294
Views
15
CrossRef citations to date
0
Altmetric
Articles

Metabolomics Approach to Risk Assessment: Methoxyclor Exposure in Rats

, , , , , , , , , , & show all
Pages 1352-1368 | Published online: 29 Dec 2009

REFERENCES

  • Al-JamalJ. H.DubinN. H.The effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlorAm. J. Obstet. Gynecol.200018210991102
  • BorgeestC.GreenfeldC.TomicD.FlawsJ. A.The effects of endocrine disrupting chemicals on the ovaryFront. Biosci.2002a7d1941d1948
  • BorgeestC.MillerK. P.GuptaR.GreenfeldC.HruskaK. S.HoyerP.FlawsJ. A.Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiolBiol. Reprod.20047018281835
  • BorgeestC.SymondsD.MayerL. P.HoyerP. B.FlawsJ. A.Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouseToxicol. Sci.2002b68473478
  • BundyJ. G.LenzE. M.BaileyN. J.GavaghanC. L.SvendsenC.SpurgeonD.HankardP. K.OsbornD.WeeksJ. M.TraugerS. A.SpeirP.SandersI.LindonJ. C.NicholsonJ. K.TangH.Metabonomic assessment of toxicity of 4-fluoroaniline, 3,5-difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta (Rosa): Identification of new endogenous biomarkersEnviron. Toxicol. Chem.20022119661972
  • BundyJ. G.SpurgeonD. J.SvendsenC.HankardP. K.WeeksJ. M.OsbornD.LindonJ. C.NicholsonJ. K.Environmental metabonomics: Applying combination biomarker analysis in earthworms at a metal contaminated siteEcotoxicology200413797806
  • CoenM.O'SullivanM.BubbW. A.KuchelP. W.SorrellT.Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitisClin. Infect. Dis.20054115821590
  • DuarteI. F.StanleyE. G.HolmesE.LindonJ. C.GilA. M.TangH.FerdinandR.McKeeC. G.NicholsonJ. K.Vilca-MelendezH.HeatonN.MurphyG. M.Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopyAnal. Chem.20057755705578
  • EroschenkoV. P.Abuel-AttaA. A.GroberM. S.Neonatal exposures to technical methoxychlor alters ovaries in adult miceReprod. Toxicol.19959379387
  • EroschenkoV. P.JohnsonT. J.RourkeA. W.Estradiol and pesticide metoxychlor do not exhibit additivity or synergism in the reproductive tract of adult ovariectomized miceJ. Toxicol. Environ. Health A200060407421
  • GaidoK. W.ManessS. C.McDonnellD. P.DehalS. S.KupferD.SafeS.Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: Structure–activity studiesMol. Pharmacol.200058852858
  • GanmaaD.TezukaH.EnkhmaaD.HoshiK.SatoA.Commercial cows’ milk has uterotrophic activity on the uteri of young ovariectomized rats and immature ratsInt. J. Cancer200611823632365
  • GartrellM. J.CraunJ. C.PodrebaracD. S.GundersonE. L.Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1980–March1982J. Assoc. Off. Anal. Chem.198669123145
  • GrayL. E.JrOstbyJ.CooperR. L.KelceW. R.The estrogenic and antiandrogenic pesticide methoxychlor alters the reproductive tract and behavior without affecting pituitary size or LH and prolactin secretion in male ratsToxicol. Ind. Health1999153747
  • GriffinJ. L.Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosisCurr. Opin. Chem. Biol.20037648654
  • GriffinJ. L.BollardM. E.Metabonomics: Its potential as a tool in toxicology for safety assessment and data integrationCurr. Drug Metab.20045389398
  • GriffinJ. L.KauppinenR. A.A metabolomics perspective of human brain tumoursFEBS J.200727411321139
  • HallD. L.PayneL. A.PutnamJ. M.Huet-HudsonY. M.Effect of methoxychlor on implantation and embryo development in the mouseReprod. Toxicol.199711703708
  • KimK. B.ChungM. W.UmS. Y.OhJ. S.KimS. H.NaM. A.OhH. Y.ChoW. S.ChoiK. H.Metabolomics and biomarker discovery: NMR spectral data of urine and hepatotoxicity by carbon tetrachloride, acetaminophen, and D-galactosamine in ratsMetabolomics20084377392
