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Original Articles

Immune-Regulatory Transcriptional Responses in Multiple Organs of Atlantic Salmon After Tributyltin Exposure, Alone or in Combination with Forskolin

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Pages 478-493 | Published online: 09 Mar 2011

REFERENCES

  • Akhurst , R. J. and Derynck , R. 2001 . TGF-beta signaling in cancer—A double-edged sword . Trends Cell Biol. , 11 : S44 – S51 .
  • Allner , B. , von der Gonna , S. , Griebeler , E. M. , Nikutowski , N. , Weltin , A. and Stahlschmidt-Allner , P. 2010 . Reproductive functions of wild fish as bioindicators of reproductive toxicants in the aquatic environment . Environ. Sci. Pollut. Res. , 17 : 505 – 518 .
  • Arukwe , A. 2005 . Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory (StAR) protein and cholesterol side chain cleavage (P450scc) in juvenile Atlantic salmon (Salmo salar) is a novel aspect of nonylphenol toxicity . Environ. Sci. Technol. , 39 : 9791 – 9798 .
  • Atkins , C. M. , Oliva , A. A. , Alonso , O. F. , Pearse , D. D. , Bramlett , H. M. and Dietrich , W. D. 2007 . Modulation of the cAMP signaling pathway after traumatic brain injury . Exp. Neurol. , 208 : 145 – 158 .
  • Bartee , E. , Mohamed , M. R. and GMcFadden , G. 2008 . Tumor necrosis factor and interferon: cytokines in harmony . Curr. Opin. Microbiol. , 11 : 378 – 383 .
  • Bazzigher , L. , Pavlovic , J. , Haller , O. and Staeheli , P. 1992 . Mx genes show weaker primary response to virus than other interferon-regulated genes . Virology , 186 : 154 – 160 .
  • Belkowski , S. M. , Rubin , C. S. and Prystowsky , M. B. 1998 . Isolation and analysis of a T cell clone variant exhibiting constitutively phosphorylated Ser(133) cAMP response element-binding protein . J. Immunol. , 161 : 659 – 665 .
  • Berge , J. A. , Brevik , E. M. , Bjorge , A. , Folsvik , N. , Gabrielsen , G. W. and Wolkers , H. 2004 . Organotins in marine mammals and seabirds from Norwegian territory . J. Environ. Monitor. , 6 : 108 – 112 .
  • Birchenough , A. C. , Barnes , N. , Evans , S. M. , Hinz , H. , Kronke , I. and Moss , C. 2002 . A review and assessment of tributyltin contamination in the North Sea, based on surveys of butyltin tissue burdens and imposex/intersex in four species of neogastropods . Mar. Pollut. Bull. , 44 : 534 – 543 .
  • Campbell , B. K. , Souza , C. J. H. , Skinner , A. J. , Webb , R. and Baird , D. T. 2006 . Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2,-4, and -6 . Endocrinology , 147 : 1608 – 1620 .
  • Carfi , M. , Croera , C. , Ferrario , D. , Campi , V. , Bowe , G. , Pieters , R. and Gribaldo , L. 2008 . TBTC induces adipocyte differentiation in human bone marrow long term culture . Toxicology , 249 : 11 – 18 .
  • Chen , T. C. , Hinton , D. R. , Zidovetzki , R. and Hofman , F. M. 1998 . Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas . Lab. Invest. , 78 : 165 – 174 .
  • Chesik , D. , Wilczak , N. and De Keyser , J. 2008 . IGF-1 regulates cAMP levels in astrocytes through a beta2-adrenergic receptor-dependant mechanism . Int. J. Med. Sci. , 5 : 240 – 243 .
  • Clark , R. 1997 . The somatogenic hormones and insulin-like growth factor-1: Stimulators of lymphopoiesis and immune function . Endocr. Rev. , 18 : 157 – 179 .
  • Corsini , E. , Terzoli , A. , Bruccoleri , A. , Marinovich , M. and Galli , C. L. 1997 . Induction of tumor necrosis factor-alpha in vivo by a skin irritant, tributyltin, through activation of transcription factors: Its pharmacological modulation by anti-inflammatory drugs . J. Invest. Dermatol. , 108 : 892 – 896 .
