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Original Articles

Moving From External Exposure Concentration to Internal Dose: Duration Extrapolation Based on Physiologically Based Pharmacokinetic Derived Estimates of Internal Dose

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Pages 927-950 | Published online: 24 Feb 2007

References

  • Abbas , R. and Fisher , J. W. 1997 . A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice . Toxicol. Appl. Pharmacol. , 147 : 15 – 30 . [PUBMED] [INFOTRIEVE] [CSA]
  • Andersen , M. E. 2003 . Toxicokinetic modeling and its applications in chemical risk assessment . Toxicol. Lett. , 138 : 9 – 27 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Andersen , M. E. , Gargas , M. L. , Clewell , H. J. and Severyn , K. M. 1987a . Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods . Toxicol. Appl. Pharmacol. , 89 : 149 – 157 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Andersen , M. E. , MacNaughton , M. G. , Clewell , H. J. III and Paustenbach , D. J. 1987b . Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model . Am. Ind. Hyg. Assoc. J. , 48 : 335 – 343 . [PUBMED] [INFOTRIEVE] [CSA]
  • Andersen , M. E. , Clewell , H. J. and Frederick , C. B. 1995 . Applying simulation modeling to problems in toxicology and risk assessment—A short perspective . Toxicol. Appl. Pharmacol. , 133 : 181 – 187 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Bale , A. S. , Smothers , C. T. and Woodward , J. J. 2002 . Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene . Br. J. Pharmacol. , 137 : 375 – 383 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Beckstead , M. J. , Weiner , J. L. , Eger , E. I. II , Gong , D. H. and Mihic , S. J. 2000 . Glycine and n-aminobutyric acidA receptor function is enhanced by inhaled drugs of abuse. . Mol. Pharmacol. , 57 : 1199 – 1205 . [PUBMED] [INFOTRIEVE] [CSA]
  • Boyes , W. K. and Dyer , R.S. 1983 . Pattern reversal visual evoked potentials in awake rats . Brain Res. Bulletin. , 10 : 817 – 823 . [CSA] [CROSSREF]
  • Boyes , W. K. , Bushnell , P. J. , Crofton , K. M. , Evans , M. and Simmons , J. E. 2000 . Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario . Environ. Health Persect. , 108 ( 2 ) : 317 – 322 . [CSA]
  • Boyes , W. K. , Bercegeay , M. , Ali , J. S. , Krantz , T. , McGee , J. , Evans , M. , Raymer , J. H. , Bushnell , P. J. and Simmons , J. E. 2003 . Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual function . Toxicol. Sci. , 76 : 121 – 130 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • in press . Boyes, W. K., Evans, M. V., Eklund, C., Janssen, P., and Simmons, J. E. 2005. Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model. Risk Anal.
  • Brown , R. P. , Delp , M. D. , Lindstedt , S. L. , Rhomberg , L. R. and Beliles , R. P. 1997 . Physiological parameter values for physiologically based pharmacokinetic models . Toxicol. Ind. Health , 13 ( 4 ) : 407 – 484 . [PUBMED] [INFOTRIEVE] [CSA]
  • Bruckner , J. V. , Keys , D. A. and Fisher , J. W. 2004 . The acute exposure guideline level (AEGL) program: Applications of physiologically based pharmacokinetic modeling . J. Toxicol. Environ. Health A , 67 : 1 – 14 . [CSA]
  • Bushnell , P. J. 1997 . Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats . Fundam. Appl. Toxicol. , 36 : 30 – 38 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Clewell , H. J. III , Andersen , M. E. and Barton , H. A. 2002 . A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment . Environ. Health Pespect. , 110 : 85 – 93 . [CSA]
  • Crofton , K. M. and Zhao , X. 1997 . The ototoxicity of trichloroethylene: Extrapolation and relevance of high-concentration, short-duration animal exposure data . Toxicol. Sci. , 38 : 101 – 106 .
  • Cruz , S. L. , Mirshahi , T. , Thomas , B. , Balster , R. L. and Woodward , J. J. 1998 . Effects of the abused solvent toluene on recombinant N-methyl-d-aspartate and non-N-methyl-d-aspartate receptors expressed in Xenopus oocytes . J. Pharmacol. Exp. Ther. , 286 : 334 – 340 . [PUBMED] [INFOTRIEVE] [CSA]
  • Cruz , S. L. , Balster , R. L. and Woodward , J. J. 2000 . Effects of volatile solvents on recombinant N-methyl-d-aspartate receptors expressed in Xenopus oocytes . Br. J. Pharmacol. , 131 : 1303 – 1308 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Dallas , C. E. , Gallo , J. M. , Ramanathan , R. , Muralidhara , S. and Bruckner , J. V. 1991 . Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats . Toxicol. Appl. Pharmacol. , 110 : 303 – 314 . [PUBMED] [INFOTRIEVE] [CSA]
  • Dobrev , I. D. , Andersen , M. E. and Yang , R. S. H. 2002 . In silico toxicology: Simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane . Environ. Health Pespect. , 110 : 1031 – 1039 . [CSA]
  • Easterling , M. R. , Evans , M. V. and Kenyon , E. M. 2000 . Comparative analysis of software for physiologically based pharmacokinetic modeling: Simulation, optimization and sensitivity analysis . Toxicol. Methods , 10 : 203 – 229 . [CSA] [CROSSREF]
  • Evans , M. V. , Crank , W. D. , Yang , H.-M. and Simmons , J. E. 1994 . Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats . Toxicol. Appl. Pharmacol. , 128 : 36 – 44 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Fisher , J. W. 2000 . Physioloigcally based pharmacokinetic models for trichloroethylene and its oxidative metabolites . Environ. Health Perspect. , 108 : 265 – 273 . [PUBMED] [INFOTRIEVE] [CSA]