  • KimH. S.KangT. S.KangI. H.KimT. S.MoonH. J.KimI. Y.KiH.ParkK. L.LeeB. M.YooS. D.HanS. Y.Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female ratsJ. Toxicol. Environ. Health A20056822492262
  • KuiperG. G.ShughrueP. J.MerchenthalerI.GustafssonJ. A.The estrogen receptor beta subtype: A novel mediator of estrogen action in neuroendocrine systemsFront. Neuroendocrinol.199819253286
  • LawsS. C.CareyS. A.FerrellJ. M.BodmanG. J.CooperR. L.Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in ratsToxicol. Sci.200054154167
  • ManessS. C.McDonnellD. P.GaidoK. W.Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cellsToxicol. Appl. Pharmacol.1998151135142
  • MartinezE. M.SwartzW. J.Effects of methoxychlor on the reproductive system of the adult female mouse: 2. Ultrastructural observationsReprod. Toxicol.199269398
  • MillerK. P.GuptaR. K.GreenfeldC. R.BabusJ. K.FlawsJ. A.Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathwaysToxicol. Sci.200588213221
  • NicholsonJ. K.LindonJ. C.HolmesE.‘Metabonomics’: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic dataXenobiotica19992911811189
  • NoaM.MendozaS.MasR.GamezR.ValleM.PardoB.GutierrezA.MendozaN.D-003 does not possess oestrogenic potential in-vivo: Findings of the uterotrophic assayJ. Pharm. Pharmacol.20075914331437
  • Organization for Economic Cooperation and DevelopmentOECD report of the initial work towards the validation of the rodent uterotrophic assay—Phase 1.ENV/JM/MONO(2006)200633 183-194-2583
  • OhyamaK.MakiS.SatoK.KatoY.Comparative in vitro metabolism of methoxychlor in male and female rats: Metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slicesXenobiotica200535683695
  • ParkJ. C.HongY. S.KimY. J.YangJ. Y.KimE. Y.KwackS. J.Ryu doH.HwangG. S.LeeB. M.A metabonomic study on the biochemical effects of doxorubicin in rats using (1)H-NMR spectroscopyJ. Toxicol. Environ. Health A200972374384
  • RastallR. A.GibsonG. R.GillH. S.GuarnerF.KlaenhammerT. R.PotB.ReidG.RowlandI. R.SandersM. E.Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applicationsFEMS Microbiol. Ecol.200552145152
  • RobertsonD. G.ReilyM. D.BakerJ. D.Metabonomics in preclinical drug developmentExpert Opin. Drug Metab. Toxicol.20051363376
  • SwartzW. J.CorkernM.Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnanciesReprod. Toxicol.19926431437
  • SymondsD. A.TomicD.MillerK. P.FlawsJ. A.Methoxychlor induces proliferation of the mouse ovarian surface epitheliumToxicol. Sci.200583355362
  • TateA. R.DammentS. J.LindonJ. C.Investigation of the metabolite variation in control rat urine using (1)H NMR spectroscopyAnal. Biochem.20012911726
  • UmanoT.ShiraishiK.MinobeY.YamasakiK.Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 3-amino-1,2,4-triazole based on the Organization for Economic Co-operation and Development draft protocolsArch. Toxicol.200983459467
  • WatersK. M.SafeS.GaidoK. W.Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female miceToxicol. Sci.2001634756
  • YamasakiK.MiyataK.MuroiT.EharaH.HigashiharaN.HoushuyamaS.OshimaH.MinobeY.Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4 -[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] based on the OECD draft protocolsArch. Toxicol.200781749757
  • YangJ.ZhaoX.LiuX.WangC.GaoP.WangJ.LiL.GuJ.YangS.XuG.High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis BJ. Proteome Res.20065554561

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.