  • Cuesta , A. , Meseguer , J. and Esteban , M. A. 2008 . Effects of the organochlorines p,p′-DDE and lindane on gilthead seabream leucocyte immune parameters and gene expression . Fish Shellfish Immunol. , 25 : 682 – 688 .
  • Dinarello , C. A. 1996 . Biologic basis for interleukin-1 in disease . Blood , 87 : 2095 – 2147 .
  • Duan , C. M. 1998 . Nutritional and developmental regulation of insulin-like growth factors in fish . J. Nutr. , 128 : 306S – 314S .
  • Dudimah , F. D. , Odman-Ghazi , S. O. , Hatcher , F. and Whalen , M. M. 2007 . Effect of tributyltin (TBT) on ATP levels in human natural killer (NK) cells: Relationship to TBT-induced decreases in NK function . J. Appl. Toxicol. , 27 : 86 – 94 .
  • Eder , K. J. , Clifford , M. A. , Hedrick , R. P. , Kohler , H. R. and Werner , I. 2008 . Expression of immune-regulatory genes in juvenile Chinook salmon following exposure to pesticides and infectious hematopoietic necrosis virus (IHNV) . Fish Shellfish Immunol. , 25 : 508 – 516 .
  • Eder , K. J. , Leutenegger , C. M. , Wilson , B. W. and Werner , I. 2004 . Molecular and cellular biomarker responses to pesticide exposure in juvenile chinook salmon (Oncorhynchus tshawytscha) . Mar. Environ. Res. , 58 : 809 – 813 .
  • Ekerbicer , N. , Inan , S. , Tarakci , F. and Zeren , T. 2009 . The effects of DBcAMP on the expression of eNOS, iNOS and TGF-beta in rat heart tissue . Biotech. Histochem. , 84 : 47 – 54 .
  • Ellis , D. V. and Pattisina , L. A. 1990 . Widespread neogastropod imposex - a biological indicator of global Tbt contamination . Mar. Pollut. Bull. , 21 : 248 – 253 .
  • Frouin , H. , Lebeuf , M. , Saint-Louis , R. , Hammill , M. , Pelletier , E. and M. Fournier , M. 2008 . Toxic effects of tributyltin and its metabolites on harbour seal (Phoca vitulina) immune cells in vitro . Aquat. Toxicol. , 90 : 243 – 251 .
  • Ghoneum , M. , Hussein , A. E. , Gill , G. and Alfred , L. J. 1990 . Suppression of murine natural-killer-cell activity by tributyltin—In vivo and in vitro assessment . Environ. Res. , 52 : 178 – 186 .
  • Gipperth , L. 2009 . The legal design of the international and European Union ban on tributyltin antifouling paint: Direct and indirect effects . J. Environ. Manage. , 90 : S86 – S95 .
  • Grivennikov , S. I. , Greten , F. R. and Karin , M. 2010 . Immunity, inflammation, and cancer . Cell , 140 : 883 – 899 .
  • Haddad , J. J. and Fahlman , C. S. 2002 . Redox- and oxidant-mediated regulation of interleukin-10: An anti-inflammatory, antioxidant cytokine? . Biochem. Biophys. Res. Commun. , 297 : 163 – 176 .
  • Hammerman , M. R. 1999 . The growth hormone-insulin-like growth factor axis in kidney re-revisited . Nephrol. Dialysis Transplant. , 14 : 1853 – 1860 .
  • Harford , A. J. , O'Halloran , K. and Wright , P. F. A. 2007 . Effect of in vitro and in vivo organotin exposures on the immune functions of murray cod (Maccullochella peelii peelii) . Environ. Toxicol. Chem. , 26 : 1649 – 1656 .
  • Hasko , G. and Cronstein , B. N. 2004 . Adenosine: An endogenous regulator of innate immunity . Trends Immunol. , 25 : 33 – 39 .
  • Hasko , G. , Szabo , C. , Nemeth , Z. H. , Kvetan , V. , Pastores , S. M. and Vizi , E. S. 1996 . Adenosine receptor agonists differentially regulate IL-10, TNF-alpha and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice . J. Immunol. , 157 : 4634 – 4640 .
