Biol. Chem. , 274 : 26503 – 26510 .
  • Jung , K. M. , Park , K. S. , Oh , J. H. , Jung , S. Y. , Yang , K. H. , Song , Y. S. , Son , D. J. , Park , Y. H. , Yun , Y. P. , Lee , M. K. , Oh , K. W. and Hong , J. T. 2003 . Activation of p38 MAP kinase and AP-1 during the promotion of neurite extension of PC12 cells by 15-deoxy-δ12,14-prostaglandin J2. . Mol. Pharmacol. , 63 : 607 – 616 .
  • Kamata , H. , Tanaka , C. , Yagisawa , H. , Matsuda , S. , Gotoh , Y. , Nishida , E. and Hirata , H. 1996 . Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-Acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. . J. Biol. Chem. , 271 : 33018 – 33025 .
  • Lea , T. , Steien , K. and Stormer , F. C. 1989 . Mechanism of ochratoxin A induced immunosuppression. . Mycopathologia , 107 : 153 – 159 .
  • Leppa , S. , Saffrich , R. , Ansorge , W. and Bohmann , D. 1998 . Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. . EMBO J. , 17 : 4404 – 4413 .
  • Marin , M. L. , Murtha , J. , Dong , W. and Pestka , J. J. 1996 . Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. . J. Toxicol. Environ. Health A , 48 : 379 – 396 .
  • Miki , T. , Fukui , Y. , Uemura , N. and Takeuchi , Y. 1994 . Regional difference in the neurotoxicity of ochratoxin A on the developing cerebral cortex in mice. . Dev. Brain Res. , 82 : 259 – 264 .
  • Morooka , T. and Nishida , E. 1998 . Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. . J. Biol. Chem. , 273 : 24285 – 24288 .
  • Ohki , T. , Hongo , S. , Nakada , N. , Maeda , A. and Takeda , M. 2002 . Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. . Brain Res. Dev. Brain Res. , 135 : 55 – 63 .
  • Pang , L. , Sawada , T. , Decker , S. J. and Saltiel , A. R. 1995 . Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. . J. Biol. Chem. , 270 : 13585 – 13588 .
  • Petkova-Bocharova , T. , Chernozemsky , I. N. and Castegnaro , M. 1988 . Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary system tumors in Bulgaria. . Food Addit. Contam. , 5 : 299 – 301 .
  • Poppe , S. M. , Stuckhard , J. L. and Szczech , G. M. 1983 . Postnatal behavioral effects of ochratoxin A in offspring of treated mice. . Teratology , 27 : 293 – 300 .
  • Radic , B. , Fuchs , R. , Peraice , M. and Lucic , A. 1997 . Ochratoxin A in human sera in the area with endemic nephropathy in Croatia . . Toxicol. Lett. , 91 : 105 – 109 .
  • Renzi , M. J. , Farrell , F. X. , Bittner , A. , Galindo , J. E. , Morton , M. , Trinh , H. and Jolliffe , L. K. 2002 . Erythropoietin induces changes in gene expression in PC-12 cells. . Brain Res. Mol. Brain Res. , 104 : 86 – 95 .
  • Saffer , J. D. , Jackson , S. P. and Annarella , M. B. 1991 . Developmental expression of Sp1 in the mouse. . Mol. Cell. Biol. , 11 : 2189 – 2199 .
  • Wei , X. and Sulik , K. K. 1993 . Pathogenesis of craniofacial and body wall malformations induced by ochratoxin A in mice. . Am. J. Med. Genet. , 47 : 862 – 871 .
  • Wei , X. and Sulik , K. K. 1996 . Pathogenesis of caudal dysgenesis/sirenomelia induced by ochratoxin A in chick embryos. . Teratology , 53 : 378 – 391 .
  • Xiao , Y. , Harry , G. J. and Pennypacker , K. R. 1999 . Expression of AP-1 transcription factors in rat hippocampus and cerebellum after trimethyltin neurotoxicity. . Neurotoxicology , 20 : 761 – 766 .
  • Yao , R. , Yoshihara , M. and Osada , H. 1997 . Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine. . J. Biol. Chem. , 272 : 18261 – 18266 .
  • Zawia , N. H. , Sharan , R. , Brydie , M. , Oyama , T. and Crumpton , T. 1998 . Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression. . Brain Res. Dev. Brain Res. , 107 : 291 – 298 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.