163
Views
25
CrossRef citations to date
0
Altmetric
Original Articles

Utilization of Gene Profiling and Proteomics to Determine Mineral Pathogenicity in a Human Mesothelial Cell Line (LP9/TERT-1)

, , , , &
Pages 423-436 | Published online: 12 Feb 2010

REFERENCES

  • Amati , M. , Tomasetti , M. , Mariotti , L. , Tarquini , L. M. , Valentino , M. and Santarelli , L. 2008 . Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk . Mutat Res , 655 ( 1–2 ) : 52 – 58 .
  • Aoe , K. , Hiraki , A. , Tanaka , T. , Gemba , K. , Taguchi , K. , Murakami , T. , Sueoka , N. , Kamei , T. , Ueoka , H. , Sugi , K. , Yoshino , T. and Kishimoto , T. 2006 . Expression of vascular endothelial growth factor in malignant mesothelioma . Anticancer Res. , 26 ( 6C ) : 4833 – 4836 .
  • Belitskaya-Levy , I. , Hajjou , M. , Su , W. C. , Yie , T. A. , Tchou-Wong , K. M. , Tang , M. S. , Goldberg , J. D. and Rom , W. N. 2007 . Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE) . J. Environ. Pathol. Toxicol. Oncol. , 26 ( 4 ) : 281 – 294 .
  • Bolstad , B. M. , Irizarry , R. A. , Astrand , M. and Speed , T. P. 2003 . A comparison of normalization methods for high density oligonucleotide array data based on variance and bias . Bioinformatics , 19 ( 2 ) : 185 – 193 .
  • Bremnes , R. M. , Camps , C. and Sirera , R. 2006 . Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood . Lung Cancer , 51 ( 2 ) : 143 – 158 .
  • Buder-Hoffmann , S. A. , Shukla , A. , Barrett , T. F. , Macpherson , M. B. , Lounsbury , K. M. and Mossman , B. T. 2008 . A protein kinase C{delta}-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos . Am J Pathol , 174 ( 2 ) : 449 – 459 .
  • Catalano , A. , Gianni , W. and Procopio , A. 2004 . Experimental therapy of malignant mesothelioma: New perspectives from anti-angiogenic treatments . Crit. Rev. Oncol. Hematol. , 50 ( 2 ) : 101 – 109 .
  • Choi , J. H. , Choi , K. C. , Auersperg , N. and Leung , P. C. 2004 . Overexpression of follicle-stimulating hormone receptor activates oncogenic pathways in preneoplastic ovarian surface epithelial cells . J. Clin. Endocrinol. Metab. , 89 ( 11 ) : 5508 – 5516 .
  • Committee on Asbestos: Selected Health Effects . 2006 . Asbestos: Selected cancers , Edited by: North American Institute of Medicine . Washington, DC : National Academies Press .
  • Davidson , B. , Risberg , B. , Berner , A. , Bedrossian , C. W. and Reich , R. 2006 . The biological differences between ovarian serous carcinoma and diffuse peritoneal malignant mesothelioma . Semin. Diagn. Pathol. , 23 ( 1 ) : 35 – 43 .
  • Davidson , B. , Vintman , L. , Zcharia , E. , Bedrossian , C. , Berner , A. , Nielsen , S. , Ilan , N. , Vlodavsky , I. and Reich , R. 2004 . Heparanase and basic fibroblast growth factor are coexpressed in malignant mesothelioma . Clin. Exp. Metastasis , 21 ( 5 ) : 469 – 476 .
  • Demetri , G. D. , Zenzie , B. W. , Rheinwald , J. G. and Griffin , J. D. 1989 . Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro . Blood , 74 ( 3 ) : 940 – 946 .
  • Dickson , M. A. , Hahn , W. C. , Ino , Y. , Ronfard , V. , Wu , J. Y. , Weinberg , R. A. , Louis , D. N. , Li , F. P. and Rheinwald , J. G. 2000 . Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics . Mol. Cell Biol. , 20 ( 4 ) : 1436 – 1447 .
