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Original Articles

EFFECTS OF PERINATAL EXPOSURE TO LOW DOSES OF PCB 153 AND PCB 126 ON LYMPHOCYTE PROLIFERATION AND HEMATOLOGY IN GOAT KIDS

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Pages 889-904 | Received 01 Jun 2003, Accepted 01 Jan 2004, Published online: 12 Aug 2010

REFERENCES

  • Andersen , M. , Lie , E. , Derocher , A. E. , Belikov , S. E. , Bernhoft , A. , Boltunov , A. N. , Garner , G. W. , Skaare , J. U. and Wiig , O. 2001 . Geographic variation of PCB congeners in polar bears (Ursus maritimus) from Svalbard east to the Chukchi Sea . Polar Biol. , 24 : 231 – 238 .
  • Andersson , L. , Nikolaidis , E. , Brunstrom , B. , Bergman , A. and Dencker , L. 1991 . Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius of chick embryos in ovo and in mouse thymus anlagen in vitro . Toxicol. Appl. Pharmacol. , 107 : 183 – 188 .
  • Bernhoft , A. , Wiig , O. and Skaare , J. U. 1997 . Organochlorines in polar bears (Ursus maritimus) at Svalbard . Environ. Pollut. , 95 : 159 – 175 .
  • Bernhoft , A. , Skaare , J. U. , Wiig , O. , Derocher , A. E. and Larsen , H. J. 2000 . Possible immunotoxic effects of organochlorines in polar bears (Ursus maritimus) at Svalbard . J. Toxicol. Environ. Health A , 59 : 561 – 574 .
  • Carpenter , D. O. 1998 . Polychlorinated biphenyls and human health . Int. J. Occup. Med. Environ. Health , 11 : 291 – 303 .
  • Chang , K. J. , Hsieh , K. H. , Tang , S. Y. , Tung , T. C. and Lee , T. P. 1982 . Immunologic evaluation of patients with polychlorinated biphenyl poisoning: Evaluation of delayed-type skin hypersensitive response and its relation to clinical studies . J. Toxicol. Environ. Health , 9 : 217 – 223 .
  • Cogliano , V. J. 1998 . Assessing the cancer risk from environmental PCBs . Environ. Health Perspect. , 106 : 317 – 323 .
  • Crisp , T. M. , Clegg , E. D. , Cooper , R. L. , Wood , W. P. , Anderson , D. G. , Baetcke , K. P. , Hoffmann , J. L. , Morrow , M. S. , Rodier , D. J. , Schaeffer , J. E. , Touart , L. W. , Zeeman , M. G. and Patel , Y. M. 1998 . Environmental endocrine disruption: an effects assessment and analysis . Environ. Health Perspect. , 106 ( suppl. 1 ) : 11 – 56 .
  • De Guise , S. , Martineau , D. , Beland , P. and Fournier , M. 1998 . Effects of in vitro exposure of beluga whale leukocytes to selected organochlorines . J. Toxicol. Environ. Health A , 55 : 479 – 493 .
  • del Rio , I. , Marshall , T. , Tsai , P. , Shao , Y. S. and Guo , Y. L. 2002 . Number of boys born to men exposed to polychlorinated byphenyls . Lancet , 360 : 143 – 144 .
  • DeRosa , C. , Richter , P. , Pohl , H. and Jones , D. E. 1998 . Environmental exposures that affect the endocrine system: Public health implications . J. Toxicol. Environ. Health B , 1 : 3 – 26 .
  • de Swart , R. L. , Ross , P. S. , Timmerman , H. H. , Vos , H. W. , Reijnders , P. J. , Vos , J. G. and Osterhaus , A. D. 1995a . Impaired cellular immune response in harbour seals (Phoca vitulina) feeding on environmentally contaminated herring . Clin. Exp. Immunol. , 101 : 480 – 486 .
  • de Swart , R. L. , Harder , T. C. , Ross , P. S. , Vos , H. W. and Osterhaus , A. D. 1995b . Morbilliviruses and morbillivirus diseases of marine mammals . Infect. Agents Dis. , 4 : 125 – 130 .
  • de Swart , R. L. , Ross , P. S. , Vos , J. G. and Osterhaus , A. D. 1996 . Impaired immunity in harbour seals [Phoca vitulina] fed environmentally contaminated herring . Vet Q. , 18 ( suppl. 3 ) : S127 – S128 .
