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Original Articles

A Comparative Study of Chemically Induced DNA Damage in Isolated Nasal Mucosa Cells of Humans and Rats Assessed by the Alkaline Comet Assay

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Pages 936-946 | Published online: 04 Jun 2008

REFERENCES

  • Bermudez , E. and Allen , P. F. 1984 . The assessment of DNA damage and repair in rat nasal epithelial cells . Carcinogenesis , 5 : 1453 – 1458 .
  • Buehrlen , M. , Harreus , U. A. , Gamarra , F. , Hagen , R. and Kleinsasser , N. H. 2007 . Cumulative genotoxic and apoptotic effects of xenobiotics in a mini organ culture model of human nasal mucosa as detected by the alkaline single cell microgel electrophoresis assay and the annexin V-affinity assay . Toxicol. Lett. , 169 : 152 – 161 .
  • Carbone , P. , Barbata , G. , Margiotta , G. , Tomasino , A. and Granata , G. 1981 . Low epichlorohydrin concentrations induce sister chromatid exchanges in human lymphocytes in vitro . Caryologia , 34 : 261 – 266 .
  • Dittberner , U. , Eisenbrand , G. and Zankl , H. 1988 . Cytogenetic effects of N-nitrosodiethanolamine (NDELA) and NDELA-monoacetate in human lymphocytes . J. Cancer Res. Clin. Oncol. , 114 : 575 – 578 .
  • Dunnick , J. K. , Eustis , S. L. , Piegorsch , W. W. and Miller , R. A. 1988 . Respiratory tract lesions in F344/N rats and B6C3F1 mice after inhalation exposure to 1,2-epoxybutane . Toxicology , 50 : 69 – 82 .
  • Fortoul , T. I. , Valverde , M. , Lopez , M. C. , Avila-Costa , M. R. , Avila-Casado , M. C. , Mussali-Galante , P. , Gonzalez-Villalva , A. , Rojas , E. and Ostrosky-Shejet , P. 2004 . Genotoxic differences by sex in nasal epithelium and blood leukocytes in subjects residing in a highly polluted area . Environ. Res. , 94 : 243 – 248 .
  • Giri , A. K. 1997 . Genetic toxicology of epichlorohydrin: A review . Mutat. Res. , 386 : 25 – 38 .
  • Glatt , H. , Davis , W. , Meinl , W. , Hermersdorfer , H. , Venitt , S. and Phillips , D. H. 1998 . Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture . Carcinogenesis , 19 : 1709 – 1713 .
  • Glück , U. and Gebbers , J. O. 2000 . The comet assay of nasal epithelia: measurement of DNA damage for the assessment of genotoxic air pollution . Laryngoscope , 110 : 123 – 125 .
  • Haseman , J. K. and Hailey , J. R. 1997 . An update of the National Toxicology Program database on nasal carcinogens . Mutat. Res. , 380 : 3 – 11 .
  • Hoffmann , D. , Brunnemann , K. D. , Rivenson , A. and Hecht , S. S. 1982 . N-Nitrosodiethanolamine: analysis, formation in tobacco products and carcinogenicity in Syrian golden hamsters . IARC Sci. Publ. , 41 : 299 – 308 .
  • IARC . 1999 . “ Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide ” . In IARC Monogr. Eval. Carcinogen. Risks Hum. 71 Lyon
  • IARC . 2000 . “ Some industrial chemicals ” . In IARC Monogr. Eval. Carcinogen. Risks Hum. 71 Lyon
  • Kleinsasser , N. H. , Kastenbauer , E. R. , Zieger , S. , Baluschko , T. , Wallner , B. C. and Harreus , U. A. 2003 . [Preservation of mucosal specimens before processing in the alkaline single cell microgel electrophoresis assay] . HNO , 51 : 134 – 139 .