  • Fisher , J. W. , Whittaker , T. A. , Taylor , D. H. , Clewell , H. J. and Andersen , M. E. 1989 . Physiologically based pharmacokinetic modeling of the pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid . Toxicol. Appl. Pharmacol. , 99 : 395 – 414 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Fisher , J. W. , Whittaker , T. A. , Taylor , D. H. , Clewell , H. J. and Andersen , M. E. 1990 . Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid . Toxicol. Appl. Pharmacol. , 102 : 497 – 513 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Fisher , J. W. , Gargas , M. L. , Allen , B. C. and Andersen , M. E. 1991 . Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse . Toxicol. Appl. Pharmacol. , 109 : 183 – 195 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Fisher , J. W. , Mahle , D. and Abbas , R. 1998 . A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol . Toxicol. Appl. Pharmacol. , 152 : 339 – 359 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Fox , D. A. and Boyes , W. K. 2001 . “ Toxic response of the ocular and visual system ” . In Casarett and Doull's toxicology: The basic science of poisons , 6th , Edited by: Klaassen , C. D. 565 – 595 . New York : McGraw-Hill .
  • Friberg , L. , Kylin , B. and Nystrom , A. 1953 . Toxicities of trichloroethylene and tetrachloroethylene and Fujiwara's pyridine alkali reaction . Acta Pharmacal. Toxicol. , 9 : 303 – 312 . [CSA]
  • Gargas , M. L. , Burgess , R. J. , Voisard , D. E. , Cason , G. H. and Andersen , M. E. 1989 . Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues . Toxicol. Appl. Pharmacol. , 98 : 87 – 99 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Keys , D. A. , Bruckner , J. V. , Muralidhara , S. M. and Fisher , J. W. 2003 . Tissue dosimetry expansion and cross-validation of rat and mouse physiologically based pharmacokinetic models for trichloroethylene . Toxicol. Sci. , 76 : 35 – 50 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Krishnan , K. and Andersen , M. E. 2001 . “ Physiologically based pharmacokinetic modeling in toxicology ” . In Principles and methods of toxicology , 4th , Edited by: Hayes , A. W. 193 – 241 . Philadelphia : Taylor & Francis .
  • Krishnan , K. , Haddad , S. and Pelekis , M. 1995 . A simple index for representing the discrepancy between simulations of physiological pharmacokinetic models and experimental data . Toxicol. Ind. Health , 11 : 413 – 422 . [PUBMED] [INFOTRIEVE] [CSA]
  • Lipscomb , J. C. , Fisher , J. W. , Confer , P. D. and Byczkowski , J. Z. 1998 . In vitro to in vivo extrapolation for trichloroethylene metabolism in humans . Toxicol. Appl. Pharmacol. , 152 : 376 – 387 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • McGee , J. K. , Evans , M. V. and Crank , W. D. 1995 . A versatile gas uptake inhalation system used in pharmacokinetic and metabolic studies of volatile organic compounds . Toxicol. Methods , 5 : 199 – 212 .
  • Medinsky , M. A. and Valentine , J. L. 2001 . “ Toxicokinetics ” . In Casarett and Doull's toxicology: The basic science of poisons , 6th , Edited by: Klaassen , C. D. 225 – 237 . New York : McGraw-Hill .
  • National Research Council. 2001 . Standard operating procedures for developing acute exposure guideline levels of hazardous chemicals , Washington, DC : National Academy Press .
  • Ramsey , J. C. and Andersen , M. E. 1984 . A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans . Toxicol. Appl. Pharmacol. , 73 : 159 – 175 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Simmons , J. E. , Boyes , W. K. , Bushnell , P. J. , Raymer , J. , Limsakun , T. , McDonald , A. and Simmons , J. E. 2002 . A physiologically-based pharmacokinetic model for trichloroethylene with specificity for the Long-Evans rat . Toxicol. Sci. , 69 : 3 – 15 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • ten Berge , W. F. , Zwart , A. and Appelman , L.M. 1986 . Concentration–time mortality response relationship of irritant and systemically acting vapours and gases . J. Hazard. Mater. , 13 : 301 – 309 . [CROSSREF]
  • Thrall , K. D. and Poet , T. S. 2000 . Determination of biokinetic interactions in chemical Mixtures using real-time breath analysis and physiologically based pharmacokinetic modeling . J. Toxicol. Environ. Health A , 59 : 653 – 670 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Tillar , R. , Shafer , T. J. and Woodward , J. J. 2002 . Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells . Neurochem. Int. , 41 : 391 – 397 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • in press . U.S. Environmental Protection Agency. 2002. National-scale air toxics assessment. http://www.epa.gov/ttn/atw/nata/natasaov.html, accessed May 2002.
  • Vernon , R. J. and Ferguson , R. K. 1969 . Effects of trichloroethylene on visual-motor performance . Arch. Environ. Health , 18 : 894 – 900 . [PUBMED] [INFOTRIEVE]
  • Warren , D. A. , Muralidhara , S. and Bruckner , J. V. 1994 . Strain differences in the blood and tissue levels of trichloroethylene following exposure of Sprague-Dawley and Fischer 344 (F344) rats . Toxicologist , 14 : 282 (abstr. 1083).

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