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Original Articles

Integrated Disinfection By-Products Research: Assessing Reproductive and Developmental Risks Posed by Complex Disinfection By-Product Mixtures

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Pages 1222-1234 | Published online: 17 Jul 2008

REFERENCES

  • AWWA Research Foundation. 2006. Drinking water disinfection by-products and pregnancy outcome. Denver, CO: American Water Works Association. http://www.awwarf.org/research/TopicsAndProjects/execSum/2579.aspx
  • Bielmeier , S. R. , Best , D. S. , Guidici , D. L. and Narotsky , M. G. 2001 . Pregnancy loss in the rat caused by bromodichloromethane . Toxicol. Sci. , 59 : 309 – 315 .
  • Bove , F. , Shim , Y. and Zeitz , P. 2002 . Drinking Water contaminants and adverse pregnancy outcomes: A review . Environ. Health Perspect. , 110 : 61 – 74 .
  • Bunge , A. and McDougal , J. 1999 . “ Dermal uptake ” . In Exposure to contaminants in drinking water: Estimating uptake through the skin and by inhalation , Edited by: Olin , S. 137 – 181 . Washington, DC : CRC Press .
  • Chen , J. J. , Chen , Y. J. , Rice , G. , Teuschler , L. K. , Hamernik , K. , Protzel , A. and Kodell , R. L. 2001 . Using dose addition to estimate cumulative risks from exposure to multiple chemicals . Regul. Toxicol. Pharmacol. , 34 : 35 – 41 .
  • Delaney , J. C. , Wolfe , G. W. , Kaiser , L. , Lanning , L. , Klinefelter , G. , Hunter , E. S. and Chapin , R. E. 1997 . Short-term reproductive and developmental effects of chlorodibromomethane in the S-D rat when administered in drinking water . Toxicologist , 25 : 7
  • Gallagher , M. D. , Nuckols , J. R. , Satlones , L. and Savitz , D. A. 1998 . Exposure to trihalomethanes and adverse pregnancy outcomes . Epidemiology , 9 : 484 – 489 .
  • Gennings , C. , Schwartz , P. , Carter , W. H. Jr. and Simmons , J. E. 1997 . Detection of departures from additivity in mixtures of many chemicals with a threshold model . J. Agric. Biol. Environ. Stat. , 2 : 198 – 211 .
  • Giardino , N. and Andelman , J. 1996 . Characterization of the emissions of trichloroethylene, chloroform, and 1,2-dibromo-3-chloropropane in a full-size, experimental shower . J. Expos. Anal. Environ. Epidemiol. , 6 : 413 – 423 .
  • Hertzberg , R. C. and Teuschler , L. K. 2002 . Evaluating quantitative formulas for dose-response assessment of chemical mixtures . Environ. Health Perspect. , 110 : 965 – 970 .
  • Hurni , H. and Ohder , H. 1973 . Reproduction study with formaldehyde and hexamethylenetetramine in beagle dogs . Food Cosmet. Toxicol. , 11 : 459 – 462 .
  • Huuskonen , H. , VenSalSainen , R. , Komulainen , H. and Vartiainen , T. 1997 . Developmental toxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX) in rats . Hum. Exp. Toxicol. , 16 : 61
  • Jo , W. K. , Weisel , C. P. and Lioy , P. J. 1990 . Chloroform exposure and body burden from showering with chlorinated tap water . Risk Anal. , 10 : 575 – 580 .
  • Johnson , T. , Hakkinen , P. and Reckhow , D. 1999 . “ Exposure characteristics ” . In Exposure to contaminants in drinking water: Estimating uptake through the skin and by inhalation , Edited by: Olin , S. 31 – 84 . Washington, DC : CRC Press .
  • Kavlock , R. , Chernoff , N. , Carver , B. and Kopfler , F. 1979 . Teratology studies in mice exposed to municipal drinking water concentrates during organogenesis . Food Cosmet. Toxicol. , 17 : 343 – 347 .
  • Klinefelter , G. R. , Strader , L. F. , Suarez , J. D. , Roberts , N. L. , Goldman , J. M. and Murr , A. S. 2004 . Continuous exposure to dibromoacetic acid delays pubertal development and compromises sperm quality in the rat . Toxicol. Sci. , 81 : 419 – 429 .
  • Klinefelter , G. R. , Hunter , E. S. III and Narotsky , M. G. 2001 . Reproductive and developmental toxicity associated with disinfection by-products of drinking water , Washington, DC : International Life Sciences Institute .