  • Donaldson , K. , Li , X. Y. , Dogra , S. , Miller , B. G. and Brown , G. M. 1992 . Asbestos-stimulated tumour necrosis factor release from alveolar macrophages depends on fibre length and opsonization . J. Pathol. , 168 ( 2 ) : 243 – 248 .
  • Dostert , C. , Petrilli , V. , Van Bruggen , R. , Steele , C. , Mossman , B. T. and Tschopp , J. 2008 . Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica . Science , 320 ( 5876 ) : 674 – 677 .
  • Elias , J. A. , Lee , C. G. , Zheng , T. , Shim , Y. and Zhu , Z. 2003 . Interleukin-13 and leukotrienes: An intersection of pathogenetic schema . Am. J. Respir. Cell Mol. Biol. , 28 ( 4 ) : 401 – 404 .
  • Hansen , K. and Mossman , B. T. 1987 . Generation of superoxide (O2 -.) from alveolar macrophages exposed to asbestiform and nonfibrous particles . Cancer Res. , 47 ( 6 ) : 1681 – 1686 .
  • Hansen , S. F. , Michelson , E. S. , Kamper , A. , Borling , P. , Stuer-Lauridsen , F. and Baun , A. 2008 . Categorization framework to aid exposure assessment of nanomaterials in consumer products . Ecotoxicology , 17 ( 5 ) : 438 – 447 .
  • Hevel , J. M. , Olson-Buelow , L. C. , Ganesan , B. , Stevens , J. R. , Hardman , J. P. and Aust , A. E. 2008 . Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions . BMC Genomics , 9 : 376
  • Irizarry , R. A. , Bolstad , B. M. , Collin , F. , Cope , L. M. , Hobbs , B. and Speed , T. P. 2003 . Summaries of Affymetrix GeneChip probe level data . Nucleic Acids Res. , 31 ( 4 ) : e15
  • Irizarry, R. A., Gautier, L., Bolstad, B. M., Miller, C., Astrand, M., Cope, L. M., Gentleman, R., Gentry, J., Halling, C., Huber, W., MacDonald, J., Rubinstein, B. I. P., Workman, C., and Zhang, J. 2007. affy: Methods for Affymetrix Oligonucleotide Arrays. 1.14.1 (R package version) http://www.bioconductor.org
  • Iwakawa , M. , Hamada , N. , Imadome , K. , Funayama , T. , Sakashita , T. , Kobayashi , Y. and Imai , T. 2008 . Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells . Mutat. Res. , 642 ( 1–2 ) : 57 – 67 .
  • Janssen , Y. M. , Heintz , N. H. and Mossman , B. T. 1995 . Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells . Cancer Res. , 55 ( 10 ) : 2085 – 2089 .
  • Jolliffe , I. 1986 . Principal component analysis , New York : Springer Verlag .
  • Kamp , D. W. and Weitzman , S. A. 1999 . The molecular basis of asbestos induced lung injury . Thorax , 54 ( 7 ) : 638 – 652 .
  • Karoly , E. D. , Li , Z. , Dailey , L. A. , Hyseni , X. and Huang , Y. C. 2007 . Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure . Environ. Health Perspect. , 115 ( 4 ) : 535 – 540 .
  • Kasuga , I. , Ishizuka , S. , Minemura , K. , Utsumi , K. , Serizawa , H. and Ohyashiki , K. 2001 . Malignant pleural mesothelioma produces functional granulocyte-colony stimulating factor . Chest , 119 ( 3 ) : 981 – 983 .
  • Kimura , N. , Ogasawara , T. , Asonuma , S. , Hama , H. , Sawai , T. and Toyota , T. 2005 . Granulocyte-colony stimulating factor- and interleukin 6-producing diffuse deciduoid peritoneal mesothelioma . Mod. Pathol. , 18 ( 3 ) : 446 – 450 .
  • Kindler , H. L. 2004 . Moving beyond chemotherapy: Novel cytostatic agents for malignant mesothelioma . Lung Cancer , 45 ( suppl. 1 ) : S125 – S127 .
  • Kong , W. , Vanderburg , C. , Gunshin , H. , Rogers , J. and Huang , X. 2008 . A review of independent component analysis application to microarray gene expression data . Biotechniques , 45 ( 5 ) : 501 – 520 .
