809
Views
118
CrossRef citations to date
0
Altmetric
Original Articles

Titanium Dioxide (TiO2) Nanoparticles Induce JB6 Cell Apoptosis Through Activation of the Caspase-8/Bid and Mitochondrial Pathways

, , , , , & show all
Pages 1141-1149 | Received 06 Feb 2009, Accepted 16 Mar 2009, Published online: 04 Sep 2009

REFERENCES

  • Ashkenazi, A., and Dixit, V. M., 1999. Apoptosis control by death and decoy receptors, Curr. Opin. Cell. Biol. 11 (1999), pp. 255–260.
  • Baggs, R. B., Ferin, J., and Oberdorster, G., 1997. Regression of pulmonary lesions produced by inhaled titanium dioxide in rats, Vet. Pathol. 34 (1997), pp. 592–597.
  • Bardales, R. H., Xie, S. S., Schaefer, R. F., and Hsu, S. M., 1996. Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury, Am. J. Pathol. 149 (1996), pp. 845–852.
  • Belka, C., Rudner, J., Wesselborg, S., Stepczynska, A., Marini, P., Lepple-Wienhues, A., Faltin, H., Bamberg, M., Budach, W., and Schulze-Osthoff, K., 2000. Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis, Oncogene. 19 (2000), pp. 1181–1190.
  • Bermudez, E., Mangum, J. B., Asgharian, B., Wong, B.A., Reverdy, E. E., Janszen, D. B., Hext, P. M., Warheit, D. B., and Everitt, J. I., 2002. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles, Toxicol Sci. 70 (2002), pp. 86–97.
  • Boffa, D. J., Waka, J., Thomas, D., Suh, S., Curran, K., Sharma, V. K., Besada, M., Muthukumar, T., Yang, H., Suthanthiran, M., and Manova, K., 2005. Measurement of apoptosis of intact human islets by confocal optical sectioning and stereologic analysis of YO-PRO-1-stained islets, Transplantation 79 (2005), pp. 842–845.
  • Charlot, J. F., Pretet, J. L., Haughey, C., and Mougin, C., 2004. Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells, Apoptosis 9 (2004), pp. 333–343.
  • Churg, A., Gilks, B., and Dai, J., 1999. Induction of fibrogenic mediators by fine and ultrafine titanium dioxide in rat tracheal explants, Am. J. Physiol. 277 (1999), pp. L975–L982.
  • Churg, A., Stevens, B., and Wright, J. L., 1998. Comparison of the uptake of fine and ultrafine TiO2 in a tracheal explant system, Am. J. Physiol. 274 (1998), pp. L81–L86.
  • Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M. A., Lassota, P., and Traganos, F., 1992. Features of apoptotic cells measured by flow cytometry, Cytometry 13 (1992), pp. 795–808.
  • Driscoll, K. E., Maurer, J. K., Lindenschmidt, R.C., Romberger, D., Rennard, S. I., and Crosby, L., 1990. Respiratory tract responses to dust: Relationships between dust burden, lung injury, alveolar macrophage fibronectin release, and the development of pulmonary fibrosis, Toxicol. Appl. Pharmacol. 106 (1990), pp. 88–101.
  • Durmowicz, A. G., and Stenmark, K. R., 1999. Mechanisms of structural remodeling in chronic pulmonary hypertension, Pediatr. Rev. 20 (1999), pp. e91–e102.
  • Gadaleta, P., Perfetti, X., Mersich, S., and Coulombie, F., 2005. Early activation of the mitochondrial apoptotic pathway in vesicular stomatitis virus-infected cells, Virus Res. 109 (2005), pp. 65–69.
  • Gawlitta, D., Cees, W. J., Oomens, F. P., Baaijens, P. T., and Bouten, C. V. C., 2004. Evaluation of a continuous quantification method of apoptosis and necrosis in tissue cultures, Cytotechnology 46 (2004), pp. 139–150.
  • Grossmann, J., Mohr, S., Lapentina, E. G., Fiocchi, C., and Levine, A. D., 1998. Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells, Am J Physiol. 274 (1998), pp. G1117–G1124.
  • IARC, , 2006. Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide, IARC Monogr. Eval. Carcinogen. Risks Hum. 86 (2006).
  • Idziorek, T., Estaquier, J., De Bels, F., and Ameisen, J. C., 1995. YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability, J. Immunol. Methods 185 (1995), pp. 249–258.
  • Kaida, T., Kobayashi, K., Adachi, M., and Suzuki, F., 2004. Optical characteristics of titanium oxide interference film and the film laminated with oxides and their applications for cosmetics, J. Cosmet. Sci. 55 (2004), pp. 219–220.
  • Kerr, J. F., Wyllie, A. H., and Currie, A. R., 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer 26 (1972), pp. 239–257.
  • Kuwano, K., Miyazaki, H., Hagimoto, N., Kawasaki, M., Fujita, M., Kunitake, R., Kaneko, Y., and Hara, N., 1999. The involvement of Fas–Fas ligand pathway in fibrosing lung diseases, Am. J. Respir. Cell Mol. Biol. 20 (1999), pp. 53–60.
