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Original Articles

A Prospective Blinded Evaluation of Urinary Porphyrins Verses the Clinical Severity of Autism Spectrum Disorders

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Pages 1585-1591 | Received 18 Feb 2009, Accepted 12 Jun 2009, Published online: 02 Nov 2009

REFERENCES

  • Adams, J. B., Romdalvik, J., Levine, K. E., and Hu, L. W., 2008. Mercury in first-cut baby hair of children with autism vs. typically developing children, Toxicol. Environ. Chem. 90 (2008), pp. 739–753.
  • Adams, J. B., Romdalvik, J., Ramanujam, V. M., and Legator, M. S., 2007. Mercury, lead, and zinc in baby teeth of children with autism versus controls, J. Toxicol. Environ. Health A 70 (2007), pp. 1046–1051.
  • Austin, D. W., and Shandley, K., 2008. An investigation of porphyrinuria in Australian children with autism, J. Toxicol. Environ. Health A 71 (2008), pp. 1349–1351.
  • Bradstreet, J., Geier, D. A., Kartzinel, J. J., Adams, J. B., and Geier, M. R., 2003. A case-control study of mercury burden in children with autistic spectrum disorders, J. Am. Phys. Surg. 8 (2003), pp. 76–79.
  • Brewster, M. A., 1988. Biomarkers of xenobiotic exposures, Ann. Clin. Lab. Sci. 18 (1988), pp. 306–317.
  • Daniell, W. E., Stockbridge, H. L., Labbe, R. F., Woods, J. S., Anderson, K. E., Bissell, D. M., Bloomer, J. R., Ellefson, R. D., Moore, M. R., Pierach, C. A., Schreiber, W. E., Tefferi, A., and Franklin, G. M., 1997. Environmental chemical exposures and disturbances of heme synthesis, Environ. Health Perspect. 105 (suppl. 1) (1997), pp. 37–53.
  • DeSoto, M. C., and Hitlan, R. T., 2007. Blood levels of mercury are related to diagnosis of autism: A reanalysis of an important data set, J. Child Neurol. 22 (2007), pp. 1308–1311.
  • Echeverria, D., Heyer, N. J., Martin, M. D., Naleway, C. A., Woods, J. S., and Bittner, A. C., 1995. Behavioral effects of low-level exposure to elemental Hg among dentists, Neurotoxicol. Teratol. 17 (1995), pp. 161–168.
  • Fido, A., and Al-Saad, S., 2005. Toxic trace elements in the hair of children with autism, Autism 9 (2005), pp. 290–298.
  • Geier, D. A., and Geier, M. R., 2006. A prospective assessment of porphyrins in autistic disorders: A potential marker for heavy metal exposure, Neurotoxicol. Res. 10 (2006), pp. 57–64.
  • Geier, D. A., and Geier, M. R., 2007a. A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders, J. Toxicol. Environ. Health A 70 (2007a), pp. 837–851.
  • Geier, D. A., and Geier, M. R., 2007b. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders, J. Toxicol. Environ. Health A 70 (2007b), pp. 1723–1730.
  • Geier, D. A., Kern, J. K., Garver, C. R., Adams, J. B., Audhya, T., Nataf, R., and Geier, M. R., 2009. Biomarkers of environmental toxicity and susceptibility in autism, J. Neurol. Sci. 280 (2009), pp. 101–108.
  • Gonzalez-Ramirez, D., Maiorino, R. M, Zuniga-Charles, M., Xu, Z., Hurlbut, K. M., Junco-Munoz, P., Asposhian, M. M., Dart, R. C., Diaz Gama, J. H, Echeveria, D., Woods, J. S., and Aposhian, H. V., 1995. Sodium 2,3-dimercaptopropane-1-sulfonate challenge test for mercury in humans: II. Urinary mercury, porphyrins and neurobehavioral changes of dental workers in Monterrey, Mexico, J. Pharmacol. Exp. Ther. 272 (1995), pp. 264–274.
  • Heyer, N. J., Bittner, A. C., Echeverria, D., and Woods, J. S., 2006. A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production, Toxicol. Lett. 161 (2006), pp. 159–166.
  • Holmes, A. S., Blaxill, M. F., and Haley, B. E., 2003. Reduced levels of mercury in first baby haircuts of autistic children, Int. J. Toxicol. 22 (2003), pp. 277–285, .
  • Nataf, R., Skorupka, C., Amet, L., Lam, A., Springbett, A., and Lathe, R., 2006. Porphyinuria in childhood autistic disorder: Implications for environmental toxicity, Toxicol. Appl. Pharmacol. 214 (2006), pp. 99–108.
  • Nataf, R., Skorupka, C., Lam, A., Springbett, A., and Lathe, R., 2008. Porphyrinuria in childhood autistic disorder is not associated with urinary creatinine deficiency, Pediat. Int. 50 (2008), pp. 528–532.
  • Pingree, S. D., Simmonds, P. L., Rummel, K. T., and Woods, J. S., 2001. Quantitative evaluation of urinary porphryins as a measure of kidney mercury content and mercury body burden during prolonged methlmercury exposure in rats, Toxicol. Sci. 61 (2001), pp. 234–240.
  • Rosen, J. F., and Markowitz, M. E., 1993. Trends in the management of childhood lead poisonings, Neurotoxicology 14 (1993), pp. 211–217.
  • Sajdel-Sulkowska, E. M., Lipinski, B., Windom, H., Audhya, T., and McGinnis, W., 2008. Oxidative stress in autism: Elevated cerebellar 3-nitrotyrosine levels, Am. J. Biochem. Biotechnol. 4 (2008), pp. 73–84.
  • Schopler, E., Reichler, R. J., DeVellis, R. F., and Daly, K., 1980. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS), J. Autism Dev. Dis. 10 (1980), pp. 91–103.
  • Woods, J. S., 1995. "Porphyrin metabolism as indicator of metal exposure and toxicity". In: Goyer, R. A., and Cherian, M. G., eds. Handbook of experimental pharmacology: Toxicology of metals—Biochemical aspects. Vol. 115. Berlin: Springer-Verlag; 1995. pp. 15–92.
  • Woods, J. S., 1996. Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity, Can. J. Physiol. Pharmacol. 74 (1996), pp. 210–215.
  • Woods, J. S., Echeverria, D., Heyer, N. J., Simmonds, P. L., Wilkerson, J., and Farin, F. M., 2005. The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans, Toxicol. Appl. Pharmacol. 206 (2005), pp. 113–120.
  • Woods, J. S., and Kardish, R. M., 1983. Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity-II. Studies on uroporphyrinogen decarboxylase, Biochem. Pharmacol. 32 (1983), pp. 73–78.
  • Woods, J. S., Martin, M. D., Naleway, C. A., and Echeverria, D., 1993. Urinary porphyrin profiles as a biomarker of mercury exposure: Studies on dentists with occupational exposure to mercury vapor, J. Toxicol. Environ. Health 40 (1993), pp. 235–246.

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