  • Kopfler , F. C. , Coleman , W. E. , Melton , R. G. and Tardiff , R. G. 1977 . Extraction and identification of organic micropollutants: Reverse osmosis method . Ann. NY Acad. Sci. , 298 : 20 – 30 .
  • Miltner , R. J. , Speth , T. F. , Richardson , S. D. , Krasner , S. W. , Weinberg , H. S. and Simmons , J. E. 2008 . Integrated disinfection by-products mixtures research: Disinfection of drinking water by chlorination and ozonation/postchlorination treatment scenarios . J. Toxicol. Environ. Health A , this issue
  • Narotsky , M. G. , Hamby , B. T. , Mitchell , D. S. and Kavlock , R. J. 1992 . Full-litter resorptions caused by low-molecular weight halocarbons in F-344 rats . Teratology , 45 : 472 – 473 . abstr. 67
  • Narotsky , M. G. , Weller , E. A. , Chinchilli , V. M. and Kavlock , R. J. 1995 . Nonadditive developmental toxicity in mixtures of trichloroethylene, di(2-ethylhexyl) phthalate, and heptachlor in a 5 × 5 × 5 design . Fundam. Appl. Toxicol. , 27 : 203 – 216 .
  • Narotsky , M. G. , Hamby , B. T. , Best , D. S. and Hunter , E. S. III . 1996 . In vivo developmental effects of dibromoacetic acid (DBA) and dichloroacetic acid (DCA) in mice . Teratology , 53 : 96 – 97 . abstr. 52
  • Narotsky , M. G. , Hamby , B. T. and Best , D. S. 1997a . Developmental effects of dibromoacetic acid (DBA) in a Segment II study in mice . Teratology , 55 : 67 abstr. No. P40
  • Narotsky , M. G. , Pegram , R. A. and Kavlock , R. J. 1997b . Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride in rats . Fundam. Appl. Toxicol. , 40 : 30 – 36 .
  • Narotsky , M. G. , Best , D. S. , Guidici , D. L. and Cooper , R. L. 2001 . Strain comparisons of atrazine-induced pregnancy loss in the rat . Reprod. Toxicol. , 15 : 61 – 69 .
  • Narotsky , M. G. , Best , D. S. , Rogers , E. H. , McDonald , A. , Sey , Y. M. and Simmons , J. E. 2008 . Integrated disinfection by-products mixtures research: Assessment of developmental toxicity in Sprague-Dawley rats exposed to concentrates of water disinfected by chlorination and ozonation/postchlorination . J. Toxicol. Environ. Health A , this issue
  • National Research Council . 1988 . “ Committee on Methods for In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences ” . In Complex mixtures methods for in vivo toxicity testing , Washington, DC : National Academy Press .
  • National Toxicology Program. 1997a. Chlorodibromomethane. CAS No. 124–48–1. Study Number: RDGT94003, NTIS PB97–111728. http://ntp-server.niehs.nih.gov/htdocs/RDGT-studies/RDGT94003.HTML
  • National Toxicology Program. 1997b. Dibromoacetonitrile: Short-term reproductive and developmental toxicity study when administered to Sprague-Dawley rats in the drinking water (CAS No. 3252–43–5). Study number: RDGT94014, NTIS PB97–143127 http://ntp-server.niehs.nih.gov/htdocs/RDGT-studies/RDGT94014.HTML
  • National Toxicology Program. 1997c. Bromoacetonitrile: Short-term reproductive and developmental toxicity study when administered to Sprague-Dawley rats in the drinking water (CAS No. 590–17–0). Study number: RDGT94013, NTIS PB97–167084 http://ntp-server.niehs.nih.gov/htdocs/RDGT-studies/RDGT94013.HTML
  • National Toxicology Program. 1998a. Short-term reproductive and developmental toxicity study of bromochloroacetic acid (CAS No. 5589–96–8) when administered to Sprague-Dawley rats in the drinking water. Study number: RDGT96001, NTIS PB98–172414 http://ntp-server.niehs.nih.gov/htdocs/RDGT-studies/RDGT96001.HTML
  • National Toxicology Program. 1998b. Final report of the short-term reproductive and developmental toxicity study of tribromoacetic acid (CAS No. 75–96–7) administered to Sprague-Dawley rats in the drinking water. Study number: RDGT94009, NTIS PB98–165111. http://ntp-server.niehs.nih.gov/htdocs/RDGT-studies/RDGT94009.HTML
  • Randall , J. L. , Christ , S. A. , Nolen , G. A. , Read , E. J. and Smith , M. K. 1991 . Developmental effects of dichloroacetic acid in Long-Evans rats. II. Establishment of no adverse effect level . Teratology , 43 : 454 abstr. P123
  • Rice , G. , Teuschler , L. K. , Simmons , J. E. and Hertzberg , R. C. 2005 . “ Assessing human health risks posed by environmental chemical mixtures ” . In Encyclopedia of toxicology , 2nd , Edited by: Wexler , P. 120 – 123 . New York : Elsevier Press .
