Cadmium-induced Apoptosis in Murine Macrophages is Antagonized by Antioxidants and Caspase Inhibitors

REFERENCES

• Abshire , M. K. , Buzard , G. S. , Shiraishi , N. and Waalkes , M. P. 1996 . Induction of c-myc and c-jun proto-oncogene expression in rat L6 myoblasts by cadmium is inhibited by zinc preinduction of the metallothionein gene . J. Toxicol. Environ. Health , 48 : 359 – 377 . [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Achanzar , W. E. , Achanzar , K. B. , Lewis , J. G. , Webber , M. M. and Waalkes , M. P. 2000 . Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis . Toxicol. Appl. Pharmacol. , 164 : 291 – 300 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Asada , S. , Fukuda , K. , Nishisaka , F. , Matsukawa , M. and Hamanisi , C. 2001 . Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase . Inflamm. Res. , 50 : 19 – 23 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Bennett , B. L. , Sasaki , D. T. , Murray , B. W. , O’Leary , E. C. , Sakata , S. T. , Xu , W. , Leisten , J. C. , Motiwala , A. , Pierce , S. , Satoh , Y. , Bhagwat , S. S. , Manning , A. M. and Anderson , D. W. 2001 . SP600125, an anthrapyrazolone inhibitor of Jun NH2-terminal kinase . Proc. Natl. Acad. Sci. USA , 98 : 13681 – 13686 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Beyersmann , D. and Hechtenberg , S. 1997 . Cadmium, gene regulation, and cellular signalling in mammalian cells . Toxicol. Appl. Pharmacol. , 144 : 247 – 261 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Bossy-Wetzel , E. and Green , D. R. 1999 . Apoptosis: checkpoint at the mitochondrial frontier . Mutat. Res. , 434 : 243 – 251 . [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Chacon , E. and Acosta , D. 1991 . Mitochondrial regulation of superoxide by Ca2+: An alternate mechanism for the cardiotoxicity of doxorubicin . Toxicol. Appl. Pharmacol. , 107 : 117 – 128 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Cooke , J. A. and Johnson , M. S. 1996 . “ Cadmium in small mammals ” . In Environmental contaminants in wildlife , Edited by: Beyer , N. W. , Heinz , G. H. and Redmon-Norwood , A. W. 377 – 388 . Boca Raton, FL : Lewis .
   Google Scholar
• Chuang , S. M. , Liou , G. Y. and Yang , J. L. 2000a . Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium VI is mediated through oxidative stress but does not affect cytotoxicity . Carcinogenesis , 21 : 1491 – 1500 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Chuang , S. M. , Wang , I. C. and Yang , J. L. 2000b . Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium . Carcinogenesis , 21 : 1423 – 1432 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Cooke , J. A. and Johnson , M. S. 1996 . “ Cadmium in small mammals ” . In Environmental contaminants in wildlife , Edited by: Beyer , N. W. , Heinz , G. H. and Redmon-Norwood , A. W. 377 – 388 . Boca Raton, FL : Lewis .
