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Original Articles

A Pharmacokinetic Model of the Intracellular Dosimetry of Inhaled Nickel

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Pages 445-464 | Received 06 Feb 2004, Accepted 11 Apr 2006, Published online: 29 Mar 2007

REFERENCES

  • Abbracchio , M. , Heck , J. , Caprioli , R. and Costa , M. 1981 . Differences in surface properties of amorphous and crystalline metal sulfides may explain their toxicological potency . Chemosphere , 10 : 897 – 908 .
  • Abbracchio , M. , Simmons-Hansen , J. and Costa , M. 1982 . Cytoplasmic dissolution of phagocytized crystalline nickel sulfide particles: A prerequisite for nuclear uptake of nickel . J. Toxicol. Environ. Health , 9 : 663 – 676 .
  • Alberts , B. , Bray , D. , Johnson , A. , Lewis , J. , Raff , M. , Roberts , K. and Walter , P. 1998 . “ Intracellular compartments and transport ” . In Essential cell biology. An introduction to the molecular biology of the cell , Edited by: Robertson , M. , Lawrence , E. and Neal , V. 447 – 480 . New York : Garland .
  • Andersen , A. , Berge , S. , Engeland , A. and Norseth , T. 1996 . Exposure to nickel compounds and smoking in relation to incidence of lung and nasal cancer among nickel refinery workers . J. Occup. Environ. Med , 53 : 708 – 713 .
  • Arena , V. , Sussman , N. , Redmond , C. K. , Costatino , J. P. and Trauth , J. M. 1998 . Using alternative comparison populations to assess occupation-related mortality risk . J. Occup. Environ. Med , 40 : 907 – 916 .
  • Arrouijal , F. , Hildebrand , H. , Vophi , H. and Marzin , D. 1990 . Genotoxic activity of nickel subsulphide alpha-Ni3S2 . Mutagenesis , 5 : 583 – 589 .
  • Bal , W. and Kasprzak , K. 1997 . “ Modeling the metal binding sites in core histones: Interactions of carcinogenic Ni(II) with the -CAIH- motif of histone H3 ” . In Cytotoxic, mutagenic & carcinogenic potential of heavy metals related to human environment , Edited by: Hadjiladis , N. 107 – 121 . Netherlands : Kluwer Academic .
  • Benson , J. , Barr , E. , Bechtold , W. , Dunnick , J. K. , Eastin , W. E. , Hobbs , C. H. , Kennedy , C. H. and Maples , K. R. 1994 . Fate of inhaled nickel oxide and nickel subsulfide in F344/N rats . Inhal. Toxicol , 6 : 167 – 183 .
  • Benson , J. M. , Brooks , A. L. and Henderson , R. F. 1992 . “ Comparative in vitro cytotoxicity of nickel compounds to pulmonary alveolar macrophages in rat lung epithelial cells ” . In Nickel and human health: Current perspectives , Edited by: Nieboer , E. and Nriagu , J. O. 319 – 330 . New York : John Wiley & Sons .
  • Berry , J. , Galle , P. , Poon , M. , Pot-Deprun , J. , Chouroulinkov , I. , Judde , J. G. and Dewally , D. 1984 . Electron microprobe in vitro study of interaction of carcinogenic nickel compounds with tumour cells . IARC Sci. Publ , 53 : 153 – 164 .
  • Carlsen, L. 2001. Aqueous solubilities and complex stabilities of Ni(II) species. Part I: Inorganic ligands. Draft report to the Danish EPA http://glwww/mst.dk/homepage
  • Christie , N. and Katsifis , S. 1990 . “ Nickel carcinogenesis ” . In Biological effects of heavy metals. Vol II. Metal carcinogenesis , Edited by: Foulkes , E. 95 – 128 . Boca Raton, FL : CRC Press .
  • Ciccarelli , R. and Wetterhahn , K. 1984 . Nickel-bound chromatin, nucleic acids, and nuclear proteins from kidney and liver of rats treated with nickel carbonate in vivo . Cancer Res , 44 : 3892 – 3897 .
