Chronic Carcinogenicity Study of Gasoline Vapor Condensate (GVC) and GVC Containing Methyl Tertiary-Butyl Ether in F344 Rats

REFERENCES

• Ahmed , F. E. 2001 . Toxicology and human health effects following exposure to oxygenated or reformulated gasoline . Toxicol. Lett. , 123 : 89 – 113 .
   PubMed Web of Science ®Google Scholar
• Baetcke , K. P. , Hard , G. C. , Rodgers , I. S. , McGaughy , R. E. and Tahan , L. M. 1991 . Alpha 2u-globulin: Association with chemically induced renal toxicity and neoplasia in the male rat , Washington , DC : U.S. Environmental Protection Agency . EPA/625/3-91/019F, Risk Assessment Forum
   Google Scholar
• Belpoggi , F. , Soffritti , M. and Mattoni , C. 1995 . Methyl-tertiary-butyl-ether (MTBE)—A gasoline additive causes testicular and lymphomaematopoietic cancers in rats . Toxicol. Ind. Health , 11 : 119 – 149 .
   PubMed Web of Science ®Google Scholar
• Bird , M. G. , Burleigh-Flayer , H. D. , Chun , J. S. , Douglas , J. F. , Kneiss , J. J. and Andrews , L. S. 1997 . Oncogenicity studies of inhaled methyl-tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats . J. Appl. Toxicol. , 17 : S45 – S55 .
   PubMedGoogle Scholar
• Boorman , G. A. , Eustis , S. L. , Elwell , M. R. and Leininger , J. R. , eds. 1990a . Pathology of the Fischer rat , San Diego , CA : Academic Press .
   Google Scholar
• Boorman , G. A. , Wilson , J. T. , van Zwieten , M. J. and Eutis , S. L. 1990b . “ Mammary gland ” . In Pathology of the Fischer rat , Edited by: Boorman , G. A. , Eustis , S. L. , Elwell , M. R. and Leininger , J. R. 295 – 314 . San Diego , CA : Academic Press .
   Google Scholar
• Boorman, G. A., Chapin, R. E., and Mitsumori, K. 1990c. Testis and epididymis. In Pathology of the Fischer rat, eds. G. A. Boorman, S. L. Eustis, M. R. Elwell, and J. R. Leininger, pp. 405–418. San Diego, CA: Academic Press. http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr79_main 02. tpl (http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr79_main 02. tpl)
   Google Scholar
• Boorman, G. A., Morgan, K. T., and Uriah, L. C. 1990d. Nose, larynx, and trachea. In Pathology of the Fischer rat, eds. G. A. Boorman, S. L. Eustis, M. R. Elwell, and J. R. Leininger, pp. 315–338. San Diego, CA: Academic Press. http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr79_main 02. tpl (http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr79_main 02. tpl)
   Google Scholar
• Clayton Environmental Consultants . 1993 . Gasoline vapor exposure assessment at service stations , Washington , DC : API . American Petroleum Institute (API) publication 4553
   Google Scholar
• Cook , J. C. , Klinefelter , G. R. , Hardisty , J. F. , Sharpe , R. M. and Foster , P. M. 1999 . Rodent leydig cell tumorigenesis: A review of the physiology, pathology, mechanisms, and relevance to humans . Crit. Rev. Toxicol. , 29 : 169 – 261 .
   PubMed Web of Science ®Google Scholar
• Cruzan , G. , Borghoff , S. J. , dePeyster , A. , Hard , G. C. , McClain , M. , McGregor , D. G. and Thomas , M. G. 2007 . Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents . Regul. Toxicol. Pharmacol. , 47 : 156 – 165 .
   PubMed Web of Science ®Google Scholar
• Daughtrey , W. C. , Burnett , D. M. , Podhasky , P. , Henely , M. and White , R. D. 2004 . Inhalation toxicity of gasoline and fuel oxygenates: Test sample preparation . Toxicologist , 781-S : 146
   Google Scholar
• Doi , A. M. , Hill , G. , Seely , J. , Hailey , J. R. , Kissling , G. and Bucher , J. R. 2007 . α2u-Globulin nephropathy and renal tumors in National Toxicology Program studies . Toxicol. Pathol. , 35 : 533 – 540 .
