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Original Articles

Component-Based and Whole-Mixture Techniques for Addressing the Toxicity Of Drinking-Water Disinfection By-Product Mixtures

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Pages 741-754 | Accepted 01 Jan 2004, Published online: 12 Aug 2010

REFERENCES

  • Bove , F. , Fulcomer , M. , Klotz , J. , Esmarat , J. , Duffey , E. M. and Savrin , J. E. 1995 . Public drinking water contamination and birth outcomes . Am. J. Epidemiol. , 141 : 850 – 862 .
  • Cantor , K. P. , Lynch , C. F. , Hildesheim , M. E. , Dosemeci , M. , Lubin , J. , Alavanja , M. and Craun , G. 1998 . Drinking water source and chlorination byproducts. I. Risk of bladder cancer . Epidemiology , 9 : 21 – 28 .
  • Centers for Disease Control and Prevention. 1999 . Control of infectious diseases . Morbid. Mortal. Weekly Rep. , 48 ( 29 ) : 621 – 629 .
  • DeAngelo , A. B. , Geter , D. R. , Rosenberg , D. W. , Crary , C. K. and George , M. H. 2002 . The induction of aberrant crypt foci (ACF) in the colons of rats by trihalomethanes administered in the drinking water . Cancer Lett. , 187 : 25 – 31 .
  • Dodds , L. and King , W. D. 2001 . Relation between trihalomethane compounds and birth defects . Occup. Environ. Med. , 58 : 443 – 446 .
  • Fair , P. S. 1995 . “ Influence of water quality on formation of chlorination by-products ” . In Drinking water: Critical issues in health effects research: Workshop report , 14 – 17 . Washington, DC : ILSI Press .
  • Gennings , C. , Schwartz , P. , Carter , H. and Simmons , J. E. 1997 . An efficient approach for detecting departure from additivity in mixtures of many chemicals with a threshold additivity model . J. Agric. Biol. Environ. Stat. , 2 : 198 – 211 . Erratum, 2000, 5:257–259.
  • Hertzberg , R. C. and Teuschler , L. K. 2002 . Evaluating quantitative formulas for dose-response assessment of chemical mixtures . Environ. Health Perspect. , 110 ( 6 ) : 965 – 970 .
  • Hildesheim , M. E. , Cantor , K. P. , Lynch , C. F. , Dosemeci , M. , Lubin , J. , Alavanja , M. and Craun , G. 1998 . Drinking water source and chlorination byproducts. II. Risk of colon and rectal cancers . Epidemiology , 9 : 29 – 35 .
  • International Life Sciences Institute. 1998 . Assessing toxicity of exposure to mixtures of disinfection byproducts: Research recommendations , Washington, DC : ILSI Risk Science Institute .
  • International Program on Chemical Safety. 2000a . “ Chemistry of disinfectants and disinfectant by-products ” . In Disinfectants and disinfectant by-products. Environmental health criteria 216 , 27 – 80 . Geneva : World Health Organization .
  • International Program on Chemical Safety . 2000b . “ Toxicology of disinfectant by-products ” . In Disinfectants and disinfectant by-products. Environmental health criteria 216 , 110 – 276 . Geneva : World Health Organization .
  • Keegan , T. E. , Simmons , J. E. and Pegram , R. A. 1998 . NOAEL and LOAEL determinations of acute hepato-toxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F-344 rats . J. Toxicol. Environ. Health , 55 : 65 – 75 .
  • King , W. D. and Marett , L. D. 1996 . Case-control study of bladder cancer and chlorination byproducts in treated water (Ontario, Canada) . Cancer Causes Control , 7 : 596 – 604 .
  • King , W. D. , Dodds , L. and Allen , A. C. 2000 . Relation between stillbirth and specific chlorination byproducts in public water supplies . Environ. Health Perspect. , 108 : 883 – 886 .
  • Krasner , S. W. 2001 . “ Chemistry and occurrence of disinfection by-products ” . In Microbial pathogens and disinfection by-products in drinking water , Edited by: Craun , G. F. , Hauchman , F. S. and Robinson , D. E. 197 – 209 . Washington, DC : ILSI Press .
  • Krasner , S. W. , McGuire , M. J. , Jacangelo , J. G. , Patania , N. L. , Reagan , K. M. and Aieta , E. M. 1989 . The occurrence of disinfection byproducts in U.S. drinking water . J. Am. Water Works Assoc. , 81 : 41 – 53 .
  • Krasner , S. W. , Pastor , S. , Chinn , R. , Sclimenti , M. J. , Weinberg , H. S. , Richardson , S. D. and Thruston , A. D. Jr. 2001 . “ The occurrence of a new generation of DBPs (beyond the ICR) ” . In Proc. American Water Works Association Water Quality Technology Conference , 6 – 10 . Denver, CO : American Water Works Association T8-01(CD-ROM) .
  • Lilly , P. D. , Simmons , J. E. and Pegram , R. A. 1994 . Dose-dependent vehicle differences in the acute toxicity of Bromodichloromethane . Fundam. Appl. Toxicol. , 23 : 132 – 140 .
  • Lilly , M. Z. , Sey , Y. M. , Seely , J. C. , House , D. E. and Simmons , J. E. 2004 . The influence of gavage vehicle and concurrent exposure to trichloroethylene on chloroform hepatic and renal toxicity . J. Toxicol. Environ. Health , (accepted subject to revision).
  • Narotsky , M. G. , Pegram , R. A. and Kavlock , R. J. 1997 . Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride toxicity in rats . Fundam. Appl. Toxicol. , 40 : 30 – 36 .
  • National Cancer Institute. 1976 . Report on the carcinogenesis bioassay of chloroform , Bethesda, MD : National Cancer Institute . NTIS PB-264-018.
