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Original Articles

In Vivo and In Vitro Evaluation of the Acute Toxicity, the Genotoxicity, and the Irritation Potency of Two Hexachloroethane-based Pyrotechnic Smokes

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Pages 1167-1181 | Received 19 Dec 2005, Accepted 15 Sep 2006, Published online: 15 Jun 2007

REFERENCES

  • Aalto , A. . Health risks of military smokes . Proc. Finnish Explosives Seminar 96 [in Finnish] . May 22–23 1996 , Tampere, Finland.
  • Alarie , Y. 1998 . Computer-based bioassay for evaluation of sensory irritation of airborne chemicals and its limit of detection . Arch. Toxicol. , 72 : 277 – 282 .
  • Alarie , Y. 2001 . “ Computerized animal bioassay to evaluate the effects of airborne chemicals on the respiratory tract ” . In Indoor air quality handbook , Edited by: Spengler , J. D. , Samet , J. M. and McCarthy , J. F. Vol. chapter 24 , New York : McGraw-Hill .
  • American Conference of Governmental Industrial Hygienists . . Threshold limit values for chemical substances and physical agents and biological exposure indices for 1994–1995 . Cincinnati, OH : ACGIH .
  • American Conference of Governmental Industrial Hygienists . . The threshold limit values for chemical substances and physical agents and biological exposure indices . American Conference of Governmental Industrial Hygienists . Cincinnati, OH : ACGIH .
  • American Society for Testing and Materials . 1984 . Standard test method for estimating sensory irritancy of airborne chemicals , Philadelphia, PA : ASTM . Designation E 981-84.
  • Anderson , D. , Blowers , S. D. , Marrs , T. C. and Rice , P. 1996 . An in vitro and in vivo unscheduled DNA synthesis assay with a zinc oxide/hexachloroethane (Zn/HCE) smoke . Hum. Exp. Toxicol. , 10 : 49 – 57 .
  • Blount , B. J. 1990 . Two types of metal fume fewer: mild vs. serious . Mil. Med. , 155 : 372 – 377 .
  • Boylstein , L. A. , Andersson , S. J. , Thompson , R. D. and Alarie , Y. 1995 . Characterization of the effects of an airborne mixture of chemicals on the respiratory tract and smoothing polynomial spline analysis of the data . Arch. Toxicol. , 69 : 579 – 589 .
  • Boylstein , L. A. , Luo , J. , Stock , M. F. and Alarie , Y. 1996 . An attempt to define a just detectable effect for airborne chemicals on the respiratory tract in mice . Arch. Toxicol. , 70 : 567 – 578 .
  • Brown , R. F. R. , Marrs , T. C. , Rice , P. and Masek , L. C. 1990 . The histopatology of rat lung following exposure to zinc oxide/hexachloroethane smoke or instillation with zinc chloride followed by treatment with 70 % oxygen . Environ. Health Perspect. , 85 : 81 – 87 .
  • Canadian Centre for Occupational Health and Safety . 1995 . CHEMINFO , 95 ( 4 ) November (CD database)
  • Cassel , G. , Fredriksson , S.-E. and Fängmark , I . September 1992 . Zinc and titanium smoke—Chemical composition and physical characteristics , September , Swedish Defence Research Agency . FOA report C 40277-4.9, [in Swedish]
  • Clode , S. A. , Riley , R. A. , Blowers , S. D. , Marrs , T. C. and Anderson , D. 1991 . Studies on the mutagenicity of a zinc oxide-hexachloroethane smoke . Hum. Exp. Toxicol. , 10 : 49 – 57 .
  • Cullumbine , H. 1957 . The toxicity of screening smokes . J. R. Army Med.Corps. , 103 : 119 – 132 .
  • Conkling , J. A. 1985 . Chemistry of pyrotechnics, Basic principles and theory , Vol. chapter 5 , New York : Marcel Dekker Inc .
  • DeVaull , G. E. , Dunn , W. E. , Liljegren , J. C. and Policastro , A. J. 1989 . Analysis, methods and results of hexachloroethane smoke dispersion experiments conducted as part of Atterbury-87 field studies , Argonne, IL : Prepared by Argonne National Laboratory . AD-A216048. for the U.S. Army Medical Research and Development Command, Fort Detrick, Frederick, MD
  • Glaser , U. and Mönig , F. 1990 . “ Investigation of the acute inhalative toxicity of HC- and KM-smoke in rats ” . In Feldmessungen an Tarnnebeln und Wirkmassen , Edited by: Mönig , F. J. , Debus , R. , Hochrainer , D. , Röderer , G. and Wenzel , A. Germany : Schmallenberg-Grafschaft . Bericht zum Forschungsauftrag E/W61H/G0123/D5238. Fraunhofer-Institut fur Umweltchemie und Ökotoxicologie.
  • Gupta , T. , Talukder , G. and Sharma , A. 1991 . Cytotoxicity of zinc chloride in mice in vivo . Biol. Trace Elem. Res. , 30 : 95 – 101 .
  • Heimburger , G. December 1977 . Toxicological study of zinc and titanium smokes. A literature review , December , Swedish Defence Research Agency . FOA rep. C 40072-H2, [in Swedish].
  • Helm , K. U. , Renovanz , H.-D. , Schmahl , K. and von Clarmann , M. 1971 . Die Zinknebelvergiftung und ihre Behandlung I. Chemische und Toxicologische Grundlagen . Wehrmed. Mschr. , 15 : 213 – 217 .
  • Hemmilä , M. , Hihkiö , M. , Harkoma , M. and Hagfors , M. . Training smokes evaluation program . Proc. 23rd Int. Pyrot. Seminar. 1997 . pp. 250 – 261 .
  • Hemmilä , M. , Hihkiö , M. , Harkoma , M. , Linnainmaa , K. , Kujanpää , L. and Ollikainen , T. . Toxicity and performance evaluation of the smokes in chamber tests . Proc. 27th Int. Pyrot. Seminar 2000 . pp. 163 – 174 .
  • IARC . 1987 . Overall evaluations of carcinogenicity . IARC Monogr. Eval. Carcinogen. Risks Hum. , : 440
  • IARC . 1999 . Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents, and Some Other Substances . IARC Monogr. Eval. Carcinogen. Risks Hum. , 73 : 295
  • Karlsson , N. , Cassel , G. , Fängmark , I. and Bergman , F. 1986 . A comparative study of the acute inhalation toxicity of smoke from TiO2-hexachloroethane and Zn-hexachloroethane pyrotechnic mixtures . Arch. Toxicol. , 59 : 160 – 166 .
  • Karlsson , N. , Fängmark , I. , Häggqvist , I. , Karlsson , B. , Rittfeldt , L. and Marchner , H. 1991 . Mutagenicity testing of condensates of smoke from titanium dioxide/hexachloroethane and zinc/hexachloroethane pyrotechnic mixtures . Mutat. Res. , 260 : 39 – 46 .
  • Kasanen , J.-P. , Pasanen , A.-L. , Pasanen , P. , Liesivuori , J. , Kosma , V.-M. and Alarie , Y. 1998 . Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers . Arch. Toxicol. , 72 : 514 – 523 .
  • Katz , S. , Snelson , A. , Farlow , R. , Welker , R. and Mainer , S. 1980 . Physical and chemical characterization of fog oil smoke and hexachloroethane smoke , Chicago : IIT Research Institute . U.S. Army Medical Research and Development Command Contract DAMD-17-78-C-8085. AD A080936
  • Lewis , R. J. , ed. 1992 . Sax's dangerous properties of industrial materials , 8th , New York : Van Nostrand Reinhold .
  • Lindholm , H. , Vilska , J. , Vainio , U. , Parkkinen , J. and Koskenvuo , K. 1988 . Grey smoke poisoning in 11 conscripts . Ann. Med. Mil. Fenn. , 63 : 230 – 235 . [in Finnish]
  • Macaulauy , M. B. and Mant , A. K. 1964 . Smoke-bomb poisoning. A fatal case following the inhalation of zinc chloride smoke . J. R Army Med. Corps. , 113 : 27 – 32 .
  • Marrs , T. C. , Colgrave , H. F. , Edginton , J. A. G. , Brown , R. F. R. and Cross , N. L. 1988 . The repeated dose toxicity of a zinc oxide/hexachloroethane smoke . Arch. Toxicol. , 62 : 123 – 132 .