  • Richardson , S. D. 1998 . “ Drinking water disinfection by-products ” . In The Encyclopedia of environmental analysis & remediation , Edited by: Meyers , R. A. Vol. 3 , 1398 – 1421 . New York : John Wiley & Sons .
  • Richardson , S. D. , Thruston , A. D. Jr. , Caughran , T. V. , Chen , P. H. , Collette , T. W. , Floyd , T. L. , Schenck , K. M. , Lykins , B. W. Jr. , Sun , G. R. and Majetich , G. 1999a . Identification of new ozone disinfection byproducts in drinking water . Environ. Sci. Technol. , 33 : 3368 – 3377 .
  • Richardson , S. D. , Thruston , A. D. Jr. , Caughran , T. V. , Chen , P. H. , Collette , T. W. , Floyd , T. L. , Schenck , K. M. , Lykins , B. W. Jr. , Sun , G. R. and Majetich , G. 1999b . Identification of new drinking water disinfection byproducts formed in the presence of bromide . Environ. Sci. Technol. , 33 : 3378 – 3383 .
  • Richardson , S. D. , Thruston , A. D. , Krasner , S. W. , Weinberg , H. S. , Miltner , R. J. , Schenck , K. M. , Narotsky , M. G. , McKague , A. B. and Simmons , J. E. 2008 . Integrated disinfection by-products mixtures research: Comprehensive characterization of water concentrates prepared from chlorinated and ozonated/postchlorinated drinking water . J. Toxicol. Environ. Health A , this issue
  • Simmons , J. E. , Teuschler , L. K. and Gennings , C. 2001 . “ The toxicology of disinfection by-product mixtures: Methods for multi-chemical assessment, present research efforts, and future research needs ” . In Microbial pathogens and disinfection by-products in drinking water: Health effects and management of risks , Edited by: Craun , G. F. , Hauchman , F. S. and Robinson , D. E. 325 – 340 . Washington, DC : ILSI Press .
  • Simmons , J. E. , Richardson , S. D. , Speth , T. F. , Miltner , R. J. , Rice , G. , Schenck , K. M. , Hunter , E. S. III and Teuschler , L. K. 2002 . Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts . Environ. Health Perspect. , 110 : 1013 – 1024 .
  • Simmons , J. E. , Teuschler , L K. , Gennings , C. , Speth , T. F. , Richardson , S. D. , Miltner , R. J. , Narotsky , M. G. , Schenck , K. D. , Hunter , E. S. 3rd , Hertzberg , R. C. and Rice , G. 2004 . Component-based and whole-mixture techniques for addressing the toxicity of drinking-water disinfection by-product mixtures . J. Toxicol. Environ. Health A , 67 : 741 – 754 .
  • Simmons , J. E. , Richardson , S. D. , Teuschler , L. K. , Miltner , R. J. , Speth , T. F. , Schenck , K. M. , Hunter , E. S. III and Rice , G. 2008 . The research issues underlying the Four-Lab study: Integrated disinfection by-products mixtures research . J. Toxicol. Environ. Health A , this issue
  • Smith , M. K. , Randall , J. R. , Ford , L. D. , Tocco , D. R. and York , R. G. 1987 . Developmental effects of dichloroacetonitrile (DCAN) in Long-Evans rats . Teratology , 35 : 58A abstr. P57
  • Smith , M. K. , Randall , J. L. , Read , E. J. and Stober , J. A. 1990 . Developmental effects of chloroacetic acid in the Long-Evans rat . Teratology , 41 : 593 abstr. P164
  • Speth , T. F. , Miltner , R. J. , Richardson , S. D. and Simmons , J. E. 2008 . Integrated disinfection by-products (DBPs) mixtures research: Concentration by reverse osmosis membrane techniques of DBPs from water disinfected by chlorination and ozonation/postchlorination . J. Toxicol. Environ. Health A , this issue
  • Teuschler , L. K. and Simmons , J. E. 2003 . Approaching DBP toxicity as a mixtures problem . J. Am. Water Works Assoc. , 95 : 131 – 138 .
  • Teuschler , L. K. , Klauning , J. , Carney , E. , Chambers , J. , Conolly , R. , Gennings , C. , Giesy , J. , Hertzberg , R. , Klaassen , C. , Kodell , R. , Paustenbach , D. and Yang , R. 2002 . Support of science-based decisions concerning the evaluation of the toxicology of mixtures: A new beginning . Regul. Toxicol. Pharmacol. , 3 : 34 – 39 .