  • Kumar-Singh , S. , Weyler , J. , Martin , M. J. , Vermeulen , P. B. and Van Marck , E. 1999 . Angiogenic cytokines in mesothelioma: A study of VEGF, FGF-1 and -2, and TGF beta expression . J. Pathol. , 189 ( 1 ) : 72 – 78 .
  • Lake , R. A. and Robinson , B. W. 2005 . Immunotherapy and chemotherapy—A practical partnership . Nat Rev Cancer , 5 ( 5 ) : 397 – 405 .
  • Lee , P. J. , Zhang , X. , Shan , P. , Ma , B. , Lee , C. G. , Homer , R. J. , Zhu , Z. , Rincon , M. , Mossman , B. T. and Elias , J. A. 2006 . ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo . J. Clin. Invest. , 116 ( 1 ) : 163 – 173 .
  • Lemaire , I. and Ouellet , S. 1996 . Distinctive profile of alveolar macrophage-derived cytokine release induced by fibrogenic and nonfibrogenic mineral dusts . J. Toxicol. Environ. Health , 47 ( 5 ) : 465 – 478 .
  • Linder , C. , Linder , S. , Munck-Wikland , E. and Strander , H. 1998 . Independent expression of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with carcinoma and sarcoma . Anticancer Res. , 18 ( 3B ) : 2063 – 2068 .
  • Liu , J. Y. , Brass , D. M. , Hoyle , G. W. and Brody , A. R. 1998 . TNF-alpha receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers . Am. J. Pathol. , 153 ( 6 ) : 1839 – 1847 .
  • Lund , L. G. and Aust , A. E. 1992 . Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand breaks in phi X174 RFI DNA . Carcinogenesis , 13 ( 4 ) : 637 – 642 .
  • Lund , L. G. , Williams , M. G. , Dodson , R. F. and Aust , A. E. 1994 . Iron associated with asbestos bodies is responsible for the formation of single strand breaks in phi X174 RFI DNA . Occup. Environ. Med. , 51 ( 3 ) : 200 – 204 .
  • Manning , C. B. , Vallyathan , V. and Mossman , B. T. 2002 . Diseases caused by asbestos: Mechanisms of injury and disease development . Int. Immunopharmacol. , 2 ( 2–3 ) : 191 – 200 .
  • Masood , R. , Kundra , A. , Zhu , S. , Xia , G. , Scalia , P. , Smith , D. L. and Gill , P. S. 2003 . Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops . Int. J. Cancer , 104 ( 5 ) : 603 – 610 .
  • Merritt , M. A. , Green , A. C. , Nagle , C. M. and Webb , P. M. 2008 . Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer . Int. J. Cancer , 122 ( 1 ) : 170 – 176 .
  • Miyazaki , Y. , Araki , K. , Vesin , C. , Garcia , I. , Kapanci , Y. , Whitsett , J. A. , Piguet , P. F. and Vassalli , P. 1995 . Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis . J. Clin. Invest. , 96 ( 1 ) : 250 – 259 .
  • Mossman , B. T. , Bignon , J. , Corn , M. , Seaton , A. and Gee , J. B. 1990 . Asbestos: Scientific developments and implications for public policy . Science , 247 ( 4940 ) : 294 – 301 .
  • Mossman , B. T. and Churg , A. 1998 . Mechanisms in the pathogenesis of asbestosis and silicosis . Am. J. Respir. Crit. Care Med. , 157 ( 5 Pt 1 ) : 1666 – 1680 .
  • Mossman , B. T. and Gee , J. B. 1989 . Asbestos-related diseases . N. Engl. J. Med. , 320 ( 26 ) : 1721 – 1730 .
  • Muramatsu , T. and Muramatsu , H. 2008 . Glycosaminoglycan-binding cytokines as tumor markers . Proteomics , 8 ( 16 ) : 3350 – 3359 .
  • Nishimura , M. , Itoh , K. , Ito , K. , Yanada , M. , Terauchi , K. , Fushiki , S. and Shimada , J. 2006 . Autocrine growth by granulocyte colony-stimulating factor in malignant mesothelioma . Ann. Thoracic Surg. , 82 ( 5 ) : 1904 – 1906 .