   Google Scholar
• Descotes , J. 1992 . Immunotoxicology of cadmium . IARC Sci. Publ. , 118 : 385 – 390 . [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Dirsch , V. M. , Kirschke , S. O. , Estermeier , M. , Steffan , B. and Vollmar , A. M. 2004 . Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria . Oncogene , 23 : 1586 – 1593 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Galan , A. , Garcia-Bermejo , M. L. , Troyano , A. , Vilaboa , N. E. , de Blas , E. , Kazanietz , M. G. and Aller , P. 2000 . Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells . J. Biol. Chem. , 275 : 11418 – 11424 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Galan , A. , Garcia-Bermejo , L. , Troyano , A. , Vilaboa , N. E. , Fernandez , C. , de Blas , E. and Aller , P. 2001 . The role of intracellular oxidation in death induction apoptosis and necrosis in human promonocytic cells treated with stress inducers cadmium, heat, X-rays . Eur. J. Cell Biol. , 80 : 312 – 320 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Gomez , D. A. , Martinez-Martinez , S. , Calvo , V. , Armesilla , A. L. and Redondo , J. M. 1996 . JNK c-Jun NH2-terminal kinase is a target for antioxidants in T lymphocytes . J. Biol. Chem. , 271 : 26335 – 26340 . [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Guyton , K. Z. , Liu , Y. , Gorospe , M. , Xu , Q. and Holbrook , N. J. 1996 . Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury . J. Biol. Chem. , 271 : 4138 – 4142 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Habeebu , S. S. , Liu , J. and Klaassen , C. D. 1998 . Cadmium-induced apoptosis in mouse liver . Toxicol. Appl. Pharmacol. , 149 : 203 – 209 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Hamada , T. , Tanimoto , A. and Sasaguri , Y. 1997 . Apoptosis induced by cadmium . Apoptosis , 2 : 359 – 367 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Harstad , E. B. and Klaassen , C. D. 2002 . Tumor necrosis factor-α-null mice are not resistant to cadmium chloride-induced hepatotoxicity . Toxicol. Appl. Pharmacol. , 179 : 155 – 162 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• IARC . 1993 . Cadmium, mercury, and exposures in the glass manufacturing industry. Working group views and expert opinions . IARC Monogr. Eval. Carcinogen. Risks Hum. , 58 : 41 – 117 . [CSA]
   PubMedGoogle Scholar
• Inanami , O. , Ohta , T. , Ito , S. and Kuwabara , M. 1999 . Elevation of intracellular calcium ions is essential for the H2O2-induced activation of SAPK/JNK but not for that of p38 and ERK in Chinese hamster V79 cells . Antioxidant Redox Signal. , 1 : 501 – 508 . [CSA]
   PubMed Web of Science ®Google Scholar
• Irato , P. , Santovito , G. , Piccinni , E. and Albergoni , V. 2001 . Oxidative burst and metallothionein as a scavenger in macrophages . Immunol. Cell Biol. , 79 : 251 – 254 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Ishido , M. , Homma-Takeda , S. , Tohyama , C. and Suzuki , T. 1998 . Apoptosis in rat renal proximal tubular cells induced by cadmium . J. Toxicol. Environ. Health A , 55 : 1 – 12 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Ishido , M. , Suzuki , T. , Adachi , T. and Kunimoto , M. 1999 . Zinc stimulates DNA synthesis during its antiapoptotic action independently with increments of an antiapoptotic protein, Bcl-2, in porcine kidney LLC-PK1 cells . J. Pharmacol. Exp. Ther. , 290 : 923 – 928 . [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Jarup , L. 2003 . Hazards of heavy metal contamination . Br. Med. Bull. , 68 : 167 – 182 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Johnson , V. J. , He , Q. , Kim , S. H. , Kanti , A. and Sharma , R. P. 2003 . Increased susceptibility of renal epithelial cells to TNFα-induced apoptosis following treatment with fumonisin B1 . Chem. Biol. Interact. , 145 : 297 – 309 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Kim , J. and Sharma , R. P. 2004 . Kim, J.-Y., and Sharma, R. P. 2004. Calcium-mediated activation of c-jun NH2-terminal kinase JNK and apoptosis in response to cadmium in murine macrophages . Toxicol. Sci. , 81 : 518 – 527 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Kim , J. , Kim , S. , Johnson , V. J. and Sharma , R. P. 2005 . Extracellular signal-regulated kinase-signaling-dependent G2/M arrest and cell death in murine macrophages by cadmium . Environ. Toxicol. Chem. , 24 : 3069 – 3077 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Kondoh , M. , Araragi , S. , Sato , K. , Higashimoto , M. , Takiguchi , M. and Sato , M. 2002 . Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells . Toxicology. , 170 : 111 – 117 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Li , M. , Kondo , T. , Zhao , Q. L. , Li , F. J. , Tanabe , K. , Arai , Y. , Zhou , Z. C. and Kasuya , M. 2000 . Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria-dependent pathways . J. Biol. Chem. , 275 : 39702 – 39709 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Middleton , E. Jr. , Kandaswami , C. and Theoharides , T. C. 2000 . The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer . Pharmacol. Rev. , 52 : 673 – 751 . [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Muzio , M. , Stockwell , B. R. , Stennicke , H. R. , Salvesen , G. S. and Dixit , V. M. 1998 . An induced proximity model for caspase-8 activation . J. Biol. Chem. , 273 : 2926 – 2930 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Nath , R. , Prasad , R. , Palinal , V. K. and Chopra , R. K. 1984 . Molecular basis of cadmium toxicity . Prog. Food Nutr. Sci. , 8 : 109 – 163 . [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Nunez , G. , Benedict , M. A. , Hu , Y. and Inohara , N. 1998 . Caspases: The proteases of the apoptotic pathway . Oncogene , 17 : 3237 – 3245 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• O’Brien , P. and Salacinski , H. J. 1998 . Evidence that the reactions of cadmium in the presence of metallothionein can produce hydroxyl radicals . Arch. Toxicol. , 72 : 690 – 700 . [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Ramirez , D. C. and Gimenez , M. S. 2003 . Induction of redox changes, inducible nitric oxide synthase and cyclooxygenase-2 by chronic cadmium exposure in mouse peritoneal macrophages . Toxicol. Lett. , 145 : 121 – 132 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Remondino , A. , Kwon , S. H. , Communal , C. , Pimentel , D. R. , Sawyer , D. B. , Singh , K. and Colucci , W. S. 2003 . β-Adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway . Circ. Res. , 92 : 136 – 138 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Richter , C. , Par , J. W. and Ames , B. 1998 . Normal oxidative damage to mitochondrial and nuclear DNA is extensive . Proc. Natl. Acad. Sci. USA , 85 : 6465 – 6467 . [CSA]
   Web of Science ®Google Scholar
• Sauer , H. , Wartenberg , M. and Hescheler , J. 2001 . Reactive oxygen species as intracellular messengers during cell growth and differentiation . Cell Physiol Biochem. , 11 : 173 – 186 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Schaeffer , H. J. and Weber , M. J. 1999 . Mitogen-activated protein kinases: specific messages from ubiquitous messengers . Mol. Cell Biol. , 19 : 2435 – 2444 . [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Shih , C. M. , Ko , W. C. , Wu , J. S. , Wei , Y. H. , Wang , L. F. , Chang , E. E. , Lo , T. Y. , Cheng , H. H. and Chen , C. T. 2004 . Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts . J. Cell Biochem. , 91 : 384 – 397 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Shimizu , M. , Hochadel , J. F. and Waalkes , M. P. 1997 . Effects of glutathione depletion on cadmium-induced metallothionein synthesis, cytotoxicity, and proto-oncogene expression in cultured rat myoblasts . J. Toxicol. Environ. Health , 51 : 609 – 621 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Son , M. H. , Kang , K. W. , Lee , C. H. and Kim , S. G. 2001 . Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 ERK1/2 in conjunction with p38 kinase or c-jun NH2-terminal kinase JNK. Complete inhibition of the potentiated toxicity by U0126 an ERK1/2 and p38 kinase inhibitor . Biochem. Pharmacol. , 62 : 1379 – 1390 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Spruill , M. D. , Song , B. , Whong , W. Z. and Ong , T. 2002 . Proto-oncogene amplification and overexpression in cadmium-induced cell transformation . J. Toxicol. Environ. Health A , 65 : 2131 – 2144 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Stohs , S. J. , Bagchi , D. , Hassoun , E. and Bagchi , M. 2001 . Oxidative mechanisms in the toxicity of chromium and cadmium ions . J. Environ. Pathol. Toxicol. Oncol. , 20 : 77 – 88 . [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Wang , X. , Martindale , J. L. , Liu , Y. and Holbrook , N. J. 1998 . The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival . Biochem. J. , 333 ( Pt 2 ) : 291 – 300 . [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Watjen , W. , Cox , M. , Biagioli , M. and Beyersmann , D. 2002 . Cadmium-induced apoptosis in C6 glioma cells: Mediation by caspase-9 activation . Biometals , 15 : 15 – 25 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Wei , Y. H. and Lee , H. C. 2002 . Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging . Exp. Biol. Med. Maywood , 227 : 671 – 682 . [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Yan , L. and Cirillo , J. D. 2004 . Infection of murine macrophage cell lines by Legionella pneumophila . FEMS Microbiol. Lett. , 230 : 147 – 152 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Yuan , C. , Kadiiska , M. , Achanzar , W. E. , Mason , R. P. and Waalkes , M. P. 2000 . Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis . Toxicol. Appl. Pharmacol. , 164 : 321 – 329 . [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar