608
Views
26
CrossRef citations to date
0
Altmetric
Articles

An Exposure Assessment of DI-(2-Ethylhexyl) Phthalate (DEHP) and DI-n-Butyl Phthalate (DBP) in Human Semen

, , , , , , & show all
Pages 1463-1469 | Published online: 29 Dec 2009

REFERENCES

  • AitkenJ. R.KrauszC.Oxidative stress, DNA damage and the Y chromosomeReproduction2001122497506
  • www.atsdr.cdc.gov/toxprofiles Agency for Toxic Substances and Disease Registry. 1995. Toxicological profile for diethyl phthalate
  • www.atsdr.cdc.gov/toxprofiles/tp135.pdf Agency for Toxic Substances and Disease Registry. 2001. Di-n-butylphthalate
  • www.atsdr.cdc.gov/toxprofiles/tp9.pdf Agency for Toxic Substances and Disease Registry. 2002. Toxicological profile for di(2-ethylhexyl) phthalate
  • AkingbemiB. T.KlinefelterG. R.ZirkinB. R.HardyM. P.Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbancesProc. Natl. Acad. Sci. USA.2004101775780
  • AutianJ.Toxicity and health threats of phthalate esters: Review of the literatureEnviron. Health Perspect.19734326
  • BarrosoG.MorshediM.OehningerS.Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoaHum. Reprod.20001513381344
  • BlountB. C.MilgramK. E.SilvaM. J.MalekN. A.ReidyJ. A.NeedhamL. L.BrockJ. W.Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MSAnal. Chem.20007241274134
  • BradburyJ.UK panics over phthalates in baby milk formulaeLancet19963471541
  • CavaliereB.MacchioneB.SindonaG.TagarelliA.Tandem mass spectrometry in food safety assessment: The determination of phthalates in olive oilJ. Chromatogr. A.20081205137143
  • ChoiS. M.YooS. D.LeeB. M.Toxicological characteristics of endocrine-disrupting chemicals: Developmental toxicity, carcinogenicity, and mutagenicityJ. Toxicol. Environ. Health B20047124
  • CortonJ. C.LapinskasP. J.Peroxisome proliferator-activated receptors: Mediators of phthalate ester-induced effects in the male reproductive tractToxicol. Sci.200583417
  • DeRosaC.RichterP.PohlH.JonesD. E.Environmental exposures that affect the endocrine system: Public health implicationsJ. Toxicol. Environ. Health B19981326
  • DutyS. M.SilvaM. J.BarrD. B.BrockJ. W.RyanL.ChenZ.HerrickR. F.ChristianiD. C.HauserR.Phthalate exposure and human semen parametersEpidemiology2003a14269277
  • DutyS. M.SinghN. P.SilvaM. J.BarrD. B.BrockJ. W.RyanL.HerrickR. F.ChristianiD. C.HauserR.The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assayEnviron. Health Perspect.2003b11111641169
  • EmaM.Antiandrogenic effects of dibutyl phthalate and its metabolite, Mono-butyl phthalate, in ratsCongenit. Anomolies200242297308
  • EmaM.HarazonoA.MiyawakiE.OgawaY.Developmental effects of di-n-butyl phthalate after a single administration in ratsJ.Appl. Toxicol.199717223229
  • EmaM.MiyawakiE.Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancyReprod. Toxicol.200115189194
  • GrayL. E.JrOstbyJ.FurrJ.PriceM.VeeramachaneniD. N.ParksL.Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male ratToxicol. Sci.200058350365
  • GorczycaW.TraganosF.JesionowskaH,.DarynkiewiczPresence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: Analogy to apoptosis of somatic cellsExp. Cell Res.1993207202205
  • HashizumeKNanyaJ.TodaC.YasuiT.NaganoH.KojimaN.Phthalate esters detected in various water samples and biodegradation of the phthalates by microbes isolated from river waterBiol. Pharm. Bull.200225209214
  • HauserR.MeekerJ. D.DutyS.SilvaM. J.CalafatA. M.Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolitesEpidemiology200617682691
  • HauserR.Urinary phthalate metabolites and semen quality: A review of a potential biomarker of susceptibilityInt. J. Androl.200831112117
  • HauserR.MeekerJ. D.SinghN. P.SilvaM. J.RyanL.DutyS.CalafatA. M.DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolitesHum. Reprod.200722688695
  • HeindelJ. J.ChapinR. E.Inhibition of FSH-stimulated camp accumulation by mono (2-ethylhexyl) phthalate in primary rat Sertoli cell culturesToxicol. Appl. Pharmacol.198997377385
  • HeindelJ. J.PowellC. J.Phthalate ester effects on rat Sertoli cell function in vitro: Effects of phthalate side chain and age of animalToxicol. Appl. Pharmacol.1992115116123
  • JoblingS.ReynoldsT.WhiteJ. A.ParkerM. G.SumpterJ. P.A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenicEnviron. Health Perspect.1995103582587
  • JonssonB. A.RichthoffJ.RylanderL.GiwercmanA.HagmarL.Urinary phthalate metabolites and biomarkers of reproductive function in young menEpidemiology200516487493
  • KasaharaE.SatoE. F.MiyoshiM.KonakaR.HiramotoK.SasakiJ.TokudaM.NakanoY.InoueM.Role of oxidative stress in germ cell apoptosis induced by di (2-ethylhexyl) phthalateBiochem. J.2002365849856
  • KavlockR.BoekelheideK.ChapinR.CunninghamM.FaustmanE.FosterP.GolubM.HendersonR.HinbergI.LittleR.SeedJ.SheaK.TabacovaS.TylR.WilliamsP.ZacharewskiT.NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalateReprod. Toxicol.200216453487
  • KesslerW.PhokhaW.CsanadyC.FilserJ.No background concentrations of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in blood of ratsArch. Toxicol.2001756264
  • KesslerW.NumtipW.GroteK.CsanadyG. A.ChahoudI.FilserJ. G.Blood burden of di(2-ethylhexyl) phthalate and its primary metabolite mono(2-ethylhexyl) phthalate in pregnant and nonpregnant rats and marmosetsToxicol. Appl. Pharmacol.2004195142153
  • KooH. J.LeeB. M.Estimated exposure to phthalates in cosmetics and risk assessmentJ. Toxicol. Environ. Health A20046719011914
  • KooH. J.LeeB. M.Human monitoring of phthalates and risk assessmentJ. Toxicol. Environ. Health A20056813791392
  • KooJ. W.ParhamF.KohnM. C.MastenS. A.BrockJ. W.NeedhamL. L.PortierC. J.The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference populationEnviron. Health Perspect2002110405410
  • KurataY.KidachiF.YokoyamaM.ToyotaN.TsuchitaniM.KatohM.Subchronic toxicity of Di(2-ethylhexyl)phthalate in common marmosets: Lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasiaToxicol. Sci.1998424956
  • LatiniG.Monitoring phthalate exposure in humansClin. Chim. Acta20053612029
  • LatiniG.De FeliceC.PrestaG.Del VecchioA.ParisI.RuggireiF.MazzeoP.In utero exposure to di(2-ethylhexyl)phthalate and duration of human pregnancyEnviron. Health Perspect.200311117831785
  • LeeB. M.KooH. J.Hershberger assay for antiandrogenic effects of phthalatesJ. Toxicol. Environ. Health A20077013651370
  • LiL. H.JesterW. F.OrthJ. M.Effects of relatively low levels of mono(2 ethylhexyl)phthalate on cocultured Sertoli cells and gonocytes from neonatal ratsToxicol. Appl. Pharmacol.1998153258265
