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Original Articles

Induction of DNA Double-Strand Breaks in the H4IIE Cell Line Exposed to Environmentally Relevant Concentrations of Copper, Cadmium, and Zinc, Singly and in Combinations

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Pages 155-163 | Published online: 30 Jan 2009

REFERENCES

  • Aastrup , P. , Riget , F. , Dietz , R. and Asmund , G. 2000 . Lead, zinc, cadmium, mercury, selenium and copper in Greenland caribou and reindeer (Rangifer tarandus) . Sci. Total Environ. , 245 : 149 – 159 .
  • Asmuss , M. , Mullenders , L. H. F. , Eker , A. and Hartwig , A. 2000 . Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair . Carcinogenesis , 21 : 2097 – 2104 .
  • Berg , J. M. and Shi , Y. 1996 . The galvanization of biology: A growing appreciation for the roles of zinc . Science , 271 : 1081 – 1085 .
  • Bertin , G. and Averbeck , D. 2006 . Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review) . Biochimie , 88 : 1549 – 1559 .
  • Bradley , M. O. , Taylor , V. I. , Armstrong , M. J. and Galloway , S. M. 1987 . Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and DNA double-strand breaks . Mutat. Res. , 189 : 69 – 79 .
  • Bray , T. M. and Bettger , W. J. 1990 . The physiological role of zinc as an antioxidant . Free Radical Biol. Med. , 8 : 281 – 291 .
  • Chan , H. M. and Cherian , M. G. 1992 . Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium . Toxicology , 72 : 281 – 290 .
  • Dally , H. and Hartwig , A. 1997 . Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells . Carcinogenesis , 18 : 1021 – 1026 .
  • Damelin , L. H. , Vokes , S. , Whitcutt , J. M. , Damelin , S. B. and Alexander , J. J. 2000 . Hormesis: A stress response in cells exposed to low levels of heavy metals . Hum. Exp. Toxicol. , 19 : 420 – 430 .
  • Dehn , L.-A. , Sheffield , G. G. , Follmann , E. H. , Duffy , L. K. , Thomas , D. L. , Bratton , G. R. , Taylor , R. J. and O'Hara , T. M. 2005 . Trace elements in tissues of phocid seals harvested in the Alaskan and Canadian Arctic: Influence of age and feeding ecology . Can. J. Zool. , 83 : 726 – 746 .
  • Devergnas , S. , Chimienti , F. , Naud , N. , Pennequin , A. , Coquerel , Y. , Chantegrel , J. , Favier , A. and Seve , M. 2004 . Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: A real-time RT–PCR study . Biochem. Pharmacol. , 68 : 699 – 709 .
  • Eaton , D. L. and Gilbert , S. S. 2008 . “ Principles of toxicology ” . In Casarett & Doull's toxicology: The basic science of poisons , 7th , Edited by: Klaasen , C. D. 11 – 44 . New York : McGraw-Hill .
  • Evans , M. D. , Dizdaroglu , M. and Cooke , M. S. 2004 . Oxidative DNA damage and disease: induction, repair and significance . Mutat. Res. , 568 : 1 – 61 .
  • Fatur , T. , Lah , T. T. and Filipič , M. 2003 . Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells . Mutat. Res. , 529 : 109 – 116 .
  • Filipič , M. and Hei , T. K. 2004 . Mutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage . Mutat. Res. , 546 : 81 – 91 .
  • Fotakis , G. and Timbrell , J. A. 2006 . Role of trace elements in cadmium chloride uptake in hepatoma cell lines . Toxicol. Lett. , 164 : 97 – 103 .
  • Fotakis , G. , Cemeli , E. , Anderson , D. and Timbrell , J. A. 2005 . Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line . Toxicol. In Vitro , 19 : 481 – 489 .
  • Galán , A. , García-Bermejo , L. , Troyano , A. , Vilaboa , N. E. , Fernández , C. , de Blas , E. and Aller , P. 2001 . The role of intracellular oxidation in death induction (apoptosis and necrosis) in human promonocytic cells treated with stress inducers (cadmium, heat, X-rays) . Eur. J. Cell Biol. , 80 : 312 – 320 .
  • Gamberg , M. , Palmer , M. and Roach , P. 2005 . Temporal and geographic trends in trace element concentrations in moose from Yukon, Canada . Sci. Total Environ. , 351–352 : 530 – 538 .
  • Grant , G. M. , Jackman , S. M. , Kolanko , C. J. and Stenger , D. A. 2001 . JP-8 jet fuel-induced DNA damage in H4IIE rat hepatoma cells . Mutat. Res. , 490 : 67 – 75 .
  • Hartwig , A. 1998 . Carcinogenicity of metal compounds: possible role of DNA repair inhibition . Toxicol. Lett. , 102/103 : 235 – 239 .