  • Elliott , J. E. , Kennedy , S. W. and Lorenzen , A. 1997 . Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius) . J. Toxicol. Environ. Health , 51 : 57 – 75 .
  • Fernie , K. J. , Bortolotti , G. R. , Smits , J. E. , Wilson , J. , Drouillard , K. G. and Bird , D. M. 2000 . Changes in egg composition of American kestrels exposed to dietary polychlorinated biphenyls . J. Toxicol. Environ. Health A , 60 : 291 – 303 .
  • Fischer , L. J. , Seegal , R. F. , Ganey , P. E. , Pessah , I. N. and Kodavanti , P. R. 1998 . Symposium overview: Toxicity of non-coplanar PCBs . Toxicol. Sci. , 41 : 49 – 61 .
  • Fox , L. L. and Grasman , K. A. 1999 . Effects of PCB 126 on primary immune organ development in chicken embryos . J. Toxicol. Environ. Health A , 58 : 233 – 244 .
  • Glynn , A. W. , Wolk , A. , Aune , M. , Atuma , S. , Zettermark , S. , Maehle-Schmid , M. , Darnerud , P. O. , Becker , W. , Vessby , B. and Adami , H. O. 2000 . Serum concentrations of organochlorines in men: A search for markers of exposure . Sci. Total Environ. , 263 : 197 – 208 .
  • Grasman , K. A. and Whitacre , L. L. 2001 . Effects of PCB 126 on thymocyte surface marker expression and immune organ development in chicken embryos . J. Toxicol. Environ. Health A , 62 : 191 – 206 .
  • Hansen , L. G. 1998 . Stepping backward to improve assessment of PCB congener toxicities . Environ. Health Perspect. , 106 ( suppl. 1 ) : 171 – 189 .
  • Heaton , S. N. , Bursian , S. J. , Giesy , J. P. , Tillitt , D. E. , Render , J. A. , Jones , P. D. , Verbrugge , D. A. , Kubiak , T. J. and Aulerich , R. J. 1995 . Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology . Arch. Environ. Contam. Toxicol. , 29 : 411 – 417 .
  • Holene , E. , Nafstad , I. , Skaare , J. U. , Krogh , H. and Sagvolden , T. 1999 . Behavioural effects in female rats of postnatal exposure to sub-toxic doses of polychlorinated biphenyl congener 153 . Acta Paediatr. Suppl. , 88 : 55 – 63 .
  • Holladay , S. D. and Smialowicz , R. J. 2000 . Development of the murine and human immune system: Differential effects of immunotoxicants depend on time of exposure . Environ. Health Perspect. , 108 ( suppl. 3 ) : 463 – 473 .
  • Kerkvliet , N. I. , Baecher-Steppan , L. , Smith , B. B. , Youngberg , J. A. , Henderson , M. C. and Buhler , D. R. 1990 . Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): Structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus . Fundam. Appl. Toxicol. , 14 : 532 – 541 .
  • Kitamura , K. , Kikuchi , Y. , Watanabe , S. , Waechter , G. , Sakurai , H. and Takada , T. 2000 . Health effects of chronic exposure to polychlorinated dibenzo-P-dioxins (PCDD), dibenzofurans (PCDF) and coplanar PCB (Co-PCB) of municipal waste incinerator workers . J. Epidemiol. , 10 : 262 – 270 .
  • Kremer , J. , Gleichmann , E. and Esser , C. 1994 . Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation . J. Immunol. , 153 : 2778 – 2786 .
  • Lahvis , G. P. , Wells , R. S. , Kuehl , D. W. , Stewart , J. L. , Rhinehart , H. L. and Via , C. S. 1995 . Decreased lymphocyte responses in free-ranging bottlenose dolphins (Tursiops truncatus) are associated with increased concentrations of PCBs and DDT in peripheral blood . Environ. Health Perspect. , 103 ( suppl. 4 ) : 67 – 72 .
  • Larsen , H. J. 1979 . A whole blood method for measuring mitogen-induced transformation of sheep lymphocytes . Res. Vet. Sci. , 27 : 334 – 338 .
  • Lu , Y. C. and Wu , Y. C. 1985 . Clinical findings and immunological abnormalities in Yu-Cheng patients . Environ. Health Perspect. , 59 : 17 – 29 .