  • Nowak , A. K. , Lake , R. A. , Kindler , H. L. and Robinson , B. W. 2002 . New approaches for mesothelioma: Biologics, vaccines, gene therapy, and other novel agents . Semin. Oncol. , 29 ( 1 ) : 82 – 96 .
  • Nymark , P. , Lindholm , P. M. , Korpela , M. V. , Lahti , L. , Ruosaari , S. , Kaski , S. , Hollmen , J. , Anttila , S. , Kinnula , V. L. and Knuutila , S. 2007 . Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines . BMC Genomics , 8 : 62
  • Ohbayashi , H. , Nosaka , H. , Hirose , K. , Yamase , H. , Yamaki , K. and Ito , M. 1999 . Granulocyte colony stimulating factor-producing diffuse malignant mesothelioma of pleura . Intern. Med. , 38 ( 8 ) : 668 – 670 .
  • R Development Core Team. 2007. R: A language and environment for statistical computing. R Foundation for Statistical omputing. Available at http://cran.r-project.org/doc/manuals/refman.pdf
  • Ramos-Nino , M. E. , Heintz , N. , Scappoli , L. , Martinelli , M. , Land , S. , Nowak , N. , Haegens , A. , Manning , B. , Manning , N. , MacPherson , M. , Stern , M. and Mossman , B. 2003 . Gene profiling and kinase screening in asbestos-exposed epithelial cells and lungs . Am. J. Respir. Cell Mol. Biol. , 29 ( 3 suppl ) : S51 – S58 .
  • Reid , A. , Segal , A. , Heyworth , J. S. , de Klerk , N. H. and Musk , A. W. 2009 . Gynecologic and breast cancers in women after exposure to blue asbestos at Wittenoom . Cancer Epidemiol. Biomarkers Prev. , 18 ( 1 ) : 140 – 147 .
  • Robledo , R. and Mossman , B. 1999 . Cellular and molecular mechanisms of asbestos-induced fibrosis . J. Cell Physiol. , 180 ( 2 ) : 158 – 166 .
  • Ruco , L. P. , de Laat , P. A. , Matteucci , C. , Bernasconi , S. , Sciacca , F. M. , van der Kwast , T. H. , Hoogsteden , H. C. , Uccini , S. , Mantovani , A. and Versnel , M. A. 1996 . Expression of ICAM-1 and VCAM-1 in human malignant mesothelioma . J. Pathol. , 179 ( 3 ) : 266 – 271 .
  • Ruosaari , S. , Hienonen-Kempas , T. , Puustinen , A. , Sarhadi , V. K. , Hollmen , J. , Knuutila , S. , Saharinen , J. , Wikman , H. and Anttila , S. 2008 . Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients . BMC Med. Genomics , 1 : 55
  • Sabo-Attwood , T. , Ramos-Nino , M. , Bond , J. , Butnor , K. J. , Heintz , N. , Gruber , A. D. , Steele , C. , Taatjes , D. J. , Vacek , P. and Mossman , B. T. 2005 . Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis . Am. J. Pathol. , 167 ( 5 ) : 1243 – 1256 .
  • Schmitter , D. , Lauber , B. , Fagg , B. and Stahel , R. A. 1992 . Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines: Interleukin-6 production as a common feature . Int. J. Cancer , 51 ( 2 ) : 296 – 301 .
  • Schulte , P. , Geraci , C. , Zumwalde , R. , Hoover , M. and Kuempel , E. 2008 . Occupational risk management of engineered nanoparticles . J. Occup. Environ. Hyg. , 5 ( 4 ) : 239 – 249 .
  • Shukla , A. , Flanders , T. , Lounsbury , K. M. and Mossman , B. T. 2004 . The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity . Cancer Res. , 64 ( 21 ) : 7780 – 7786 .
  • Shukla , A. , Jung , M. , Stern , M. , Fukagawa , N. K. , Taatjes , D. J. , Sawyer , D. , Van Houten , B. and Mossman , B. T. 2003a . Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis . Am. J. Physiol. Lung Cell. Mol. Physiol. , 285 ( 5 ) : L1018 – L1025 .