  • Conway , K. , Wang , X. W. , Xu , L. and Costa , M. 1987 . Effect of magnesium on nickel-induced genotoxicity and cell transformation . Carcinogenesis , 8 : 1115 – 1121 .
  • Coogan , T. , Latta , D. , Snow , E. and Costa , M. 1989 . Toxicity and carcinogenicity of nickel compounds . CRC Crit. Rev. Toxicol , 19 : 341 – 384 .
  • Costa , M. 1983 . Approaches toward studying genotoxicity and potential carcinogenicity of metal compounds in vitro . J. Parenter. Sci. Technol , 37 : 231 – 237 .
  • Costa , M. 1993 . Molecular targets of nickel and chromium in human and experimental systems . Scand. J. Work Environ. Health , 19 : 71 – 74 .
  • Costa , M. 1995 . Model for the epigenetic mechanism of action of nongenotoxic carcinogens . Am. J. Clin. Nutr , 61 : 666S – 669S .
  • Costa , M. and Heck , J. 1984 . Perspectives on the mechanism of nickel carcinogenesis . Adv. Inorg. Biochem , 6 : 285 – 309 .
  • Costa , M. and Mollenhauer , H. 1980 . Phagocytosis of nickel subsulfide particles during the early stages of neoplastic transformation in tissue . Cancer Res , 40 : 2688 – 2694 .
  • Costa , M. , Abbracchio , M. and Simmons-Hansen , J. 1981a . Factors influencing the phagocytosis, neoplastic transformation, and cytotoxicity of particulate nickel compounds in tissue culture systems . Toxicol. Appl. Pharmacol , 60 : 313 – 323 .
  • Costa , M. , Simmons-Hansen , J. , Bedrossian , C. , Bonura , J. and Caprioli , R. M. 1981b . Phagocytosis, cellular distribution and carcinogenic activity of particulate nickel compounds in tissue culture . Cancer Res , 41 : 2868 – 2876 .
  • Costa , M. , Heck , J. and Robison , S. 1982 . Selective phagocytosis of crystalline metal sulfide particles and DNA strand breaks as a mechanism for the induction of cellular transformation . Cancer Res , 42 : 2757 – 2763 .
  • Costa , M. , Yan , Y. , Zhao , D. and Salnikow , K. 2003 . Molecular mechanisms of nickel carcinogenesis: Gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-inducing cell signaling . J. Environ. Monit , 5 : 222 – 223 .
  • Cragle , D. , Hollis , D. , Newport , T. and Shy , C. 1984 . A retrospective cohort mortality study among workers occupationally exposed to metallic nickel powder at the Oak Ridge gaseous diffusion plant . IARC Sci. Publ , 53 : 57 – 63 .
  • Dally , H. and Hartwig , A. 1997 . Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells . Carcinogenesis , 18 : 1021 – 1026 .
  • Datta , A. , Misra , M. , North , S. and Kasprzak , K. 1992 . Enhancement by nickel(II) and L-histidine of 2'-deoxyguanosine oxidation with hydrogen peroxide . Carcinogenesis , 13 : 283 – 287 .
  • Doll , R. , Andersen , A. , Cooper , W. C. , Cosmatos , I. , Cragle , D. L. and Easton , D. 1990 . Report of the International Committee on Nickel Carcinogenesis in Man . Scand. J. Work Environ. Health , 61 : 1 – 82 .
  • Dowjat , W. , Huang , X. , Cosentino , S. and Costa , M. 1996 . Peroxidase deficiency of nickel-transformed hamster cells correlates with their increased resistance to cytotoxicity of peroxides . Biometals , 9 : 151 – 156 .
  • Edelman , D. and Roggli , V. 1989 . The accumulation of nickel in human lungs . Environ. Health Perspect , 81 : 221 – 224 .
  • Egedahl , R. , Carpenter , M. and Lundell , D. 2001 . Mortality experience among employees at a hydrometallurgical nickel refinery and fertiliser complex on Fort Saskatchewan, Alberta (1954–95) . Occup. Environ. Med , 58 : 711 – 715 .
  • English , J. , Parker , R. , Sharma , R. and Oberg , S. G. 1981 . Toxicokinetics of nickel in rats after intratracheal administration of a soluble and insoluble form . Am. Ind. Hyg. Assoc. J , 42 : 486 – 492 .