  • LimD. S.ShinB. S.YooS. D.KimH. S.KwackS. J.AhnM. Y.LeeB. M.Toxicokinetics of phthalic acid: the common final metabolite of phthalic acid esters in ratsJ. Toxicol. Environ. Health A.20077013441349
  • LloydS. C.FosterP. M.Effect of mono-(2-ethylhexyl) phthalate on follicle-stimulating hormone responsiveness of cultured rat Sertoli cellToxicol. Appl. Pharmacol.198895484489
  • MettangT.ThomasS.KieferT.FischerF. P.KuhlmannU.WodarzR.RettenmeierA. W.The fate of leached di(2-ethylhexyl)phthalate (DEHP) in patients undergoing CAPD treatmentPerit. Dial. Int.19961614
  • NässbergerL.ArbinA.ÖsteliusJ.Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysisNephron198745286290
  • OlleroM.Gil-GuzmanE.LopezM. C.SharmaR. K.AgarwalA.LarsonK.EvensonD.ThomasA. J.Jr.AlvarezJ. G.Characterization of subsets of human spermatozoa at different stages of maturation: Implications in the diagnosis and treatment of male infertilityHum. Reprod.20011619121921
  • PantN.ShuklaM.KumarP. DShuklaY.MathurN.KumarG. Y.SaxenaD. K.Correlation of phthalate exposures with semen qualityToxicol. Appl. Pharmacol.2008231112116
  • PollackG. M.BuchananJ. F.SlaughterR. L.KohliR. K.ShenD. D.Circulating concentrations of di(2-ethylhexyl)phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysisToxicol. Appl. Pharmacol.198579257267
  • PoonR.LecavalierP.MuellerR.ValliV. E.ProcterB. G.ChuI.Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl)phthalate in the ratFood Chem. Toxicol.199735225239
  • PughG.JrIsenbergJ. S.KamendulisL. M.AckleyD. C.ClareL. J.BrownR.LingtonA. W.SmithJ. H.KlaunigJ. E.Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeysToxicol. Sci200056181188
  • RichburgJ. H.BoekelheideK.Mono-(2-ethylhexyl)phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testesToxicol. Appl. Pharmacol.19961374250
  • SatohK.NonakaR.IkedaM.SatohT.KamimuraH.NagaiF.Study on androgenic and anti-androgenic effects of phthalate esters with the reporter gene assay using AR-EcoScreen, stable transfected CHO-K1 cellsAnn. Rep. Tokyo Metr. Inst. Ph.200455307314
  • SchettlerT.Human exposure to phthalates via consumer productsInt. J. Androl.200629134139
  • SilvaM. J.BarrD. B.ReidyJ. A.KatoK.MalekN. A.HodgeC. C.HurtzD.3rdCalafatA. M.NeedhamL. L.BrockJ. W.Glucuronidation patterns of common urinary and serum monoester phthalate metabolitesArch. Toxicol200377561567
  • SilvaM. J.ReidyJ. A.PreauJ. L.SamandarE.NeedhamL. L.CalafatA. M.Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessmentBiomarker200611113
  • WilliamsJ.FosterP. M.The production of lactate and pyruvate sensitive indices of altered rat Sertoli cell function in vitro following the addition of various testicular toxicantsToxicol. Appl. Pharmacol.198894160170
  • WongJ. S.GillS. S.Gene expression changes induced in mouse liver by di(2-ethylhexyl)phthalateToxicol. Appl. Pharmacol.2002185160196
  • ZhangY. H.ChenB. H.ZhengL. X.WuX. Y.Study on the level of phthalates in human biological samplesZhonghua Yu Fang Yi Xue Za Zhi200337429434
  • ZhangY.JiangX.ChenB.Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAELReprod. Toxicol200418669676
  • ZhangY. H.ZhengL. X.ChenB. H.Phthalate exposure and human semen quality in Shanghai: A cross-sectional studyBiomed. Enrviron. Sci.200619205209

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.