  • McKinney , J. D. and Waller , C. L. 1998 . Molecular determinants of hormone mimicry: Halogenated aromatic hydrocarbon environmental agents . J. Toxicol. Environ. Health B , 1 : 27 – 58 .
  • Oehme , M. 1991 . Dispersion and transport paths of toxic persistent organochlorines to the Arctic—Levels and consequences . Sci. Total Environ. , 106 : 43 – 53 .
  • Olsson , M. , Karlsson , B. and Ahnland , E. 1994 . Diseases and environmental contaminants in seals from the Baltic and the Swedish west coast . Sci. Total Environ. , 154 : 217 – 227 .
  • Ross , P. S. , de Swart , R. L. , Reijnders , P. J. , van Loveren , H. , Vos , J. G. and Osterhaus , A. D. 1995 . Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbor seals fed herring from the Baltic Sea . Environ. Health Perspect. , 103 : 162 – 167 .
  • Safe , S. H. 1994 . Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment . Crit. Rev. Toxicol. , 24 : 87 – 149 .
  • Shadel , B. N. , Evans , R. G. , Roberts , D. , Clardy , S. , Jordan-Izaguirre , D. , Patterson , D. G. Jr. and Needham , L. L. 2001 . Background levels of non-ortho-substituted (coplanar) polychlorinated biphenyls in human serum of Missouri residents . Chemosphere , 43 : 967 – 976 .
  • Shin , H. J. , Gye , M. H. , Chung , K. H. and Yoo , B. S. 2002 . Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells . Toxicol. Lett. , 135 : 25 – 31 .
  • Skaare , J. U. , Bernhoft , A. , Derocher , A. , Gabrielsen , G. W. , Goksoyr , A. , Henriksen , E. , Larsen , H. J. , Lie , E. and Wiig , O. 2000 . Organochlorines in top predators at Svalbard—occurrence, levels and effects . Toxicol. Lett. , 112–113 : 103 – 109 .
  • Smialowicz , R. J. , DeVito , M. J. , Riddle , M. M. , Williams , W. C. and Birnbaum , L. S. 1997 . Opposite effects of 2,2´,4,4´,5,5´-hexachlorobiphenyl and 2,3,7,8- tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice . Fundam. Appl. Toxicol. , 37 : 141 – 149 .
  • Thomas , P. T. and Hinsdill , R. D. 1979 . The effect of perinatal exposure to tetrachlorodibenzo-p-dioxin on the immune response of young mice . Drug Chem. Toxicol. , 2 : 77 – 98 .
  • Tryphonas , H. , Luster , M. I. , Schiffman , G. , Dawson , L. L. , Hodgen , M. , Germolec , D. , Hayward , S. , Bryce , F. , Loo , J. C. and Mandy , F. 1991 . Effect of chronic exposure of PCB (Aroclor 1254) on specific and nonspecific immune parameters in the rhesus (Macaca mulatta) monkey . Fundam. Appl. Toxicol. , 16 : 773 – 786 .
  • Voie , O. A. and Fonnum , F. 1998 . Ortho substituted polychlorinated biphenyls elevate intracellular [Ca2+] in human granulocytes . Environ. Toxicol. Pharmacol. , 5 : 105 – 112 .
  • Voie , O. A. , Wiik , P. and Fonnum , F. 1998 . Ortho-substituted polychlorinated biphenyls activate respiratory burst measured as luminol-amplified chemoluminescence in human granulocytes . Toxicol. Appl. Pharmacol. , 150 : 369 – 375 .
  • Weisglas-Kuperus , N. , Sas , T. C. , Koopman-Esseboom , C. , van der Zwan , C. W. , De Ridder , M. A. , Beishuizen , A. , Hooijkaas , H. and Sauer , P. J. 1995 . Immunologic effects of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch infants . Pediatr. Res. , 38 : 404 – 410 .
  • Wu , Y. C. , Hsieh , R. P. and Lu , Y. C. 1984 . Altered distribution of lymphocyte subpopulations and augmentation of lymphocyte proliferation in chronic PCB poisoned patients . Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi , 17 : 177 – 187 .

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