  • Heemskerk , V. H. , Daemen , M. and Buurman , W. A. 1999 . Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation . Cytokine Growth Factor Rev. , 10 : 5 – 14 .
  • Holzinger , D. , Jorns , C. , Stertz , S. , Boisson-Dupuis , S. , Thimme , R. , Weidmann , M. , Casanova , J. L. , Haller , O. and Kochs , G. 2007 . Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling . J. Virol. , 81 : 7776 – 7785 .
  • Hong , S. , Zou , J. , Crampe , M. , Peddie , S. , Scapigliati , G. , Bols , N. , Cunningham , C. and Secombes , C. J. 2001 . The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta . Vet. Immunol. Immunopathol. , 81 : 1 – 14 .
  • Horiguchi , T. , Shiraishi , H. , Shimizu , M. and Morita , M. 1994 . Imposex and organotin compounds in Thais clavigera and T. Bronni in Japan . J. Mar. Biol. Ass. UK , 74 : 651 – 669 .
  • Ingerslev , H. C. , Cunningham , C. and Wergeland , H. I. 2006 . Cloning and expression of TNF-alpha, IL-1 beta and COX-2 in an anadromous and landlocked strain of Atlantic salmon (Salmo salar L.) during the smolting period . Fish Shellfish Immunol. , 20 : 450 – 461 .
  • Iwamura , C. , Aihara , M. , Nakazawa , M. , Takahashi , K. , Yoshioka , N. , Matsukura , S. , Hirasawa , T. , Minami , M. and Ikezawa , Z. 2006 . Effects of tributyltin on the development of atopic dermatitis-like eruptions in DS-Nh mice . Int. Arch. Allergy Immunol. , 141 : 337 – 345 .
  • Jang , S. I. , Hardie , L. J. and Secombes , C. J. 1994 . Effects of transforming growth-factor beta(1) on rainbow-trout Oncorhynchus-mykiss macrophage respiratory burst activity . Dev. Comp. Immunol. , 18 : 315 – 323 .
  • Kagawa , H. , en , K. , Okuzawa , K. and Tanaka , H. 2003 . Effects of luteinizing hormone and follicle-stimulating hormone and insulin-like growth factor-I on aromatase activity and P450 aromatase gene expression in the ovarian follicles of red seabream . Pagrus major. Biol. Reprod. , 68 : 1562 – 568 .
  • Kagawa , H. , Kobayashi , M. , Hasegawa , Y. and Aida , K. 1994 . Insulin and insulin-like growth-factor-I and growth-factor-II induce final maturation of oocytes of red seabream, Pagrus major, in vitro . Gen. Comp. Endocrinol. , 95 : 293 – 300 .
  • Kajiwara , N. , Niimi , S. , Watanabe, Ito , M., Y. , Takahashi , S. , Tanabe , S. , Khuraskin , L. S. and Miyazaki , N. 2002 . Organochlorine and organotin compounds in Caspian seals (Phoca caspica) collected during an unusual mortality event in the Caspian Sea in 2000 . Environ. Pollut. , 117 : 391 – 402 .
  • Kannan , K. , Guruge , K. S. , Thomas , N. J. , Tanabe , S. and Giesy , J. P. 1998 . Butyltin residues in southern sea otters (Enhydra lutris nereis) found dead along California coastal waters . Environ. Sci. Technol. , 32 : 1169 – 1175 .
  • Kato , T. , Tada-Oikawa , S. , Takahashi , K. , Saito , K. , Wang , L. , Nishio , A. , Hakamada-Taguchi , R. , Kawanishi , S. and Kuribayashi , K. 2006 . Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation . Eur. J. Immunol. , 36 : 1199 – 1209 .
  • Kato , T. , Uchikawa , R. , Yamada , M. , Arizono , N. , Oikawa , S. , Kawanishi , S. , Nishio , A. , Nakase , H. and Uribayashi , K. 2004 . Environmental pollutant tributyltin promotes Th2 polarization and exacerbates airway inflammation . Eur. J. Immunol. , 34 : 1312 – 1321 .
  • Kergosien , D. H. and Rice , C. D. 1998 . Macrophage secretory function is enhanced by low doses of tributyltin-oxide (TBTO), but not tributyltin-chloride (TBTCl) . Arch. Environ. Contam. Toxicol. , 34 : 223 – 228 .