  • Evans , R. , Davies , P. and Costa , M. 1982 . Video time-lapse microscopy of phagocytosis and intracellular fate of crystalline nickel sulfide particles in cultured mammalian cells . Cancer Res , 42 : 2729 – 2735 .
  • Feren , K. , Farrants , G. and Reith , A. 1992 . “ Phagocytosis and transformation of primary epithelial respiratory cells by alpha-Ni3S2 ” . In Nickel and human health: Current perspectives , Edited by: Nieboer , E. and Nriagu , J. O. 353 – 362 . New York : John Wiley & Sons .
  • Grimsrud , T. K. , Berge , S. R. , Haldorsen , T. and Andersen , A. 2002 . Exposure to different forms of nickel and risk of lung cancer . Am. J. Epidemiol , 156 : 1123 – 1132 .
  • Hansen , K. 1985 . “ Solubility of metallic nickel and nickel oxides in a biological fluid at different pH levels ” . In Progress in nickel toxicology. Proceedings of the 3rd International Congress on Nickel Metabolism and Toxicology , Edited by: Brown , S. S. and Sunderman , F. W. 73 – 76 . Boston : Blackwell Scientific .
  • Harnett , P. , Robison , S. , Swartzendruber , D. E. and Costa , M. 1982 . Comparison of protein RNA and DNA binding and cell cycle specific growth inhibitory effects of nickel compounds in cultured cells . Toxicol. Appl. Pharmacol , 64 : 20 – 30 .
  • Hartwig , A. , Kruger , I. and Beyersmann , D. 1994a . Mechanisms in nickel genotoxicity: The significance of interactions with DNA repair . Toxicol. Lett , 72 : 353 – 358 .
  • Hartwig , A. , Mullenders , L. , Schlepegrell , R. , Kasten , U. and Beyersmann , D. 1994b . Nickel(II) interferes with the incision step in nucleotide excision repair in mammalian cells . Cancer Res , 54 : 4045 – 4051 .
  • Hausinger , R. P. 1992 . “ Biological utilization of nickel ” . In Nickel in Human Health: Current Perspectives , Edited by: Nieboer , E. and Nriagu , J. O. 21 – 36 . New York : John Wiley & Sons .
  • Heck , J. and Costa , M. 1982a . Extracellular requirements for the endocytosis of carcinogenic crystalline nickel sulfide particles by facultative phagocytes . Toxicol Lett , 12 : 243 – 250 .
  • Heck , J. and Costa , M. 1982b . Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells . Cancer Lett , 15 : 19 – 26 .
  • Hildebrand , H. , D'Hooghe , M. , Shirali , P. , Bailly , C. and Kerchkaert , J. P. 1990 . Uptake and biological transformation of beta NiS and alpha Ni3S2 by human embryonic pulmonary epithelial cells (L132) in culture . Carcinogenesis , 11 : 1943 – 1950 .
  • Hildebrand , H. , Decaestecker , A. , Arrouijal , F. and Martinez , R. 1991 . In vitro and in vivo uptake of nickel sulfides by rat lymphocytes . Arch. Toxicol , 65 : 324 – 329 .
  • Hirano , S. , Shimada , T. , Osugi , J. , Kodama , N. and Suzuki , K. T. 1994 . Pulmonary clearance and inflammatory potency of intratracheally instilled or acutely inhaled nickel sulfate in rats . Arch. Toxicol , 68 : 548 – 554 .
  • Hong , Y. , Paik , S. , Lee , H. , Lee , K. H. and Jang , S. M. 1997 . Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen . Environ. Health Perspect , 105 : 744 – 748 .
  • Horie , A. , Tanaka , I. , Haratake , J. , Kodama , Y. and Tsuchiya , K. 1985 . “ Electron microscopy of pulmonary lesions, including carcinoma, induced by inhalation exposure of rats to nickel oxide aerosol ” . In Progress in nickel toxicology. Proceedings of the 3rd International Congress on Nickel Metabolism and Toxicology , Edited by: Brown , S. S. and Sunderman , F. W. 41 – 44 . Boston : Blackwell Scientific .