  • Kleinsasser , N. H. , Wallner , B. C. , Kastenbauer , E. R. , Muenzenrieder , R. K. and Harreus , U. A. 2000 . Comparing the genotoxic sensitivities of human peripheral blood lymphocytes and mucosa cells of the upper aerodigestive tract using the Comet assay . Mutat. Res. , 467 : 21 – 30 .
  • Kuchenmeister , F. 1994 . Thesis: Etablierung und Erprobung einer Technik, die erlaubt, DNA-Schäden an einzelnen Nasenschleimhautzellen der Ratte und des Menschen nachzuweisen , Heidelberg : DKFZ (German Cancer Research Center) .
  • Laskin , S. , Sellakumar , A. R. , Kuschner , M. , Nelson , N. , La , Mendola , Rusch , S. , Katz , G. M. , Dulak , N. C. and Albert , R. E. 1980 . Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats . J. Natl. Cancer Inst. , 65 : 751 – 757 .
  • Loeppky , R. N. , Fuchs , A. , Janzowski , C. , Humberd , C. , Goelzer , P. , Schneider , H. and Eisenbrand , G. 1998 . Probing the mechanism of the carcinogenic activation of N-nitrosodiethanolamine with deuterium isotope effects: In vivo induction of DNA single-strand breaks and related in vitro assays . Chem. Res. Toxicol. , 11 : 1556 – 1566 .
  • Mussali-Galante , P. , Avila-Costa , M. R. , Pinon-Zarate , G. , Martinez-Levy , G. , Rodriguez-Lara , V. , Rojas-Lemus , M. , Avila-Casado , M. C. and Fortoul , T. I. 2005 . DNA damage as an early biomarker of effect in human health . Toxicol. Ind. Health , 21 : 155 – 166 .
  • Norppa , H. , Hemminki , K. , Sorsa , M. and Vainio , H. 1981 . Effect of monosubstituted epoxides on chromosome aberrations and SCE in cultured human lymphocytes . Mutat. Res. , 91 : 243 – 250 .
  • Pacini , S. , Giovannelli , L. , Gulisano , M. , Peruzzi , B. , Polli , G. , Boddi , V. , Ruggiero , M. , Bozzo , C. , Stomeo , F. , Fenu , G. , Pezzatini , S. , Pitozzi , V. and Dolara , P. 2003 . Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, Italy . Environ. Mol. Mutagen. , 42 : 127 – 135 .
  • Pool-Zobel , B. L. , Lotzmann , N. , Knoll , M. , Kuchenmeister , F. , Lambertz , R. , Leucht , U. , Schroder , H. G. and Schmezer , P. 1994 . Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples . Environ. Mol. Mutagen. , 24 : 23 – 45 .
  • Reznik , G. , Reznik-Schuller , H. , Ward , J. M. and Stinson , S. F. 1980 . Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane . Br. J. Cancer , 42 : 772 – 781 .
  • Singh , N. P. , McCoy , M. T. , Tice , R. R. and Schneider , E. L. 1988 . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp. Cell Res. , 175 : 184 – 191 .
  • Stinson , S. F. , Reznik , G. and Ward , J. M. 1981 . Characteristics of proliferative lesions in the nasal cavities of mice following chronic inhalation of 1,2-dibromoethane . Cancer Lett. , 12 : 121 – 129 .
  • Thornton-Manning , J. R. and Dahl , A. R. 1997 . Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes . Mutat. Res. , 380 : 43 – 59 .
  • Wenghoefer , M. , Pesch , B. , Harth , V. , Broede , P. , Fronhoffs , S. , Landt , O. , Brüning , T. , Abel , J. , Bolt , H. M. , Herberhold , C. , Vetter , H. and Ko , Y. D. 2003 . Association between head and neck cancer and microsomal epoxide hydrolase genotypes . Arch. Toxicol. , 77 : 37 – 41 .
  • White , A. D. 1980 . In vitro induction of SCE in human lymphocytes by epichlorohydrin with and without metabolic activation . Mutat. Res. , 78 : 171 – 176 .

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