  • Hedge , M. L. , Hazra , T. K. and Mitra , S. 2008 . Early steps in the DNA base excision/single strand interruption repair pathway in mammalian cells . Cell Res. , 18 : 27 – 47 .
  • Helleday , T. , Lo , J. , van Gent , D. C. and Engelward , B. P . 2007 . DNA double strand break repair: From mechanistic understanding to cancer treatment . DNA Repair , 6 : 923 – 936 .
  • Ho , E. , Courtemanche , C. and Ames , B. N. 2003 . Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts . J. Nutr. , 133 : 2543 – 2548 .
  • Ho , E. 2004 . Zinc deficiency, DNA damage and cancer risk . J. Nutr. Biochem. , 15 : 572 – 578 .
  • Ikemoto , T. , Kunito , T. , Tanaka , H. , Baba , N. , Miyazaki , N. and Tanabe , S. 2004 . Detoxification mechanism of heavy metals in marine mammals and seabirds: Interaction of selenium with mercury, silver, copper, zinc, and cadmium in liver . Arch. Environ. Contam. Toxicol. , 47 : 402 – 413 .
  • Jin , Y. H. , Clark , A. B. , Slebos , R. J. C. , Al-Refai , H. , Taylor , J. A. , Kunkel , T. A. , Resnick , M. A. and Gordenin , D. A. 2003 . Cadmium is a mutagen that acts by inhibiting mismatch repair . Nat. Genet. , 34 : 326 – 329 .
  • Kägi , J. H. R. and Schäffer , A. 1988 . Biochemistry of metallothionein . Biochemistry , 27 : 8509 – 8515 .
  • Kim , S. C. , Cho , M. K. and Kim , S. G. 2003 . Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency . Toxicol. Lett. , 144 : 325 – 336 .
  • Klaassen , J. D. , Liu , J. and Choudhuri , S. 1999 . Metallothionein: An intracellular protein to protect against cadmium toxicity . Annu. Rev. Pharmacol. Toxicol. , 39 : 267 – 294 .
  • Kraemer , L. D. , Campbell , P. G. C. and Hare , L. 2005 . A field study examining metal elimination kinetics in juvenile yellow perch (Perca flavescens) . Aquat. Toxicol. , 75 : 108 – 126 .
  • Kr⊘kje , Å. , Bingham , C. , Tuven , R. H. and Gabrielsen , G. W. 2006 . Chromosome aberrations and DNA strand breaks in glaucous gull (Larus hyperboreus) chicks fed environmentally contaminated gull eggs . J. Toxicol. Environ. Health A , 69 : 159 – 174 .
  • Liu , J. , Goyer , R. A. and Waalkes , M. P. 2008 . “ Toxic effects of metals ” . In Casarett & Doull's toxicology: The basic science of poisons , Edited by: Klaasen , C. D. , Amdur , M. O. and Doull , J. 931 – 979 . New York : McGraw-Hill .
  • Moriwaki , H. , Osborne , M. R. and Phillips , D. H. 2008 . Effects of mixing metal ions on oxidative DNA damage mediated by a Fenton-type reduction . Toxicol. In Vitro , 22 : 36 – 44 .
  • Mosmann , T. 1983 . Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays . J. Immunol. Methods , 65 : 55 – 63 .
  • Mukherjee , J. J. , Gupta , S.K. , Kumar , S. and Sikka , H. C. 2004 . Effects of cadmium (II) on (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage response in human fibroblasts and DNA repair: A possible mechanism of cadmium's cogenotoxicity . Chem. Res. Toxicol. , 17 : 287 – 293 .
  • Murata , M. , Gong , P. , Suzuki , K. and Koizumi , S. 1999 . Differential metal response and regulation of human heavy metal-inducible genes . J. Cell. Physiol. , 180 : 105 – 113 .
  • Oliveira , S. C. B. , Corduneanu , O. and Oliveira-Brett , A. M. 2008 . In situ evaluation of heavy metal–DNA interactions using an electrochemical DNA biosensor . Bioelectrochemistry , 72 : 53 – 58 .
  • Olsvik , P. A. , Gundersen , P. , Andersen , R. A. and Zachariassen , K. E. 2001 . Metal accumulation and metallothionein in brown trout, Salmo trutta, from two Norwegian rivers differently contaminated with Cd, Cu and Zn . Comp. Biochem. Physiol. C , 128 : 189 – 201 .
  • Park , J. D. , Liu , Y. and Klaassen , C. D. 2001 . Protective effect of metallothionein against the toxicity of cadmium and other metals . Toxicology , 163 : 93 – 100 .
  • Pfeiffer , P. 1998 . The mutagenic potential of DNA double-strand break repair . Toxicol. Lett. , 96–97 : 119 – 129 .
  • Pourahmad , J. and O'Brien , P. J. 2000 . A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+ . Toxicology , 143 : 263 – 273 .
  • Pourahmad , J. , Ross , S. and O'Brien , P. J. 2001 . Lysosomal involvement in hepatocyte cytotoxicity induced by Cu2+ but not Cd2+ . Free Radical Biol. Med. , 30 : 89 – 97 .
  • Rau , M. A. , Whitaker , J. , Freedman , J. H. and Di Giulio , R. T. 2004 . Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants . Comp. Biochem. Physiol. , 137 : 335 – 342 .