   PubMed Web of Science ®Google Scholar
• ExxonMobil Biomedical Sciences, Inc . 2009 . Gasoline vapor condensate characterization , Annandale , NJ : ExxonMobil Biomedical Sciences, Inc . Study Number 167490
   Google Scholar
• Gopinath , C. , Prentice , D. E. and Lewis , D. J. 1987 . Atlas of experimental toxicological pathology , Edited by: Gresham , G. A. Norwell , MA : MTP Press Limited .
   Google Scholar
• Halder , C. A. , Van Gorp , G. S. , Hatoum , N. S. and Warne , T. M. 1986 . Gasoline vapor exposures. Part I. Characterization of workplace exposures . Am. Ind. Hyg. Assoc. J. , 47 : 164 – 172 .
   PubMedGoogle Scholar
• Hall , W. C. 1990 . “ Peritoneum, retroperitoneum, mesentery, and abdominal cavity ” . In Pathology of the Fischer rat , Edited by: Boorman , G. A. , Eustis , S. L. , Elwell , M. R. and Leininger , J. R. 63 – 69 . San Diego , CA : Academic Press .
   Google Scholar
• Hard , G. C. 1998 . Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent . Toxicol. Pathol. , 26 : 104 – 112 .
   PubMed Web of Science ®Google Scholar
• Hard , G. C. and Khan , K. N. 2004 . A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment . Toxicol. Pathol. , 32 : 171 – 180 .
   PubMed Web of Science ®Google Scholar
• Haseman , J. K. , Arnold , J. and Eustis , S. L. 1990 . “ Tumor incidences in Fischer 344 rats: NTP historical data ” . In Pathology of the Fischer rat , Edited by: Boorman , G. A. , Eustis , S. L. , Elwell , M. R. and Leininger , J. R. 555 – 564 . San Diego , CA : Academic Press .
   Google Scholar
• Health Effects Institute . 1996 . The potential health effects of oxygenates added to gasoline: A review of the current literature , Cambridge , MA : Health Effects Institute . A special report of the Institute's Oxygenates Evaluation Committee
   Google Scholar
• Health Effects Institute . 2001 . Metabolism of ether oxygenates added to gasoline , Cambridge , MA : Health Effects Institute . Research report 102
   Google Scholar
• MacFarland , H. N. , Ulrich , C. E. , Holdsworth , C. E. , Ketchen , D. N. , Halliwell , W. H. and Blum , S. C. 1984 . A chronic inhalation study with unleaded gasoline vapor . J. Am. Coll. Toxicol. , 3 : 231 – 248 .
   Google Scholar
• Mennear , J. H. 1997 . Carcinogenicity studies on MTBE: Critical review and interpretation . Risk Anal. , 17 : 673 – 681 .
   PubMed Web of Science ®Google Scholar
• National Toxicology Program. 1999. Toxicology Data Managment System Historicla Control Tumor Incidence Summary http://ntp-server.niehs.nih.gov/ntp/research/database_searches/historical_controls/path/r_inhar.txt (http://ntp-server.niehs.nih.gov/ntp/research/database_searches/historical_controls/path/r_inhar.txt)
   Google Scholar
• Prentice , D. E. and Meikle , A. W. 1995 . A review of drug-induced leydig cell hyperplasia and neoplasia in the rat and some comparisons with man . Hum. Exp. Toxicol. , 14 : 562 – 572 .
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency. 24 CFR 79, Subpart F. Protection of the environment; Registration of fuels and fuel additives. http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr79_main 02. tpl (http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr79_main 02. tpl)
   Google Scholar
• U.S. Environmental Protection Agency. 40 CFR 79.58(c) . Protection of the environment; Registration of fuels and fuel additives. ,
   Google Scholar
• U.S. Environmental Protection Agency. 40 CFR 79.60 . Good Laboratory Practice (GLP) standards for inhalation exposure health effects testing. ,
   Google Scholar
• U.S. Environmental Protection Agency . 1991 . “ Alpha 2-microglobulin: Association with chemically induced renal toxicity and neoplasia in the mail rat ” . In Risk assessment forum , 85 Washington , DC : U.S. Government Printing Office .
   Google Scholar
• U.S. Environmental Protection Agency . 1998 . Risk assessment forum. Assessment of thyroid follicular cell tumors , Washington , DC : U.S. EPA . EPA/630/R-97/002
   Google Scholar