  • Lademann, J., Weigmann, H., Rickmeyer, C., Barthelmes, H., Schaefer, H., Mueller, G., and Sterry, W., 1999. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice, Skin Pharmacol. Appl. Skin Physiol. 12 (1999), pp. 247–256.
  • Lee, K. P., Trochimowicz, H. J., and Reinhardt, C. F., 1985. Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years, Toxicol. Appl. Pharmacol. 79 (1985), pp. 179–192.
  • Levine, A. J., 1997. p53, the cellular gatekeeper for growth and division, Cell 88 (1997), pp. 323–331.
  • Liu, X., Van Vleet, T., and Schnellmann, R. G., 2004. The role of calpain in oncotic cell death, Annu. Rev. Pharmacol. Toxicol. 44 (2004), pp. 349–370.
  • Lombaert, N., De Boeck, M., Decordier, I., Cundari, E., Lison, D., and Kirsch-Volders, M., 2004. Evaluation of the apoptogenic potential of hard metal dust (WC-Co), tungsten carbide and metallic cobalt, Toxicol. Lett. 154 (2004), pp. 23–34.
  • Long, T. C., Tajuba, J., Sama, P., Saleh, N., Swartz, C., Parker, J., Hester, S., Lowry, G. V., and Veronesi, B., 2007. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro, Environ. Health Perspect. 115 (2007), pp. 1631–1637.
  • Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X., 1998. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors, Cell 94 (1998), pp. 481–490.
  • Luther, W. E., 2004. Industrial application of nanomaterials—Chances and risks, Future Technol. 54 (2004), pp. 1–112.
  • Matute-Bello, G., Winn, R. K., Jonas, M., Chi, E. Y., Martin, T. R., and Liles, W. C., 2001. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: Implications for acute pulmonary inflammation, Am. J. Pathol. 158 (2001), pp. 153–161.
  • Oberdorster, G., Ferin, J., and Lehnert, B. E., 1994. Correlation between particle size, in vivo particle persistence, and lung injury, Environ. Health Perspect. 102 (suppl. 5) (1994), pp. 173–179, .
  • Oltvai, Z. N., and Korsmeyer, S. J., 1994. Checkpoints of dueling dimers foil death wishes, Cell 79 (1994), pp. 189–192.
  • Piacenza, L., Irigoin, F., Alvarez, M. N., Peluffo, G., Taylor, M. C., Kelly, J. M., Wilkinson, S. R., and Radi, R., 2007. Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: Cytoprotective action of mitochondrial iron superoxide dismutase overexpression, Biochem. J. 403 (2007), pp. 323–334.
  • Raff, M. C., 1992. Social controls on cell survival and cell death, Nature 356 (1992), pp. 397–400.
  • Rahman, Q., Lohani, M., Dopp, E., Pemsel, H., Jonas, L., Weiss, D. G., and Schiffmann, D., 2002. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts, Environ. Health Perspect. 110 (2002), pp. 797–800.
  • Robison, S. H., Cantoni, O., and Costa, M., 1982. Strand breakage and decreased molecular weight of DNA induced by specific metal compounds, Carcinogenesis 3 (1982), pp. 657–662.
  • Sayes, C. M., Wahi, R., Kurian, P. A., Liu, Y., West, J. L., Ausman, K. D., Warheit, D. B., and Colvin, V. L., 2006. Correlating nanoscale titania structure with toxicity: A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells, Toxicol. Sci. 92 (2006), pp. 174–185.
  • Steller, H., 1995. Mechanisms and genes of cellular suicide, Science 267 (1995), pp. 1445–1449.
  • Tabet, L., Bussy, C., Amara, N., Setyan, A., Grodet, A., Rossi, M. J., Pairon, J. C., Boczkowski, J., and Lanone, S., 2009. Adverse effects of industrial multi-walled carbon nanotubes on human pulmonary cells, J. Toxicol. Environ. Health A 72 (2009), pp. 60–73.
  • Tewari, M., Quan, L. T., O'Rourke, K, Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M., 1995. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase, Cell 81 (1995), pp. 801–809.
  • Wang, J. J., Sanderson, B. J., and Wang, H., 2007. Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells, Mutat Res. 628 (2007), pp. 99–106.
  • Warheit, D. B., Hansen, J. F., Yuen, I. S., Kelly, D. P., Snajdr, S. I., and Hartsky, M. A., 1997. Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation, Toxicol. Appl. Pharmacol. 145 (1997), pp. 10–22.
  • White, S. R., Williams, P., Wojcik, K. R., Sun, S., Hiemstra, P. S., Rabe, K. F., and Dorscheid, D. R., 2001. Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells, Am. J. Respir. Cell Mol. Biol. 24 (2001), pp. 282–294.
  • Wolf, R., Matz, H., Orion, E., and Lipozencic, J., 2003. Sunscreens—The ultimate cosmetic, Acta Dermatovenerol. Croat. 11 (2003), pp. 158–162.
  • Wyllie, A. H., Kerr, J. F., and Currie, A. R., 1980. Cell death: The significance of apoptosis, Int. Rev. Cytol. 68 (1980), pp. 251–306.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.