  • Thompson , D. L. , Warner , S. D. and Robinson , V. B. 1974 . Teratology studies in orally administered chloroform in the rat and rabbit . Toxicol. Appl. Pharmacol. , 29 : 348 – 357 .
  • U.S. Environmental Protection Agency . 1997 . Exposure factors handbook , Vol. 1 , Washington, DC : National Center for Environmental Assessment . EPA/600/P-95/001Fb
  • U.S. Environmental Protection Agency . 1998 . National primary drinking water regulations; Disinfectants and disinfection by-products notice of data availability . Fed. Reg. , 63 ( 61 ) : 15674 – 15692 .
  • U.S. Environmental Protection Agency . 1999 . Research report on the risk assessment of mixtures of disinfection by-products (DBPs) in drinking water , Cincinnati, OH : Office of Research and Development, National Center for Environmental Assessment . EPA/600/R-03/039
  • U.S. Environmental Protection Agency . 2000a . The Information Collection Rule Auxiliary 1 Database , Washington, DC : Office of Water . EPA/815/C-00/002
  • U.S. Environmental Protection Agency . 2000b . Review of animal studies for reproductive and developmental toxicity assessment of drinking water contaminants: Disinfection by-products (DBPs) Prepared for the Office of Water by R. W. Tyl under contract with RTI, project 07639. October
  • U.S. Environmental Protection Agency. 2000c. Supplementary guidance for conducting health risk assessment of chemical mixtures. Washington, DC: Office of Research and Development. EPA/630/R-00/002. Available in pdf format www.epa.gov/NCEA/raf/chem_mix.htm
  • U.S. Environmental Protection Agency . 2003 . The feasibility of performing cumulative risk assessments for mixtures of disinfection by-products in drinking water , Cincinnati, OH : National Center for Environmental Assessment . EPA/600/R-03/051
  • U.S. Environmental Protection Agency. 2004. Benchmark dose. Washington, DC: U.S. Environmental Protection Agency. Accessed April http://cfpub2.epa.gov/nceapublication.cfm
  • U.S. Geological Survey. 2004. Pesticides and pesticide degradates in the East Fork Little Miami River and William H. Harsha Lake, Southwestern Ohio, 1999–2000. USGS Water Resources Investigation Report 03–4216 http://water.usgs.gov/pubs/wri/wri034216/
  • Waller , K. , Swan , S. H. , DeLorenze , G. and Hopkins , B. 1998 . Trihalomethanes in drinking water and spontaneous abortion . Epidemiology , 9 : 134 – 140 .
  • Waller , K. , Swan , S. H. , Windham , G. C. and Fenster , L. 2001 . Influence of exposure assessment methods on risk estimates in an epidemiologic study of total trihalomethane exposure and spontaneous abortion . J. Expos. Anal. Environ. Epidemiol. , 11 : 522 – 531 .
  • Weinberg , H. 1999 . Disinfection byproducts in drinking water: The analytic challenge . Anal. Chem. News Features , 4 : 801A – 808A .
  • Weisel , C. and Chen , W. 1994 . Exposure to chlorination by-products from hot water uses . Risk Anal. , 14 : 101 – 106 .
  • Weisel , C. , Kim , H. , Haltmeier , P. and Klotz , J. 1999 . Exposure estimates to disinfectant by-products of chlorinated drinking water . Environ. Health Perspect. , 107 : 103 – 110 .
  • Wilkes , C. 1999 . “ Case study ” . In Exposure to contaminants in drinking water: Estimating uptake through the skin and by inhalation , Edited by: Olin , S. 183 – 224 . Washington, DC : CRC Press .
  • Windam , G. C. , Waller , K. , Anderson , M. , Fenster , L. , Mendola , P. and Swan , S. 2003 . Chlorination by-products in drinking water and menstrual cycle function . Environ. Health Perspect. , 111 : 935 – 941 .
  • Wolfe , G. W. , Kaiser , L. B. , Mowry , R. N. , Klinefelter , G. , Hunter , E. S. and Chapin , R. E. 1999 . Short-term reproductive and developmental effects of tribromoacetic acid, bromochloroacetic acid, and bromodichloromethane in the S-D rat when administered in the drinking water . Toxicologist , 48 : 16 abstr. 76
  • Wright , J. M. and Bateson , T. F. 2005 . A sensitivity analysis of bias in relative risk estimates due to disinfection by-product exposure misclassification . J. Expos. Anal. Environ. Epidemiol. , 15 : 212 – 216 .

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