  • Hsieh , T. , Yu , C. and Oberdorster , G. 1999a . A dosimetry model of nickel compounds in the rat lung . Inhal. Toxicol , 11 : 229 – 248 .
  • Hsieh , T. , Yu , C. and Oberdorster , G. 1999b . Modeling of deposition and clearance of inhaled Ni compounds in the human lung . Regul. Toxicol. Pharmacol , 30 : 18 – 28 .
  • Huang , X. , Frenkel , K. , Klein , C. and Costa , M. 1993 . Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence . Toxicol. Appl. Pharmacol , 120 : 29 – 36 .
  • Huang , X. , Klein , C. and Costa , M. 1994a . Crystalline Ni3S2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein . Carcinogenesis , 15 : 545 – 548 .
  • Huang , X. , Zhuang , Z. , Frenkel , K. , Klein , C. and Costa , M. 1994b . The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis . Environ. Health Perpect , 102 : 281 – 284 .
  • Huang , X. , Kitahara , J. , Zhitkovich , A. , Dowjat , K. and Costa , M. 1995 . Heterochromatic proteins specifically enhance nickel-induced 8-oxo-dg formation . Carcinogenesis , 16 : 1753 – 1759 .
  • Jaramillo , A. and Sonnenfeld , G. 1989 . Effects of amorphous and crystalline nickel sulfide on induction of interferons-alpha/beta and -gamma and interleukin-2 . Environ. Res , 48 : 275 – 286 .
  • Kawanishi , S. , Inoue , S. and Yamamoto , K. 1989 . Site-specific DNA damage induced by nickel(II) ion in the presence of hydrogen peroxide . Carcinogenesis , 10 : 2231 – 2235 .
  • Kawanishi , S. , Inoue , S. and Yamamoto , K. 1994 . Active oxygen species in DNA damage induced by carcinogenic metal compounds . Environ. Health Perspect , 102 : 17 – 20 .
  • Kawanishi , S. , Oikawa , S. , Inoue , S. and Nishino , K. 2002 . Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides . Environ. Health Perpect , 110 : 789 – 791 .
  • Klein , C. , Conway , K. , Wang , X. , Bhamra , R. , Lin , X. , Cohen , M. D. , Annab , L. , Barrett , C. J. and Costa , M. 1991a . Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control . Science , 251 : 796 – 799 .
  • Klein , C. , Frenkel , K. and Costa , M. 1991b . The role of oxidative processes in metal carcinogenesis . Chem. Res. Toxicol , 4 : 592 – 604 .
  • Klein , C. , Snow , E. and Frenkel , K. 1998 . “ Molecular mechanisms in metal carcinogenesis: role of oxidative stress ” . In Molecular biology of free radicals in human diseases , Edited by: Aruoma , O. and Halliwell , B. 79 – 137 . London : OICA International .
  • Kuehn , K. and Sunderman , F. 1982 . Dissolution half-times of nickel compounds in water, rat serum, and renal cytosol . J. Inorg. Biochem , 17 : 29 – 39 .
  • Landolph , J. R. , Verma , A. , Ramnath , J. and Clemens , F. 2002 . Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds . Environ. Health Perpect , 110 : 845 – 850 .
  • Lee , Y. W. , Klein , C. , Kargacin , B. , Salnikow , K. , Kitahara , J. , Dowjat , K. , Zhitkovich , A. , Christie , N. and Costa , M. 1995 . Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: A new model for epigenetic carcinogens . Mol. Cell. Biol , 15 : 2547 – 2557 .
  • Lin , X. , Dowjat , W. and Costa , M. 1994 . Nickel-induced transformation of human cells causes loss of the phosphorylation of the retinoblastoma protein . Cancer Res , 54 : 2751 – 2754 .
  • Magnus , K. , Andersen , A. and Hogetveit , A. 1982 . Cancer of respiratory organs among workers at nickel refinery in Norway . Int. J. Cancer , 30 : 681 – 685 .