  • Shukla , A. , Lounsbury , K. M. , Barrett , T. F. , Gell , J. , Rincon , M. , Butnor , K. J. , Taatjes , D. J. , Davis , G. S. , Vacek , P. , Nakayama , K. I. , Nakayama , K. , Steele , C. and Mossman , B. T. 2007 . Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C‐delta knockout mice . Am. J. Pathol. , 170 ( 1 ) : 140 – 151 .
  • Shukla , A. , Macpherson , M. B. , Hillegass , J. , Ramos-Nino , M. E. , Alexeeva , V. , Vacek , P. M. , Bond , J. P. , Pass , H. I. , Steele , C. and Mossman , B. T. 2008 . Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity . Am. J. Respir. Cell Mol. Biol. , 41 ( 1 ) : 114 – 123 .
  • Shukla , A. , Stern , M. , Lounsbury , K. M. , Flanders , T. and Mossman , B. T. 2003b . Asbestos-induced apoptosis is protein kinase C delta-dependent . Am. J. Respir. Cell Mol. Biol. , 29 ( 2 ) : 198 – 205 .
  • Simeonova , P. P. and Luster , M. I. 1995 . Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages . Am. J. Respir. Cell Mol. Biol. , 12 ( 6 ) : 676 – 683 .
  • Smyth , G. K. 2004 . Linear models and empirical Bayes methods for assessing differential expression in microarray experiments . Stat. Appl. Genet. Mol. Biol. , 3 article 3
  • Smyth , G. K. 2005 . “ Limma: Linear models for microarray data ” . In Bioinformatics and computational biology solutions using R and Bioconductor , Edited by: Gentleman , R. , Carey , V. , Dudoit , S. , Irizarry , R. and Huber , W. New York : Springer . pp. 397–420
  • Steiner , G. , Suter , L. , Boess , F. , Gasser , R. , de Vera , M. C. , Albertini , S. and Ruepp , S. 2004 . Discriminating different classes of toxicants by transcript profiling . Environ. Health Perspect. , 112 ( 12 ) : 1236 – 1248 .
  • Stevens , T. , Krantz , Q. T. , Linak , W. P. , Hester , S. and Gilmour , M. I. 2008 . Increased transcription of immune and metabolic pathways in naive and allergic mice exposed to diesel exhaust . Toxicol. Sci. , 102 ( 2 ) : 359 – 370 .
  • Strizzi , L. , Catalano , A. , Vianale , G. , Orecchia , S. , Casalini , A. , Tassi , G. , Puntoni , R. , Mutti , L. and Procopio , A. 2001 . Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma . J. Pathol. , 193 ( 4 ) : 468 – 475 .
  • Terabe , M. , Park , J. M. and Berzofsky , J. A. 2004 . Role of IL-13 in regulation of anti-tumor immunity and tumor growth . Cancer Immunol. Immunother. , 53 ( 2 ) : 79 – 85 .
  • Vallyathan , V. , Mega , J. F. , Shi , X. and Dalal , N. S. 1992 . Enhanced generation of free radicals from phagocytes induced by mineral dusts . Am. J. Respir. Cell Mol. Biol. , 6 ( 4 ) : 404 – 413 .
  • Wang , Y. , Faux , S. P. , Hallden , G. , Kirn , D. H. , Houghton , C. E. , Lemoine , N. R. and Patrick , G. 2004 . Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite . Int. J. Oncol. , 25 ( 1 ) : 173 – 178 .
  • Worley , L. A. , Long , M. D. , Onken , M. D. and Harbour , J. W. 2008 . Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling . Melanoma Res. , 18 ( 3 ) : 184 – 190 .
  • Yang , H. , Testa , J. R. and Carbone , M. 2008 . Mesothelioma epidemiology, carcinogenesis, and pathogenesis . Curr. Treat. Options Oncol. , 9 ( 2–3 ) : 147 – 157 .
  • Yoshimoto , A. , Kasahara , K. , Saito , K. , Fujimura , M. and Nakao , S. 2005 . Granulocyte colony-stimulating factor-producing malignant pleural mesothelioma with the expression of other cytokines . Int. J. Clin. Oncol. , 10 ( 1 ) : 58 – 62 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.