  • Lane , R. , Ghazi , S. O. and Whalen , M. M. 2009 . Increases in cytosolic calcium ion levels in human natural killer cells in response to butyltin exposure . Arch. Environ. Contam. Toxicol. , 57 : 816 – 825 .
  • Lappas , C. M. , Sullivan , G. W. and Linden , J. 2005 . Adenosine A(2A) agonists in development for the treatment of inflammation . Expert Opin. Invest. Drugs , 14 : 797 – 806 .
  • Lehmann , J. M. , McKee , D. D. , Watson , M. A. , Willson , T. M. , Moore , J. T. and Kliewer , S. A. 1998 . The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions . J. Clin. Invest. , 102 : 1016 – 1023 .
  • Leong , J. A. C. , Trobridge , G. D. , Kim , C. H. Y. , Johnson , M. and Simon , B. 1998 . Interferon-inducible Mx proteins in fish . Immunol. Rev. , 166 : 349 – 363 .
  • Liu , Y. R. , Ye , W. L. , Zeng , X. M. , Ren , W. H. , Zhang , Y. Q. and Mei , Y. A. 2008 . K+ channels and the cAMP-PKA pathway modulate TGF-beta 1-incluced migration of rat vascular myofibroblasts . J. Cell. Physiol. , 216 : 835 – 843 .
  • Lokman , P. M. , George , K. A. N. , Divers , S. L. , Algie , M. and Young , G. 2007 . 11-Ketotestosterone and IGF-1 increase the size of previtellogenic oocytes from shortfinned eel, Anguilla australis, in vitro . Reproduction , 133 : 955 – 967 .
  • Lorenz , J. J. , Furdon , P. J. , Taylor , J. D. , Verghese , M. W. , Chandra , G. , Kost , T. A. , Haneline , S. A. , Roner , L. A. and Gray , J. G. 1995 . A cyclic adenosine-3′,5′-monophosphate signal is required for the induction of Il-1-beta by Tnf-alpha in human monocytes . J. Immunol. , 155 : 836 – 844 .
  • Lv , X. F. , Zhou , Q. F. , Luo , W. R. , Cao , D. D. , Jiang , G. B. and Deng , Y. L. 2009 . Interacting effects of tributyltin and 17 beta-estradiol in male Chinese loach (Misgumus anguillicaudatus) . Environ. Toxicol. , 24 : 531 – 537 .
  • Maestro , M. A. , Planas , J. V. , Moriyama , S. , Gutierrez , J. , Planas , J. and Swanson , P. 1997 . Ovarian receptors for insulin and insulin-like growth factor I (IGF-I) and effects of IGF-I on steroid production by isolated follicular layers of the preovulatory coho salmon ovarian follicle . Gen. Comp. Endocrinol. , 10 : 189 – 201 .
  • Misumi , I. , Yada , T. , Leong , J. A. C. and Schreck , C. B. 2009 . The effect of in vitro exposure to tributyltin on the immune competence of chinook salmon (Oncorhynchus tshawytscha) leukocytes . Arch. Environ. Contam. Toxicol. , 56 : 229 – 237 .
  • Moses , H. L. and Serra , R. 1996 . Regulation of differentiation by TGF-beta . Curr. Opin. Genet. Dev. , 6 : 581 – 586 .
  • Nakata , H. , Sakakibara , A. , Kanoh , M. , Kudo , S. , Watanabe , H. , Nagai , N. , Miyazaki , N. , Asano , Y. and Tanabe , S. 2002 . Evaluation of mitogen-induced responses in marine mammal and human lymphocytes by in-vitro exposure of butyltins and non-ortho coplanar PCBs . Environ. Pollut. , : 120245 – 253 .
  • Naviglio , S. , Spina , A. , Marra , M. , Sorrentino , A. , Chiosi , E. , Romano , M. , Improta , S. , Budillon , A. , Illiano , G. , Abbruzzese , A. and Caraglia , M. 2007 . Adenylate cyclase/cAMP pathway downmodulation counteracts apoptosis induced by IFN-alpha in human epidermoid cancer cells . J. Interferon Cytokine Res. , 27 : 129 – 136 .