  • Maximilien , R. Critical review of animal carcinogenesis by nickel and its inorganic compounds—Part 1—Analytical review—Conclusions . Report EUR 12456 en/1. . 1989 . Luxembourg: Commission of the European Communities Directorate-General Telecommunications, Information Industries and Innovation, June
  • Menzel , D. 1988 . Planning and using PB-PK models: An integrated inhalation and distribution model for nickel . Toxicol. Lett , 43 : 67 – 83 .
  • Menzel , D. , Deal , D. , Tayyeb , M. , Wolpert , R. L. , Boger , J. R. , Shoaf , C. R. , Sandy , J. , Wilkinson , K. and Francovitch , R. J. 1987 . Pharmacokinetic modeling of the lung burden from repeated inhalation of nickel aerosols . Toxicol. Lett , 38 : 33 – 43 .
  • Miura , T. , Patierno , S. , Sakuramoto , T. and Landolph , J. 1989 . Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds . Environ. Mol. Mutagen , 14 : 65 – 78 .
  • National Toxicology Program . 1996a . Toxicology and carcinogenesis studies of nickel oxide (CAS No. 1313-99-1) in F344/N rats and B6C3F1 mice (inhalation studies) , Research Triangle Park : NC . Technical Report Series No. 451
  • National Toxicology Program . 1996b . Toxicology and carcinogenesis studies of nickel subsulfide (CAS No. 12035-72-2) in F344/N rats and B6C3F1 mice (inhalation studies) , Research Triangle Park : NC . Technical Report Series No. 453
  • National Toxicology Program . 1996c . Toxicology and carcinogenesis studies of nickel sulfate hexahydrate (CAS No. 10101-97-0) in F344/N rats and B6C3F1 mice (inhalation studies) , Research Triangle Park : NC . Technical Report Series No. 454
  • Novelli , E. , Rodrigues , N. and Ribas , B. 1995 . Superoxide radical and toxicity of environmental nickel exposure . Hun Exp. Toxicol , 14 : 248 – 251 .
  • Oberdorster , G. 1989 . Dosimetric principles for extrapolating results of rat inhalation studies to humans, using an inhaled Ni compound as an example . Health Phys , 57 : 213 – 220 .
  • Oller , A. 2002 . Respiratory carcinogenicity assessment of soluble nickel compounds . Environ. Health Perpect , 110 : 841 – 844 .
  • Oller , A. , Costa , M. and Oberdorster , G. 1997 . Carcinogenicity assessment of selected nickel compounds . Toxicol. Appl. Pharmacol , 143 : 152 – 166 .
  • Ottolenghi , A. D. , Haseman , J. K. , Payne , W. W. , Falk , H. L. and MacFarland , H. N. 1975 . Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats . J. Natl. Cancer Inst , 54 : 1165 – 1172 .
  • Parfett , C. 1992 . Induction of proliferin gene expression by diverse chemical agents that promote morphological transformation in C3H/10T1/2 cultures . Cancer Lett , 64 : 1 – 9 .
  • Patierno , S. and Costa , M. 1985 . DNA–protein cross-links induced by nickel compounds in intact cultured mammalian cells . Chem. Biol. Interact , 55 : 75 – 91 .
  • Patierno , S. , Sugiyama , M. , Basilion , J. and Costa , M. 1985 . Preferential DNA–protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin . Cancer Res , 45 : 5787 – 5794 .
  • Patierno , S. , Dirscherl , L. and Xu , J. 1993 . Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds . Mutat. Res , 300 : 179 – 193 .
  • Peto , J. , Cuckle , H. , Doll , R. , Hermon , R. and Morgan , L. 1983 . Respiratory cancer mortality of Welsh nickel refinery workers . IARC Sci. Publ , 53 : 37 – 46 .
  • Robison , S. , Cantoni , O. , Heck , J. D. and Costa , M. 1983 . Soluble and insoluble nickel compounds induce DNA repair synthesis in cultured mammalian cells . Cancer Lett , 17 : 273 – 279 .
  • Saito , K. and Menzel , D. 1986 . Accumulation and efflux of nickel from cultured pneumocytes . Tohoku J. Exp. Med , 148 : 295 – 302 .