  • National Toxicology Program. 1987 . Toxicology and carcinogenesis studies of bromodichloromethane in F344/N rats and B6C3F1 mice (gavage studies) , 88 – 2537 . Research Triangle Park, NC : National Toxicology Program . Tech. Rep. No. 321. NIH publication
  • National Toxicology Program . 1989 . Toxicology and carcinogenesis studies of bromoform in F344/N rats and B6C3F1 mice (gavage studies) , Research Triangle Park, NC : National Toxicology Program . Tech. Rep. No. 350. NIH.
  • Richardson , S. D. 1998 . “ Identification of drinking water disinfection byproducts ” . In Encyclopedia of environ-mental analysis and remediation , Edited by: Meyers , R. A. 1398 – 1421 . New York : John Wiley and Sons. .
  • Richardson , S. D. , Simmons , J. E. and Rice , G. 2002 . DBPs: The next generation . Environ. Sci. Technol. , 36 : 197A – 205A .
  • Simmons , J. E. , Teuschler , L. K. and Gennings , C. 2001 . “ The toxicology of disinfection by-products: meth-ods for multi-chemical assessment, present research efforts and future research needs ” . In Microbial pathogens and disinfection by-products in drinking water: Heath effects and management of risks , Edited by: Craun , G. F. , Hauchman , F. S. and Robinson , D. E. 325 – 340 . Washington, DC : ILSI Press .
  • Simmons , J. E. , Richardson , S. D. , Speth , T. F. , Miltner , R. J. , Rice , G. , Schenck , K. M. , Hunter , S. E. III. and Teuschler , L. K. 2002 . Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts . Environ. Health Perspect. , 110 ( 6 ) : 1013 – 1024 .
  • Singer , P. C. 1995 . “ Disinfection by-products: From source to tap ” . In Drinking water: Critical issues in health effects research: Workshop report , 7 – 8 . Washington, DC : ILSI Press .
  • Stevens , A. A. , Moore , L. A. , Slocum , C. J. , Smith , B. L. , Seeger , D. R. and Ireland , J. C. 1989 . Disinfection by-products: Current perspectives , Denver, CO : American Water Works Association. .
  • Teuschler , L. K. and Simmons , J. E. 2003 . Approaching disinfection byproduct (DBP) toxicity as a mixtures problem . Am. Water Works Assoc. J. , 95 : 131 – 138 .
  • Teuschler , L. K. , Gennings , C. , Hartley , W. R. , Stitler , W. M. , Colman , J. T. , Hertzberg , R. C. , Thiyagarajah , A. , Lipscomb , J. C. and Simmons , J. E. 2000 . A multiple-purpose design approach to the evaluation of risks from mixtures of disinfection by-products . Drug Chem. Toxicol. , 23 : 307 – 321 .
  • Teuschler , L. K. , Hertzberg , R. C. , Rice , G. E. and Simmons , J. E. (in press) . EPA project-level research strategies for chemical mixtures: Targeted research for meaningful results . Pharmacol. Toxicol ,
  • U.S. Environmental Protection Agency. 1986 . Guidelines for the Health Risk Assessment of Chemical Mix-tures . Fed. Reg. , 51 ( 185 ) : 34014 – 34025 .
  • U.S. Environmental Protection Agency. 1999 . Research report on the risk assessment of mixtures of disinfection by-products (DBPs) in drinking water , Cincinnati, OH : U.S. Environmental Protection Agency . EPA/600/R-03/039. Office of Research and Development/ National Center for Environmental Assessment
  • U.S. Environmental Protection Agency. 2000a . Supplementary guidance for conducting health risk assessment of chemical mixtures , Washington, DC : U.S. Environmental Protection Agency . EPA/630/R-00/002
  • U.S. Environmental Protection Agency. 2000b . Conducting a risk assessment for mixtures of disinfection by-products in drinking water treatment systems , Cincinnati, OH : U.S. Environmental Protection Agency . EPA/600/R-03/040. Office of Research and Develop-ment/National Center for Environmental Assessment
  • U.S. Environmental Protection Agency. 2003a . Integrated Risk Information System (IRIS). Bromoform
  • U.S. Environmental Protection Agency. 2003b . Integrated Risk Information System (IRIS). Chlorodibromo-methane
  • U.S. Environmental Protection Agency. 2003c . Integrated Risk Information System (IRIS). Chloroform
  • U.S. Environmental Protection Agency . 2003d . Integrated Risk Information System (IRIS). Dichlorobro-momethane
  • Waller , K. , Swan , S. H. , DeLorenze , G. and Hopkins , B. 1998 . Trihalomethanes in drinking water and spontaneous abortion . Epidemiology. , 9 : 134 – 140 .
  • Waller , K. , Swan , S. H. , Windham , G. C. and Fenster , L. 2001 . Influence of exposure assessment methods on risk estimates in an epidemiologic study of total trihalomethane exposure and spontaneous abor-tion . J. Expos. Anal. Environ. Epidemiol. , 11 : 522 – 531 .
  • Weinberg , H. S. , Krasner , S. W. , Richardson , S. D. and Thurston , S. D. Jr. 2002 . The occurrence of disinfec-tion by-products of health concern in drinking water: Results of a nationwide DBP occurrence study. , Athens, GA : National Exposure Research Laboratory, U.S. Environmental Protection Agency . EPA/600/ R-02/068.
  • Woo , Y.-T. , Lai , D. , McLain , J. L. , Manibusan , M. K. and Dellarco , V. 2002 . Use of mechanism-based struc-ture-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products . Environ. Health Perspect. , 110 ( 1 ) : 75 – 87 .

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