  • Sagripanti , J.-L. , Goering , P. L. and Lamanna , A. 1991 . Interactions of copper with DNA and antagonism by other metals . Toxicol. Appl. Pharmacol. , 110 : 477 – 485 .
  • Savinov , V. , Gabrielsen , G. W. and Savinova , T. N. 2003 . Cadmium, zinc, copper, arsenic, selenium and mercury in seabirds from the Barents Sea: Levels, inter-specific and geographical differences . Sci. Total Environ. , 306 : 133 – 158 .
  • Seth , R. , Yang , S. , Choi , S. , Sabean , M. and Roberts , E. A. 2004 . In vitro assessment of copper-induced toxicity in the human hepatoma line, Hep G2 . Toxicol. In Vitro , 18 : 501 – 509 .
  • Shih , C.-M. , Ko , W.-C. , Wu , J.-S. , Wei , Y.-H. , Wang , L.-F. , Chang , E.-E. , Lo , T.-Y- , Cheng , H.-H. and Chen , C.-T. 2004 . Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts . J. Cell. Biochem. , 91 : 384 – 397 .
  • Shugart , L. R. 2000 . DNA damage as a biomarker of exposure . Ecotoxicology , 9 : 329 – 340 .
  • Son , M. H. , Kang , K. W. , Lee , C. H. and Kim , S. G. 2001 . Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK) Complete inhibition of the potentiated toxicity by U0126 an ERK1/2 and p38 kinase inhibitor . Biochem. Pharmacol. , 62 : 1379 – 1390 .
  • Stern , B. R. , Solioz , M. , Krewski , D. , Aggett , P. , Aw , T.-C. , Baker , S. , Crump , K. , Dourson , M. , Haber , L. , Hertzberg , R. , Keen , C. , Meek , B. , Rudenko , L. , Schoeny , R. , Slob , W. and Starr , T. 2007 . Copper and human health: Biochemistry, genetics and strategies for modelling dose-response relationships . J. Toxicol. Environ. Health B , 10 : 157 – 222 .
  • Storelli , M. M. , Storelli , A. , D'Addabbo , R. , Marano , C. , Bruno , R. and Marcotrigiano , G. O. 2005 . Trace elements in loggerhead turtles (Caretta caretta) from the eastern Mediterranean Sea: overview and evaluation . Environ. Pollut. , 135 : 163 – 170 .
  • Szuster-Ciesielska , A. , Stachura , A. , Słotwińska , M. , Kamińska , T. , Śnieżko , R. , Paduch , R. , Abramczyk , D. , Filar , J. and Kandefer-Szerszeń , M. 2000 . The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures . Toxicology , 145 : 159 – 171 .
  • Takamure , Y. , Shimada , H. , Kiyozumi , M. , Yasutake , A. and Imamurac , Y. 2006 . A possible mechanism of resistance to cadmium toxicity in male Long–Evans rats . Environ. Toxicol. Pharmacol. , 21 : 231 – 234 .
  • Theodorakis , C. W. , D'Surney , S. J. and Shugart , L. R. 1994 . Detection of genotoxic insult as DNA strand breaks in fish blood cells by agarose gel electrophoresis . Environ. Toxicol. Chem. , 13 : 1023 – 1031 .
  • Uauy , R. , Olivares , M. and Gonzalez , M. 1998 . Essentiality of copper in humans . Am. J. Clin. Nutr. , 67 : 952S – 959S .
  • Urani , C. , Melchioretto , P. , Canevali , C. and Crosta , G. F. 2005 . Cytotoxicity and induction of protective mechanisms in HepG2 cells exposed to cadmium . Toxicol. In Vitro , 19 : 887 – 892 .
  • Valko , M. , Morris , H. and Cronin , M. T. D. 2005 . Metals, toxicity and oxidative stress . Curr. Med. Chem. , 12 : 1161 – 1208 .
  • Waisberg , M. , Joseph , P. , Hale , B. and Beyersmann , D. 2003 . Molecular and cellular mechanisms of cadmium carcinogenesis . Toxicology , 192 : 95 – 117 .
  • Wang , Y. , Fang , J. , Leonard , S. S. and Rao , K. M. K. 2004 . Cadmium inhibits the electron transfer chain and induces reactive oxygen species . Free Radical Biol. Med. , 36 : 1434 – 1443 .
  • Watanabe , T. , Kiron , V. and Satoh , S. 1997 . Trace minerals in fish nutrition . Aquaculture , 151 : 185 – 207 .
  • Wätjen , W. , Michels , G. , Steffan , B. , Niering , P. , Chovolou , Y. , Kampkötter , A. , Tran-Thi , Q.-H. , Proksch , P. and Kahl , R. 2005 . Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis . J. Nutr. , 135 : 525 – 531 .
  • Whyte , J. J. , Schmitt , C. J. and Tillitt , D. E. 2004 . The H4IIE cell bioassay as an indicator of dioxin-like chemicals in wildlife and the environment . Crit. Rev. Toxicol. , 34 : 1 – 83 .
  • Würgler , F. E. and Kramers , P. G. N. 1992 . Environmental effects of genotoxins (eco-genotoxicology) . Mutagenesis , 7 : 321 – 327 .

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