Effects of Gut Microflora on Pharmacokinetics of Hesperidin: A Study on Non-Antibiotic and Pseudo-Germ-Free Rats

REFERENCES

• Ameer , B. , Weintraub , R. A. , Johnson , J. V. , Yost , R. A. and Rouseff , R. L. 1996 . Flavanone absorption after naringin, hesperidin, and citrus administration . Clin. Pharmacol. Ther. , 60 : 34 – 40 .
   PubMed Web of Science ®Google Scholar
• Booth , A. N. , Jones , F. T. and Deeds , F. 1958 . Metabolic fate of hesperidin, eriodictyol, homoeridictyol, and diosmin . J. Biol. Chem. , 230 : 661 – 668 .
   PubMed Web of Science ®Google Scholar
• Chiba , H. , Uehara , M. and Wu , J. 2003 . Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice . J. Nutr. , 133 : 1892 – 1897 .
   PubMed Web of Science ®Google Scholar
• Choudhury , R. , Srai , S. K. , Debnam , E. and Rice-Evans , C. A. 1999 . Urinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration . Free Radical Biol. Med. , 27 : 278 – 286 .
   PubMed Web of Science ®Google Scholar
• Emim , J. A. , Oliveira , A. B. and Lapa , A. J. 1994 . Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice . J. Pharm. Pharmacol. , 46 : 118 – 122 .
   PubMed Web of Science ®Google Scholar
• Felgines , C. , Texler , O. , Morand , C. , Manach , C. , Scalbert , A. , Régérat , F. and Rémésy , C. 2000 . Bioavailability of the flavanone naringenin and its glycosides in rats . Am. J. Physiol. Gastrointest. Liver Physiol. , 279 : 1148 – 1154 .
   PubMed Web of Science ®Google Scholar
• Galati , E. M. , Monforte , M. T. , Kirjavainen , S. , Forestieri , A. M. , Trovato , A. and Tripodo , M. M. 1994 . Biological effects of hesperidin, a citrus flavonoid. (Note I): Antiinflammatory and analgesic activity . Farmacologie , 40 : 709 – 712 .
   PubMedGoogle Scholar
• Garg , A. , Garg , S. , Zaneveld , L. J. D. and Singla , A. K. 2001 . Chemistry and pharmacology of the citrus bioflavonoid hesperidin . Phytother. Res. , 15 : 655 – 669 .
   PubMed Web of Science ®Google Scholar
• Griffiths , L. A. and Borrow , A. 1972 . Metabolism of flavonoid compounds in germ-free rats . Biochem. J. , 130 : 1161 – 1162 .
   PubMed Web of Science ®Google Scholar
• Guzmán-Gutiérrez , S. L. and Navarrete , A. 2009 . Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers . Planta Med. , 75 : 295 – 301 .
   PubMed Web of Science ®Google Scholar
• Hackett , A. M. , Marsh , I. , Barrow , A. and Griffiths , L. A. 1979 . The biliary excretion of flavanones in the rat . Xenobiotica , 9 : 491 – 501 .
   PubMed Web of Science ®Google Scholar
• Kawaguchi , K. , Kikuchi , S. , Hasunuma , R. , Maruyama , H. , Yoshikawa , T. and Kumazawa , Y. 2004 . A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice . Biol. Pharm. Bull. , 27 : 679 – 683 .
   PubMed Web of Science ®Google Scholar
• Kim , Y. S. , Kim , J. J. , Cho , K. H. , Jung , W. S. , Moon , S. K. , Park , E. K. and Kim , D. H. 2008 . Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells . J. Microbiol. Biotechnol. , 18 : 1109 – 1114 .
   PubMed Web of Science ®Google Scholar
• King , L. C. , Kohan , M. J. , George , S. E. , Lewtas , J. and Claxton , L. D. 1990 . Metabolism of 1-nitropyrene by human, rat, and mouse intestinal flora: Mutagenicity of isolated metabolites by direct analysis of HPLC fractions with a microsuspension reverse mutation assay . J. Toxicol. Environ. Health , 31 : 179 – 192 .
   PubMed Web of Science ®Google Scholar
• Lee , D. S. , Kim , Y. S. , Ko , C. N. , Cho , K. H. , Bae , H. S. , Lee , K. S. , Kim , J. J. , Park , E. K. and Kim , D. H. 2002 . Fecal metabolic activities of herbal components to bioactive compounds . Arch. Pharm. Res. , 25 : 165 – 169 .
   PubMedGoogle Scholar
• Loscalzo , L. M. , Wasowski , C. , Paladini , A. C. and Marder , M. 2008 . Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines . Eur. J. Pharmacol. , 580 : 306 – 313 .
   PubMed Web of Science ®Google Scholar
• Manach , C. , Morand , C. , Gil-Izquierdo , A. , Bouteloup-Demange , C. and Remesy , C. 2003 . Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice . Eur. J. Clin. Nutr. , 57 : 235 – 242 .
   PubMed Web of Science ®Google Scholar
• Manning , B. W. , Cerniglia , C. E. and Federle , T. W. 1986 . Biotransformation of 1-nitropyrene to 1-aminopyrene and N-formyl-1-aminopyrene by the human intestinal microbiota . J. Toxicol. Environ. Health , 18 : 339 – 346 .
   PubMed Web of Science ®Google Scholar
• Matsumoto , H. , Ikoma , Y. , Sugiura , M. , Yano , M. and Hasegawa , Y. 2004 . Identification and quantification of the conjugated metabolites derived from orally administred hesperidin in rat plasma . J. Agric. Food Chem. , 52 : 6653 – 6659 .
   PubMed Web of Science ®Google Scholar
• Monforte , M. T. , Trovato , A. , Kirjavainen , S. , Forestieri , A. M. , Galati , E. M. and Lo Curto , R. B. 1995 . Biological effects of hesperidin, a Citrus flavonoid. (Note II): Hypolipidemic activity on experimental hypercholesterolemia in rat . Farmacologie , 50 : 595 – 599 .
   PubMedGoogle Scholar
• Morehead , M. C. , Franklin , W. , Fu , P. P. , Evans , F. E. , Heinze , T. M. and Cerniglia , C. E. 1994 . Metabolism of 7-nitrobenz[a]anthracene by intestinal microflora . J. Toxicol. Environ. Health , 43 : 369 – 380 .
   PubMed Web of Science ®Google Scholar
• Nielsen , S. E. , Breinholt , V. , Justesen , U. , Cornett , C. and Dragsted , L. O. 1998 . In vitro biotransformation of flavonoids by rat liver microsomes . Xenobiotica , 28 : 389 – 401 .
   PubMed Web of Science ®Google Scholar
• Ohtsuki , K. , Abe , A. and Mitsuzumi , H. 2003 . Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature . J. Nutr. Sci. Vitaminol. , 49 : 447 – 450 .
   PubMed Web of Science ®Google Scholar
• Park , S. H. , Park , E. K. and Kim , D. H. 2005 . Passive cutaneous anaphylaxis-inhibitory activity of flavanones from citrus unshiu and Poncirus trifoliata . Planta Med. , 71 : 24 – 27 .
   PubMed Web of Science ®Google Scholar
• Richardson , K. E. , Fu , P. P. and Cerniglia , C. E. 1988 . Metabolism of 1-, 3-, and 6-nitrobenzo[a]pyrene by intestinal microflora . J. Toxicol. Environ. Health , 23 : 527 – 537 .
   PubMed Web of Science ®Google Scholar
• Walle , T. 2004 . Absorption and metabolism of flavonoids . Free Radical Biol. Med. , 36 : 829 – 837 .
   PubMed Web of Science ®Google Scholar