  • Marrs , T. C. , Clifford , W. E. and Colgrave , H. F. 1983 . Pathological changes produced by exposure of rabbits and rats to smokes from mixtures of hexachloroethane and zinc oxide . Toxicol. Lett. , 19 : 247 – 252 .
  • National Institute for Occupational Safety and Health . 1992 . Recommendations for occupational safety and health. Compendium of policy documents and statements , Cincinnati, OH : U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 92-100 .
  • Occupational Safety and Health Administration . 2002 . Computerized information system , Washington, DC : OSHA .
  • Ollikainen , T. 2001 . Oxidant and asbestos fiber induced toxicity in human lung cells (dissertation) , Helsinki : Hakapaino . People Work Res. Rep. 43
  • Ollikainen , T. , Knuuttila , A. , Suhonen , S. , Taavitsainen , M. , Jekunen , A. , Mattsson , K. and Linnainmaa , K. 2000 . In vitro sensitivity of normal human mesothelial and malignant mesothelioma cell lines to four new chemotherapeutic agents . Anticancer Drugs. , 11 : 93 – 99 .
  • Puhakka , A. , Ollikainen , T. , Soini , Y. , Kahlos , K. , Säily , M. , Koistinen , P. , Pääkkö , P. , Linnainmaa , K. and Kinnula , V. L. 2002 . Modulation of DNA single-strand breaks by intracellular glutathione in human lung cells exposed to asbestos fibres . Mutat. Res. , 514 : 7 – 17 .
  • Pulkkanen , K. J. , Laukkanen , M. O. , Naarala , J. and Ylä-Herttuala , S. 2000 . False-positive apoptosis signal in mouse kidney and liver detected with TUNEL assay . Apoptosis. , 5 : 329 – 333 .
  • Schenker , M. B. , Speizer , F. E. and Taylor , J. O. 1981 . Acute upper respiratory symptoms resulting from exposure to zinc chloride aerosol . Environ. Res. , 25 : 317 – 324 .
  • Sittig , M. 1985 . Handbook of toxic and hazardous chemicals and carcinogens , 2nd , Park Ridge, NJ : Noyes .
  • Stocum , W. E. and Hamilton , R. G. 1976 . A risk analysis of exposure to high concentrations of zinc chloride smoke , Albuquerque, NM : Sandia Laboratories . SAND76-0386
  • Sörbo , B. 1973 . Injuries caused by smoke ammunition . Försvarsmedicin , 9 : 167 – 171 . [in Swedish]
  • Tukiainen , P. 1979 . Fatal pulmonary reaction due to inhalation of zinc chloride . Ann. Med. Mil. Fenn. , 54 : 177 – 180 . [in Finnish]
  • U.S. Department of Health and Human Services . 1993 . Hazardous substances data bank (HSDB online database). , Bethesda, MD : National Toxicology Information Program, National Library of Medicine . MD
  • U.S. Environmental Protection Agency . 1993 . Integrated Risk Information System (IRIS) on hexachloroethane , Cincinnati, OH : Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development .
  • U.S. National Research Council, Committee on Toxicology . 1997 . Toxicity of military smokes and obscurants , Vol. 1 , Washington, DC : National Academy Press .
  • Viayaraghavan , R. , Schaper , M. , Thompson , R. , Stock , M. F. and Alarie , Y. 1993 . Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract . Arch. Toxicol. , 67 : 478 – 490 .
  • Vijayaraghavan , R. , Schaper , M. , Thompson , R. , Stock , M. F. , Boylstein , L. A. , Luo , J. E. and Alarie , Y. 1994 . Computer assisted recognition and quantitation of the effects of airborne chemicals acting at different areas of the respiratory tract in mice . Arch. Toxicol. , 68 : 490 – 499 .
  • Young , J. Y. , Smart , D. A. , Allen , J. T. , Parmer , D. L. , Rosencrance , A. B. , Brueggeman , E. E. and Broski , F. H. 1989 . Field exposure of chemical school students and cadre to fog oil and hexachloroethane (HC) smokes , Frederick, MD : U. S. Army Biomedical Research and Development Laboratory . Tech. rep. 8908

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