  • Negatu , Z. , Hsiao , S. M. and Wallace , R. A. 1998 . Effects of insulin-like growth factor-I on final oocyte maturation and steroid production in Fundulus heteroclitus . Fish Physiol. Biochem. , 19 : 13 – 21 .
  • Noble , P. W. , Lake , F. R. , Henson , P. M. and Riches , D. W. H. 1993 . Hyaluronate activation of Cd44 induces insulin-like growth factor-I expression by a tumor-necrosis-factor-alpha dependent mechanism in murine macrophages . J. Clin. Invest. , 91 : 2368 – 2377 .
  • Nygaard , R. , Husgard , S. , Sommer , A. I. , Leong , J. A. C. and Robertsen , B. 2000 . Induction of Mx protein by interferon and double-stranded RNA in salmonid cells . Fish Shellfish Immunol. , 10 : 435 – 450 .
  • Ohta , Y. , Nakagawa , K. , Imai , Y. , Katagiri , T. , Koike , T. and Takaoka , K. 2008 . Cyclic AMP enhances smad-mediated BMP signaling through PKA-CREB pathway . J. Bone Mineral Metab. , 26 : 478 – 484 .
  • Ohtaki , K. , Aihara , M. , Takahashi , H. , Fujita , H. , Takahashi , K. , Funabashi , T. , Hirasawa , T. and Ikezawa , Z. 2007 . Effects of tributyltin on the emotional behavior of C57BL/6 mice and the development of atopic dermatitis-like lesions in DS-Nh mice . J. Dermatol. Sci. , 47 : 209 – 216 .
  • Parrizas , M. , Saltiel , A. R. and LeRoith , D. 1997 . Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways . J. Biol. Chem. , 272 : 154 – 161 .
  • Pavlikova , N. , Kortner , T. M. and Arukwe , A. 2010 . Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin . Chem. Biol. Interact. , 185 : 119 – 127 .
  • Pitossi , F. , Blank , A. , Schroder , A. , Schwarz , A. , Hussi , P. , Schwemmle , M. , Pavlovic , J. and Staeheli , P. 1993 . A functional Gtp-binding motif is necessary for antiviral activity of Mx proteins . J. Virol. , 67 : 6726 – 6732 .
  • Petersen , S. and Gustavson , K. 2000 . Direct toxic effects of TBT on natural enclosed phytoplankton at ambient TBT concentrations of coastal waters . Ecotoxicology , 9 : 273 – 285 .
  • Presti , R. M. , Popkin , D. L. , Connick , M. , Paetzold , S. and Virgin , H. W. 2001 . Novel cell type-specific antiviral mechanism of interferon gamma action in macrophages . J. Exp. Med. , 193 : 483 – 496 .
  • Randelli , E. , Buonocore , F. and Scapigliati , G. 2008 . Cell markers and determinants in fish immunology . Fish Shellfish Immunol. , 25 : 326 – 340 .
  • Rotchell , J. M. and Ostrander , G. K. 2003 . Molecular markers of endocrine disruption in aquatic organisms . J. Toxicol. Environ. Health B , 6 : 453 – 495 .
  • Secombes , C. J. , Bird , S. , Cunningham , C. and Zou , J. 1999 . Interleukin-1 in fish . Fish Shellfish Immunol. , 9 : 335 – 343 .
  • Shah , Y. M. , Ma , X. C. , Morimura , K. , Kim , I. and Gonzalez , F. J. 2007 . Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappa B target gene expression . Am. J. Physiol. Gastrointestinal Liver Physiol. , 292 : G1114 – G1122 .
  • Snoeij , N. J. , Punt , P. M. , Penninks , A. H. and Seinen , W. 1986 . Effects of tri-normal-butyltin chloride on energy metabolism, macromolecular synthesis, precursor uptake and cyclic-AMP production in isolated rat thymocytes . Biochim. Biophys. Acta , 852 : 234 – 243 .
  • Sommer , N. , Loschmann , P. A. , Northoff , G. H. , Weller , M. , Steinbrecher , A. , Steinbach , J. P. , Lichtenfels , R. , Meyermann , R. , Riethmuller , A. , Fontana , A. , Dichgans , J. and Martin , R. 1995 . The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis . Nat. Med. , 1 : 244 – 248 .