  • Salnikow , K. , Cosentino , S. , Klein , C. and Costa , M. 1994 . Loss of thrombospondin transcriptional activity in nickel-transformed cells . Mol. Cell. Biol , 14 : 851 – 858 .
  • Salnikow , K. , Davidson , T. and Costa , M. 2002 . The role of hypoxia-inducible signaling pathway in nickel carcinogenesis . Environ. Health Perpect , 110 : 831 – 834 .
  • Sen , P. and Costa , M. 1985 . Induction of chromosomal damage in Chinese hamster ovary cells by soluble and particulate nickel compounds: Preferential fragmentation of the heterochromatic long arm of the X-chromosome by carcinogenic crystalline NiS particles . Cancer Res , 45 : 2320 – 2325 .
  • Sen , P. and Costa , M. 1986a . Incidence and localization of sister chromatid exchanges induced by nickel and chromium compounds . Carcinogenesis , 7 : 1527 – 1533 .
  • Sen , P. and Costa , M. 1986b . Pathway of nickel uptake influences its interaction with heterochromatic DNA . Toxicol. Appl. Pharmacol , 84 : 278 – 285 .
  • Sen , P. , Conway , K. and Costa , M. 1987 . Comparison of the localization of chromosome damage induced by calcium chromate and nickel compounds . Cancer Res , 47 : 2142 – 2147 .
  • Shi , X. , Dalal , N. and Kasprzak , K. 1992 . Generation of free radicals from lipid hydroperoxides by Ni2+ in the presence of oligopeptides . Arch. Biochem. Biophys , 299 : 154 – 162 .
  • Shi , X. , Dalal , N. and Kasprzak , S. 1993 . Generation of free radicals in reactions of Ni(II)-thiol complexes with molecular oxygen and model lipid hydroperoxides . J. Inorg. Biochem , 15 : 211 – 225 .
  • Snow , E. 1992 . Metal carcinogenesis: Mechanistic implications . Pharmacol. Ther , 53 : 31 – 65 .
  • Sunderman , F. , Hopfer , S. , Knight , J. , McCully , K. S. , Cecutti , A. G. , Thornhill , P. G. , Conway , K. , Miller , C. , Patierno , S. R. and Costa , M. 1987 . Physicochemical characteristics and biological effects of nickel oxides . Carcinogenesis , 8 : 305 – 315 .
  • Takenaka , S. , Hochrainer , D. and Oldiges , H. 1985 . “ Alveolar proteinosis induced in rats by long-term inhalation of nickel oxide ” . In Progress in nickel toxicology. Proceedings of the 3rd International Congress on Nickel Metabolism and Toxicology , Edited by: Brown , S. S. and Sunderman , F. W. 89 – 92 . Boston : Blackwell Scientific .
  • Teissier , E. , Shirali , P. , Hannothiaux , M. , Marez , T. and Haguenoer , J. M. 1994 . Interactions of alpha–Ni3S2 with guinea pig alveolar macrophages and liberation of inflammatory mediators . J. Appl. Toxicol , 14 : 167 – 171 .
  • Wehner , A. , Busch , R. , Olson , R. and Craig , D. K. 1975 . Chronic inhalation of nickel oxide and cigarette smoke by hamsters . Am. Ind. Hyg. Assoc. J , 36 : 801 – 810 .
  • Zhong , Z. , Troll , W. , Koenig , K. and Frenkel , K. 1990 . Carcinogenic sulfide salts of nickel and cadmium induce H202 formation by human polymorphonuclear leukocytes . Cancer Res , 50 : 7564 – 7570 .
  • Zhuang , Z. , Shen , Y. , Shen , H. M. , Ng , V. and Ong , C. N. 1996 . DNA strand breaks and poly (ADP-ribose) polymerase activation induced by crystalline nickel subsulfide in MRC-5 lung fibroblast cells . Hum. Exp. Toxicol , 15 : 891 – 897 .
  • Zoroddu , M. A. , Schinocca , L. , Kowalik-Jankowska , T. , Kozlowski , H. , Salnikow , K. and Costa , M. 2002 . Molecular mechanisms in nickel carcinogenesis: Modeling Ni(II) binding site in histone H4 . Environ. Health Perpect , 110 : 719 – 723 .

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