  • Strand , J. and acobsen , J. A. 2005 . Accumulation and trophic transfer of organotins in a marine food web from the Danish coastal waters . Sci. Total Environ. , 350 : 72 – 85 .
  • Takahashi , S. , Le , L. T. H. , Saeki , H. , Nakatani , N. , Tanabe , S. , Miyazaki , N. and Fujise , Y. 2000 . Accumulation of butyltin compounds and total tin in marine mammals . Water Sci. Technol. , 42 : 97 – 108 .
  • Tomiyama , K. , Yamaguchi , A. , Kuriyama , T. and Arakawa , Y. 2009 . Analysis of mechanisms of cell death of T-lymphocytes induced by organotin agents . J. Immunotoxicol. , 6 : 184 – 193 .
  • van Buul-Offers , S. C. and Kooijman , R. 1998 . The role of growth hormone and insulin-like growth factors in the immune system . Cell. Mol. Life Sci. , 54 : 1083 – 1094 .
  • Wajant , H. , Pfizenmaier , K. and Scheurich , P. 2003 . Tumor necrosis factor signaling . Cell Death Different. , 10 : 45 – 65 .
  • Webb , J. G. , Tan , Y. , Jaffa , M. A. and Jaffa , A. A. 2010 . Evidence for prostacyclin and cAMP upregulation by bradykinin and insulin-like growth factor 1 in vascular smooth muscle cells . J. Receptors Signal Transduct. , 30 : 61 – 71 .
  • Weber , G. M. and Sullivan , C. V. 2000 . Effects of insulin-like growth factor-I on in vitro final oocyte maturation and ovarian steroidogenesis in striped bass . Morone saxatilis. Biol. Reproduct. , 63 : 1049 – 1057 .
  • Weber , G. M. and Sullivan , C. V. 2005 . Insulin-like growth factor-1 induces oocyte maturational competence but not meiotic resumption in white bass (Morone chrysops) follicles in vitro: Evidence for rapid evolution of insulin-like growth factor action . Biol. Reproduct. , 72 : 1177 – 1186 .
  • Whalen , M. M. , Ghazi , S. , Loganathan , B. G. and Hatcher , F. 2002a . Expression of CD16, CD18 and CD56 in tributyltin-exposed human natural killer cells . Chem. Biol. Interact. , 139 : 159 – 176 .
  • Whalen , M. M. and Green , C. B. 1998 . Lysis-sensitive targets stimulate an elevation of cAMP in human natural killer cells . Immunology , 93 : 415 – 420 .
  • Whalen , M. M. , Green , S. A. and Loganathan , B. G. 2002b . Brief butyltin exposure induces irreversible inhibition of the cytotoxic function on human natural killer cells, in vitro . Environ. Res. , 88 : 19 – 29 .
  • Whalen , M. M. and Loganathan , B. G. 2001 . Butyltin exposure causes a rapid decrease in cyclic AMP levels in human lymphocytes . Toxicol. Appl. Pharmacol. , 171 : 141 – 148 .
  • Wilson , S. , Dzon , L. , Reed , A. , Pruitt , M. and Whalen , M. M. 2004 . Effects of in vitro exposure to low levels of organotin and carbarnate pesticides on human natural killer cell cytotoxic function . Environ. Toxicol. , 19 : 554 – 563 .
  • Xing , D. M. and Bonanno , J. A. 2009 . Effect of cAMP on TGF beta 1-induced corneal keratocyte-myofibroblast transformation . Invest. Ophthalmol. Visual Sci. , 50 : 626 – 633 .
  • Zidek , Z. 1999 . Adenosine-cyclic AMP pathways and cytokine expression . Eur. Cytokine Network , 10 : 319 – 328 .
  • Zhou , C. , Tabb , M. M. , Nelson , E. L. , Grun , F. , Verma , S. , Sadatrafiei , A. , Lin , M. , Mallick , S. , Forman , B. M. , Thummel , K. E. and Blumberg , B. 2006 . Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation . J. Clin. Invest. , 116 : 2280 – 2289 .

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